Pharmaceutics
·
2023
·Vol. 16
·期 1
·45
·
IF 5.4
Xiaowei Zhang,Rundong Zhu,Xingzhi Wang,Hao Wang,Zushun Xu,Yongan Wang,Dongqin Quan,Liao Shen
Local chemotherapy is an alternative therapeutic strategy that involves direct delivery of drugs to the tumor site. This approach avoids adverse reactions caused by the systemic distribution of drugs and enhances the tumor-suppressing effect by concentrating the drugs at the tumor site. Drug-loaded microspheres are injectable sustained-release drug carriers that are highly suitable for local chemotherapy. However, a complex preparation process is one of the main technical difficulties limiting the development of microsphere formulations. In this study, core-shell structured microspheres loaded with paclitaxel (PTX; with a core-shell structure, calcium alginate outer layer, and a poly (lactic acid-co-glycolic acid) copolymer inner layer, denoted as PTX-CA/PLGA-MS) were prepared using coaxial electrostatic spray technology and evaluated in vitro and in vivo. PTX-CA/PLGA-MS exhibited a two-stage drug release profile and enhanced anti-tumor effect in animal tumor models. Importantly, the preparation method reported in this study is simple and reduces the amount of organic solvent(s) used substantially.Keywords:chemotherapy;controlled drug-release;microspheres;electrostatic spray
研究领域:
肿瘤学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Tao Yan,Hui Ren,Jie Liu,Qingjie Jiao
To improve reaction rate of energetic materials, electrospray technology was applied to develop microspheres in which recrystallized cyclotrimethylene trinitramine (RDX) was integrated with nano-Al (nAl) particles and Viton through a two-solvent strategy. Results on morphology properties and chemical heterogeneity demonstrated that the electrosprayed microspheres were hollow spheres containing well-dispersed RDX . It was suggested that RDX nano-crystals adhere tightly on both sides of the nAl@Viton skeletons, thereby increasing the contact area among components. The thermal analysis of the microspheres indicated that nAl particles accelerated the energy release by decreasing the apparent activation energy for microsphere decomposition. Experimental results showed that electrosprayed nAl@RDX@Viton had shorter laser ignition delay and more vigorous combustion flame than the physical mixture, which benefitted from the characteristic structure and synergistic effects of the components.
研究领域:
材料科学
·
能源工程
✓ 已验证
产品关联
DOI
高影响因子
CARBON
·
2021
·
IF 9.594
Meilian Cao,Qingxiang Wang,Wanli Cheng,Siqi Huan,Yi Hu,Zhaoxuan Niu,Guangping Han,Haitao Cheng,Ge Wang
Despite the great advantages of interconnected porous architectures of three-dimensional carbon as functional materials , apparent common drawbacks restricting their widespread applications are high cost and non-renewable of the carbon precursors and complicated activation procedures. In this study, biomass-derived honeycomb-like multilayered carbon (HMC) is synthesized by electrospraying and direct carbonization for the first time. Poly (methyl methacrylate) (PMMA) is mixed with biomass-derived lignin, the only carbon source, to form lignin/PMMA microspheres and microbowls by electrospraying. One-step carbonization of prepared micromaterials to obtain ultralight HMC, and the microstructures and pore size of carbon materials are controllable by adjusting the applied voltage of electrospraying. The obtained HMC-13 by carbonization of lignin/PMMA microspheres possesses interconnected carbon skeleton, partially graphitized structure and hierarchical pore system composed of macropores, mesopores and micropores. Benefiting from the structural advantages, HMC-13 as electrode of supercapacitor delivers a high specific capacitance of 348 F g −1 at 0.5 A g −1 in aqueous electrolytes. Additionally, the supercapacitor exhibits excellent cycling stability with only 4% capacitance loss after 10 000 cycles. Based on these encouraging results, environmental friendliness and facile synthesis strategy, the biomass-derived ultralight porous carbon material holds great promise for facilitating wasted biomass utilization and developing sustainable energy products.
研究领域:
材料科学
·
能源工程
·
环境科学
✓ 已验证
DOI
高影响因子
TALANTA
·
2018
·
IF 4.244
Dongqin Tan,Jing Jin,Longxing Wang,Xueqin Zhao,Cuicui Guo,Xiaoli Sun,Dhanjai,Xianbo Lu,Jiping Chen
As one of the most important analytical techniques for accurate quantification of bisphenol compounds, liquid chromatography coupled to online electrospray ionization (ESI) tandem mass spectrometry exhibits relative weak ESI response in negative mode, which greatly reduces their sensitivity and limits their detection at trace levels, especially in complex samples such as blood. Based on the facilitated deprotonation of bisphenol molecule under alkaline condition, post-column injection of ammonium hydroxide (NH 3 ·H 2 O) to mass spectrometer was explored to enhance the ionization efficiency of BPA and its eight analogs and improve their analytical sensitivity. Parameters effecting response intensity and stability were investigated, including mass concentration and flow rate of NH 3 ·H 2 O. Under the optimal conditions with the addition of 2% (w/w) of NH 3 ·H 2 O at 4 μL min −1 , the instrument detection limits for bisphenol compounds were greatly lowered to 0.001–0.04 ng mL −1 , which were 2–28.6 times lower than the result obtained without injecting NH 3 ·H 2 O, except TBBPA (0.03 ng mL −1 in either case). The relative standard deviations (RSDs) for instrument repeatability of BPA and its analogs at three different concentration levels were in a range of 1.2–20%. Furthermore, a decreased matrix effects (90–111%) for bisphenols (except TBBPA) analysis in serum extracts were found compared with the result obtained without NH 3 ·H 2 O injection (43–111%). The results demonstrated that the improved instrumental method coupled with suitable pretreatment techniques is more feasible to analyze bisphenol compounds in complex bio-samples.
