CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Jiawei Du,Lu Zhang,Zhaohan Yu,Beibei Huang,Qikuan Cheng,Yunming Wang
The long-standing trilemma between damping performance, electrical insulation, and mechanical properties remains a fundamental constraint on the development of polymer piezoelectric damping composites due to the formation of continuous conductive networks. Herein, we introduce a yolk–shell filler architecture for polymer composites, which efficiently consumes mechanical energy by converting it first into electrical energy and subsequently into thermal energy. The polymer composites thus achieved an optimal balance: significantly enhanced damping performance (an 84% increase), excellent electrical insulation (volume resistivity of 10 8 Ω·m), and improved mechanical strength (a 7.07% increase). Through systematic comparative studies with other filler types, we further decoupled the individual contributions of material composition and structural design to the overall damping performance. Moreover, the yolk-shell particles exhibit broad compatibility across diverse polymer matrices, demonstrating strong potential for application in electronics, transportation, and other damping systems for vibration and impact mitigation.
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International Journal of Peptide Research and Therapeutics
·
2026
·Vol. 32
·期 5
·79
·
IF 2.5
Jia Wenbo,Chen Haodong,Yuan Libo,Duan Bingchao,Lv Mingxiu,Duan Qunpeng,Fang Yuan,Zhao Dongxin
Background Peptides are versatile building blocks for nanomaterials. Their self-assembled hydrogels feature tunable properties and good biocompatibility, enabling applications in cell culture, tissue engineering, and drug delivery. Peptide self-assembly arises from the synergy of multiple noncovalent interactions; among them, π–π stacking between aromatic residues is widely considered to be associated with ordered assembly in aromatic peptides. Methods Eight aromatic heptapeptides containing a “-Y-F-F-” motif were designed to examine how subtle variations in side-chain hydrophobicity correlate with self-assembly and gelation behaviors commonly attributed to aromatic stacking. Results Fluorescence and FT-IR results indicated that replacing Gly with the slightly bulkier and more hydrophobic Ala between two Phe residues is associated with more ordered networks, and only AA, GA, Fmoc-AA, and Fmoc-GA formed hydrogels under the tested conditions. And TEM/AFM and rheological measurements further revealed qualitative differences in nanofiber morphologies and sequence-dependent self-healing behavior among these gels. As a proof of concept, AA and GA gels exhibited low cytotoxicity, and their DOX-loaded gels displayed pH-responsive release. Notably, A-DOX showed a 66.91% higher cumulative release at pH 6.0 than at pH 7.4, leading to more sustained inhibition of HeLa cell proliferation compared with free DOX. Conclusion These results revealed that aromatic stacking together with an appropriate degree of hydrophobicity favors ordered peptide assembly, and that modest sequence changes can translate into distinct gel structures and drug-release functions.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2026
·
IF 4.6
Y. Yan,F.F. Huang,D.W. Wu,L. Li,N. Zhang,M.L. Huang
MPS-TGA synergy enables stable, controllable cyanide-free Au Sn co-deposition. • MPS selectively coordinates with Au + , while TGA coordinates with both Au + and Sn 2+ . • Au Sn co-deposition follows an irreversible, diffusion-controlled mechanism. • Baths remain stable for six months, consistently yielding reproducible Au Sn coatings. • Au Sn eutectic coating is mirror-bright, flat ( R a < 30 nm) and homogeneous after reflow. To replace toxic cyanide-based and unstable complex systems, a cyanide-free Au Sn electroplating bath using sodium 3-mercapto-1-propanesulfonate (MPS) and thioglycolic acid (TGA) as coordinating ligands, and the underlying co-deposition mechanism is systematically elucidated. The bath enables green processing, high bath stability (stable for six months) and superior coating quality. Electrochemical