Minerals
·
2021
·Vol. 11
·期 1
·58
·
IF 2.644
Yinfei Liao,Xingwei Song,Maoyan An,Zhe Yang,Xiaodong Hao,Hourui Ren
The wetting film evolution process is essential for flotation, especially in bubble–particle attachment. A mixed collector has been proved effective in promoting flotation. In this paper, the effect of a mixed collector (MC) composed by n-dodecane (D) and oleic acid (OA) on wetting film evolution was investigated using the extended Derjagin–Landau–Verwey–Overbeek (EDLVO) theory, the Stefan–Reynolds model, induction time, and zeta potential measurement. The hydrophobic force constant between bubble and coal treated by different collectors was analyzed. The results showed that MC was superior in reducing the induction time and increasing the zeta potential. When bubbles interacted with coal treated by MC, they had relatively low interaction energy, high critical film thickness, and high drainage rate. The order of hydrophobic force constant was no reagent < D < OA < MC. It indicated that the hydrophobic interaction between bubbles and coal particles treated by MC was the strongest because of the synergistic effect of D and OA.Keywords:wetting film;EDLVO theory;Stefan–Reynolds model;collector;hydrophobic force constant
研究领域:
矿物加工工程
·
界面化学
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Bing Qiu,Chao Yuan,Mingtai Sun,Weijie Hu,Hua Tan,Suhua Wang
Owing to their unique plasmonic properties, noble metals have been the materials of choice for photovoltaics, photocatalysis and sensors. Here, we demonstrate novel gold(Au) monolayers with tailorable particle diameters and optical property on transparent indium tin oxide (ITO) using a simple electrochemical deposition. The nanoparticles on ITO are spherical and isolated, and are identified as Au 0 nanoparticles. The gold nanoparticles are uniformly distributed on ITO surface, but the gold nanoparticle sizes increase and the particle population densities decrease at lower current densities, resulting in higher light scattering. There is a positive correlation between mean particle size and maximum extinction wavelength of gold nanoparticles prepared with different current densities under a fixed total charge, whereas the maximum extinction wavelength of gold nanoparticles does not change with the total charge under the fixed current densities. The localized surface plasmon resonance change of Au nanoparticles on ITO can be effectively tuned by regulating deposition current density. With the existence of alkanethiols on Au monolayers surface, the original pink color of gold monolayers changed to blue after immersion in toluene for 30 min, indicating hydrophobic force produced by oil-in-water (O/W) or water-in-oil (W/O) phenomenon caused gold nanoparticles to migrate and produce a color change.
研究领域:
材料科学
·
光学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2023
·
IF 6
Guang Tian,Xiangxiang Li,Falin He,Shuqi Guo,Yaoyue Wang,Yuze Li,Wansong Zong,Rutao Liu
Chromium (Cr) poses potential threats on human and ecological health through both food and environmental pathways. However, the response mechanisms of Cr to function-related proteins in human subjects and the differential effects in the case of different valence states of Cr are still lacking. Herein, the binding interactions and mechanisms of lysozyme to Cr(III) and Cr(VI) were investigated by isothermal titration microcalorimetry, multi-spectroscopy, enzyme activity assay, and molecular simulations. Our results indicated that the binding of Cr in different valence states with lysozyme was a relatively affinity process and mainly driven by hydrophobic forces. Both Cr species induced the looseness of backbone for lysozyme and the enhancement of hydrophilicity around the backbone microenvironment. Otherwise, the α-helix of lysozyme was decreased with different valence states of Cr, while Cr(III) showed a greater degree of influence and a stronger regularity. Interestingly, no significant changes in the microenvironment around aromatic amino acid residues were observed under the exposure of different valence states of Cr. Differential structural changes of lysozyme resulted in activity alterations. At 80 mg·L −1 of Cr, Cr (VI) reduced the lysozyme activity to 81.44% of the control, while the lysozyme activity was significantly reduced to 24.45% under the exposure of Cr (III). Further molecular docking showed that amino acids near the binding sites of different valence states of Cr with lysozyme were not identical, but the enzyme active site, Asp52, was all within the binding pocket. This study elucidates the differential toxicity effects and interaction mechanisms of Cr in different valence states, and offers a comprehensive strategy for exploring the in vitro responses of toxicants exposure.
