JOURNAL OF POLYMER RESEARCH
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2024
·Vol. 32
·期 1
·1-13
·
IF 2.6
Zhang Xian,Jiang Shuai,Guo Jianming,Xin Zhong
The stretchable, biodegradable, thermos-responsive, biocompatible and novel poly(1,3-propylene sebacate)-co-poly(glycerol sebacate) polyurethanes (PPGSU), based on poly(glycerol sebacate) (PGS) and poly(1,3-propylene sebacate) (PPS), were synthesized using simple solvent-based two-step method. The comprehensively properties of PPGSU, including the chemical structure, crystalline structure, thermal stability, mechanical performance, water absorption, degradation behavior, drug release behavior, temperature-responsive shape memory effect, as well as biocompatibility were investigated in detail. The impact of the different ratio of PPS and PGS on the properties of final PPGSU product was also studied. The introduction of PPS in the poly(glycerol sebacate urethance) (PGSU) system could increase the glass transition temperature ( T g ) and stretchability. The PPGSU polymers showed adjustable tensile strength ranging from 0.5 MPa to 1.3 MPa, as well as the degradable rate and shape memory effect. Furthermore, these elastomers exhibited promising in vitro biocompatibility with adult mouse fibroblasts L929 cells, indicative of their potential for medical applications. Additionally, the possible potential application of biodegradable PPGSU elastomers in the field of drug delivery were examined. Overall, this research offers new perspectives on the development of biomaterials with tailored properties for medical applications.
研究领域:
材料科学
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生物医学工程
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生物材料学
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产品关联
DOI
高影响因子
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2017
·Vol. 130
·期 2
·935-941
·
IF 1.953
Han Lipeng,Ma Guixiang,Xie Shaolei,Sun Jinhe,Jia Yongzhong,Jing Yan
Shape-stabilized composite phase change materials composed of sebacic acid (SA) and MCM-41 were prepared by a facile blending and impregnating method. Various characterization techniques were carried out to characterize their structural and thermal properties, including thermogravimetry (TG) analyses and differential scanning calorimetry (DSC), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy. The XRD and FT-IR results indicated the interactions between SA and MCM-41, such as the capillary force and the hydrogen bonding, resulting in the confined crystallization process. As a result, the SA that was confined was amorphous. The TG analysis results showed that the presence of MCM-41 practically resulted in an overlapping of the two decomposition stages. The DSC analysis demonstrated that a decrease in the SA content was accompanied by a continuous decrease in the melting point and phase change enthalpy of the composites.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
BIOCATALYSIS AND BIOTRANSFORMATION
·
2022
·
IF 2.325
Mingxin Zhu,Shuyi Guo,Rongchen Mang,Hua Zhou
Sebacic esters have excellent lubricity, thermal stability, and biodegradability and therefore are widely used as aerospace lubricants, metal working oil, or engine oil. They are mainly produced by chemical synthesis which, however, may cause environmental pollution, its enzymatic synthesis represents a more environmentally friendly alternative. A few reports have described the synthesis of sebacic esters employing immobilised lipases, but these biocatalytic reactions were exclusively carried out in solvent-free systems and thus, could have been limited by slow reaction rates and high reaction temperatures due to poor enzyme dispersion, low substrate solubility, and high viscosity of the reaction mixture. The current study investigated the biosynthesis of dioctyl sebacate in toluene by Novozym 435, a commercial immobilised lipase. The reaction parameters were investigated using the single factor approach and an orthogonal array design. The optimal conditions obtained were as follows: 10 mL toluene, sebacic acid,1 mmol (202.25 mg); molar ratio of sebacic acid to 1-octanol, 1:3; Novozym 435, 0.03 g; 4 Å molecular sieves, 1.5 g; reaction temperature, 40 °C; reaction time, 30 h. A dioctyl sebacate conversion rate of 93% was achieved under these optimal conditions. In particular, the addition of molecular sieves to the reaction mixture markedly improved the product yield. The reaction temperature was low enough to make the operation easy and energy-efficient and therefore, well suited for large-scale production.