analyses reveal that MPS selectively coordinates with Au + , whereas TGA coordinates with both Au + and Sn 2+ , forming stable Au-MPS-TGA and Sn-TGA complexes. This synergistic coordination negatively shifts the deposition onset potentials of Au and Sn to −0.99 V and − 1.09 V (vs. SCE), respectively, narrowing their gap to 0.1 V and establishing the Au Sn co-deposition onset at −1.03 V (vs. SCE). Optimal concentration ratios are c (MPS): c (Au) = 8:1–12:1, c (SnCl 2 ): c (Au) = 3.0:1–4.0:1 and c (TGA): c (Au) = 8:1–10:1, under which Sn deposition is accelerated and the operating current density range is broadened to 2–6 ASD, yielding controllable and reproducible coating compositions (16.7–50.0 at.%Sn). The Au Sn co-deposition follows an irreversible, diffusion-controlled mechanism with a low activation energy ( E a ) of 9.50–27.36 kJ/mol, driven by sufficient overpotential to overcome the initial energy barrier for complex dissociation, thereby promoting fine-grained nucleation and growth. Consequently, the mirror-bright, flat Au Sn eutectic coating electroplated at 3 A/dm 2 (ASD) exhibits dense, uniform and residue-free deposits, which transform into a homogeneous eutectic microstructure after reflow. Download: Download high-res image (499KB) Download: Download full-size image
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ACS Omega
·
2026
·Vol. 11
·期 35
·53469-53476
·
IF 5.2
Lu Xin,Yuan Fangfang,Han Xiaojie,Qin Tingting,Wang Qianqian,Li Zengli,Ge Chuanjun,Shi Wenqing,Bai Haijiao,Wang Pei
Desmopressin, a synthetic
analog of vasopressin widely used in
the treatment of diabetes insipidus and bleeding disorders, is a representative
disulfide-containing peptide therapeutic prepared by Fmoc-based solid-phase
peptide synthesis (SPPS). Its unique sequence architecture, particularly
the spatial proximity between the N-terminal mercaptopropionic acid
residue Mpa(1) and the Tyr(2) residue, provides a distinct structural
environment for investigating sequence-dependent side reactions during
peptide manufacturing. The tert- butyl ( t- Bu) protecting group is widely employed for side-chain protection
in Fmoc-based solid-phase peptide synthesis (SPPS). However, under
certain reaction conditions, the highly reactive t- Bu + carbocation generated during acidic deprotection can
participate in nonspecific alkylation, leading to challenging process-related
impurities. In this study, we investigated a unique and highly site-selective
+56 Da impurity observed during side-chain deprotection. High-resolution
MS/MS analysis unambiguously identified this species as a site-selective
product arising from the migration of t- Bu from the
Tyr(2) side chain to the thiol group of Mpa(1). Based on the structural
features of desmopressin, in particular, the spatial proximity between
Tyr(2) and Mpa(1), we propose that the formation of this impurity
most plausibly proceeds via a vicinal-thiol-induced intramolecular
migration mechanism, which competes significantly with the conventional
diffusion-controlled carbocation intermediate intermolecular pathway.
Strengthening the scavenger conditions failed to eliminate this impurity,
further supporting the intramolecular migration mechanism induced
by vicinal thiol. This finding accounts for the observed site selectivity
that cannot be explained by the conventional carbocation intermediate
pathway alone. Guided by these mechanistic insights, we re-evaluated
the necessity of Tyr side-chain protection and proposed a “source-elimination”
strategy. Experimental validation demonstrated that the use of unprotected
Fmoc-Tyr-OH (free phenolic hydroxyl) completely suppressed the formation
of the t- Bu migration impurity and improved the crude
peptide purity to 93.5%. Overall, this study elucidates the formation
mechanism of t- Bu migration impurities and provides
a broadly applicable, mechanism-driven strategy for process optimization
in solid-phase peptide synthesis. While this study focuses on the
desmopressin system, the findings highlight a proximity-driven reactivity
pattern that may be relevant to other thiol-containing peptide sequences.