研究领域:
环境科学
·
毒理学
·
生物化学
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
FUEL
·
2025
·
IF 7.5
Shiwei Wang,Songjiang Chen,Chengyong Wang,Yongzhong Hu
This study quantitatively demonstrated the flotation enhancement of coarse low-rank coal using innovative oily bubble technology, combining experimental characterization with advanced theoretical modeling. Systematic X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy revealed that the coal surface contains 53.43 % oxygen-containing functional groups and 38.14 % hydroxyl groups, which traditionally hinder flotation efficiency. The novel application of oily bubbles, generated through hydrodynamic cavitation, remarkably improved coarse particle (1.00–0.75 mm) recovery, achieving up to 78.94 % yield compared to 73.28 % with conventional flotation. The extended DLVO theory revealed a fundamental mechanistic shift: while air bubbles exhibited repulsive energy barriers (critical thickness = 21.02 nm), oily bubbles created attractive interactions with a negative total energy barrier owing to their minimal polar component (46.88 % vs. 0.82 %, respectively). Complementary Stefan–Reynolds modeling showed that oily bubbles accelerated wetting film drainage by 3.6 times, with hydrophobic force constants markedly surpassing those of air bubble systems. These findings provide new insights into interfacial science and address a persistent industry challenge—the inefficient recovery of coarse low-rank coal particles. Future studies will focus on scaling up the oily bubble generation system for industrial deployment.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Yu Tian,Zhijie Zhu,Qing Li,Jing Zhang,Cai-Feng Wang,Guan Wu,Shen Shen Li,Ji Jun Xiao,Su Chen
Methods that allow the self-assembly of colloidal nano/micro-particles into controllable structures are highly important in many applications, such as photonics, biosensors and electronic chemicals. However, the complicated procedures, low assembly efficiency and multiscale integration of self-assembly of colloidal particles have become great challenges. Here, we first develop a hydrophobic-force-induced self-assembly (HFSA) method to fabricate homogeneous and binary colloidal microdroplets by the feed of volatile fluorocarbon oil. Specially, both mono-color and dual-color colloidal photonic crystals (CPCs) can be architected via HFSA in an efficient (within 200 s), coffee-ring free and visualized fashion. Additionally, such effective HFSA process is further confirmed by dissipative particle dynamics (DPD) simulations. Moreover, a variety of multi-structural colored CPCs are available by using hydrophobic reagents, combining with the visualized HFSA process. This work presents an easy-to-perform platform for designing orderly structural materials, which will significantly highlight the development of colloidal assembly methodology.
研究领域:
材料科学
·
光子学
·
胶体化学
·
自组装技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
·
2020
·
IF 1.697
Jiali Gu,Siyao Zheng,Heng Zhao,Ting Sun
Multi-spectroscopic and molecular docking methods were used to study the interaction between triclosan (TCS) and bovine serum albumin (BSA). The results indicated that the fluorescence quenching of BSA by TCS was due to the formation of TCS–BSA complex through static quenching. This result was also demonstrated by time-resolved fluorescence experiment. The binding constants and number of binding sites between TCS and BSA were 1.30 × 105 M−1 and 1.17 at 298 K, respectively. The thermodynamic parameters were studied in detail which suggested that hydrophobic forces and hydrogen bond played major roles in the TCS–BSA interaction. Moreover, the site marker competitive experiments and docking studies revealed that TCS could bind BSA into site I in subdomain IIA. All the results of UV–vis spectrophotometry, circular dichroism spectroscopy and synchronous fluorescence spectroscopy showed that interaction between TCS and BSA induced conformation changes of BSA.
研究领域:
生物化学
·
分子生物学
·
光谱学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
·
IF 3.232
Qiulan Zhang,Zhi Zhu,Yongnian Ni
Foods generally contain special ingredients which easily to interact with drugs human intaking, thus affecting drug efficacy and excretion, and even cause adverse reactions. Vitamin C (Vit. C) is abundant in fresh fruits and vegetables. It plays a regulatory role in redox metabolism, and its absence can cause scurvy. Aspirin (ASP) can be used to treat many diseases, is the earliest, common and widely used as antipyretic, analgesic and antirheumatic medicine. Human serum albumin (HSA) is the most abundant protein in vertebrate plasma and has the property of combining and transporting endogenous and exogenous substances. In this paper, the effects of Vit. C on the combination of ASP and HSA were studied by multi-spectra and voltammetric approaches. Fluorescence spectra showed that the quenching mode between Vit. C and HSA is dynamic, and the main binding force is hydrophobic force . The quenching mode between ASP and HSA is static one, and the main binding force is hydrogen bond and van der Waals force . For ternary biological system of (HSA–ASP)–Vit. C, the binding constant decreases compared with HSA–Vit. C system. However, for (HSA–Vit. C)–ASP system, the binding constant does not change when compared with binary system of HSA–ASP. Based on the technology combination of voltammetry , infrared, three-dimensional fluorescence and circular dichroism (CD), it is proved that the existence of ASP will influence the binding process of Vit. C to HSA. It could be concluded that taking Vit. C first doesn't affect the absorption of ASP and may be good for health; in contrast, it is not good to take Vit. C immediately as one have just taken ASP, because the existence of ASP reduce the absorption of Vit. C for human body.
