NEW JOURNAL OF CHEMISTRY
·
2017
·Vol. 41
·期 4
·1834-1839
·
IF 3.269
Ying Zhang,Zijian Gao,Zhe Yu,Xiuyan Ren,Lijie Duan,Guang Hui Gao
In this manuscript, hydrogels with pH-tunable mechanical properties were prepared via transforming the non C–C covalent synergistic interactions of hydrogen bonding, metal ion coordination and hydrophobic effects. The fracture stress of hydrogels exhibited a tendency to firstly decrease and then increase with an increase of pH from 3.0 to 9.0. That is, the fracture stress was enhanced due to the synergistic interactions of hydrophobic effects and hydrogen bonding among carboxylic acid groups at pH 3.0. Then, the strength gradually decreased due to the disappearance of hydrogen bonding at pH from 3.0 to 5.0. Moreover, the fracture stress was also significantly enhanced at pH over 5.0 due to the synergistic interactions of hydrophobic effects and metal ion coordination. Consequently, it is envisioned that the strategy to design novel hydrogels with pH-tunable mechanical properties would provide more interesting directions for hydrogels based on non C–C covalent synergistic interactions in potential biomedical applications.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Yu Lin,Kai Wu,Xin Zhou,Yunsheng Xia
For nanocrystals (NCs) self-assembly, understanding the chemical and supramolecular interactions among building blocks is significant for both fundamental scientific interests and rational nanosuperstructure construction. However, it has remained an extreme challenge for many self-assembly systems due to the lack of appropriately quantitative approaches for the corresponding exploration. Herein, by combination of the proposed colorimetric method for cationic surfactant quantitation and all-atom simulations, we manage to present a clear chemical picture for the thiol molecules modulated self-assembly of gold nanorods (GNRs), one of the earliest and most convenient methods for the fabrication of freestanding GNR self-assemblies. It is revealed that the self-assembly of GNRs is driven by the hydrophobic effects of the alkyl chains of the modified cationic surfactants, as their bilayer structure is destroyed by the added thiol molecules. In other words, the actual roles of the thiol molecules for causing GNRs assembly are indirectly inductive effects instead of the previously believed direct electrostatic attraction and/or hydrogen-bond linking effects of the binding thiol molecules. Furthermore, the GNRs exhibit diameter-dependent assembly behaviors: thicker GNRs tend to adopt the end-to-end assembly mode, while thin ones prefer the side-by-side assembly mode, further demonstrating that hydrophobic effects among the build blocks are the driving force for the GNRs assembly.
研究领域:
纳米材料科学
·
化学
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产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2023
·
IF 4.4
Bo Yang,Panpan Ren,Lu Xing,Shenghan Wang,Chenglin Sun
Insights into the solute-induced water structural transformations are essential to understand the role of water in biological and chemical reaction processes. Herein, the structural changes in water induced by amphiphilic organic molecules were investigated using concentration-dependent derivative Raman spectroscopy (DRS) combined with two-dimensional Raman correlation spectroscopy (2D Raman-COS). We shall restrict our attention in this work to binary mixtures of water with dimethyl sulfoxide (DMSO), acetone, and isopropanol (IPA), all of which have similar chemical structures. The spectral changes in O:H and O H stretching modes illustrate that the solute molecules induce an enhancement of the water structure in dilute solutions, where the enhanced degree of water structure is closely related to the size of the dipole moment of organic molecules. In addition, the transformations of solute-induced water-specific structures were evaluated by 2D Raman-COS, which shows that the strong hydrogen bond (H-bond) structure of water is more sensitive to organic molecules and induces a transition to the weak H-bond structure of water.