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BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
·
2025
·
IF 1.3
Zhai Zhenyu,Zhang Yi-Heng P Job
Formate oxidase (FOX) has applications in enzymatic assays, pollutant biodegradation, and bioorganic chemistry. However, its sources are few and none of them have significant activity above pH 7. We performed bioinformatic mining of FOX and identified 579 potential sequences. Two FOXs from Aspergillus nomiae (AnFOX) and Trichophyton rubrum (TrFOX) were expressed in E. coli. AnFOX had an alkalinity-tolerant pH activity range. It not only had a Km value for formate one order of magnitude lower, but also had far higher catalytic activity under non-acidic conditions. Spectroscopic and mass spectrometry analyses found that AnFOX contains an 8-formyl FAD cofactor. AnFOX enabled the H2O2-dependent sulfoxidation of thioanisole over pH 6-8. Structural analysis and kinetic studies revealed that the acidic residue E142, positioned on the surface adjacent to the isoalloxazine ring of flavin, could contribute to the unique pH preference. This novel FOX could greatly expand the applicability under non-acidic conditions.
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ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Lin Lin,Wei Han,Guang Li,Jingjing Zhang
The widespread adoption of composite solid electrolytes (CSEs) in solid-state lithium metal batteries has been significantly impeded by insufficient room-temperature ionic conductivity, primarily due to high energy barriers for Li-ion transport across ceramic/polymer interfaces. While interfacial modification has emerged as a key strategy, the structural and mechanistic principles governing efficient ion transport remain poorly understood. Here, we address this challenge through an innovative interface engineering approach, constructing a molecular bridge between Li7La3Zr2O12 nanofibers (LLZO NFs) and poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) using a 3-(methacryloyloxy)propyltrimethoxysilane (MPS) linker. This design achieves multiple synergistic effects: (1) robust chemical bonding enables uniform dispersion of ceramic nanofibers even at high loadings (60 wt %); (2) polar MPS moieties effectively adsorb and reorganize solvated species at the ceramic/polymer interface; and (3) optimized Li+ coordination via dual bonding configurations (Li···O═C with MPS and Li···F–C with PVDF-HFP) drastically reduces the interfacial energy barrier (−0.456 eV), creating continuous ion transport highways across the interface. Systematic investigation of the linker’s structure–property relationship reveals key design principles for interfacial chemistry. The resulting composite electrolyte (CLPH–OH) with 60 wt % of functionalized LLZO NFs delivers an exceptional ionic conductivity of 8.3 × 10–4 S cm–1 at room temperature. Remarkably, Li//CLPH–OH//Li symmetric cells achieve stable cycling for 2000 h at 0.1 mA cm–2, and LiFePO4 full cells retain 93.6% capacity after 300 cycles at 0.5 C. This study provides both fundamental insights into interfacial ion transport mechanisms and a strategy for designing high-performance solid-state electrolytes through precise molecular-level interface engineering.
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Sustainable Materials and Technologies
·
2026
·
IF 9.7
Qian Wang,Qiuchen Wang,Xuelin Zhang,Yuheng Zhang,Xinyue Chi,Weijian Yuan,Dianpeng Qi,Jianfeng Wu
Selective aerobic oxidation of thioethers to sulfoxides over efficient visible-light photocatalysts is an essential yet highly challenging transformation in catalytic oxidation chemistry. Herein, we introduce an asymmetric perylene diimide–based π-conjugated polymer (BCPDI) with intrinsic polarization that enhances charge transport and tunes the local microenvironment to efficiently regulate reactive oxygen species(ROS) generation for efficient thioether oxidation. DFT calculations show that symmetry breaking separates frontier orbitals and creates an internal electrostatic potential gradient, thereby accelerating charge carrier transport and driving O 2 reduction to generate superoxide radicals (·O 2 − ), whereas symmetric analogs produce only singlet oxygen ( 1 O 2 ) via energy transfer. Driven by the synergistic effect of electron and energy transfer pathways, BCPDI achieved over 99% conversion and selectivity for thioether oxidation under ambient conditions, outperforming most recently reported materials. In addition, BCPDI also exhibits a superior catalytic activity for thioether oxidation (e.g., aromatic thioethers, aliphatic sulfide, and Mustard Gas sulfide). This study provides a new approach for the design of catalysts for photocatalytic aerobic oxidation of thioethers and deepens the understanding of thioether activation mechanisms mediated by photogenerated charge carriers and reactive oxygen species.
