Biocompatibility and osteointegration of implants are highly desired in orthopedic and dentistry applications. The synthesis of a coating with ideal biocompatibility and osteogenic effect carries practical significance for improving the bio-inertness of pure Ti implants. Metal–organic frameworks (MOFs) are effective surface modification agents in bone regeneration applications. Bio-MOF-1, a classic type of biofriendly MOF with a bio-derived constitution, possesses biocompatibility and osteogenic potential resulting from its Zn core and adenine ligand. In this study, bio-MOF-1 coatings at multiple concentrations were synthesized on alkali-heat treated Ti, and their cytocompatibility and osteogenic properties were systematically examined both in vitro and in vivo. Coatings were characterized to confirm the successful synthesis of bio-MOF-1 coatings. These coatings exhibited advanced thermostability, excellent biocompatibility, and stable Zn2+ release, which up-regulated the expression of osteogenesis-related genes and proteins. Furthermore, bio-MOF-1 coating of Ti implants enhanced early osseointegration at the bone–implant interface. This study demonstrates the promising potential of bio-MOF-1 coatings with the osteogenic effect for surface modification in bone tissue engineering.
Searching for the efficient and sustainable inhibitors to defend metal corrosion in the marine environment has received a great deal attention in both academia and industry. In this work, a new strategy was developed to encapsulate benzimidazole (BI) inhibitor guest molecules into the micropores of bio-MOF-1, which was constructed with the other natural adenine inhibitor. Electrochemical characterizations revealed that the slowly sustained release of BI and adenine inhibitors from the BI@bio-MOF-1 composite presented excellent anti-corrosion durability in the whole mild steel corrosion process. The impedance arc value attained approximately 5000 Ω·cm2 at initially 2 h and further increased to 6000 Ω·cm2 after 5 days immersion in 0.5 M NaCl solution, and the inhibition efficiency reached 85.36% due to the synergistic dual inhibitive effect of BI@bio-MOF-1 composite. The dual inhibition-based bio-MOF-1 composite equipped strong metal-chelating capability and response durability, exhibiting high potentiality for metal anti-corrosion applications.
危险品化学品经营许可证（带存储）