研究领域:
药理学
·
生物化学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROTEIN AND PEPTIDE LETTERS
·
2022
·Vol. 29
·期 12
·1051-1060
·
IF 1.927
Gao Chengxia,Du Huizhi
Objective: The work aimed to compare the binding between the two main components of Polygala tenuifolia Willd. and two cholinesterases (ChEs) by using a variety of spectral techniques. Methods: Two main components of Polygala tenuifolia Willd. included Tenuifolin (Ten) and Onjisaponin
B (Onj B), and two ChEs included acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Results: The UV-visible absorption spectra results showed that Ten had no effect on the structure of ChEs, and the combination of Onj B with ChEs changed its structure. Onj B statically quenched
the endogenous fluorescence of both of ChEs, Ten dynamically quenched the endogenous fluorescence of AChE with no effect on BChE. The fluorescence quenching rate of ChEs by Onj B was much higher than that of AChE by Ten, and only one binding site of each protein spontaneously interacted with
the compound to bind to or collide. Synchronous fluorescence results showed that Ten and Onj B quenched the fluorescence intensity by affecting tryptophan and tyrosine residues in cholinesterases, respectively. Hydrophobic force played an important role in the interaction between Ten and AChE,
and van der Waals force and hydrogen bond were the main driving forces for the binding of Onj B to ChEs. The Enzyme activity test showed that Onj B inhibited ChE activity, and Ten never inhibited ChE activity. Conclusion: Onj B has the potential to inhibit ChE activity and increase the
neurotransmitter acetylcholine content in the nerve system, improving the Alzheimer's disease (AD).
研究领域:
药理学
·
生物化学
·
神经科学
✓ 已验证
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Huijian Shi,Falin He,Chengqian Huo,Jingqiang Wan,Hengyu Song,Fei Du,Rutao Liu
Plastic fragments are widely distributed in different environmental media and has recently drawn special attention due to its difficulty in degradation and serious health and environmental problems. Among, nanoplastics (NPs) are smaller in size, larger in surface/volume ratio, and more likely to easily adsorb ambient pollutants than macro plastic particles. Moreover, NPs can be easily absorbed by wide variety of organisms and accumulate in multiple tissues/organs and cells, thus posing a more serious threat to living organisms. Alpha-amylase ( α -amylase) is a hydrolase, which can be derived from various sources such as animals, plants, and microorganisms . Currently, no studies have concentrated on the binding of NPs with α -amylase and their interaction mechanisms by employing a multidimensional strategy. Hence, we explored the interaction mechanisms of polystyrene nanoplastics (PS-NPs) with α -amylase by means of multispectral analysis, in vitro enzymatic activity analysis, and molecular simulation techniques under in vitro conditions. The findings showed that PS-NPs had the capability to bind with the intrinsic fluorescence chromophores , leading to fluorescence changes of these specific amino acids. This interaction also caused the alterations in the micro-environment of the fluorophore residues mainly tryptophan (TRP) and tyrosine (TYR) residues of α -amylase. PS-NPs interaction promoted the unfolding and partial expansion of polypeptide chains and the loosening of protein skeletons, and destroyed the secondary structure (increased random coil contents and decreased α -helical contents) of this protein, forming a larger particle size of the PS-NPs- α -amylase complex. Moreover, the enzymatic activity of α -amylase in vitro was found to be inhibited in a concentration dependent manner, thereby impairing its physiological functions. Further molecular simulation found that PS-NPs had a higher tendency to bind to the active site of α -amylase, which is the cause for its structural and functional changes. Additionally, the hydrophobic force played a major role in mediating the binding interactions between PS-NPs and α -amylase. Taken together, our study indicated that PS-NPs interaction can initiate the abnormal physiological functions of α -amylase through PS-NPs-induced structural and conformational alternations.