研究领域:
化学工程
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生物化学
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环境科学
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产品关联
DOI
高影响因子
Advanced Fiber Materials
·
2020
·Vol. 2
·期 2
·105-117
·
IF 0
Yang Xiaoping,Li Lingfeng,Yang Dongzhi,Nie Jun,Ma Guiping
Biomimetic scaffolds made by synthetic materials are usually used to replace the natural tissues aimed at speeding up the skin regeneration. In this study, a flexible and cytocompatible poly(glycerol sebacate)@poly- l -lactic acid (PGS@PLLA) fibrous scaffold with a core–shell structure was fabricated by coaxial electrospinning, where the shell PLLA was used to be a skeleton with pores on the fibrous surface. The fibrous morphology with pores on the surface of the prepared fibers was observed by SEM. The core–shell microstructure of PGS@PLLA fibers was confirmed by TEM and Laser Scanning Confocal Microscopy (LSCM). In addition, the prepared fibers exhibited a strong ability to repair tissues of the skin wound, where the stability of cell security and proliferation, and the lower inflammatory response were all superior to those of pure PLLA scaffold. It’s worth noting that the percentage of skin tissue was regenerated by 95% within 14 days, which suggests the potential application for electrospun-based synthetic fibrous scaffolds on wound healing.
研究领域:
生物医学工程
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材料科学
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组织工程
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产品关联
DOI
EUROPEAN POLYMER JOURNAL
·
2022
·
IF 5.546
Peng Wei,Longlong Li,Li Wang,Jinfei Yan,Jiahao Li,Caihong Chen,Yifeng Zhang
In this study, a series of high-performance biobased liquid crystal copolyesters derived from 6-hydroxy-2-naphthoic acid (HNA), 4, 4ʹ-Dihydroxybiphenyl (BP), biobased 2,5-furandicarboxylic acid (FDCA) and sebacic acid (SeA) were successfully designed and prepared via “one-pot” melt polycondensation method. The addition of nonlinear and rigid FDCA units broke the regularity of the molecular chain but increased the chain rigidity, thus, endowing the unique thermal behavior, which the melting temperature decreased from 163.0 to 125.3 ℃, while the glass transition temperature decreased first and then increased slightly to 75.7 ℃ as increased the FDCA units to 7.5 mol%. Furthermore, DSC and XRD results showed that a small amount (1 mol%) of FDCA units did not impair crystallization ability of the copolyesters, whereas excess of FDCA hindered the molecular chain packing. The DMA results also demonstrated that the addition of FDCA restricts the chain motion and improves the rigidity of the copolyester as reflected by the higher storage modulus. The incorporation of nonlinear FDCA units lowered the initial degradation temperature slightly, but still exhibited enough thermal stability to be melt processed as compared with its relative low melting temperatures. The copolyesters exhibited a broad temperature range of nematic liquid crystal phase as well as shear thinning and viscous melt flow behavior, which were beneficial for its melt processing. The tensile strength and modulus of the injection molded splines were in range of 82.51–103.27 MPa and 2.05–2.72 GPa, respectively, which were much higher than the common biobased copolyesters such as PLA, PCL and other FDCA-containing polyesters. The increased modulus and decreased fracture strain of the copolyesters containing FDCA units further verified the high rigidity of the molecular chain. Moreover, the in-vitro cytotoxicity and water contact angle results proved that the copolyesters have good biocompatibility. The resulted copolyesters combined with excellent melt processing ability, mechanical property and good biocompatibility have great promising applications as biomedical and biodegradable materials.
研究领域:
材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 138
·期 43
·51274
·
IF 3.125
Huichao Zhu,Jianjun Yang,Mingyuan Wu,Qingyun Wu,Jiuyi Liu,Jianan Zhang
Two castor oil acid esters containing a ketal or ketone group (KCL or CL), as alternative plasticizers for poly(vinyl chloride) (PVC), were prepared. The structures were confirmed by 1 H NMR and FTIR spectroscopies. The effects of the presence of a ketal or ketone group in these compounds on PVC plasticization were examined. The DMA and SEM results showed that both plasticizers were miscible with PVC and exhibited excellent plasticizing properties, compared to those of dioctyl phthalate (DOP). The PVC plasticized by KCL displayed a lower T g value of 20.6 ° C, which was lower than that of PVC plasticized with DOP (22.3 ° C) and PVC plasticized with CL (40.5 ° C). Tensile tests indicated that PVC plasticized using KCL showed a 37% higher of elongation at break than PVC plasticized by CL and 30% higher than PVC plasticized by DOP. The plasticizing mechanism was also investigated. Moreover, exudation, volatility, and extraction tests, along with TGA indicated that the presence of ketal groups effectively improved the migration resistance of plasticizer and the thermal stability of PVC blends. Taken together, introducing ketal groups into plasticizer might be an effective strategy for improving its plasticizing efficiency.
