CHEMISTRY-A EUROPEAN JOURNAL
·
2016
·Vol. 23
·期 16
·3850-3862
·
IF 5.771
Tuan-Wei Sun,Ying-Jie Zhu,Feng Chen
Graphical Highly flexible multifunctional biopaper with superior mechanical properties, comprising chitosan and high-weight-fraction ultralong hydroxyapatite nanowires (UHANWs/CS) is reported. This material is promising for various biomedical applications such as wound dressing, bone-fracture fixation, and bone-defect repair. Highly flexible multifunctional biopaper comprising ultralong hydroxyapatite nanowires and chitosan (UHANWs/CS), with high weight fractions of ultralong hydroxyapatite nanowires (UHANWs) up to 100 wt. %, is reported. The as-prepared UHANWs/CS composite biopaper has high flexibility and superior mechanical properties even when the weight fraction of UHANWs is as high as 90 wt. %. In contrast, the control samples consisting of hydroxyapatite nanorods and chitosan (HANRs/CS) with weight fractions of HANRs higher than 66.7 wt.% cannot be obtained in the form of the flexible membrane. The ultimate tensile strength and Young's modulus of the UHANWs/CS composite biopaper are about 3.2 times and 4.3 times those of the HANRs/CS membrane with the same weight fraction of HAP, respectively. In addition, the UHANWs/CS composite biopaper (90 wt. % UHANWs) can be used for color printing using a commercial ink-jet printer. The surface wettability, swelling ratio, and water vapor transmission rate of the UHANWs/CS composite biopaper are adjustable by changing the addition amount of UHANWs. In vitro experiments indicate that the UHANWs/CS composite biopaper has good degradability, high acellular bioactivity and high biocompatibility. The as-prepared UHANWs/CS composite biopaper is therefore promising for various biomedical applications such as wound dressing, bone-fracture fixation, and bone-defect repair.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
Biomaterials Science
·
2019
·Vol. 7
·期 12
·5044-5053
·
IF 5.251
Zi-Fei Zhou,Tuan-Wei Sun,Yun-Hao Qin,Ying-Jie Zhu,Ying-Ying Jiang,Yang Zhang,Jun-Jian Liu,Jin Wu,Shi-Sheng He,Feng Chen
One-dimensional hydroxyapatite (HA) particularly mimics the structure of mineralized collagen fibrils and displays superior mechanical properties such as toughness. Herein, we report Se-doped HA/chitosan (Se-HA/CS) biopapers constructed with self-assembled Se-doped HA nanowires and chitosan. The Se-HA/CS biopapers with high flexibility and manufacturability can not only be further processed into arbitrary shapes by folding or using scissors but also display high performances in in vitro/vivo anti-bone tumor studies. The Se-HA/CS biopapers are more inclined to inhibit the growth of tumor cells (HCS 2/8 and SJSA cells) than that of normal human bone marrow stromal cells (hBMSCs). The potential mechanisms of this meaningful anti-tumor effect were investigated, such as reactive oxygen species accumulation and the activation of apoptosis and the underlying signal pathway involved (including caspase family, Bcl-2 family and JNK/STAT3). The results demonstrate that Se-HA/CS biopapers may inhibit the growth of HCS 2/8 and SJSA cells by synchronously inducing JNK activation and STAT3 inhibition and consequently promote the apoptosis of these cells. Furthermore, the in vivo anti-tumor studies confirm that the Se-HA/CS biopapers obviously suppress the growth of patient-derived xenograft tumor models.
研究领域:
材料科学
·
生物材料
·
肿瘤学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
Chemistry-An Asian Journal
·
2017
·Vol. 12
·期 6
·655-664
·
IF 4.083
Tuan-Wei Sun,Ying-Jie Zhu,Feng Chen,Yong-Gang Zhang
Graphical A perfectly good paper : A composite biopaper made of ultralong hydroxyapatite nanowires (UHANWs) and collagen (Col) exhibits high flexibility, superior mechanical properties, high cytocompatibility, and excellent cellular attachment performance as compared with the pure collagen and hydroxyapatite nanorods/Col membranes, and is promising for applications in various biomedical fields such as guided bone regeneration. Highly flexible hydroxyapatite/collagen (HAP/Col) composite membranes are regarded to be significant for guided bone regeneration application owing to their similar chemical composition to that of natural bone, excellent bioactivity and good osteoconductivity. However, the mechanical strength of the HAP/Col composite membranes is usually weak, which leads to difficult surgical operations and low mechanical stability during the bone healing process. Herein, highly flexible ultralong hydroxyapatite nanowires/collagen (UHANWs/Col) composite biopaper sheets with weight fractions of UHANWs ranging from 0 to 100 % are facilely synthesized. The UHANWs are able to weave with each other to construct a three-dimensional fabric structure in the collagen matrix, providing a strong interaction between UHANWs and an intermolecular force between UHANWs and the collagen matrix. The as-prepared UHANWs/Col composite biopaper exhibits improved mechanical properties and high flexibility. More importantly, the as-prepared highly flexible 70 wt % UHANWs/Col composite biopaper exhibits an excellent cytocompatibility and outstanding cellular attachment performance as compared with the pure collagen and 70 wt % HAP nanorods/Col membranes. In consideration of its superior mechanical properties and outstanding cellular attachment performance, the as-prepared UHANWs/Col composite biopaper is promising for applications in various biomedical fields such as guided bone regeneration.
