NEW JOURNAL OF CHEMISTRY
·
2013
·Vol. 37
·期 12
·3849-3852
·
IF 2.966
Jie Zhao,Yongqian Xu,Hongjuan Li,Aiping Lu,Shiguo Sun
A highly selective fluorescent probe for detection of hydrazine exhibiting good performance in a physiological environment has been developed over other closely related analytes. Furthermore, hydrazine in diluted human blood was tested and the method was applied in live cells.
研究领域:
生物化学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Denan Kong,Qunchao Zhang,Jun You,Yuanyuan Cheng,Cheng Hong,Zihe Chen,Tao Jiang,Tonghui Hao
Adhesion loss of hydrocolloid wound dressings is ubiquitous clinical problem, which seriously reduces the therapeutic efficiency and patient experience. In order to address this problem, the clarification on adhesion loss mechanism and the development of effective alternatives of commercial hydrocolloid dressings are urgent and inevitable. Herein, adhesion loss mechanism of hydrocolloid dressings was investigated using sodium carboxymethyl cellulose (CMC)-filled hydrocolloid dressings exposing to physiological environment as model. The adhesion mechanism and contact angle tests were combined to obtain surface energy of dressings. The results indicated that the dissolution, swelling and exudation of CMC occurred successively (concentration reached 1.607 g/L after 10 h). The effused CMC led to the dramatic increase in surface energy (from 14.5–80.7 mN/m) and adhesion loss appeared. This work explored the origin of adhesion loss of hydrocolloid wound dressings and might promote the designing of hydrocolloid dressings with both excellent humidity control and sustained self-adhesiveness.
研究领域:
医学材料学
·
伤口护理
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 26
·1-21
·
IF 2.8
Duan Mengqi,Zheng Haotian,Yan Yongjie,Sun Jiaxiao,Ni Qi,Ni Qingqing
Graphene membrane have insufficient mechanical and electrical properties due to their weak interlayer bonding and unstable interfacial structure. This constrains their applications in flexible sensors and functional electronic devices. To address the problem, a flexible graphene oxide membrane (GOM) were prepared using a solvent-evaporation method for reinforced interfacial mechanical and electrical properties. Their intrinsic interfacial structure was subsequently optimized through a combination of hydriodic acid thermal reduction and densification processing. The findings reveal that the reduced graphene oxide films, which were subjected to hydriodic acid reduction at 60 °C (rGOM@60) and subsequent moderate densification, exhibited markedly enhanced mechanical strength and electrical conductivity. Remarkably, the tensile strength reached 23.6 MPa, while the electrical conductivity increased to 149 S/cm. The optimized membrane demonstrated excellent long-term electrical stability in the simulated physiological conditions. The membrane showed the resistivity fluctuations less than 8% after continuous powering in saline for 96 h, minor resistivity fluctuations after 13 bending cycles, and minimal fragmentation after ball-milling. What is more, the membrane exhibited favorable biocompatibility, which was evidenced by a contact angle of 79.4° and cell viability comparable to the control group. The flexible graphene films hold promising applications, such as in the fields of biosensors and functional electronic devices.
研究领域:
材料科学
·
纳米科技
·
生物医学工程
·
柔性电子学
·
功能材料
·
生物传感器
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Guodong Liu,Faxing Zou,Wei He,Junfei Li,Yajie Xie,Mengjiao Ma,Yudong Zheng
Bacterial cellulose (BC) has good network structure, biocompatibility, and excellent mechanical properties, and is widely used in the field of biomaterials. The controllable degradation of BC can further broaden its application. Oxidative modification and cellulases may endow BC with degradability, but these methods inevitably lead to the obvious reduction of its initial mechanical properties and uncontrolled degradation. In this paper, the controllable degradation of BC was realized for the first time by using a new controlled release structure that combines the immobilization and release of cellulase. The immobilized enzyme has higher stability and is gradually released in the simulated physiological environment, and its load can control the hydrolysis rate of BC well. Furthermore, the BC-based membrane prepared by this method retains the favorable physicochemical performance of the original BC, including flexibility and great biocompatibility, and holds good application prospects in drug control release or tissue repair.
