Small
·
2025
·Vol. 21
·期 33
·2504201
·
IF 12.1
Keding Chen,Xiaolong Shi,Yanghuan Shen,Bin Gou,Li Yang,Yingdong Li,Jin Gong,Yu Wang,Jingchao Chai,Yun Zheng,Wei Zhang,Zhihong Liu
The narrow electrochemical stability window (ESW) and poor thermal stability of poly(1,3-dioxolane) (PDOL) solid polymer electrolyte severely restrict its application. In this study, poly(1,3-dioxolane) dimethacrylate (PDOL-DMA) is designed and synthesized to replace the unstable terminal hydroxyl groups with unsaturated C═C double bond. The cross-linked quasi-solid electrolyte (CPDOL-DMA QSE) demonstrates a wide ESW of 4.5 V versus Li + /Li and a high Li + transference number of 0.64. This crosslinked network facilitates lithium salt dissociation, weakens Li + -polymer interactions, and achieves the reversibility of lithium metal anode disolution/deposition. For CPDOL-DMA QSE, capacity retention is 83% after the 400th cycle at 25 °C. Moreover, it can perform stable cycling with 82% retention after 200 cycles at an elevated temperature of 80 °C. Due to the high oxygen content of the repeating units in CPDOL-DMA, microcalorimetry and accelerated calorimetry results further confirm the high safety of the CPDOL-DMA QSE. This work provides insights into the design of polyether polymer electrolytes with high oxygen contents, realizing thermo-electrochemical stability in lithium metal batteries.
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ACS Applied Bio Materials
·
2024
·
IF 4.6
Xinxin Luo,Haifeng Ni,Jie Lu,Jie Feng,Xiaozhou Mou,Jing Zhang
Cancer has become a highly prevalent disease and poses serious threats to human health. Conventional cancer treatments still face high risks of recurrence. Training the immune system to recognize and eliminate tumors via external stimulation, such as vaccines, emerges as a promising approach for cancer prevention and treatment. However, injectable vaccines may have limited immune activation, causing difficulties in maintaining long-term immune surveillance of tumorigenesis by tumor-specific cytotoxic T cells. Here, degradable zwitterionic cryogels were prepared using the cryogelation technique. The cryogenic preparation maintained the biological activities of tumor antigens and immune adjuvants loaded in the cryogels. The macroporous structure endowed the injectability of cryogels into the body via conventional syringes. In the presence of proteases, the cryogels degraded, allowing sustained release of antigens and adjuvants, ensuring continued dendritic cell (DC) recruitment and antigen presentation to maturing tumor-specific cytotoxic T cells. In vivo experiments demonstrated that the cryogel cancer vaccines elicited robust immune activation and effectively modulated tumor microenvironments. The combination with photothermal therapy significantly inhibited tumor growth, showing great potential for preventing postoperative recurrence. Additionally, the zwitterionic cryogels were biocompatible without obvious toxicities during degradation. The cryogels could serve as effective vaccine platforms to prevent cancer recurrence after surgery.
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ACS Applied Polymer Materials
·
2026
·Vol. 8
·期 14
·11602-11617
·
IF 5.2
Xu Yue,Du Yanwei,Liang Jingshi,Ding Xiaochu,Zhang Chunling,Zhang Zhihui,Liu Bo
Endogenous signaling molecules are essential for coordinated
wound
healing, yet current donor-based dressings typically provide only
single-mediator delivery with limited release duration. Here, a multifunctional
hydrogel dressing, HEVCTM, is developed by free radical copolymerization
of N -hydroxyethyl acrylamide (HEAA) with a hydrogen
peroxide (H 2 O 2 ) releasing donor (VIM-CAT) and
a hydrogen sulfide (H 2 S) releasing donor (TBA-MA). The
hydrogel enables temporally programmed release, with rapid H 2 O 2 delivery within 24 h for early stage antibacterial
action and sustained H 2 S release for up to 7 days to alleviate
inflammation and promote angiogenesis during later healing stages.
HEVCTM exhibits potent antibacterial activity against Escherichia coli (99.6%) and Staphylococcus aureus (99.97%), significantly enhances macrophage
M2 polarization (52.4%), and shows favorable antioxidant, hemostatic,
adhesive, and pro-angiogenic properties. Moreover, in an infected
mouse wound model, HEVCTM significantly accelerated wound healing
and promoted tissue regeneration. This work provides a bioactive hydrogel
platform that matches the dynamic requirements of wound healing and
effectively accelerates tissue repair.
