JOURNAL OF APPLIED POLYMER SCIENCE
·
2012
·Vol. 125
·期 4
·2867-2873
·
IF 1.289
Yehai Yan,Na Lu,Jian Cui,Jinfang Zhang
A new fluorescent copolymer, poly(1-vinylimidazole- co -(1-pyrene) methyl 2-methyl-2-propenote) (VI- co -PyMMP), has been designed and synthesized by a free-radical copolymerization of VI and PyMMP as well as characterized using ultraviolet (UV), Fourier transform infrared spectroscopy (FTIR), 1 H NMR, and fluorescence spectroscopies. The monomer reactivity ratios are determined by two methods of Fineman-Ross ( r 1 = 0.28 ± 0.04 for VI, r 2 = 1.32 ± 0.11 for PyMMP) and Kelen-Tüdös ( r 1 = 0.23 ± 0.05, r 2 = 1.22 ± 0.12). Based on the reactivity ratios, the monomer sequence lengths and Q and e for PyMMP monomer are further calculated. The results suggest that the copolymerization of VI and PyMMP is a nonideal copolymerization without an azeotropic point (i.e., r 1 < 1, r 2 > 1 and r 1 r 2 < 1) and has a low alternation tendency. The conclusions drawn in this work may not only direct the later synthesis of the copolymers but also enrich the database of free-radical copolymerization. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
研究领域:
高分子化学
·
功能高分子
·
荧光材料
·
聚合物合成
·
材料化学
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Ruiwei Xu,Yi Zhang,Yingfeng Gao,Shuyu Jia,Seokho Choi,Yifan Xu,Jicheng Gong
DNA adducts are widely recognized as biomarkers of exposure to environmental carcinogens and associated health effects in toxicological and epidemiological studies. This study presents a targeted and sensitive method for comprehensive DNA adductome analysis using ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-QqQ-MS/MS). The method was developed using calf thymus DNA, with careful optimization of mass spectrometric parameters, chromatographic separation conditions, and pretreatment methods. Ultimately, a targeted method was established for 41 DNA adducts, which showed good linearity (R 2 ≥0.992), recovery (80.1–119.4 %), accuracy (81.3–117.8 %), and precision (relative standard deviation <14.2 %). The established method was employed to analyze DNA adducts in peripheral blood cells from pregnant women in Shanxi and Beijing. Up to 23 DNA adducts were successfully detected in samples of varying sizes. From 2 μg of maternal DNA samples, seven specific adducts were identified: 5-methyl-2'-deoxycytidine (5-MedC), 5-hydroxymethyl-2'-deoxycytidine (5-HmdC), N 6 -methyl-2'-deoxyadenosine (N 6 -MedA), 8-hydroxy-2'-deoxyguanosine (8-OHdG), 5-hydroxy-2'-deoxycytidine (5-OHdC), 1,N 6 -etheno-2'-deoxyadenosine (1,N 6 -εdA), and N 2 -methyl-2'-deoxyguanosine (N 2 -MedG). This study reveals that exposure to higher concentrations of ambient air pollutants may elevate the levels of DNA methylation and oxidative damage at different base sites, highlighting the application potential of DNA adducts as sensitive biomarkers of air pollution exposure.
研究领域:
环境健康
·
毒理学
·
流行病学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2025
·
IF 2.1
Hongyue Guo,Yifang Wu,Qingsong Li
To separate the azeotropic system of 2-methyl-2-butanol and water, the liquid–liquid equilibria (LLE) data of water + 2-methyl-2-butanol + solvents (anisole, isoamyl alcohol, 1-octanol, ethyl acetate, methyl isobutyl ketone) were obtained at 308.2 K under 101.3 kPa, and all systems are Treybal’s type II. The distribution coefficient and selectivity coefficient were used to evaluate the effect of extraction and separation of water and 2-methyl-2-butanol. Meanwhile, quantum chemical methods were used to analyze intermolecular interactions. Finally, the Non-random Two Liquids and UNIQUAC thermodynamic models were used to correlate the LLE data to obtain binary interaction parameters with the RMSD being less than 0.19%. Meanwhile, the consistency of regression parameters of NRTL and UNIQUAC models was verified by the GUI-MATLAB tool.
