MOLECULES
·
2019
·Vol. 24
·期 7
·1343
·
IF 3.06
You Luo,Bin Peng,Weiqian Wei,Xiaofei Tian,Zhenqiang Wu
Guava (Psidium guajavaL., Myrtaceae) leaves have been used as a folk herbal tea to treat diabetes for a long time in Asia and North America. In this study, we isolated polysaccharides from guava leaves (GLP), and evaluated its antioxidant activity in vitro and anti-diabetic effects on diabetic mice induced by streptozotocin combined with high-fat diet. The results indicated that GLP exhibited good DPPH, OH, and ABTS free-radical scavenging abilities, and significantly lowered fasting blood sugar, total cholesterol, total triglycerides, glycated serum protein, creatinine, and malonaldehyde. Meanwhile, it significantly increased the total antioxidant activity and superoxide dismutase (SOD) enzyme activity in diabetic mice, as well as ameliorated the damage of liver, kidney, and pancreas. Thus, polysaccharides from guava leaves could be explored as a potential antioxidant or anti-diabetic agents for functional foods or complementary medicine.Keywords:polysaccharides;guava leaves;antioxidant;anti-diabetic
研究领域:
药理学
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生物化学
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营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DRYING TECHNOLOGY
·
2020
·
IF 2.988
Xuan Liu,Xu Yan,Jinfeng Bi,Xinye Wu,Jianing Liu,Mo Zhou
The influence of different drying techniques on guava was investigated, including phenolic components and antioxidant activities. Through drying processes, total phenolic content (TPC) increased and formation of small molecular phenolic acids (multi-methoxy benzoic acid and sinapic acid) was promoted. UPLC-ESI-QTOF-MS determination showed flavanol compounds, hydrolyzable tannins, ellagic acid conjugates and cinnamic acid derivatives were four predominant phenolics of guava. Drying treatments caused degradation of catechin and its derivatives. Contrarily, drying treatments contributed to higher contents of procyanidin trimers. Moreover, thermal drying treatments led to degradation of macromolecular tannins and formation of smaller molecular tannins and ellagic acid conjugates, while simultaneously reduced the stabilities of most intrinsic ellagic acid conjugates. Furthermore, drying processes increased the yield of cinnamic acid dihexose, probably generating from lignin or phenolics–carbohydrate complex. Freeze drying and hot air drying showed better performance on retention of TPC and enhancement of antioxidant activity (AA).
研究领域:
食品科学
·
植物化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2023
·
IF 8.8
Baizhou Lu,Zhanqiang Fang,Pokeung Eric Tsang,Jinhua Wu
To overcome the bottlenecks of the conventional zero-valent iron Fenton-like (ZVI/H 2 O 2 ) process, such as low reagent utilization, low applicable pH, and iron sludge contamination, guava leaf extract (GLE) was used as a green promoter to enhance ZVI/H 2 O 2 process in this study. Compared with the ZVI/H 2 O 2 system, the removal rate and k obs of norfloxacin by the ZVI/H 2 O 2 /GLE system were increased by 33.76% and 2.19 times, respectively. The experimental investigation of the mechanism showed that the attack of reactive oxygen species was the main pathway for the removal of pollutants, and three types of reactive oxygen species ( 1 O 2 , O 2 − ,·OH) generations in the ZVI/H 2 O 2 /GLE system were effectively promoted by the introduction of GLE. The reactivity improvement was mainly due to the decrease of pH. At the same time, the chelation of iron ions by GLE promoted the Fe(III)/Fe(II) cycle on the catalyst surface was also a minor mechanism to improve the reactivity. This study provides a crucial reference for the practical application of guava leaf to promote the ZVI/H 2 O 2 process in environmental pollution control .