研究领域:
生物物理学
·
化学
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Haichang Ding,Baoqiang Li,Zonglin Liu,Gang Liu,Shouzhi Pu,Yujie Feng,Dechang Jia,Yu Zhou
Injectable chitosan hydrogels exhibit excellent biological properties for application in biomedical engineering, however most of these hydrogels have limited applicability because “Swelling” can induce volume expansion of conventional hydrogels implanted in the body damages the surrounding tissues. Here, we report a new “Nonswelling” pentenyl chitosan (PTL-CS) hydrogel via N‒acylation reaction to graft an UV crosslinkable short hydrophobic alkyl chain ( n ‒pentenyl groups). The incorporated pentenyl groups can be crosslinked by UV irradiation to form hydrophobic chains via combination termination, which generate strong hydrophobic effect to extrude the excess water in hydrogel, resulting in a “Nonswelling” state at biological temperature. Furthermore, the PTL-CS solution showed no cytotoxicity in vitro and minimally invasive treatment in vivo demonstrated the PTL-CS hydrogel no adverse effects in a rat model. The nonswelling injectable and UV crosslinkable chitosan hydrogel hold potential applications in smart biomaterials and biological engineering as well as providing a new natural hydrogel in minimally invasive tissue engineering..
研究领域:
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2020
·
IF 5.065
Han Jia,Wenjian Huang,Yugui Han,Qiuxia Wang,Juan He,Jinyong Song,Jiajun Dai,Hui Yan,Dexin Liu
The effects of both hydrophilic and hydrophobic SiO 2 nanoparticles (NPs) on the viscoelasticity of stearyltrimethylammonium bromide/sodium salicylate wormlike micelles (WLMs) solutions were investigated. The micelle-nanoparticle junctions obviously increased the contour length L c of the WLMs to facilitate the viscoelasticity of WLMs solution, which could be reflected by cryo-TEM images and Maxwell model. The effects of SiO 2 NPs on the zero-shear viscosity and the flow activation energies of WLMs with different surfactant alkyl chain lengths were explored in the controlled experiments. It was found that the viscoelasticity of WLMs/NPs mixture was associated with the strength of the hydrophobic effect between the SiO 2 NPs and surfactant molecules in the micelle-nanoparticle junction. The number densities of micelle-nanoparticle junction in hydrophilic and hydrophobic SiO 2 NPs systems were calculated by the mathematical model to confirm our proposed hypothesis.
研究领域:
材料科学
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化学工程
·
界面科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2021
·
IF 7.086
Yifan Liu,Zuxue Liang,Chunxiang Lin,Xiaoxia Ye,Yuancai Lv,Pingfan Xu,Minghua Liu
An amphiphilic cellulose aerogel (HCNC-TPB/TMC) was fabricated by grafting 1,3,5-Tris (4-aminophenyl)benzene (TPB) and trimesoyl chloride (TMC) onto the aldehyde nanocellulose through Schiff alkali and substitution reaction. The obtained HCNC-TPB/TMC exhibited good morphology with cellulose fiber and owned abundant hydrophilic amino and carboxyl groups and hydrophobic aromatic groups. The batch adsorption experiments demonstrated that HCNC-TPB/TMC showed excellent adsorption performance ( Q max = 526.32 mg g −1 ) for sodium diclofenac (DCF), wide pH applicability (4–10) and outstanding stability and reusability. The DCF adsorption obeyed the pseudo-second-order kinetic model and the Langmuir isotherm, and underwent a spontaneous exothermic process. The main adsorption mechanisms involved electrostatic interaction, hydrogen bonds , π-π stacking interaction and hydrophobic effect. Importantly, the introduced carboxyl aromatic groups on TMC could effectively strengthen the hydrogen bonds and the π-π stacking between HCNC-TPB/TMC and DCF.