研究领域:
化学工程
·
物理化学
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DOI
高影响因子
iScience
·
2023
·
IF 5.8
Ye Zhao,Xueyong Yin,Yang Yu,Shihao Huang,Hao Feng,Shuang Wang,Yiming Cai,Ruofan Zhao,Shuai Gao,Ye Liu,Zhengxin Zhang,Xinyu Zhao,Ruonan Qiao,Jialin Yuan,Weichen Guan,Huiping Yang,Yun Shi,Haishui Shi
Huddling behavior, a typical social interaction among animals, has the benefits of obtaining social support and adapting environment. Huddling behavior is determined by social (social hierarchy), environmental factors (stress events), and the neuroendocrine system. Nevertheless, the huddling behavior of different social hierarchies and the underlying mechanisms have not been fully elucidated. In the present study, acute 2-methyl-2-thiazoline (2 MT) can induce huddling behavior and significantly increase serum levels of testosterone (T) in mice; and the increased T level was positively correlated with huddling behavior. Further, the T treatment significantly increased the huddling behavior in mice under 2 MT exposure condition. More interestingly, T can quickly promote dominant individuals to occupy safe positions when huddling together under predator odor. Collectively, T can rapidly regulate the individual's adaptive response to threats in a social rank-dependent manner, which provides a new perspective for the in-depth study of the influencing factors and underlying mechanisms of huddling behavior.
研究领域:
神经生物学
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内分泌学
·
行为学
✓ 已验证
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Yanying Hao,Anping Tian,Jin Zhu,Jinshi Fan,Yong Yang
5-Hydroxymethyl-2-furancarboxylic acid (HFCA), a promising biomonomer from renewable resources, was used to synthesize two bio-based plasticizers, namely, hexyl 5-((hexanoyloxy)methyl)-2-furancarboxylate (HHMFC) and dihexyl 5,5′-(oxybis(methylene))bis(furan-2-carboxylate) (DHOBFC). The chemical structures of these prepared plasticizers were confirmed using Fourier transform infrared and nuclear magnetic resonance, and then, their plasticization effects on poly(vinyl chloride) (PVC) were also studied. As a result, HFCA-based plasticizers were miscible with PVC and exhibited excellent plasticization performances, compared with commercial dioctyl phthalate. It was noted that HHMFC had a much better plasticizing effect on the PVC film than DHOBFC; however, it displayed a poorer volatility resistance and exudation resistance, which could be attributed to its smaller molecular weight. Besides, because each rigid furan ring of the synthesized plasticizers contained one oxygen atom, the polarity of HFCA-based plasticizers was improved, which inhibited them from migrating from the PVC matrix into nonpolar solvents. Therefore, the HFCA-based plasticizers have good potential as primary plasticizers for PVC.
研究领域:
材料科学
·
化学工程
·
高分子科学
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2025
·Vol. 30
·期 6
·1254
·
IF 4.6
Yuexia Qin,Zhuyu Zheng,Di Liu,Shuhua Sun,Xiaolei Zhao,Lei Lv,Dengyu Xie,Zhonghui Han,Jinxing He
The effects of furfural and 5-methyl-2-furfural produced by the Maillard reaction on PhIP formation were investigated in chemical models and roasted pork patties. In the chemical models, the results indicated that increasing levels of furfural (r = −0.7338, R2= 0.9557) and 5-methyl-2-furfural (r = −0.7959, R2= 0.9864) significantly reduced PhIP formation, displaying a strong linear correlation. The effects of furfural and 5-methyl-2-furfural on the precursors of phenylalanine (Phe) and phenylacetaldehyde showed a significant reduction in the Phe level, while the level of phenylacetaldehyde was not increased. In addition, neither furfural nor 5-methyl-2-furfural could significantly reduce creatinine or PhIP. Further mechanism studies showed that furfural (5-methyl-2-furfural) directly captured Phe to form the corresponding Schiff base compounds a (2-((furan-2-ylmethylene) amino)-3-phenylpropanoic acid) and b (2-(((5-methylfuran-2-yl)methylene)amino)-3-phenylpropanoic acid). This process reduced the production of phenylacetaldehyde, thereby inhibiting the PhIP formation pathway. More importantly, these two compounds were detected in roasted pork patties to which glucose was added. The above pathway was finally confirmed in roasted pork patties. These results revealed that furfural and 5-methyl-2-furfural, formed during the Maillard reaction, play a significant role in inhibiting the formation of PhIP by reacting with Phe.