研究领域:
分析化学
·
环境科学
·
毒理学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2020
·
IF 3.871
Lei Xiao,Lujia Zhao,Xiang Ke,Tengyue Zhang,Gazi Hao,Yubing Hu,Guangpu Zhang,Hu Guo,Wei Jiang
Nanothermites have a promising study in micro propellant due to its faster reaction rate, higher energy-release efficiency, and significantly enhanced combustion performance. However, most thermites prepared by physical mixing are easy to separate during the propellant preparation process, significantly impeding the embodiment of the advantages of thermite. In this study, Al/CuO/PVDF microspheres incorporating high explosive RDX have been successfully assembled by electrospray technology. The thermal and combustion performance of the composite microspheres have significantly improved. They have shorter delay time, burning time, and higher pressure, pressurization rate than the physical mixtures, which are attributed to their uniform structure and the interaction of the components. And based on combustion tests, the combustion performance of microspheres is mainly affected by the content of RDX. These results indicate that the electrospray technology and adding RDX into microspheres are effective methods to prepare nanothermites with enhanced reactivity.
研究领域:
材料科学
·
燃烧与爆炸领域
✓ 已验证
产品关联
DOI
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2019
·
IF 1.795
Feng Wang,Hongye Wang,Asghar Ali,Yimeng Zhang,Xiaoqiang Cui,Yang Liu
Herein, green luminescence poly-vinylidene fluoride (PVDF) encapsulated CsPbBr 3 nanocrystals (CsPbBr 3 @ PVDF) with full width at half maximum (FWHM) of 20 nm were successfully prepared through one-pot electrospray process. The as prepared perovskite spheres showed outstanding stability in water, and displayed low cytotoxicity, which were applied for cell membrane imaging.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
SENSORS
·
2015
·Vol. 15
·期 4
·8931-8944
·
IF 2.245
Xiang Qian,Jie Xu,Cilong Yu,Yan Chen,Quan Yu,Kai Ni,Xiaohao Wang
Monolithically integrated emitters have been increasingly applied to microfluidic devices that are coupled to mass spectrometers (MS) as electrospray ionization sources (ESI). A new method was developed to fabricate a duplicable structure which integrated the emitter into a poly(dimethylsiloxane) chip corner. Two photoresist layers containing a raised base which guaranteed the precise integration of the electrospray tip emitter and ensured that the cutting out of the tip exerted no influence even during repeated prototyping were used to ease the operation of the process. Highly stable ESI-MS performance was obtained and the results were compared with those of a commercial fused-silica capillary source. Furthermore, chip-to-chip and run-to-run results indicated both reliability and reproducibility during repeated fabrication. These results reveal that the proposed chip can provide an ideal ion source for MS across many applications, especially with the perspective to be widely used in portable MS during on-site analysis.Keywords:microfluidic chip;multi-layer soft lithography;electrospray ionization
研究领域:
分析化学
·
质谱分析
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Shixiang Dong,Jing Li,Shuai Zhang,Ning Li,Bo Li,Liqin Ge
Bowl-like polymer microspheres (BPMs) of polyfluoroimide (PIF) with a single cave and interior porosity are successfully prepared in this work by using one-step electrospray (ES) technique. The effects of polymer solution and process control parameters on the surface appearance and sizes of resulting microspheres are investigated. The experimental results indicate that the cyclopentanone (CPT) is used as the solvent, polymer microspheres with porous structure, tailed and elongated, single-cave and beaded fibers can be prepared respectively. Compared to the cyclopentanone, the N, N-dimethylacetamide (DMAC) solvent contributes to the formation of microspheres with spherical and rough surface structure. The diameters of BPMs and single-cave can be regulated by varying the PIF solution concentration, applied voltage and flow rate during the electrospray process. The diameter ranges for the obtained PIF microspheres are 2.75-5.03 μm with single-cave at 1.11-2.72 μm respectively. The sizes of both the single-cave and microspheres tend to reduce with the decrease of flow rate or increase of applied voltage. These BPMs with interior porosity have a broad application prospect in microreactor, catalyst supports, drug carrier and captures for cells due to its large effective surface area and strong absorption capacity.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2021
·
IF 5.302
Ruiji Zhang,Xing Zhang,Chen Xing,Li Hu,Fangwei Guo,Xin Wang,Xiaofeng Zhao
The thermal cycling lifetime of thermal barrier coatings was doubled when deposited by electro-sprayed (ESP) microspheres instead of by commercial hollow spherical powders. It was believed that partial-molten nodules with featured microstructures inherited from the feedstock microspheres were the main contributor for prolonged thermal cycling durability due to improved fracture toughness and strain tolerance. The maximum lifetime was observed on samples with 20−30 vol.% of partial-molten microspheres. The hierarchy pores may both slow down the crack propagation by triggering multi-deflecting and promote cracking by reducing the tendency of interfacial deflection, the net effect depends on situation. The ESP coatings exhibited bimodal Weibull moduli upon indentation, which was regarded as originated from the hierarchy porous structure. Finally, the criterion was verified by micro-indentation and residual stain-stress evaluation by Raman spectroscopy .