研究领域:
环境科学
·
生物化学
·
分子生物学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Hongxia Tan,Hongyuan Zhou,Ting Guo,Yuhao Zhang,Liang Ma
Hidden mycotoxins have been reported to be “protected” by macromolecular substances to escape routine determination, but release to free mycotoxins under gastrointestinal conditions. Nowadays, the hidden zearalenone (ZEN) that binding with macromolecular zein has been found in maize. However, the binding mechanism of ZEN with zein in maize has not been clarified. In this study, the formation of ZEN-zein complex was investigated applying ultrafiltration, multi-spectroscopic and molecular modeling techniques. The steady-state and transient fluorescence analysis suggested the ZEN could interact with zein to form the complex driven by hydrophobic force and hydrogen bonds, which is in accordance with the molecular modeling studies. The conformational changes of zein induced by binding with ZEN were revealed by Fourier transform infrared spectroscopy (FTIR) and circular dichroism (CD). Elucidating the binding mechanism between zein and ZEN could help the development of detecting hidden ZEN and guarantee the safety of maize products.
研究领域:
食品科学
·
毒理学
·
分析化学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2024
·
IF 10.5
Danping Wang,Yuetong Huang,Jun Yuan,Shuo Wang,Jingzhe Sheng,Yingjie Zhao,Hao Zhang,Xiyan Wang,Yuanhao Yu,Xianbao Shi,Zhonggui He,Tian Liu,Bingjun Sun,Jin Sun
In the prodrug-based self-assembled nanoassemblies, prodrugs usually consist of drug modules, response modules, and modification modules. Modification modules play a critical role in regulating the nano-assembly ability of the prodrugs. Herein, we carried out a “fatty alcoholization” strategy and chose various lengths of aliphatic alcohol chains (AC) as modification modules to construct disulfide bond bridged paclitaxel (PTX) prodrug nanoassemblies. The PTX-AC prodrugs would self-assemble into nanoassemblies (PTX-AC PNs) with higher drug loading, stability, and tumor selectivity than commercial preparations. After comprehensive exploration, we found the chain length (AC 12 , AC 16 , AC 20 , AC 24 ) of modification modules affected the assembly of PTX-AC PNs, further leading to disparate in vivo fate and antitumor efficacy. With the increase of the chain length of the modification modules (from AC 12 to AC 20 ), the assembly ability of the nanoassemblies was improved, attributed to the appropriate enhancement of hydrophobic force. When the chain length was further increased to AC 24 , the excessive hydrophobic force will lead to the aggregation of prodrugs and weaken the assembly ability. Therefore, PTX-AC 20 PNs with proper chain length may solve the paradox of efficacy and tolerance in 4 T1 breast tumor owing to their optimal nano-assembly stability and modest redox-sensitivity. In short, this work highlighted the importance of screening optimal modification modules in developing prodrug nanoassemblies.
研究领域:
药学
·
纳米技术
·
癌症研究
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Shuo Yang,Ruoxuan Peng,Leitao Cao,Jing Ren,Jinrong Yao,Xin Chen,Zhengzhong Shao,Shengjie Ling
The remarkable mechanical properties of silk fibroin originate from its hierarchical fibrous architecture spanning multiple length scales; however, how these intricate networks precisely govern macroscopic mechanical behavior remains incompletely understood. Here, experimental characterization with computational modeling is integrated to elucidate the structural and molecular mechanisms underpinning silk fibril network formation and mechanical function. High-resolution imaging coupled with deep-learning-based morphological extraction enables precise quantification of critical architectural features within the networks. Coarse-grained molecular dynamics simulations reveal that network mechanical properties and stability are predominantly governed by interfibrillar interaction strengths, with hydrophobic forces identified as the primary molecular drivers of fibril bundling. Specifically, weak interfibrillar cohesive interactions result in flexible and deformable networks under applied stresses, whereas strong interactions induce excessive fibril aggregation, reducing structural adaptability and leading to premature mechanical failure. Simulations under spatially confined conditions, mimicking natural spinning processes, further clarify mechanisms essential for fibril alignment. This study significantly advances the fundamental understanding of silk's structure–property relationships, providing valuable guidelines for designing and precisely controlling silk-based materials for biomedical and structural engineering applications.
研究领域:
材料科学
·
生物物理学
·
计算建模
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）