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Zhiqiang Sun,Lei Zhao,Caihong Liu,Yufei Zhen,Jun Ma
In this study, a high capacity ( q m = 1351 mg g −1 ) with fast adsorption process (t < 5 min) towards bisphenol A (BPA) from water was achieved by an in-situ sp 2 C dominant N-doped carbon (polydopamine-carbon, PDA-C). The adsorption mechanism facilitating to the superior removal performance of PDA-C was systematically investigated by relationship study (adsorption capacity VS physiochemical property) and theoretical calculation. It could be concluded that the dominant sp 2 C ( I D /I G = 0.92–1.02) and N-heteroatom (2.26–5.09 at. %) in PDA-C contributed to enhancing the adsorptive interactions of π-π electron donor-acceptor and hydrophobic effect between the PDA-C and BPA, thus realized a ~1.8 times enhancement of q m in comparison with the conventional carbon (PRF-C). Calculated adsorption energy from the density functional theory (DFT) further demonstrated that the adsorption potential of N-doped carbon towards BPA increased linearly with increasing doping of N-heteroatom, especially for the pyridinic N which determined the hydrophobic effect of carbon. This finding firstly points out the dominant strengthening mechanism of N-heteroatom for carbonaceous adsorbent. The synthesized PDA-C showed a promising environmental application potential as revealed from the stable BPA adsorption efficiency in the interferences (H + /OH − , NaCl and HA), dynamic adsorption operation and multiple cycling test.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
ACS Nano
·
2019
·
IF 13.903
Shenyu Yang,Bo Li,Chunxian Wu,Weiwei Xu,Mei Tu,Yun Yan,Jianbin Huang,Markus Drechsler,Steve Granick,Lingxiang Jiang
Coacervation is liquid–liquid phase separation ubiquitous in industrial applications and cellular biology. Inspired by cellular manipulation of coacervate droplets such as P granules, we report here a regulatory strategy to manipulate synthetic coacervation in a spatiotemporally controllable manner. Two oppositely charged small molecules are shown to phase separate into coacervate droplets in water as a result of electrostatic attraction, hydrophobic effect, and entropy. We identify a down regulator, β-cyclodextrin, to disrupt the hydrophobic effect, thus dissolving the droplets, and an up regulator, amylase, to decompose β-cyclodextrin, thus restoring the droplets. The regulation kinetics is followed in real time on a single-droplet level, revealing diffusion-limited dissolution and reaction-limited condensation, respectively, taking ∼4 s and 2–3 min. Versatility of this strategy to manipulate the coacervation is demonstrated in two aspects: spatially distributed coacervation in virtue of amylase-grafted hydrogel frameworks and coacervate transportation across membranes and hydrogel networks via a disassemble-to-pass strategy. The current regulatory pairs and strategies are anticipated to be general for a wide variety of synthetic self-assembly systems.
研究领域:
材料科学
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生物物理学
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化学工程
·
细胞生物学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 90
·87461-87468
·
IF 3.289
Qing Ge,Dingshuo Lou,Shui Lu,Wei Zhang,Li Zhang,Xinping Wang
Poly(ionic liquid)s (PILs) have promising potential to form assemblies with ordered structures in organic media, but experimental investigation on the detailed aggregation behavior of PILs has seldom been involved. In this study, a series of N-alkyl imidazolium-based PILs with different chemical composition in their n-propanol solution was investigated by conductivity measurements. TEM images indicate that PILs with long alkyl chains exhibit onion-like multilamellar structures. The thermodynamic parameters suggest that aggregation of PILs in their good solvents (n-PrOH) is spontaneous, driven by entropy change associated with a hydrophobic effect. As increasing alkyl chain length from 8 to 16, the contribution of per alkyl chain to ΔGθm for PIL aggregation is found to decrease by more than 2 times. The nonsolvent (H2O) contribution to change of Gibbs free energy as well as critical aggregation concentration (CAC) decrease linearly with the volume fraction of water in mixed solvents, implying that PIL aggregation becomes more favorable with the addition of nonsolvent. The results mentioned above play an important role in understanding the aggregation process of PIL in an organic solvent and developing functional materials with well-ordered structures.