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JOURNAL OF MEDICINAL CHEMISTRY
·
2026
·
IF 7.3
Yang Liuxin,Cheng Yiyu,Qin Si,Jiang Jun,Zhong Shiyi,Bi Xinyue,Xu Jiali,Wang Kai,Qiu Shuang,Li Xiang
Cellular resilience to therapy often arises from adaptive
mechanisms
that safeguard iron–sulfur (Fe–S) proteins. Here, we
present a rational strategy to overcome such resilience by integrating
two synergistic vulnerabilities, copper toxicity and Fe–S cluster
homeostasis, into a single molecular scaffold. Inspired by a bacterial
sulfur mobilization (SUF) inhibitor, we hybridized its core structure
with a copper-transporting 8-hydroxyquinoline moiety to generate HDQ , HDQ-S , HDQ-Ph , and HDQ-Me . They coordinate copper via hydroxyquinoline and efficiently transport
copper into cancer cells, with HDQ-Me achieving an efficacy
comparable to that of the clinical copper ionophore elesclomol ( ES ). Strikingly, HDQ alone suppresses Fe–S
proteins across multiple functions, including respiration, iron homeostasis,
and DNA replication. HDQ -mediated copper loading triggers
cuproptosis hallmarks, DNA damage, and ATP collapse, generating a
synergistic lethality. This work establishes HDQs as
bifunctional tools that cotarget copper and Fe–S protein homeostasis,
validating a convergent therapeutic strategy against resilient cells.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 2
·121733
·
IF 7.5
Qing Yang,Yanmei Deng,Shuangjiang Li,Xiliang Li,Tingyan Ye,Yi Liu,Yunfei Zhi,Shaoyun Shan
The conversion of CO 2 into cyclic carbonates is crucial for achieving carbon neutrality and enabling resource recycling. Developing efficient heterogeneous catalysts from renewable biomass is a key direction in green catalysis. This study designed a green and efficient heterogeneous catalyst (MCA-PIL) by acetylating bamboo-derived cellulose to construct a porous cellulose acetate support, followed by immobilization of 1-methyl-3-allylimidazolium bromide. The catalyst was systematically characterized using FTIR, XPS, solid-state 13 C NMR etc., which confirmed its chemical structure, hierarchical porosity, and thermal stability. Under optimized conditions (120 ℃, 1.5 MPa CO 2 , 8 h), MCA‑PIL achieved a 99 % yield of chloropropene carbonate from CO 2 and epichlorohydrin without solvent or co-catalyst. The catalyst exhibited broad substrate scope across various epoxides and maintained high activity over five consecutive cycles. Kinetic studies indicated first-order reaction kinetics with an apparent activation energy of 48.35 kJ·mol −1 . Experimental and density functional theory (DFT) analyses revealed a synergistic three-step mechanism: cooperative activation of the epoxide and CO 2 by surface hydroxyl groups and the imidazolium ring, followed by Br - -induced ring-opening, CO 2 insertion, and cyclization to form the product with concurrent catalyst regeneration. This work provides new design principles for biomass‑based catalysts and demonstrates a synergistic strategy integrating CO 2 valorization with renewable material development.
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ADVANCED MATERIALS
·
2026
·
IF 29.1
Yueyao Wang,Yuxiang Zhang,Shiqing Jia,Chun Feng,Xinfeng Tao,Binbin Xu,Shaoliang Lin
Nanosheet materials are tremendously attractive for their specific planar architecture and large surface area. However, fabricating nanosheet structures with morphological and functional control across spatial domains from the 2D to 3D scale remains a great challenge. Herein, we report a facile one-pot strategy for creating nanosheets with tunable geometries and multilevel hierarchies based on a liquid crystalline (LC) block copolymer. By finely tuning the assembly conditions, a variety of nanosheet morphologies were achieved, including multilayer leaf-like nanosheets (MLNs), multilayer rectangular nanosheets (MRNs), 3D stacked leaf-like nanosheets (SLNs), 3D stacked rectangular nanosheets (SRNs), and stacked flower-like nanosheets (SFNs). The formation of diverse nanosheet structures relies on LC ordering and the nucleation and growth tendencies of the copolymer. Particularly, we demonstrate that these hierarchical nanosheets are promising additives for polymer reinforcement. By mimicking biological reinforcing principles, SLNs integrating a large surface area with layered and anisotropic characteristics exhibit efficient toughening and strengthening effects through effective energy dissipation and crack deflection. This study not only offers a facile strategy for the design of nanosheet materials with precise control of their morphologies and dimensions but also provides new insight into using hierarchical nanosheet structures to achieve advanced polymer performance.