研究领域:
食品科学
·
营养学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2023
·
IF 2.6
Shuai Yan,Haojian Zhang,Renjie Xu,Zonghua Wang
Experimental mole fraction solubility of methyl 2-aminopyridine-4-carboxylate in methanol/ethanol/isopropanol/n-propanol/acetonitrile/toluene/water/N,N-dimethylformamide (DMF) and ethanol/n-propanol/acetonitrile/DMF + water was determined by the isothermal saturation method between 278.15 and 323.15 K at 101.2 kPa. For methyl 2-aminopyridine-4-carboxylate + monosolvents, the increase of temperature was synchronized with the increase of solubility, and the maximum solubility (0.0377 and 323.15 K) was obtained in methyl 2-aminopyridine-4-carboxylate + toluene. For methyl 2-aminopyridine-4-carboxylate + mixed solvents, in addition to temperature, the proportion of cosolvents was also the main influencing factor, and the maximum solubility of methyl 2-aminopyridine-4-carboxylate (0.02845 and 323.15 K) was obtained in DMF + water at wDMF = 0.9. The Jouyban–Acree model (J-A), van’t Hoff–Jouyban–Acree model (V-J-A), and modified Apelblat–Jouyban–Acree model (A-J-A) were utilized to correlate the solubility of methyl 2-aminopyridine-4-carboxylate in four binary solvent mixtures, and Apelblat model, van’t Hoff model, and λh model were used to correlate the methyl 2-aminopyridine-4-carboxylate solubility in eight monosolvents. This study presented insights into modulating a methyl 2-aminopyridine-4-carboxylate crystallization process and understanding equilibrium behaviors in different solvents.
研究领域:
化学工程
·
药物科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2014
·Vol. 2
·期 44
·7785-7794
·
IF 0
Longchao Bai,Lin Tan,Lijuan Chen,Songtao Liu,Yanmei Wang
Poly(2-methyl-2-oxazoline) (PMOXA) has been proved to be a kind of potential antifouling coating material. In this work, a series of comb copolymers, poly[(2-methyl-2-oxazoline)-random-glycidyl methacrylate] (PMOXA-r-GMA), with a variety of compositions were synthesized by free radical polymerization of the oligo(2-methyl-2-oxazoline) methacrylate macromonomer and glycidyl methacrylate, and then characterized and used to coat silicon/glass surfaces. A one-step coating procedure by a simple annealing protocol was used to yield covalent and cross-linked PMOXA-based antifouling coatings. The coatings were rigorously characterized in terms of the surface chemical composition, hydrophilicity, thickness and morphology using X-ray photoelectron spectroscopy (XPS), the water contact angle (WCA) test, ellipsometry and atomic force microscopy. The results demonstrated that the PMOXA-r-GMA brushes could successfully be bonded onto silicon/glass surfaces. Finally, the fouling resistance ability of the modified surface was evaluated by analyzing the adsorption of bovine serum albumin protein, bacterial cell attachment and platelet adhesion, which indicated that the modified silicon/glass surfaces had a superior resistance to protein, bacterial cell and platelet adsorption, and the performance of fouling resistance was enhanced with the content of PMOXA segments in the copolymers.
研究领域:
材料科学
·
生物医学工程
·
表面化学
✓ 已验证
DOI
PubMed
BIOCHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 3.475
Yu Zhang,Xiaohui Di,Wen Wang,Miaojia Song,Qiang Yu,Zhongming Wang,Zhenhong Yuan,Xiaoyan Chen,Huijuan Xu,Ying Guo
Methyl-2-furoate (MF) is a high-value compound, and can be produced via esterification of furoic acid derived from biobased furfural. Herein, CAL-B and [bmim][PF 6 ] were the most efficient lipase and organic medium for MF production, respectively. Based on mass action law and reaction reversibility, a mathematical model was developed. Data analysis showed the newly proposed binary regression was apparently more suitable compared to the commonly used unitary regression. The enzymatic promotion factor m i for esterification and hydrolysis was 1.8159 and 0, while the alcohol inhibition factor n i was 0 and 0.06436, respectively. Both the activation energy E a, i for esterification and hydrolysis was 84 kJ/mol, and the pre-exponential factor A i was 7.1408×10 13 and 7.8962×10 13 , respectively. Kinetics study demonstrated that CAL-B held significantly more dominant esterification activity compared to hydrolysis activity, whereas alcohol just inhibited hydrolysis activity instead of esterification activity, and the relationship between esterification/hydrolysis rate constants k i and temperature agreed with Arrhenius equation. The maximum MF yield was 82.5 % at 24 h, and the yield decreased to 75.4 % after 1 re-use of CAL-B, but maintained about 20 % for next 4 cycles. Totally, the developed model and binary regression analysis method is ideal for in-depth examination of lipase-catalyzed kinetics in heterogeneous system.