研究领域:
环境科学
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污染控制
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绿色化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Food Measurement and Characterization
·
2017
·Vol. 11
·期 4
·1959-1968
·
IF 0.536
Arslan Muhammad,Rakha Allah,Khan Moazzam Rafiq,Zou Xiaobo
Celiac disease (CD) is a genetic autoimmune disorder of the small intestine, occurring in genetically predisposed people with a prevalence of about 1% in global population. To combat the CD, lifelong adherence to gluten free (GF) diet is required. The GF breads are generally deficient in nutrients such as dietary fiber, antioxidants, vitamins, minerals etc. To overcome this deficiency, GF bread was supplemented with guava pulp powder (GPP) at 5 different level (0, 2.5, 5.0, 7.5 and 10%). Guava ( Psidium guajava ) contains dietary fiber and total phenolics content, 12.72% and 927.66 mg gallic acid equivalent (GAE)/100 g, respectively. Results showed that, the addition of GPP significantly (p < 0.05) increased the crude fiber and total phenolic content of GF bread from 0.92 to 2.45% and 14.46 to 103.77 mg GAE/100 g respectively. The loaf volume increased up to a level of 492.00 cm 3 , hence decreased the hardness from 2.58 to 2.38 N. Furthermore, as the concentration of GPP increased from (0–10%) the L* value of GF bread decreased. The addition of GPP, non-significantly (p > 0.05) affected the protein content and calorific value of GF bread. Sensorial analysis showed that, GF bread supplemented with 5% of GPP presented overall acceptability better when compared with control.
研究领域:
食品科学
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营养学
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医学
✓ 已验证
产品关联
DOI
高影响因子
Materials
·
2019
·Vol. 12
·期 18
·2923
·
IF 2.972
You Luo,Haiqing Liu,Shanzhong Yang,Jiarui Zeng,Zhenqiang Wu
The aim of this work was to develop green and bioactive films with sodium alginate incorporating guava leaf extracts. Seven formulations were performed with a different sodium alginate: Guava leaf water extract (WE)/ethanolic extract (EE) proportions (100:0, 90:10, 85:15, 80:20), and glycerol were used as a plasticizer. The HPLC-PDA analysis showed the main phenolic compounds in WE were gallic acid, ellagic acid, quercetin-3-O-β-D-xylopyranoside, avicularin and quercetin. The main polyphenols in EE were rutin, isoquercitrin, quercetin-3-O-β-D-xylopyranoside, avicularin, quercitrin, quercetin and kaempferol. Guava leaf extracts could greatly enhance the antioxidant activity, antibacterial activity, tensile strength and water solubility of the sodium alginate film as well as the water barrier property, while inducing a decrease in the moisture content and elongation at the break. The FTIR and SEM analyses indicated that intermolecular hydrogen bonding between the guava leaf extract and sodium alginate resulted in a more compact structure in the composite films. These results indicated that sodium alginate-guava leaf extract films might be developed into antiradical and antimicrobial food packaging materials.Keywords:bioactive film;sodium alginate;guava leaf extract;polyphenol;antioxidant;antibacterial
研究领域:
食品科学
·
材料科学
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植物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2024
·
IF 6
Dan Wang,Baiqian Wang,Xuejiao Jin,Yuanyuan Peng,Jinyan Zhao,Meng Zhang,Yunlu Wei,Zhijian Long,Qiyang Chen
This study aimed to optimize the extraction of feijoa pulp pectin and discuss the impact of different extraction methods on the physicochemical and functional properties of pectin. Under the optimum conditions, the pectin yields of microwave-enzyme-assisted extraction (PMEAE, 13.31%) and enzyme-assisted extraction (PEAE, 9.26%) were significantly higher than that of conventional heating extraction (PCHE, 7.64%). Compared to PCHE, PMEAE and PEAE exhibited higher degree of esterification of 68.43% and 67.89%, respectively, coupled with more highly branched side chains, which was confirmed by Fourier-transform infrared (FTIR) analysis. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) analysis showed that PMEAE and PEAE exhibited superior thermal stability. PEAE and PMEAE owned higher viscosity and superior antioxidant biological activity than PCHE. This study suggested that feijoa pectin by microwave enzyme-assisted or enzyme-assisted extraction contained more branched side chains and had better physicochemical and functional properties.