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COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2026
·
IF 8.2
Zeqi Zhang,Xiaoying Xu,Xue Bi,Wenchao Zhang,Rongjie Yang
In order to simultaneously enhance the flame retardancy and mechanical performance of vinyl ester resin (VER) and its carbon fiber composites (VER/CF), while maintaining the room temperature curing characteristics of VER, a nitrogen-containing phosphonium ionic liquid, P4447N[BMP], was synthetized through an ion-exchange process. P4447N[BMP] demonstrated excellent solubility in VER and did not interfere with its room temperature curing process. With the incorporation of 15 wt% P4447N[BMP], the limiting oxygen index (LOI) of the modified resin (P4447N[BMP]15/VER) and its carbon fiber composite (P4447N[BMP]15/VER/CF) increased to 27.7% and 36.4%, respectively. In addition, P4447N[BMP]15/VER and P4447N[BMP]15/VER/CF exhibited lower heat and smoke release during combustion than the unmodified systems. Mechanistic investigations indicated that the flame-retardant efficacy of P4447N[BMP] originated from its synergistic action in both the gaseous and condensed phases. Benefiting from the ionic bonds in P4447N[BMP] and its reactivity with both the resin matrix and the sizing agent on the carbon fiber surface, the incorporation of P4447N[BMP] markedly enhanced the mechanical properties of the cured resin and its carbon fiber composites. Specifically, the flexural moduli of P4447N[BMP]15/VER and P4447N[BMP]15/VER/CF exhibited increases of 22.2% and 41.0%, respectively. Moreover, P4447N[BMP] contributed to an increase of the glass transition temperature of both the cured resin and the corresponding carbon fiber composites. This work presents a viable route to engineer flame-resistant VER systems and corresponding carbon-fiber composites for advanced industrial applications.
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ACS Applied Polymer Materials
·
2026
·
IF 5.2
Liu Qin,Ding Yunshan,Wei Ping,Sun Hui
Viruses typically possess spike-like surface structures
that play
pivotal roles in their biological functions, including host cell invasion
and signal transduction. Despite the structural advantages of virus-like
architectures, the controlled fabrication of artificial virus-like
nanoparticles (VNPs) remains a significant challenge. Herein, a series
of amphiphilic glycopolymers are designed and synthesized to self-assemble
into VNPs with controlled tentacles on their surfaces. As the initial
concentration increases, the morphology of the assemblies gradually
evolves from spherical nanoparticles to virus-like nanostructures
with an increased number and length of the tentacles. The existence
of glucose moieties is crucial for driving this morphological transformation
owing to their strong hydrogen-bonding interactions and ultrahydrophilicity.
Monitoring the formation process of the VNPs, we found that spherical
nanoparticles were formed at the early stage of self-assembly. With
an increasing water content, the nanoparticles gradually deform and
develop surface wrinkles, followed by the emergence and elongation
of tentacles upon further water addition, leading to the formation
of VNPs, which exhibit morphology-promoted and glucose transporter
1-mediated endocytosis. These findings highlight the significance
of glycosyl groups in promoting the formation of VNPs and provide
fresh insights into the controlled preparation of artificial biomimetic
nanomaterials with precise structures and tailored functionalities.
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COMPOSITES PART B-ENGINEERING
·
2026
·
IF 14
Tongjun Yang,Rongli Li,Mingtao Ding,Lihua Zhang,Haibo Xie
The development of mechanically robust, antimicrobial, and UV-shielding poly(lactic acid) (PLA) film is highly desired as food packaging materials. Herein, aldehyde-functionalized chitin nanocrystals (ChNCs-PVMA) with immobilized AgNPs (Ag@ChNCs-PVMA), were prepared and applied as multi-functional biomass-based nanofillers for PLA. The surface-grafted poly(vanillin methacrylate) (PVMA) chains not only effectively improve the interfacial interaction between the nanocrystal and PLA, but also act as reductant and stabilizer for the in situ synthesis of AgNPs by the abundant aldehyde groups. The incorporation of Ag@ChNCs-PVMA nanofillers into PLA matrix displays reinforcing, antimicrobial, and UV-shielding functions. The PLA/Ag@ChNCs-PVMA-5 film achieves complete absorption of UVC (200-275 nm) and UVB (275-320 nm), and ∼90% absorption at the region of UVA (320-400 nm), while maintaining good transparency. Furthermore, the PLA/Ag@ChNCs-PVMA-5 film exhibit excellent antimicrobial activity against E. coli and S. aureus . These interesting results support the composite films to be applied in food packaging, demonstrating prolonged preservation time of strawberries.
