JOURNAL OF POLYMER RESEARCH
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2024
·Vol. 32
·期 1
·1-13
·
IF 2.6
Zhang Xian,Jiang Shuai,Guo Jianming,Xin Zhong
The stretchable, biodegradable, thermos-responsive, biocompatible and novel poly(1,3-propylene sebacate)-co-poly(glycerol sebacate) polyurethanes (PPGSU), based on poly(glycerol sebacate) (PGS) and poly(1,3-propylene sebacate) (PPS), were synthesized using simple solvent-based two-step method. The comprehensively properties of PPGSU, including the chemical structure, crystalline structure, thermal stability, mechanical performance, water absorption, degradation behavior, drug release behavior, temperature-responsive shape memory effect, as well as biocompatibility were investigated in detail. The impact of the different ratio of PPS and PGS on the properties of final PPGSU product was also studied. The introduction of PPS in the poly(glycerol sebacate urethance) (PGSU) system could increase the glass transition temperature ( T g ) and stretchability. The PPGSU polymers showed adjustable tensile strength ranging from 0.5 MPa to 1.3 MPa, as well as the degradable rate and shape memory effect. Furthermore, these elastomers exhibited promising in vitro biocompatibility with adult mouse fibroblasts L929 cells, indicative of their potential for medical applications. Additionally, the possible potential application of biodegradable PPGSU elastomers in the field of drug delivery were examined. Overall, this research offers new perspectives on the development of biomaterials with tailored properties for medical applications.
研究领域:
材料科学
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生物医学工程
·
生物材料学
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 138
·期 43
·51274
·
IF 3.125
Huichao Zhu,Jianjun Yang,Mingyuan Wu,Qingyun Wu,Jiuyi Liu,Jianan Zhang
Two castor oil acid esters containing a ketal or ketone group (KCL or CL), as alternative plasticizers for poly(vinyl chloride) (PVC), were prepared. The structures were confirmed by 1 H NMR and FTIR spectroscopies. The effects of the presence of a ketal or ketone group in these compounds on PVC plasticization were examined. The DMA and SEM results showed that both plasticizers were miscible with PVC and exhibited excellent plasticizing properties, compared to those of dioctyl phthalate (DOP). The PVC plasticized by KCL displayed a lower T g value of 20.6 ° C, which was lower than that of PVC plasticized with DOP (22.3 ° C) and PVC plasticized with CL (40.5 ° C). Tensile tests indicated that PVC plasticized using KCL showed a 37% higher of elongation at break than PVC plasticized by CL and 30% higher than PVC plasticized by DOP. The plasticizing mechanism was also investigated. Moreover, exudation, volatility, and extraction tests, along with TGA indicated that the presence of ketal groups effectively improved the migration resistance of plasticizer and the thermal stability of PVC blends. Taken together, introducing ketal groups into plasticizer might be an effective strategy for improving its plasticizing efficiency.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
Advanced Fiber Materials
·
2020
·Vol. 2
·期 2
·105-117
·
IF 0
Yang Xiaoping,Li Lingfeng,Yang Dongzhi,Nie Jun,Ma Guiping
Biomimetic scaffolds made by synthetic materials are usually used to replace the natural tissues aimed at speeding up the skin regeneration. In this study, a flexible and cytocompatible poly(glycerol sebacate)@poly- l -lactic acid (PGS@PLLA) fibrous scaffold with a core–shell structure was fabricated by coaxial electrospinning, where the shell PLLA was used to be a skeleton with pores on the fibrous surface. The fibrous morphology with pores on the surface of the prepared fibers was observed by SEM. The core–shell microstructure of PGS@PLLA fibers was confirmed by TEM and Laser Scanning Confocal Microscopy (LSCM). In addition, the prepared fibers exhibited a strong ability to repair tissues of the skin wound, where the stability of cell security and proliferation, and the lower inflammatory response were all superior to those of pure PLLA scaffold. It’s worth noting that the percentage of skin tissue was regenerated by 95% within 14 days, which suggests the potential application for electrospun-based synthetic fibrous scaffolds on wound healing.