研究领域:
食品科学
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化学工程
·
生物技术
✓ 已验证
DOI
高影响因子
CHEMISTRY & BIODIVERSITY
·
2025
·
IF 2.5
Shao-Qian Wang,Hui Yuan,Hao-Qiang Qin,Ming-Yue Peng,Ming-Xiao Cui,Ke-Hai Liu
This research emphasized the extraction and separation of polysaccharides derived from Syzygium jambos (L.) Alston (PSJAP-5), as well as analyses of their structural characteristics and immunomodulatory activities. This study initially employed response surface methodology to determine the extraction conditions of polysaccharides. The average molecular weight of PSJAP-5 was 58 102 Da, and its monosaccharide composition was galactose, arabinose, galacturonic acid, glucuronic acid, and rhamnose (39.84:29.13:21.97:6.02:4.17). In vitro studies showed that PSJAP-5 promoted the proliferation and phagocytosis of macrophages. Meanwhile, PSJAP-5 (25–200 µg/mL) promoted the release of NO and ROS, and increased the levels of IL-6, TNF-α, and IL-1β. After pretreating macrophages with TLR4, NF-κB, and MAPK inhibitors, the immunoenhancing effects of PSJAP-5 on macrophages treated with the inhibitors were decreased. Similarly, PSJAP-5 promoted the phosphorylation of p38 in the MAPK signaling pathway and reduced the phosphorylation of IκBα in the NF-κB signaling pathway in RAW264.7 cells. PSJAP-5 might serve as a potential immunomodulator for the treatment of diseases characterized by impaired immune function. Graphical This study focused on extracting and purifying a polysaccharide (PSJAP-5) from Syzygium jambos (L.) Alston, analyzing its structural properties, and evaluating its immunomodulatory effects.
研究领域:
免疫学
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天然产物化学
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药用植物学
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分子生物学
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糖生物学
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中药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Haoning Yang,Yu Mu,Dan Zheng,Tess Puopolo,Lejie Zhang,Zhuo Zhang,Sai Gao,Navindra P. Seeram,Hang Ma,Xueshi Huang,Liya Li
Guavinoside B (GUB) is a characteristic constituent from guava with strong antioxidant activity ; however, its low water solubility limits its utilization. Herein, we investigated the interaction between GUB and zein , a prolamin with self-assembling property, using multiple spectroscopic methods and fabricated GUB-zein-NaCas nanoparticles (GUB- Z -N NPs) via the antisolvent coprecipitation approach. GUB caused fluorescence quenching to zein via the static quenching mechanism. Fourier-transform infrared spectroscopy and computational analysis revealed that GUB bound to zein via van der Waals interaction , hydrogen bond , and hydrophobic forces. The GUB- Z -N NPs were in the nanometric size range (< 200 nm) and exhibited promising encapsulation efficiency and redispersibility after freeze-drying. These particles remained stable for up to 31 days at 4 °C and great resistance to salt and pH variation, and displayed superior antioxidant activity to native GUB. The current study highlights the potential of zein-based nanoparticles as delivery vehicles for GUB in the food industry.
研究领域:
食品科学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Essential Oil Bearing Plants
·
2017
·
IF 0.493
Chang Xu,Zhengang Liang,Dan Tang,Tongjie Xiao,Makoto Tsunoda,Yingxia Zhang,Lini Zhao,Shiming Deng,Yanting Song
In this paper, the volatile components extracted from guava leaves by steam distillation (SD) was investigated and comprehensively analyzed for the first time. To obtain more sensitive and accurate analysis, the sample preparation procedure for Gas Chromatography-Mass Spectrometry (GC-MS) analysis of the volatile compounds was investigated and then 27 compounds were identified in the samples obtained by SD method. The volatile components in guava leaf were made up largely of sesquiterpenoids, including α-cubebene, caryophyllene, aromadendrene, α-cadinene, and calamenene. The results indicated that the volatile components from the guava leaves extracted by SD technology was quite different, and the research provided comprehensive information for the volatile compounds in the guava leaves.