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Journal of Macromolecular Science Part A-Pure and Applied Chemistry
·
2025
·
IF 2.4
Junyao Zhang,Hongwei Zhou,Kexuan Wang,Huihui Zheng,Ping Wu,Xilang Jin,Hanbin Liu
Conductive hydrogels with integrated high mechanical robustness and conductivity are increasingly explored in flexible electronic devices. Herein, ionically conductive hydrogels are designed by molecularly hybridizing hydrophilic polymers and hydrophobic polymers into one network. Formation of polymer network occurs among double bond end-capped polyethylene glycol (A-PEG-A), double bond end-capped polydimethylsiloxane (A-PDMS-A) and pentaerythritol tetra(3-mercaptopropionate) (PETMP) via an efficient thiol-ene click crosslinking process. PDMS helps to improve the mechanical properties of hydrogels and KCl is introduced as a conductive component. Compared with pure PEG hydrogel, the stretchability and tensile strength of molecularly hybridized conductive hydrogels (PEG-PDMS/K+ hydrogels) are increased by 9 times and 27 times, respectively. Utilizing PEG-PDMS/K+ hydrogels as key signal-converting materials, flexible mechanosensors, including resistive strain sensors, piezoresistive pressure sensors and capacitive pressure sensors, are fabricated and further demonstrated in monitoring various strains and pressures generated during joint bending, finger pressing, handwriting, water droplets dripping, etc. Overall, the molecularly hybridized conductive hydrogels are expected to provide a versatile molecular approach to functional hydrogels for future soft devices.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yiyang Kang,Yan Jiao,Han Song,Yinuo Wan,Hao Ning,Lixia Bao,Weibo Kong,Jiliang Wang
In nature, many plants and animals like aloe vera and snail rely on secreted mucus containing abundant hydrophilic polysaccharides, protein, and metal ions to maintain surface wettability and antibacterial properties. Inspired by this natural design, a biomimetic superhydrophilic polysaccharide based on lactic acid and maltotetraose, named PLM, was developed. Zinc acetate was introduced to construct a physical crosslinked network through the complexation between Zn 2+ and oxygen atoms, accompanied by an antibacterial effect on Escherichia coli and Staphylococcus aureus . PLM not only shows good spinnability, evidenced by a porous film with superior water absorption ability, but also can be used as a superhydrophilic coating on various substrates (e.g., polyethylene), with a minimal water contact angle of 5.68°. The strong affinity of PLM for water molecules that has been validated by Raman spectra and molecular dynamics simulations, along with nanoscale roughness, imparts great anti-fogging and anti-oil-fouling properties to coatings. Even after repeated heating-cooling cycles, tape adhesion, or mechanical friction, PLM coatings still present durable hydrophilicity, derived from the improved PLM intermolecular force and the adhesion of PLM to substrates by the dynamic crosslinked structure. The three-in-one multifunctional PLM reveals wide applicability and practicality in the fields of green coatings and films.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.5
Na Wang,Hanyu Ren,Tongtong Li,Chunhui Luo
Designing hydrogels with antibacterial, antifouling, lubricating, wet-adhesive, and highly mechanical properties is crucial for articular cartilage replacement. However, achieving such a combination remains a big challenge. To tackle this issue, a PCG matrix with a compressive strength of 42 MPa was prepared from polyvinyl alcohol, grape seed protein and chitosan via the multiple linkages (crystalline domains, hydrogen bonds, and ionic interactions). Next, the introduction of sulfobetaine methacrylate in the top layer endowed the hydrogel antifouling and lubricating performances. Subsequently, ciprofloxacin (CIP) was encapsulated via the self-assembly of soybean lecithin (SL) in water using the thin-film hydration method, followed by soaking the pre-hydrogel into the aqueous dispersion. Compared with PCG hydrogel, the antibacterial effects on E. coli and S. aureus were increased by 2250% and 1700% respectively. Meanwhile, the SPA gel achieved antibacterial rate of ~100% against both types of bacteria. In addition, the hydrophilic phosphatidylcholine groups of SL formed a boundary lubrication layer, reducing the coefficient of friction to 0.018. Finally, a gelatin-tannic acid adhesive layer was coated on the bottom to obtain the resultant SPA gel. The amino acids and polyphenol groups endowed the hydrogel with robust wet adhesion. Owing to the biocompatible materials and green process, the obtained SPA hydrogel had a cell viability of 96.7%, indicating excellent cytocompatibility. This biomimetic design successfully replicated the structures and performances of articular cartilages, making it promising for cartilage replacements.
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