研究领域:
生物医学工程
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材料科学
·
组织工程
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产品关联
DOI
Acta Biomaterialia
·
2018
·
IF 6.383
Zihao Wang,Yifan Ma,YanXiang Wang,Yutong Liu,Kai Chen,Zihan Wu,Shuang Yu,Yuan Yuan,Changsheng Liu
Poly (glycerol sebacate) (PGS), a tough elastomer, has been widely explored in tissue engineering due to the desirable mechanical properties and biocompatibility. However, the complex curing procedure (high temperature and vacuum) and limited hydrophilicity (∼90° of wetting angle) greatly impede its functionalities. To address these challenges, a urethane-based low-temperature setting, PEGylated PGS bioelastomer was developed with and without solvent. By simultaneously tailoring PEG and hexamethylene diisocyanate (HDI) contents, the elastomers X-P-mUs (X referred to the PEG content and m referred to HDI content) with a broad ranging mechanical properties and customized hydrophilicity were constructed. The X-P-mUs synthesized exhibited adjustable tensile Young’s modulus, ultimate tensile strength and elongation at break in the range of 1.0 MPa–14.2 MPa, 0.3 MPa–7.6 MPa and 53.6%–272.8%, with the water contact angle varying from 28.6° to 71.5°, respectively. Accordingly, these elastomers showed favorable biocompatibility in vitro and mild host response in vivo . Furthermore, the potential applications of X-P-mU elastomers prepared with solvent-base and solvent-free techniques in biomedical fields were investigated. The results showed that these X-P-mU elastomers with high molding capacity at mild temperature could be easily fabricated into various shapes, used as reinforcement for fragile materials, and controllable delivery of drugs and proteins with excellent bioactivity, demonstrating that the X-P-mU elastomers could be tailored as potential building blocks for diverse applications in biomedical research. Statement of Significance Poly(glycerol sebacate) (PGS), a tough biodegradable elastomer, has received great attentions in biomedical field. But the complex curing procedure and limited hydrophilicity greatly hamper its functionality. Herein, a urethane-based low-temperature setting, PEGylated PGS (PEGS-U) bioelastomer with highly-customized mechanical properties, hydrophilicity and biodegradability was first explored. The synthesized PEGS-U showed favorable biocompatibility both in vitro and in vivo . Furthermore, the PEGS-U elastomer could be easily fabricated into various shapes, used as reinforcement for fragile materials, and controllable delivery of drugs and proteins with excellent bioactivity. This versatile, user-tunable bioelastomers should be a promising biomaterials for biomedical applications.
研究领域:
生物医学工程
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材料科学
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组织工程
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DOI
PubMed
高影响因子
Polymers
·
2019
·Vol. 11
·期 6
·965
·
IF 3.164
Yanxiang Wang,Haiwa Wu,Zihao Wang,Jingjing Zhang,Jing Zhu,Yifan Ma,Zhaogang Yang,Yuan Yuan
Poly(glycerol sebacate) (PGS), a biodegradable elastomer, has been extensively explored in biomedical applications for its favorable mechanical properties and biocompatibility. Efforts have been made to fabricate multifunctional PGS copolymer in recent years, in particular PGS-co-PEG (poly(glycerol sebacate)-co-polyethylene glycol) polymers. However, rare research has been systematically conducted on the effect of reactant ratios on physicochemical properties and biocompatibility of PGS copolymer till now. In this study, a serial of PEGylated PGS (PEGS) with PEG content from 20% to 40% and carboxyl to hydroxyl from 0.67 to 2 were synthesized by thermal curing process. The effects of various PEGS on the mechanical strength and biological activity were further compared and optimized. The results showed that the PEGS elastomers around 20PEGS-1.0C/H and 40PEGS-1.5C/H exhibited the desirable hydrophilicity, degradation behaviors, mechanical properties and cell viability. Subsequently, the potential applications of the 20PEGS-1.0C/H and 40PEGS-1.5C/H in bone repair scaffold and vascular reconstruction were investigated and the results showed that 20PEGS-1.0C/H and 40PEGS-1.5C/H could significantly improve the mechanical strength for the calcium phosphate scaffolds and exhibited preferable molding capability for fabrication of the vascular substitute. These results confirmed that the optimized PEGS elastomers should be promising multifunctional substrates in biomedical applications.Keywords:poly(glycerol sebacate) (PGS);polyethylene glycol (PEG);biomedical application;biodegradable elastomer
研究领域:
材料科学
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生物医学工程
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DOI
PubMed
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 97
·79703-79714
·
IF 3.84
Hengsong Shi,Qi Gan,Xiaowei Liu,Yifan Ma,Jun Hu,Yuan Yuan,Changsheng Liu
Polylactic acid (PLA) has been extensively researched in biomedical engineering applications due to its superior mechanical strength and biocompatibility in vivo. But the inherent brittleness, slow degradability and inferior hydrophilicity greatly hamper its successful application. Here, a biodegradable crosslinked elastomer poly(glycerol sebacate) (PGS) was adapted to modify PLA scaffold for bone tissue engineering in this study. A highly interconnected and large porous, three-dimensional (3D) PLA-based scaffold was prepared by a NaCl particulate-leaching method and the PGS prepolymer (pre-PGS) was introduced either by pre-molding binary blend (B.B) or by surface coating (S.C) of a homogeneous PGS onto PLA-based scaffolds with and without oxygen plasma pretreatment (O.P and D.C). After curing at 130 °C, the resulting PLA/PGS scaffolds all exhibited well interconnected open-cell structures. The incorporation of PGS to PLA both by B.B and S.C could effectively improve the hydrophilicity, degradation, toughness and ductility, and the best efficacy was observed for the S.C with the oxygen plasma pretreatment. Specifically, at the ratio of PLA/PGS 9 : 1 and 7 : 3, the fracture strain of the PLA/PGS scaffolds by O.P were improved from 8% (pure PLA) to 13% and 24%, respectively. Further studies indicated that enhanced hydrophilicity and increased surface roughness were the main contributors to the above positive effect of oxygen-based plasma treatment. Additionally, these hybrid PLA/PGS scaffolds exhibited good mineralization, high cell biocompatibility, and enhanced cell adhesion and osteogenic differentiation for bone mesenchymal stem cells (BMSCs), especially for scaffolds by S.C. The present results suggest that the surface coating of PGS with oxygen-based plasma pretreatment is an effective strategy to modify the properties of PLA and the hybrid PLA/PGS scaffold represents a promising candidate in the formulation of bone tissue regeneration.