研究领域:
材料科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2025
·
IF 5
Wang Guoqiang,Zhang Mengke,Shi Longqing,Qi Chao,Zhao Zhenxiao,Hu Hongliang,Jin Yujie,Hu Jing
Long-chain polyesters were prepared by melt polymerization using tetradecanedioic acid (TA) and aliphatic diols containing C2-10 as raw materials. The materials were characterised using a range of analytical techniques, including tensile testing, rheological testing, dynamic mechanical analysis (DMA), wide-angle X-ray diffraction (WAXD), differential scanning calorimetry (DSC), gel permeation chromatography (GPC), and thermal gravimetric analysis (TGA). An investigation was conducted to ascertain the impact of diol chain length on a number of characteristics, including mechanical properties, crystalline structures, chemical composition, thermal stability, and thermal transition properties. All polyesters had high weight-average molecular weights (> 57000 g/mol). In addition, the crystallization temperature and melting temperature were affected by the chain length of diols. Poly(ethylene tetradecanedioate) (PETd) had a higher crystallization temperature (69.1 °C) and melting temperature (89.0 °C) compared to the other four polyesters, which may be due to its short-chain structure and the kink structures. All polyesters have the same crystal structure like polyethylene. In addition, poly(ethylene tetradecanedioate) (PETd), poly(butylene tetradecanedioate) (PBTd), and poly(octenyl tetradecanedioate) (POTd) exhibited polyethylene-like mechanical properties with comparable tensile strength and elongation at break. It is anticipated that bio-based polyesters will prove to be a highly promising material.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
POLYMER TESTING
·
2017
·
IF 2.464
Xiaolan Zhang,Chuanlong Jia,Xiuying Qiao,Tianyi Liu,Kang Sun
Porous mSF/PGS and CS/PGS composite scaffolds were prepared by the combination of poly(glycerol sebacate) (PGS) with silk fibroin microfibers (mSF) and chitosan (CS) as modifiers through particulate leaching and freeze-drying techniques. Both mSF/PGS and CS/PGS scaffolds show highly interconnected and open porous structures, and the crosslink density and water absorption of PGS were obviously enhanced by the modifiers. Moreover, the silk fibroin microfiber and chitosan can slow down and control the degradation rate of PGS. The biocompatibility of these porous PGS based composite scaffolds for skin tissue engineering was evaluated by cell culture experiments, and the results indicate of the good attachment, proliferation and deep penetration of cells into these composite scaffolds.
研究领域:
生物材料学
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组织工程学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Wei Zhang,Yueshuang Wang,Ai Li,Yadong Lv,Guangxian Li,Qi Yang,Miqiu Kong
In this work, different fractions of poly(sebacic acid anhydride) (PSA) are used to control the molecular networks of epoxy vitrimers synthesized from diglycidyl ether of bisphenol A (DGEBA) and glutaric anhydride (GA) under the initiation of 1,4-benzenedimethanol (BDM). It is found that the toughness and self-healing performance of the modified epoxy vitrimer are significantly improved by the introduction of PSA with a long alkyl chain. Particularly, with the addition of 10 wt % PSA, the impact toughness and elongation at break of the epoxy vitrimer are increased by 1966.2 and 855.2%, respectively; meanwhile, the self-healing and reprocessing performances are improved. Furthermore, relative mechanisms are proposed in terms of the reaction of PSA with a long alkyl chain in the molecular network structure. Specifically, under the initiation of the hydroxyls of BDM, not only carboxyl groups can be formed via the ring-opening of GA but also sebacic acid (SA) can be formed via the reaction of the anhydride of PSA, so that abundant dicarboxylic acids can react with the epoxide groups of DGEBA, and thus PSA with a long alkyl chain can be introduced into the molecular networks of the epoxy vitrimer. As a result, the transesterification and the relaxation of the molecular networks are advanced, and the toughness is significantly improved. This work supplies a simple method to prepare toughened catalyst-free epoxy vitrimers with self-healing and reprocessing properties.