研究领域:
生物化学
·
酶工程
✓ 已验证
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2020
·
IF 2.69
Ye Han Yan,Muhammad Atif,Ren Yong Liu,Hai Kun Zhu,Li Juan Chen
In this work, the comb-like poly(2-methyl-2-oxazoline) copolymer, poly(2-aminoethyl methacrylate-random-poly(2-methyl-2-oxazoline) (PMOXA-r-AEMA, PMA) is synthesized, and the CuSO4/H2O2-triggered dopamine/PMA co-deposition process is investigated. Ellipsometry, water contact angle (WCA), and X-ray photoelectron spectroscopy (XPS) are used to characterize the thickness, hydrophilicity, and surface composition of PMA-based coatings. PMA is facilely anchored to substrates within 60 min with the assistance of dopamine/polydopamine triggered by CuSO4/H2O2, and the coating thickness can achieve about 13 nm. Anti-protein adsorption and anti-blood platelet adhesion measurements are also studied to verify their antifouling properties. The adsorption capacity of FITC-BSA can be reduced to 5% of the original surface, and PMA-based coatings present excellent protein-resistant properties (∼95% reduction relative to gold surface) according to surface plasmon resonance (SPR) measurement, and it can resist adhesion of almost all blood platelets. Moreover, it is applied to a capillary inner wall for surface modification. An alkaline protein mixture and egg white proteins are successfully separated, and present excellent stability. The relative standard deviation (RSD) of migration time is lower than 0.71%. The practicability of this promising PMA-based coatings with this preparation strategy can be used for further proteomics analysis.
研究领域:
材料科学
·
生物医学工程
·
表面化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2016
·Vol. 180
·期 2
·210-227
·
IF 1.606
Cao Yingying,Deng Dun,Sun Aijun,Zhang Yun,Hu Yunfeng
Chiral 2-chloropropanoic acids and their ester derivatives are crucial intermediates in the synthesis of many chemicals, especially herbicides. The enzymatic synthesis of chiral 2-chloropropanoic acids and their ester derivatives by esterases was not easily achieved, because the structural difference between the two enantiomers was too small to be recognized by esterases. Herein, we report the expression and functional characterization of one novel low temperature-resistant esterase EST12–7 identified from the genome of Pseudonocardia antitumoralis SCSIO 01299 isolated from the sediments of the South China Sea. Biocatalyst EST12–7 could hydrolyze racemic methyl 2-chloropropinate and generate optically pure ( R )-methyl 2-chloropropinate with high enantiomeric excess (>99 %) and conversion (>49 %) after process optimization. Notably, the addition of different surfactants and using surfactants of different concentrations in the kinetic resolution catalyzed by EST12–7 could greatly affect the enantiomeric excess and conversion rate of product ( R )-methyl 2-chloropropinate.
研究领域:
生物化学
·
酶工程
·
有机合成
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2018
·
IF 2.196
Liping Wang,Saisai Zhou,Pan Li,Pengzhou Li,Qingsong Li,Yingmin Yu
Polyoxymethylene dimethyl ethers (DMMn) have attracted particular attention in industry as excellent oxygenated fuel additives. This study aims to reveal the liquid–liquid equilibrium (LLE) values regarding ternary mixtures {water + methylal (DMM1) + 4-methyl-2-pentanol (MIBC)}, {water + DMM2 + MIBC}, {water + DMM3 + MIBC}, and {water + DMM4 + MIBC} at 298.2 and 308.2 K under 101.3 kPa. Distribution factor and selectivity were utilized to assess the extracting capabilities of the selected extractant. The well known Hand equation and Othmer–Tobias equation were utilized to test the consistency of the LLE values. In addition, the experimental results were correlated by the UNIQUAC and NRTL thermodynamic models with all of the root-mean-square deviation values less than 0.0127,which indicated that both models agree well with the experimental tie-line data.
研究领域:
化学工程
·
热力学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）