研究领域:
高分子化学
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胶体与界面化学
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物理化学
·
功能材料
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Meng-Meng Chen,Shujie Lin,Ze-Han Wang,Shu-Xin Zhang,Fang-Yuan Chen,Junyi Chen,Dong-Sheng Guo,Qingbin Meng
Many active pharmaceutical ingredients have a specific bitter taste. To enhance patient compliance and treatment efficacy, taste-masking agents are crucial in oral drug formulations. Confronting numerous bitter drug molecules with varied structures, the pharmaceutical field strives to explore and develop universal and effective masking approaches. Here, we reported sulfonated azocalix[4]arene (SAC4A), a universal supramolecular masking agent with deep cavity that provides stronger hydrophobic effect and larger interaction area during recognition, allowing high binding affinity to bitter drug molecules. Moreover, bitter drugs could deeply buried in the cavity, with the bitterness effectively masked. As a result, SAC4A can bind to 16 different bitter drugs with high affinities, encompassing alkaloids, flavonoids, terpenoids, and more, while maintaining high biocompatibility. As anticipated, SAC4A effectively masks the unpalatable bitter taste associated with these drugs. Consequently, SAC4A is a promising universal and effective supramolecular masking agent.
研究领域:
药学
·
药物递送系统
·
超分子化学
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Shuangshou Wang,Haili Wang,Yuwen Ding,Wenzhi Li,Hongrui Gao,Zongpeng Ding,Peng Lin,Jing Gu,Mingfu Ye,Tingxuan Yan,Hongmei Chen,Jin Ye
Herein, a robust instrument-free point-of-care tests (POCTs) strategy was proposed for rapid naked-eye detection of artificial food colorants (AFCs) using filter paper as a sampling and response device. Indicator papers were prepared by one-step polycondensation of silane coupling agents onto glass microfiber filter papers, then colorimetric cards with fine color mappings to AFCs concentration gradients were handily fabricated by AFCs extraction with indicator papers via electrostatic interaction and hydrophobic effect. The lowest concentration for AFCs visual detection was as low as 10 −6 M and the whole POCTs process could be finished within 1 min. Furtherly, color information (RGB and gray-scale values) of AFCs-stained indicator papers and colorimetric cards from smartphone APP was used to reconstruct digitized colorimetry and reinforce its validity by mitigating the possible errors from subjective judgement on colors. Finally, such a dual-mode POCTs strategy was experimentally proved to be highly reliable for rapid visual detection of three AFCs (brilliant blue, Allura red, and sunset yellow) in real drinks by contrast with several instrumental methods like spectrophotometry, HPLC and MS. Due to its fine portability, speediness, low cost and user-friendliness, this strategy paves a promising way for AFCs-related food safety control.
研究领域:
食品科学
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分析化学
·
即时检测
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产品关联
DOI
高影响因子
CHIRALITY
·
2018
·Vol. 30
·期 8
·996-1004
·
IF 1.833
Yuanyuan Li,Qiang Li,Nan Zhu,Zhuxian Gao,Yulong Ma
The graphene oxide (GO) was covalently coupled to the surfaces of silica gel (SiO 2 ) microspheres by amide bond to get the graphene oxide@silica gel (GO@SiO 2 ). Then, the GO@SiO 2 was reduced with hydrazine to the reduced graphene oxide@silica gel (rGO@SiO 2 ), and the cellulose derivatives were physically coated on the surfaces of rGO@SiO 2 to prepare a chiral stationary phase (CSP) for high performance liquid chromatography. Under the optimum experimental conditions, eight benzene-enriched enantiomers were separated completely, and the resolution of trans-stilbene oxide perfectly reached 4.83. Compared with the blank column of non-bonded rGO, the separation performance is better on the new CSP, which is due to the existence of rGO to produce special retention interaction with analytes, such as π-π stacking, hydrophobic effect, π-π electron-donor–acceptor interaction, and hydrogen bonding. Therefore, the obtained CSP shows special selectivity for benzene-enriched enantiomers, improves separation selectivity and efficiency, and rGO plays a synergistic effect with cellulose derivatives on enantioseparation.
研究领域:
分析化学
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材料科学
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色谱学
·
纳米技术
·
有机化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）