研究领域:
生物医学工程
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材料科学
·
再生医学
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DOI
高影响因子
Polymers
·
2023
·Vol. 15
·期 15
·3168
·
IF 5
Ruixue Niu,Zhening Zheng,Xuedong Lv,Benqiao He,Sheng Chen,Jiaying Zhang,Yanhong Ji,Yi Liu,Liuchun Zheng
The introduction of long-chain branched structures into biodegradable polyesters can effectively improve the melt strength and blow-molding properties of polyesters. In this study, pentaerythritol (PER) was used as a branching agent to synthesize branched poly(butylene dodecanedioate) (PBD), and the resulting polymers were characterized by Nuclear Magnetic Resonance Proton Spectra (1H NMR) and Fourier Transform Infrared spectroscopy (FT-IR). It was found that the introduction of a small amount of PER (0.25–0.5 mol%) can generate branching and even crosslinking structures. Both impact strength and tensile modulus can be greatly improved by the introduction of a branching agent. With the introduction of 1 mol% PER content in PBD, the notched impact strength of PBD has been increased by 85%, and the tensile modulus has been increased by 206%. Wide-angle X-ray diffraction and differential scanning calorimetry results showed that PER-branched PBDs exhibited improved crystallization ability compared with linear PBDs. Dynamic viscoelastics revealed that shear-thickening behaviors can be found for all branched PBD under low shear rates.Keywords:biodegradable;polyester;poly(butylene dodecanedioate);branched;mechanical properties;rheological properties
研究领域:
材料科学
·
化学工程
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 20
·3279-3290
·
IF 5.047
Shuang Yu,Jun Shi,Yutong Liu,Jiawen Si,Yuan Yuan,Changsheng Liu
The treatment of bone defects in the field of periodontology and oral implantology has been a major clinical problem to date. Guided bone regeneration (GBR), based on ideal barrier membranes to provide space maintenance and selectively promote the regeneration of the damaged area by prevention of invasion by the fibrous tissues, represents the most promising strategy at present. In this study, the mechanically robust and flexible membrane PEGylated poly(glycerol sebacate) (PEGS) coordinated by β-TCP nanoparticles (PEGS/β-TCP) was developed by a simple prepolymer mixing-in situ crosslinking method. By tailoring the content of β-TCP (0, 10, 50, and 90 wt% relative to the prepolymer), the resultant PEGS/β-TCP composite membranes exhibited controllable degradation rate and reinforced mechanical properties. The maximum tensile strength of 9.58 ± 0.02 MPa was presented by the P20T50 group (weight ratio of β-TCP to PEGS20 prepolymer was 50%), about 1.5-fold higher than that of P20T0 without β-TCP. For cellular responses, the PEGS/β-TCP membranes showed desirable cell attachment and viability on rat bone mesenchymal stem cells (rBMSCs). The incorporation of β-TCP definitely enhanced the alkaline phosphatase activity and promoted mineralization, thus facilitating the osteogenic differentiation. The in vivo result obtained for the rat calvarial defect model reaffirmed the favorable bone regenerative ability of the fabricated membranes, especially for P20T50 with the highest bone volume/tissue volume ratio (BV/TV) at both 4 weeks (17.26 ± 1.49%) and 8 weeks (23.24 ± 2.85%) after the surgery. Therefore, the PEGS/β-TCP composite membranes prepared by this prepolymer mixing-in situ crosslinking process will be a prospective biomaterial for the GBR therapy.
