Pharmaceutics
·
2023
·Vol. 16
·期 1
·45
·
IF 5.4
Xiaowei Zhang,Rundong Zhu,Xingzhi Wang,Hao Wang,Zushun Xu,Yongan Wang,Dongqin Quan,Liao Shen
Local chemotherapy is an alternative therapeutic strategy that involves direct delivery of drugs to the tumor site. This approach avoids adverse reactions caused by the systemic distribution of drugs and enhances the tumor-suppressing effect by concentrating the drugs at the tumor site. Drug-loaded microspheres are injectable sustained-release drug carriers that are highly suitable for local chemotherapy. However, a complex preparation process is one of the main technical difficulties limiting the development of microsphere formulations. In this study, core-shell structured microspheres loaded with paclitaxel (PTX; with a core-shell structure, calcium alginate outer layer, and a poly (lactic acid-co-glycolic acid) copolymer inner layer, denoted as PTX-CA/PLGA-MS) were prepared using coaxial electrostatic spray technology and evaluated in vitro and in vivo. PTX-CA/PLGA-MS exhibited a two-stage drug release profile and enhanced anti-tumor effect in animal tumor models. Importantly, the preparation method reported in this study is simple and reduces the amount of organic solvent(s) used substantially.Keywords:chemotherapy;controlled drug-release;microspheres;electrostatic spray
研究领域:
肿瘤学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Tao Yan,Hui Ren,Jie Liu,Qingjie Jiao
To improve reaction rate of energetic materials, electrospray technology was applied to develop microspheres in which recrystallized cyclotrimethylene trinitramine (RDX) was integrated with nano-Al (nAl) particles and Viton through a two-solvent strategy. Results on morphology properties and chemical heterogeneity demonstrated that the electrosprayed microspheres were hollow spheres containing well-dispersed RDX . It was suggested that RDX nano-crystals adhere tightly on both sides of the nAl@Viton skeletons, thereby increasing the contact area among components. The thermal analysis of the microspheres indicated that nAl particles accelerated the energy release by decreasing the apparent activation energy for microsphere decomposition. Experimental results showed that electrosprayed nAl@RDX@Viton had shorter laser ignition delay and more vigorous combustion flame than the physical mixture, which benefitted from the characteristic structure and synergistic effects of the components.
研究领域:
材料科学
·
能源工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Chuan Huang,Zhijian Yang,Yanchun Li,Baohui Zheng,Qilong Yan,Lifeng Guan,Guan Luo,Shangbin Li,Fude Nie
Nano-aluminum, as a potential replacement of micro-aluminum, has attracted significant research interests in energetic fields due to its high reactivity. However, the intrinsic high surface area of nanoparticles drives nano-aluminum encounter challenges in handling process and prone to large aggregation, significantly impeding the further application of nano-aluminum. In this work, nano-aluminum based microspheres incorporating hexanitrohexaazaisowurtzitane (CL-20) are directly fabricated by electrospray deposition. These as-prepared microspheres were in high monodispersity and their size ranges from 8 to 16 μm. The surface morphology of such microspheres was adjustable by using different polymers as binder. Thermal behavior results show that CL-20 has no appreciable effect on the reactivity of nano-aluminum while the fluoropolymer binder (F2314) facilitates the oxidation of nano-aluminum. Nevertheless, the presence of CL-20 can significantly enhance the reactivity of nano-aluminum in the combustion behavior tests, where electrosprayed microspheres exhibit outstanding performance in comparison to physical mixed sample, presenting a high pressurization rate, peak pressure and short burning time. These excellent properties are possibly attributed to their uniform microstructure. Therefore, the use of electrospray method can offer a promising strategy to fabricate the microstructure controllable microspheres.