研究领域:
材料科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
Acta Biomaterialia
·
2018
·
IF 6.383
Zihao Wang,Yifan Ma,YanXiang Wang,Yutong Liu,Kai Chen,Zihan Wu,Shuang Yu,Yuan Yuan,Changsheng Liu
Poly (glycerol sebacate) (PGS), a tough elastomer, has been widely explored in tissue engineering due to the desirable mechanical properties and biocompatibility. However, the complex curing procedure (high temperature and vacuum) and limited hydrophilicity (∼90° of wetting angle) greatly impede its functionalities. To address these challenges, a urethane-based low-temperature setting, PEGylated PGS bioelastomer was developed with and without solvent. By simultaneously tailoring PEG and hexamethylene diisocyanate (HDI) contents, the elastomers X-P-mUs (X referred to the PEG content and m referred to HDI content) with a broad ranging mechanical properties and customized hydrophilicity were constructed. The X-P-mUs synthesized exhibited adjustable tensile Young’s modulus, ultimate tensile strength and elongation at break in the range of 1.0 MPa–14.2 MPa, 0.3 MPa–7.6 MPa and 53.6%–272.8%, with the water contact angle varying from 28.6° to 71.5°, respectively. Accordingly, these elastomers showed favorable biocompatibility in vitro and mild host response in vivo . Furthermore, the potential applications of X-P-mU elastomers prepared with solvent-base and solvent-free techniques in biomedical fields were investigated. The results showed that these X-P-mU elastomers with high molding capacity at mild temperature could be easily fabricated into various shapes, used as reinforcement for fragile materials, and controllable delivery of drugs and proteins with excellent bioactivity, demonstrating that the X-P-mU elastomers could be tailored as potential building blocks for diverse applications in biomedical research. Statement of Significance Poly(glycerol sebacate) (PGS), a tough biodegradable elastomer, has received great attentions in biomedical field. But the complex curing procedure and limited hydrophilicity greatly hamper its functionality. Herein, a urethane-based low-temperature setting, PEGylated PGS (PEGS-U) bioelastomer with highly-customized mechanical properties, hydrophilicity and biodegradability was first explored. The synthesized PEGS-U showed favorable biocompatibility both in vitro and in vivo . Furthermore, the PEGS-U elastomer could be easily fabricated into various shapes, used as reinforcement for fragile materials, and controllable delivery of drugs and proteins with excellent bioactivity. This versatile, user-tunable bioelastomers should be a promising biomaterials for biomedical applications.
研究领域:
生物医学工程
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材料科学
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组织工程
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2017
·Vol. 135
·期 14
·46076
·
IF 1.86
Zhen Jia,Jinggang Wang,Liyuan Sun,Jin Zhu,Xiaoqing Liu
A serials of fully bio-based poly(ethylene dodecanedioate-2,5-furandicarboxylate) (PEDF) were synthesized from Dodecanedioic acid (DDCA), 2,5-Furandicarboxylic acid (2,5-FDCA), and ethylene glycol through a two-step procedure consisted of transesterification and polycondensation. After their chemical structures were confirmed by Nuclear Magnetic Resonance and Fourier Transform Infrared Spectroscopy, their thermal, mechanical, and biodegradation properties were investigated in detail. Results showed that the chemical composition of PEDFs could be easily controlled by the feeding mole ratio of DDCA to FDCA and they possessed the characteristic of random copolyester with the intrinsic viscosity ranged from 0.82 to 1.2 dL/g. With the varied mole ratio of DDCA to FDCA, PEDFs could be changed from semicrystalline thermoplastic to the completely amorphous elastomer, indicated by the elongation at break ranged from 4 for poly(ethylene 2,5-furandicarboxylate) to 1500% for amorphous PEDF-40. The amorphous PEDF-30 and PEDF-40 showed satisfactory shape recovery after cyclic tensile test, which was the typical behavior for elastomer. Enzymatic degradation test indicated that all the PEDFs were biodegradable and the degradation rate was heavily affected by their chemical compositions. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46076.
研究领域:
材料科学
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生物学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Linchuan Cong,Yupeng Wu,Nan Lin,Xinxin Li,Fangbing Liu,Fuyu Han,Jin Yang,Ciduo Wang,Haibo Lin
Dimethyl sebacate is an essential organic chemical, yet its conventional high-temperature pyrolytic synthesis process is marked by complexity, energy intensity, environmental pollution, and volatile raw material supplies. Presently, electrochemical synthesis emerges as a promising, environmentally sustainable method for one-step dimethyl sebacate synthesis via anodic decarboxylation coupling with monomethyl adipate. However, the existing process falls short in achieving the desired selectivity and current efficiency, particularly when operating at high current densities, thus impeding its broader industrial adoption. This study, synergizing density functional theory computations with experimental methods, conducts a comprehensive multidimensional analysis of the electrochemical performance at high current densities across four distinct electrode types: Pt plate, RuO 2 /Ti, PbO 2 , and graphite electrodes. It underscores the strong electron-orbital hybridization between adsorbed monomethyl adipate and the platinum electrode, resulting in an enhanced propensity for electron transfer at the electrode interface and facilitating the decarboxylation of monomethyl adipate coupling into dimethyl sebacate. Subsequently, through single-factor experiments and response surface methodology, an exhaustive analysis of the various factors influencing the electrolysis process is conducted, including supporting electrolyte, current density, H 2 O content, neutralization, and monomethyl adipate concentration. The optimal electrolysis operation configuration offers a robust theoretical foundation and technical framework for the large-scale implementation of green, energy-efficient electrochemical synthesis technology for dimethyl sebacate in industrial settings.
研究领域:
化学工程
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）