研究领域:
生物医学材料
·
组织工程
✓ 已验证
DOI
PubMed
高影响因子
MOLECULES
·
2025
·Vol. 30
·期 5
·996
·
IF 4.6
Yu Zhang,Ying-Jie Zhu,Si-Yi Li,Li-Ying Dong,Han-Ping Yu
With an ultrahigh aspect ratio and a similar chemical composition to the biomineral in bone and tooth, ultralong hydroxyapatite nanowires (UHAPNWs) exhibit a meritorious combination of high flexibility, excellent mechanical performance, high biocompatibility, and bioactivity. Despite these exciting merits, the rapid and green synthesis of UHAPNWs remains challenging. In this work, we have developed an environment-friendly, rapid, and highly efficient synthesis of ultrathin UHAPNWs by the microwave-assisted calcium oleate precursor hydrothermal method using biogenic creatine phosphate as the bio-phosphorus source. Owing to the controllable hydrolysis of bio-phosphorus-containing creatine phosphate and the highly efficient heating of microwave irradiation, ultrathin UHAPNWs with a homogeneous morphology of several nanometers in diameter (single nanowire), several hundred micrometers in length, and ultrahigh aspect ratios (>10,000) can be rapidly synthesized within 60 min. This effectively shortens the synthesis time by about two orders of magnitude compared with the traditional hydrothermal method. Furthermore, ultrathin UHAPNWs are decorated in situ with bioactive creatine and self-assembled into nanowire bundles along their longitudinal direction at the nanoscale. In addition, ultrathin UHAPNWs exhibit a relatively high specific surface area of 84.30 m2g–1and high ibuprofen drug loading capacity. The flexible bio-paper constructed from interwoven ibuprofen-loaded ultrathin UHAPNWs can sustainably deliver ibuprofen in phosphate-buffered saline, which is promising for various biomedical applications such as tissue regeneration with anti-inflammatory and analgesic functions.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Junkai Zeng,Xiangwu Geng,Yifan Tang,Zhi-Chao Xiong,Ying-Jie Zhu,Xiongsheng Chen
Cutaneous wounds accompanied by bacterial infections and impaired angiogenesis might be lethal and remain a challenging issue in clinical fields, causing an urgent need for the multifunctional wound dressings with effective disinfection and wound tissue regenerative abilities. Herein, we report a flexible photothermal biopaper (named BP/HAP:Cu 2+ ) with the integration of two-dimensional photothermal-capable black phosphorus nanosheets (BPNSs) and one-dimensional antibacterial Cu 2+ -doped ultralong hydroxyapaptite (HAP:Cu 2+ ) nanowires for accelerated healing of the infected wound. The as-prepared BP/HAP:Cu 2+ biopaper exhibits the stable porous networked structure, high porosity, good biocompatibility, superior photothermal conversion ability and antibacterial function. The photothermal effect generated by BPNSs conjugated with the sustained release of Cu 2+ ions can damage the bacterial membrane and enhance glutathione oxidation, achieving a synergistic high antibacterial efficiency on Staphylococcus aureus of 97.0%. Moreover, the BP/HAP:Cu 2+ biopaper can effectively promote in vitro angiogenesis of human umbilical vein endothelial cells. Results of animal experiments further reveal that the BP/HAP:Cu 2+ biopaper as the wound dressing under near infrared laser irradiation significantly enhances the wound healing by simultaneously eliminating bacteria and accelerating angiogenesis. Taken together, the BP/HAP:Cu 2+ photothermal biopaper has a promising therapeutic potential for rapid healing of infected wounds.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
·
伤口愈合
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）