研究领域:
材料科学
·
工程学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
·
2019
·Vol. 57
·期 8
·421-430
·
IF 2.596
Guohui Zhang,Panpan Wang,Xiaoxiao Zhang,Chunhui Xiang,Lili Li
Superhydrophobic polycaprolactone (PCL) membranes with hierarchical structure were fabricated via alternate electrospinning/electrospraying techniques. Electrospun PCL/methyl silicone oil (PCL/MSO) nanofibers were employed as substrate. PCL/MSO-PCL microspheres (PCL/MSO-PCL MS ) hierarchical membrane was prepared via electrosprayed PCL MS as an additional layer on the substrate. Field emission scanning electron microscopy images showed the formation of hierarchical PCL/MSO-PCL MS membranes. Compared to pure PCL fibers substrate (120 ± 1.3°), the water contact angle (WCA) of MSO-modified PCL membrane was 142 ± 0.7°. The most interesting observation was that the WCA of PCL MS without any modification could be achieved to 146 ± 2.8°. On this basis, PCL/MSO-PCL MS hierarchical membrane possessed superhydrophobic surface with 150 ± 0.6° of WCA. The excellent surface roughness and air-pocket capacity of hierarchical membranes would make the membranes more hydrophobic. The maximum oil ( n -hexane) adsorption capacity of PCL/MSO-PCL MS membrane was 32.53 g g −1 . Oil–water separation efficiencies of the superhydrophobic membranes were all higher than 99.93% after 10 cycles. The hierarchically structured PCL superhydrophobic membranes indicate the potential applications of environmentally friendly biopolymers as separation membranes. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019 , 57 , 421–430
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2013
·Vol. 131
·期 10
·
IF 1.395
Hongtao Liu,Jiangang Zhou,Danying Zuo,Xiuying Liu,Shaojin Gu,Weilin Xu
Morphological, thermal, and mechanical features of electrosprayed and electrospun deposition of the silk-inspired polyurethane (PU) containing GlycineAlanineGlycineAlanine (GlyAlaGlyAla, the featured peptide sequence of silkworm silk fibroin) tetrapeptide, which was synthesized by the traditional liquid-phase peptide synthesis method and the classical two-step polymerization method using Boc-protected amino acids and diisocyanates as starting materials, were characterized. The results show that the synthesized silk-inspired PU dissolved in tetrahydrofuran (THF) can be easily electrosprayed or electrospun into the film form, although its molecular weight ranging from 13,000 to 15,000 is quite low. Elastomeric fibrous membranes with surface morphologies of “droplets,” “bead-on-string,” and “nonwoven fibers” have been obtained by electrospraying and electrospinning the silk-inspired PU/THF solution of varying concentrations. The thermograms confirm high thermostability of the silk-inspired PU between 350 and 400°C due to the polar peptide linkages. The tanδ peak of dynamic mechanical analysis curve corresponding to its glass transition temperatures is detected at −34.3°C. Its elongation at break is about 140–150%, and the breaking tensile strength ranges from 22 to 27 MPa, which is consistent with the data of other PUs containing l -alanine residue. Information provided by this study can be used to better understand the correlation between the natural and man-made silk polymers. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40245.
研究领域:
材料科学
·
生物材料学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL LETTERS
·
2016
·
IF 1.088
Yinjuan Chen,Chongsheng Xu,Fuxing Xu,Kai Yang,Qiang Wang,Xin Zhao,Yuanyuan Wang,Bin Chen,Chuan-Fan Ding
An electro-filtering spray ionization source for ambient mass spectrometry is reported. The ion source was assembled with a conical metal filter with a paper cone. The performance of the new ion source was characterized by the analysis of soil. Soil was directly introduced into the filter-paper cone and solvent was added. Ions were produced at the filter-paper tip when a high voltage was applied. The results by electro-filtering spray ionization were in good agreement with the results using conventional electrospray ionization with complex sample preparation. Advantages of electro-filtering spray ionization include simplicity, speed, and convenient operation that may allow in situ analysis in ambient atmospheric conditions.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）