研究领域:
材料科学
·
能源领域
✓ 已验证
产品关联
DOI
高影响因子
Micromachines
·
2021
·Vol. 12
·期 3
·252
·
IF 2.891
Feiyu Fang,Han Wang,Huaquan Wang,Xiaofei Gu,Jun Zeng,Zixu Wang,Xindu Chen,Xin Chen,Meiyun Chen
In this work, a novel flexible electrically resistive-type MXene/Thermoplastic polyurethanes(TPU) based strain sensors was developed by a composite process of electrospinning (ES) and electrostatic spray deposition (ESD). Compared with other deposition processes, the sensing layer prepared by ESD has better adhesion to the ES TPU nanofiber membrane and is not easy to crack during the stretching process, thereby greatly improving the working range of the strain sensor. Furthermore, we obtained the sandwich structure easily by ES on the surface of the sensing layer again. This will help make the stress distribution more uniform during the stretching process and further increase the strain sensing range. The ESD-ES strain sensors were attached on skin to monitor various human motions. The results demonstrate that our ESD-ES strain sensors have wide application prospects in smart wearable device.Keywords:strain sensor;electrospinning;electrostatic spray deposition;MXene
研究领域:
材料科学
·
电子工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBON
·
2021
·
IF 9.594
Meilian Cao,Qingxiang Wang,Wanli Cheng,Siqi Huan,Yi Hu,Zhaoxuan Niu,Guangping Han,Haitao Cheng,Ge Wang
Despite the great advantages of interconnected porous architectures of three-dimensional carbon as functional materials , apparent common drawbacks restricting their widespread applications are high cost and non-renewable of the carbon precursors and complicated activation procedures. In this study, biomass-derived honeycomb-like multilayered carbon (HMC) is synthesized by electrospraying and direct carbonization for the first time. Poly (methyl methacrylate) (PMMA) is mixed with biomass-derived lignin, the only carbon source, to form lignin/PMMA microspheres and microbowls by electrospraying. One-step carbonization of prepared micromaterials to obtain ultralight HMC, and the microstructures and pore size of carbon materials are controllable by adjusting the applied voltage of electrospraying. The obtained HMC-13 by carbonization of lignin/PMMA microspheres possesses interconnected carbon skeleton, partially graphitized structure and hierarchical pore system composed of macropores, mesopores and micropores. Benefiting from the structural advantages, HMC-13 as electrode of supercapacitor delivers a high specific capacitance of 348 F g −1 at 0.5 A g −1 in aqueous electrolytes. Additionally, the supercapacitor exhibits excellent cycling stability with only 4% capacitance loss after 10 000 cycles. Based on these encouraging results, environmental friendliness and facile synthesis strategy, the biomass-derived ultralight porous carbon material holds great promise for facilitating wasted biomass utilization and developing sustainable energy products.
研究领域:
材料科学
·
能源工程
·
环境科学
✓ 已验证
DOI
高影响因子
TALANTA
·
2018
·
IF 4.244
Dongqin Tan,Jing Jin,Longxing Wang,Xueqin Zhao,Cuicui Guo,Xiaoli Sun,Dhanjai,Xianbo Lu,Jiping Chen
As one of the most important analytical techniques for accurate quantification of bisphenol compounds, liquid chromatography coupled to online electrospray ionization (ESI) tandem mass spectrometry exhibits relative weak ESI response in negative mode, which greatly reduces their sensitivity and limits their detection at trace levels, especially in complex samples such as blood. Based on the facilitated deprotonation of bisphenol molecule under alkaline condition, post-column injection of ammonium hydroxide (NH 3 ·H 2 O) to mass spectrometer was explored to enhance the ionization efficiency of BPA and its eight analogs and improve their analytical sensitivity. Parameters effecting response intensity and stability were investigated, including mass concentration and flow rate of NH 3 ·H 2 O. Under the optimal conditions with the addition of 2% (w/w) of NH 3 ·H 2 O at 4 μL min −1 , the instrument detection limits for bisphenol compounds were greatly lowered to 0.001–0.04 ng mL −1 , which were 2–28.6 times lower than the result obtained without injecting NH 3 ·H 2 O, except TBBPA (0.03 ng mL −1 in either case). The relative standard deviations (RSDs) for instrument repeatability of BPA and its analogs at three different concentration levels were in a range of 1.2–20%. Furthermore, a decreased matrix effects (90–111%) for bisphenols (except TBBPA) analysis in serum extracts were found compared with the result obtained without NH 3 ·H 2 O injection (43–111%). The results demonstrated that the improved instrumental method coupled with suitable pretreatment techniques is more feasible to analyze bisphenol compounds in complex bio-samples.
研究领域:
分析化学
·
环境科学
·
毒理学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2020
·
IF 3.871
Lei Xiao,Lujia Zhao,Xiang Ke,Tengyue Zhang,Gazi Hao,Yubing Hu,Guangpu Zhang,Hu Guo,Wei Jiang
Nanothermites have a promising study in micro propellant due to its faster reaction rate, higher energy-release efficiency, and significantly enhanced combustion performance. However, most thermites prepared by physical mixing are easy to separate during the propellant preparation process, significantly impeding the embodiment of the advantages of thermite. In this study, Al/CuO/PVDF microspheres incorporating high explosive RDX have been successfully assembled by electrospray technology. The thermal and combustion performance of the composite microspheres have significantly improved. They have shorter delay time, burning time, and higher pressure, pressurization rate than the physical mixtures, which are attributed to their uniform structure and the interaction of the components. And based on combustion tests, the combustion performance of microspheres is mainly affected by the content of RDX. These results indicate that the electrospray technology and adding RDX into microspheres are effective methods to prepare nanothermites with enhanced reactivity.