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INORGANIC CHEMISTRY
·
2026
·
IF 4.6
Shuang Yu,Hui-Li Guo,Bo-Jun Yang,Mei Yang,Hui-Yuan Chen,Jing-Yu Pang,Dong-Bin Dang,Yan Bai
Polyoxovanadate (POV) clusters, with their diverse vanadium-oxo coordination modes, provide structurally well-defined inorganic nodes for constructing functional metal–organic frameworks (MOFs). In this work, four polyoxovanadate-based metal–organic frameworks [Co2(DPP)4(V4O12)]·0.25H2O (1), [M3(DPP)4(H2O)4(V6O18)]·2H2O (M = Co (2) and Ni (3)), and [Zn3(DPP)3(V6O18)] (4) (DPP = 1,3-Di(4-pyridyl)propane) were reported and structurally characterized by single-crystal X-ray diffraction. These materials feature distinct POV motifs, including cyclic {V4} units and extended {V3}/{V6} vanadium-oxo chains, providing well-defined coordination environments around the metal nodes. All four MOFs efficiently catalyzed the oxidation of aromatic thioethers using H2O2 with high selectivity for sulfoxide formation. Among them, compound 4 exhibited the highest activity and excellent recyclability over at least five cycles, consistent with its robust structural stability. Comparative catalytic and structural analyses suggest that the superior performance of 4 originates from the parallel and independent action of unsaturated V and Zn centers within its zigzag V–Zn chains. This study demonstrates that tuning POV building units and their coordination connectivity provides an effective strategy for controlling activity and selectivity in oxidation reactions.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2026
·
IF 4.6
Pan Xiao-Da,Song Yun-Kui,Sun Chong-Zhi,Yuan Chao-Yang,Zhu Zong-Min,Wang Jia-Ran,Yin Xian-Ze,Liu Hong-Tao,Liu Li,Zheng Long
Natural rubber (NR) latex is a renewable colloidal dispersion used in medical gloves, coatings, and flexible products. It is known for its excellent elasticity and film-forming ability but is limited by insufficient mechanical robustness and chemical resistance. Incorporating nanofillers, such as graphene oxide (GO), is an effective approach to enhance its performance; however, achieving strong interfacial compatibility between hydrophilic GO and the nonpolar rubber matrix remains challenging. To overcome this issue, a multifunctional interfacial design inspired by mussel adhesion chemistry was developed to construct a hierarchical and cohesive GO network within the NR latex matrix. A tannic acid-based modifier (TM) bearing catechol and thiol groups was synthesized and anchored onto latex particles via hydrogen bonding with surface proteins and phospholipids, enabling subsequent π – π interactions and hydrogen bonding with GO nanosheets. This guided the selective self-assembly of GO into a continuous segregated network along the latex particle boundaries. Hierarchical interface reinforcement was achieved through Eu 3+ ligand coordination. The incorporation of GO and enhancement of interfacial interactions promoted strain-induced crystallization, resulting in increased crystallinity and improved load transfer. The resulting composite film containing 0.5 part per hundred rubber GO and the bioinspired interface exhibited a tensile strength that was 107.8% higher than that of the pure NR latex film, while maintaining an elongation at break of 915%. Tear strength increased by 118.5%, toughness reached 61.7 MJ/m 3 , nitrogen permeability decreased by 20.1%, and antibacterial efficiency against both Escherichia coli and Staphylococcus aureus reached 99.9%. The films also exhibited enhanced resistance to organic solvents, acids, and alkalis. This study provides a green and scalable strategy for fabricating high-performance NR latex-based products suitable for medical, protective, and engineering applications.