研究领域:
生物材料学
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口腔医学
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组织工程学
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产品关联
DOI
高影响因子
POLYMER TESTING
·
2017
·
IF 2.464
Xiaolan Zhang,Chuanlong Jia,Xiuying Qiao,Tianyi Liu,Kang Sun
Porous mSF/PGS and CS/PGS composite scaffolds were prepared by the combination of poly(glycerol sebacate) (PGS) with silk fibroin microfibers (mSF) and chitosan (CS) as modifiers through particulate leaching and freeze-drying techniques. Both mSF/PGS and CS/PGS scaffolds show highly interconnected and open porous structures, and the crosslink density and water absorption of PGS were obviously enhanced by the modifiers. Moreover, the silk fibroin microfiber and chitosan can slow down and control the degradation rate of PGS. The biocompatibility of these porous PGS based composite scaffolds for skin tissue engineering was evaluated by cell culture experiments, and the results indicate of the good attachment, proliferation and deep penetration of cells into these composite scaffolds.
研究领域:
生物材料学
·
组织工程学
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产品关联
DOI
高影响因子
Lubrication Science
·
2016
·Vol. 28
·期 8
·505-519
·
IF 1.384
Fengjie Jin,Guangbin Yang,Yi Peng,Shengmao Zhang,Laigui Yu,Pingyu Zhang
N-containing borate ester (MEBE) with five-member ring structure as a lubricant additive was synthesised. The tribological properties in liquid paraffin (LP), poly-alpha-olefin (PAO) and dioctyl sebacate (DOS) were evaluated, and the action mechanisms in different base oils were also explored. It was found that as-synthesised borate ester possesses excellent antiwear performance in LP and PAO. XPS analysis suggests that the additive forms a protective film on the rubbing surfaces which is composed of BN, Fe 2 O 3 , polyoxyethylene ether and N-containing organic compounds. The inorganic and organic protective films in the metal surface effectively improve the antiwear ability of the base stock. However, when the additive MEBE was introducted into DOS base oil which is prone to adsorbing to the metal surface because of the high polarity of DOS, it influences the compactness of the film formed by the DOS, resulting in weak antiwear property. Copyright © 2016 John Wiley & Sons, Ltd.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
ANALYTICAL SCIENCES
·
2017
·Vol. 33
·期 1
·105-110
·
IF 1.228
Li Yan,Guo Ran,Liu Shengnan,He Anqi,Bao Yanan,Weng Shifu,Huang Yaping,Xu Yizhuang,Ozaki Yukihiro,Noda Isao,Wu Jinguang
In this study, the feasibility of using copper oxide (CuO) as an interface for the coupling of liquid chromatography (LC) and Fourier-transform infrared (FTIR) spectroscopy was investigated. CuO exhibits low absorption in the 4000 to 1000 cm −1 FTIR spectral region. In addition, LC-FTIR using CuO as the interface was extended to the analysis of sample mixtures containing benzamide and dioctyl sebacate; both analytes were successfully separated. After complete removal of (he mobile phase, benzamide and dioctyl sebacate were successfully identified from the FTIR spectrum. Surprisingly, the interference from adsorbed water or conventionally used LC solvents in the FTIR spectrum was completely eliminated by using CuO particles as the interface in the off-line hyphenation of LC-FTIR. Based on these results. CuO demonstrates potential as an ideal interface for LC-FTIR analysis.
研究领域:
分析化学
·
光谱学
✓ 已验证
DOI
PubMed
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2025
·
IF 2.7
Yuanjuan Sheng,Changjiang Li,Jie Jiang,Jinjin Li,Ling Zhao,Zhenhao Xi
In this study, a series of cross-linked poly(glycerol sebacate itaconic) (PGSIA) was prepared using a two-step method, involving pre-PGS oligomers with varying hydroxyl contents and molecular weights. The effects of different pre-PGS oligomers on the structure and properties of the cross-linked PGSIAs were investigated. Upon increasing the pre-PGS molecular weight, the degree of cross-linking degree of the PGSIA increased accordingly. Young's modulus and tensile strength increased dramatically from 1.97 and 1.25 MPa to 24.94 and 7.82 MPa, respectively. Meanwhile, the glass transition temperature ( T g ) increased from −15.5°C to −5.3°C. The water contact angle increased from 62.3° to 88.0°, and the degradation mass loss decreased from 12.8% to 4.3%. Upon increasing the hydroxyl content, the degree of cross-linking degree increased, along with the increase in the Young's modulus, which increased from 3.17 to 9.97 MPa, while tensile strength increased from 1.35 to 3.39 MPa. The T g decreased gradually from −7.5°C to −19.8°C. The water contact angle increased from 47.9° to 80.4°, and the loss of degradation mass loss increased from 6.1% to 23.5%. In this work, poly(glycerol sebacate itaconic) (PGSIA), was prepared by a solvent-free melt process as a green chemistry advantage.
研究领域:
生物材料
·
高分子化学
·
组织工程
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再生医学
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生物力学
·
降解材料
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）