研究领域:
植物化学
·
分析化学
✓ 已验证
DOI
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6.8
Ying-Da Zang,Hai-Jie Wu,Xin-Yi Chen,Zhi-Ling Ma,Chuang-Jun Li,Jie Ma,Xiao-Guang Chen,Li Sheng,Sen Zhang,Dong-Ming Zhang
Cisplatin is a widely used drug for the clinical treatment of tumors. However, nephrotoxicity limits its widespread use. A series of compounds including eight analogs (G3-G10) and 40 simplifiers (G11-G50) were synthesized based on the total synthesis of Psiguamer A and B, which were novel meroterpenoids with unusual skeletons from the leaves of Psidium guajava. Among these compounds, (d)-G8 showed the strongest protective effect on cisplatin-induced acute kidney injury (AKI) in vitro and vivo, and slightly enhanced the antitumor efficacy of cisplatin. A mechanistic study showed that (d)-G8 promoted the efflux of cisplatin via upregulating the copper transporting efflux proteins ATP7A and ATP7B. It enhanced autophagy through the activation of the adenosine monophosphate–activated protein kinase (AMPK) signaling pathway. (d)-G8 showed no acute toxicity or apparent pathological damage in the healthy mice at a single dose of 1 g/kg. This study provides a promising lead against cisplatin-induced AKI.
研究领域:
药理学
·
药物化学
·
毒理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2024
·
IF 8.7
Junping Wang,Hongyi Zhao,Xuexue Xue,Yutong Han,Xin Wang,Zunlai Sheng
Lycopene-rich guava ( Psidium guajava L.) exhibits significant economic potential as a functional food ingredient, making it highly valuable for the pharmaceutical and agro-food industries. However, there is a need to enhance the extraction methods of lycopene to fully exploit its beneficial uses. In this study, we evaluated various ionic liquids to identify the most effective one for extracting lycopene from guava. Among thirteen ionic liquids with varying carbon chains or anions, 1-butyl-3-methylimidazolium chloride demonstrated the highest productivity. Subsequently, a single-factor experiment was employed to test the impact of several parameters on the efficiency of lycopene extraction using this selected ionic liquid. These parameters included extraction time, ultrasonic power, liquid-solid ratio, concentration of the ionic liquid, as well as material particle size. Moreover, models of artificial neural networks using genetic algorithms (ANN-GA) and response surface methodology (RSM) were employed to comprehensively assess the first four key parameters. The optimized conditions for ionic liquid ultrasound-assisted extraction (IL-UAE) were determined as follows: 33 min of extraction time, 225 W of ultrasonic power, 22 mL/g of liquid-solid ratio, 3.0 mol/L of IL concentration, and extraction cycles of three. Under these conditions, lycopene production reached an impressive yield of 9.35 ± 0.36 mg/g while offering advantages such as high efficiency, time savings, preservation benefits, and most importantly environmental friendliness.
研究领域:
食品科学
·
植物化学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2018
·
IF 4.946
Lu Wang,You Luo,Yanan Wu,Yan Liu,Zhenqiang Wu
There are both soluble and insoluble-bound forms of phenolics in tea-leaf products. In order to increase total soluble phenolics contents, guava leaves tea (GLT) was first fermented with Monascus anka and Saccharomyces cerevisiae , and then hydrolyzed with complex enzymes . The changes in phenolics profiles, antioxidant activities and inhibitory effect on α -glucosidase in processed GLT were investigated. Compared with the un-fermented GLT, fermentation and complex enzymatic processing (FE) significantly increased the total phenolics, total flavonoids, quercetin and kaempferol contents by 2.1, 2.0, 13.0 and 6.8 times, respectively. After the FE, a major proportion of phenolics existed in the soluble form. Quercetin was released in the highest amount among different phenolics. In addition, soluble phenolic extracts from GLT following FE exhibited a highest antioxidant activity and inhibitory effect on α -glucosidase. The paper suggested an improved method for processing GLT into high-value products rich in phenolics and flavonoids aglycones with enhanced health benefits.
研究领域:
食品科学
·
植物化学
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）