研究领域:
材料科学
·
燃烧与爆炸领域
✓ 已验证
产品关联
DOI
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2019
·
IF 1.795
Feng Wang,Hongye Wang,Asghar Ali,Yimeng Zhang,Xiaoqiang Cui,Yang Liu
Herein, green luminescence poly-vinylidene fluoride (PVDF) encapsulated CsPbBr 3 nanocrystals (CsPbBr 3 @ PVDF) with full width at half maximum (FWHM) of 20 nm were successfully prepared through one-pot electrospray process. The as prepared perovskite spheres showed outstanding stability in water, and displayed low cytotoxicity, which were applied for cell membrane imaging.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
SENSORS
·
2015
·Vol. 15
·期 4
·8931-8944
·
IF 2.245
Xiang Qian,Jie Xu,Cilong Yu,Yan Chen,Quan Yu,Kai Ni,Xiaohao Wang
Monolithically integrated emitters have been increasingly applied to microfluidic devices that are coupled to mass spectrometers (MS) as electrospray ionization sources (ESI). A new method was developed to fabricate a duplicable structure which integrated the emitter into a poly(dimethylsiloxane) chip corner. Two photoresist layers containing a raised base which guaranteed the precise integration of the electrospray tip emitter and ensured that the cutting out of the tip exerted no influence even during repeated prototyping were used to ease the operation of the process. Highly stable ESI-MS performance was obtained and the results were compared with those of a commercial fused-silica capillary source. Furthermore, chip-to-chip and run-to-run results indicated both reliability and reproducibility during repeated fabrication. These results reveal that the proposed chip can provide an ideal ion source for MS across many applications, especially with the perspective to be widely used in portable MS during on-site analysis.Keywords:microfluidic chip;multi-layer soft lithography;electrospray ionization
研究领域:
分析化学
·
质谱分析
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Energetic Materials
·
2022
·
IF 2.421
Shu-Ji Wang,Di Wang,Ping Liu,Xiao-le Sun,Shi Yan,Xue-Yong Guo
TKX-50, as a representative of a new nitrogen-rich energetic compound, has attracted extensive interests due to its high energy and low sensitivity properties. As an important energetic material, combustible agent has great influence on improving the energy level of explosives and propellants. Boron powder has become the most potential combustible agent in energetic fields because of its unique performances. In this work, nano-boron-based microspheres containing TKX-50 are directly fabricated by electrospray deposition. The prepared microspheres showed high monodispersity with particle size ranging from ~1–3 μm. Thermal behavior results show that the mass gain of the electrostatically sprayed sample is 163.3%, which is much higher than that of pure boron and physically mixed samples. Combustion behavior tests show that electrosprayed microspheres exhibit outstanding performance in comparison to physical mixed sample, the peak pressure improved by 85%, the burning time decreased by 21% and the pressurization rate improved by 136%. These excellent properties are probably related to their uniform microstructure. Therefore, electrospray preparation of microspheres with controllable structure has a good application prospect in energetic materials.
研究领域:
化学
·
材料科学
·
能源科学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Shixiang Dong,Jing Li,Shuai Zhang,Ning Li,Bo Li,Liqin Ge
Bowl-like polymer microspheres (BPMs) of polyfluoroimide (PIF) with a single cave and interior porosity are successfully prepared in this work by using one-step electrospray (ES) technique. The effects of polymer solution and process control parameters on the surface appearance and sizes of resulting microspheres are investigated. The experimental results indicate that the cyclopentanone (CPT) is used as the solvent, polymer microspheres with porous structure, tailed and elongated, single-cave and beaded fibers can be prepared respectively. Compared to the cyclopentanone, the N, N-dimethylacetamide (DMAC) solvent contributes to the formation of microspheres with spherical and rough surface structure. The diameters of BPMs and single-cave can be regulated by varying the PIF solution concentration, applied voltage and flow rate during the electrospray process. The diameter ranges for the obtained PIF microspheres are 2.75-5.03 μm with single-cave at 1.11-2.72 μm respectively. The sizes of both the single-cave and microspheres tend to reduce with the decrease of flow rate or increase of applied voltage. These BPMs with interior porosity have a broad application prospect in microreactor, catalyst supports, drug carrier and captures for cells due to its large effective surface area and strong absorption capacity.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2018
·Vol. 10
·期 39
·18857-18868
·
IF 7.233
Haipeng Wang,Wulong Li,Zhanxiong Li
In this study, fluorinated polycaprolactone (PCL) block polymers with different fluorine contents were synthesized via atom transfer radical polymerization (ATRP). An electrospraying technique was used to prepare fluorinated PCL microspheres with different microstructures. In contrast to the golf ball shape of unmodified PCL microspheres displaying porous pits on the surface, block polymer PCL-PTFOA(2 h) and PCL-PTFOA(6 h) microsphere surfaces displayed regular honeycomb-like pore structures. Thermally induced and evaporation-induced phase separations are proposed as the main mechanisms involved in the formation of the porous microstructures. The micro-phase separation between the two blocks of the fluorinated PCL copolymer is another factor that promoted the uniform collapse on the microsphere surface and the formation of its rugged wall. The surface roughness of the porous microspheres significantly improved their hydrophobicity, generating coating contact angles on aluminium foil substrates that measured as high as 162.4 ± 1.5°, which revealed that the surfaces were super-hydrophobic. Lastly, cotton fabric was directly coated with the fluorinated polymer microspheres via electrospraying, resulting in super-hydrophobic surfaces and CAs reaching 160.0 ± 1.3°. The results demonstrate that electrospraying is a simple, innovative and cost-effective method for preparing polymer microspheres with controllable microstructures for fabric coating applications.
研究领域:
材料科学
·
纺织工程
·
表面化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）