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NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 47
·期 2
·828-837
·
IF 3.925
Tiantian Wan,Zulei Zhang,Hailong Wang,Yiwen Yang,Hanxing Yang,Jian Zhang,Yanbo Zeng,Lei Li,Jinchun Li
Chlorogenic acid (CGA), a cis-diol-containing compound, exhibits anti-inflammatory, antiviral, antimicrobial and anti-oxidation properties. Thus, selective determination of CGA in food products is extremely necessary. In this study, a boron affinity magnetic polymer named Fe3O4@SiO2@PIL was synthesized to detect the concentration of CGA in actual fruit samples. The Fe3O4@SiO2@PIL was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectroscopy, X-ray photoelectron spectroscopy (XPS) and thermogravimetric (TG) analysis. The results showed that the Fe3O4@SiO2@PIL has uniform morphology, good magnetic properties, suitable structure and high stability. The experimental assays showed that the Fe3O4@SiO2@PIL can detect the concentration of CGA within 7 min, and has a good linear relationship with CGA in the concentration range of 0.025–2 μM (R2 = 0.9989) with a detection limit of 10 nM (S/N = 3). Moreover, the Fe3O4@SiO2@PIL exhibited excellent selectivity and can be reused for at least 5 runs, indicating its good stability and reusability. Finally, the Fe3O4@SiO2@PIL was used to selectively separate CGA in real fruit samples with the recovery ranging from 93.4% to 103.0% and the relative standard deviation (RSD) between 0.7% and 5.1%. This study gives a new insight into the utilization of magnetic materials by grafting boric acid functionalized ionic liquids for specific and rapid detection of natural cis-diol-containing compounds.
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ENVIRONMENT INTERNATIONAL
·
2022
·
IF 13.352
Ruilong Li,Longji Zhu,Li Cui,Yong-Guan Zhu
Microplastics (MPs) have been considered as a new vector for the long-distance transport of pathogens in aquatic ecosystems. However, the composition of viral communities attached on MPs and their environmental risk are largely unknown. Here, we profiled the viral diversity and potential risk in five different MPs collected from the Beilun River based on metagenomic analysis. Nearly 2863 million raw reads were produced and assembled, and annotation resulted in the identification of 1719 different species of viruses in MPs. Viruses in polypropylene (PP) displayed the highest diversity, with about 250 specific viruses detected. Source tracking of viruses in MPs by the fast expectation–maximization microbial source tracking method (FEAST) demonstrated that viruses in upstream and downstream MPs are two major sources of viruses in estuary. Furthermore, the MP-type-dependent potential environmental risk of viruses was significant based on both antibiotic resistance genes (ARGs) and virulence factors (VFs) detected in viral metagenomes, and PP was confirmed with the highest potential environmental risk. This study reveals the high diversity and potential environmental risk of viruses in different MPs, and provides an important guidance for future environmental monitoring and understanding the potential risks associated with both viral transmission and MPs pollution.
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FOOD HYDROCOLLOIDS
·
2022
·
IF 11.504
Heng Du,Jun Liu,Boyuan Pan,Hong-Yan Yang,Guang-Bin Liu,Kui Lu
Peptide-based hydrogels were formed using low molecular weight peptides (LMWPs) derived from diphenylalanine as gelling agents. Sodium alginate (SA)was incorporated into the peptide skeleton to form a double-cross-linked hydrogel. The self-assembling mechanism was investigated by NMR, and the gelation behavior was studied by rheological tests. Hydrogen bonding and π-π stacking interactions play important roles in self-assembling of LMWPs. The rheological tests showed that the single-cross-linked hydrogel was formed by self-assembling AcNH-Thr-Phe-Phe-CONH 2 (AcTFFNH 2 , critical gelling concentration: 0.3 wt%), and the gelation temperature was in a range of 8–12 °C depending on the concentration of AcTFFNH2. The rigidity, stability and self-healing of the binary composite hydrogels were enhanced particularly when the content of AcTFFNH 2 and SA were 0.5 wt% and 0.3 wt%, respectively. Significant improvement of properties could be attributed to the double-cross-linking and enfolding in the assembled fibers with SA. These results indicate that peptide-based hydrogels formed by low molecular weight peptides have potential applications in the food industry.
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