研究领域:
生物医学工程
·
材料科学
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2024
·
IF 5.8
Rui Ding,Pandi Peng,Jingjing Huo,Kun Wang,Pengxiang Liu,Hanxue Wu,Likun Yan,Peng Li
Polypropylene (PP) mesh is widely used in hernioplasty, but it is prone to contamination by pathogenic bacteria. Here, we present an infection microenvironment-responsive metal–phenolic network (MPN) coating, which is made up of Cu2+ and tannic acid (TA) (referred to as CT coating), and is fabricated on PP meshes by layer-by-layer (LbL) assembly. The CT coating provided a robust protection for the PP mesh from pathogenic bacterial infection in a pH-responsive manner due to the pH-responsive disassembly kinetics of MPN complexes. Moreover, the PP meshes with ten CT coating cycles (PP-CT(10)) exhibited excellent stability in a physiological environment, with the killing ratio against “superbug” methicillin-resistant Staphylococcus aureus (MRSA) at pH 5.5 exceeding 99% even after 28 days of PBS (pH 7.4) immersion. In addition, the PP-CT(10) exhibited excellent in vivo anti-infective ability in a rodent subcutaneous implant MRSA infection model, and the results of histological and immunohistochemical analyses demonstrated that the reduced bacterial number alleviated the inflammatory response at implant sites. This study revealed that MPN coating is a promising strategy, which could provide a self-defensive ability for various implants to combat post-surgical infections in a pH-responsive manner.
研究领域:
材料科学
·
生物医学工程
·
生物材料
·
传染病
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Soft Matter
·
2022
·Vol. 18
·期 33
·6192-6199
·
IF 4.046
Shuyang Wang,Jieru Li,Yudong Pan,Fengkai Liu,Liangsong Zeng,Yang Gao,Tongqing Lu
Achieving tough and stable tissue adhesion under a physiological environment is of great significance for the clinical applications of hydrogel adhesives. The current tough hydrogel adhesives face challenges in the preservation of the maximal adhesion for a long time due to swelling. Here, we propose a double-network strategy for tough tissue adhesion by a hydrogel with long-term stability under a physiological environment. A double-network hydrogel consisting of a covalently crosslinked primary network with tunable hydrophilicity and a non-covalently crosslinked secondary network with functional groups is designed. The primary network exhibited hydrophobicity in the physiological environment, which could constrict the secondary network and limit the swelling of the entire hydrogel. The secondary network could form strong interlinks with tissue and provide large energy dissipation through the unzipping of its noncovalent crosslinks when separated by a force. The combination of the two networks resulted in a tough and stable tissue adhesion. A poly(N-isopropylacrylamide)/calcium alginate hydrogel synthesized based on this strategy realized an adhesion energy of 300–500 J m−2 with porcine tissues, and the maximal adhesion could be maintained for over 1000 min after submerging in a PBS solution at 37 °C. The swelling behavior of the hydrogel and changes in mechanical properties under the physiological environment are studied, and its application in repairing the aorta wound is demonstrated.
研究领域:
材料科学
·
生物医学工程
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2018
·
IF 6.042
Shan-Shan Li,Qing-Ying Kong,Miao Zhang,Fan Yang,Bin Kang,Jing-Juan Xu,Hong-Yuan Chen
The small absorption cross sections of most molecules led to the low sensitivity of traditional optical absorption spectroscopy. This obstacle might be overcome by applying the near-field plasmon resonance energy transfer (PRET) between plasmonic nanoparticle and surrounding molecules. In this work, we utilized PRET-based spectroscopy on single gold nanostars to study the specific biomolecule recognition and enzyme kinetics choosing biotin-SA pair and DNase I as models. By analyzing the changes of absorption spectra for black hole quencher 3 (BHQ3), derived from spectra difference, we explored the kinetics of specific biomolecule recognition and enzyme digestion in different physiological environment, and we found that the viscosities of media and the sizes of molecules play vital role in biomolecular recognition and enzyme digestion. Compared with the traditional optical absorption spectroscopy techniques, PRET-based spectroscopy offers a nanoscopic resolution owing to the small size of the probe, is more sensitive and achieves detection on the order of hundreds or even dozens of molecules, and can achieve high selectivity due to the specific biomolecular recognition. This method might be used in the fields of molecular diagnostics, drug discovery, cell systems, and clinical diagnostics.
研究领域:
纳米技术
·
生物物理学
·
生物化学
·
分析化学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）