ENERGY & FUELS
·
2023
·
IF 5.3
Lihan Fei,Mengxiao Qin,Zuohua Huang,Chenglong Tang
The hypergolic ignition behaviors of three ionic liquids [BMIm][DCA], [EMIm][DCA], and [EMIm][CDB] reacting with white fuming nitric acid (WFNA) were investigated using the drop test approach. Two high-speed cameras with/without a long-distance microscope and a time-resolved infrared camera were used to simultaneously record the hypergolic ignition process and the reaction region temperature evolution. Results showed two distinct hypergolic ignition modes. Specifically, for [BMIm][DCA] and [EMIm][DCA], some “vapor smoke” is generated after the fuel droplet contacts the WFNA pool, followed by sudden ejection of liquids induced by microexplosion. The measured temperature in the observation window is found to first increase, then decrease, and rise again. For [EMIm][CDB], no microexplosion is observed and the temperature monotonically increases before hypergolic ignition. It is inferred that microexplosion is caused by sufficient accumulation of gaseous intermediates or products underneath the liquid surface, and the monotonic or nonmonotonic increasing temperature is a characteristic of ignition modes. A conceptual model is proposed to illustrate the two ignition modes. In addition, the droplet impact velocity (U0) was varied from 1.1 to 2.1 m/s in the experiment. It is found that the vapor delay time (VDT), explosion delay time (EDT), and ignition delay time (IDT) are all reduced with U0 by at most 50%. For a given U0, the three time scales decrease in the order [BMIm][DCA], [EMIm][DCA], and [EMIm][CDB] (IDT as low as 14.4 ms).
研究领域:
化学工程
·
燃料化学
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产品关联
DOI
高影响因子
JOURNAL OF POROUS MATERIALS
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2015
·Vol. 22
·期 5
·1357-1362
·
IF 1.108
Yin Liuyan,Zhou Xingui,Yu Jinshan,Wang Honglei
A planetary ball-milling foaming route was employed by the protein foaming method for preparing silicon nitride (Si 3 N 4 ) foams. In comparison with the commonly used tumbling foaming route of protein foaming method, pores of the Si 3 N 4 foams fabricated by this new foaming route are more uniform in size distribution and the pores pack more compact. Furthermore, effects of the rotating speed on the structure and the property of the Si 3 N 4 foams fabricated by this new foaming route were investigated. It was indicated that the average pore size decreased with the rotating speed, whereas the count of windows on the walls increased with the rotating speed. Moreover, the windows were found to have a negative influence on the phase transformation of Si 3 N 4 from α phase to β phase.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
TETRAHEDRON
·
2021
·
IF 2.457
Xuwei Zheng,Jianan Dai,Baoxing Shen,Xing Zhang
An aggregation induced emission (AIE) fluorescent protein chromophore derivative CIC-FP for detecting protamine and heparin under physiological environment was designed and synthesized. CIC-FP exhibited good biocompatibility and a large stoke shift (91 nm), thus well attenuating the background interference, which could be used for quantitative detection of heparin and protamine . Since protamine has strong positively groups, it can interact with CIC-FP where bearing carboxyl through electrostatic interactions to form a tightly bound CIC-FP/protamine complex, thus showing superior fluorescence intensity response with a detection limit of 65.28 ng/mL. Because heparin has a stronger affinity with protamine, it would compete with CIC-FP on protamine, resulting in the release of CIC-FP and making CIC-FP change into free state with decreased fluorescence intensity . Besides, CIC-FP was successfully applied to detect spiked protamine in human serum samples. In summary, CIC-FP can be used to sensitive detection of protamine with good accuracy, which provides a new idea for designing protamine probes.
研究领域:
生物化学
·
医学检测
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产品关联
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2023
·
IF 6
Jia-wei Luo,Shan Xiao,Bo Wang,Yan-xue Cai,Ji-hui Wang
A new fermented food by utilizing pineapple by-products and whey protein as the matrix via co-fermentation with strains of lactic acid bacteria and yeast is developed. We investigated its impact on human well-being, focusing on the bioavailability and physiological viability of the resulting pineapple–whey protein fermented product (PWF) under simulated human gastrointestinal conditions. We evaluated PWF's potential as a prebiotic using in vitro fermentation assays, revealing that its probiotic components effectively reached the colon and functioned without hindrance. This transit triggered significant release of phenolic compounds, establishing an antioxidant-rich environment during simulated digestion. In vitro fermentation experiments showcased PWF's capacity to induce short-chain fatty acid production in the intestines, alongside its ability to influence the microbial community composition. Additionally, we explored how PWF-induced alterations in the gut microbiota might impact human health. The results suggested that PWF could potentially enhance metabolic pathways in the intestinal microbiota, thereby fostering a more favorable microbial ecosystem.
研究领域:
食品科学
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微生物学
·
营养学
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产品关联
DOI
高影响因子
MATERIALS & DESIGN
·
2015
·
IF 3.501
Liuyan Yin,Xingui Zhou,Jinshan Yu,Honglei Wang
Silicon nitride (Si 3 N 4 ) foams with three dimensional (3D) interconnected pore structure were prepared by a combination of protein foaming method and sacrificial template method . Hydrophobic epoxy resin (EP) particles were used as the sacrificial template. The hydrophobic character of EP particles enabled them to absorb on to the air–water interface in the foamed slurry, resulting in the formation of windows on the cell walls after the burn out of EP particles. Pore structures and properties of the Si 3 N 4 foams fabricated with adding different amount of EP powder and different sintering temperature were investigated. It was indicated that the Si 3 N 4 foam fabricated without EP powder exhibited catastrophic failure during the compression test, whereas the Si 3 N 4 foams fabricated with EP powder did not. Moreover, the Si 3 N 4 foams with large numbers of windows on the cell walls exhibited higher compressive strength than the Si 3 N 4 foam without window on its cell walls, even though the open porosities of the former were similar to the latter or even higher than the latter.
研究领域:
材料科学
·
陶瓷工程
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DOI
高影响因子
FUEL
·
2022
·
IF 8.035
Yingtao Wu,Zhi Wang,Lihan Fei,Yang Guo,Yang Liu,Chenglong Tang,Zuohua Huang
The hypergolic ignition behaviors of [AMIM][DCA] (1-allyl-3-methylimidazolium dicyanamide)/furfuryl alcohol (FA) blends reacting with white fuming nitric acid (WFNA) are investigated using drop test approach. Morphology results from two high speed cameras and temperature profiles from an infrared camera are combined in analyzing the hypergolic process. A typical hypergolic process observed in this work involves a mixing dominant stage, a stage with moderate temperature rising and vapor/secondary droplets emerging, and a stage with violent temperature rising accompanied by flame occurrence. Two kinds of delay times are used to characterize the hypergolic process which are found to be nonmonotonic with the variations of FA fractions. FA, though not hypergolic with WFNA, exhibits extensive pre-ignition heat release due to its physical and chemical properties, which enhances the hypergolic process of [AMIM][DCA]/FA blends with WFNA.
研究领域:
化学工程
·
航空航天工程
·
燃烧科学
✓ 已验证
产品关联
DOI
高影响因子
Scientific Reports
·
2025
·Vol. 15
·期 1
·1-12
·
IF 3.9
Ma Hui,Qin Ruixiu,Yao Qiufeng,Li Yier,Cong Xingshun,Wu Wenhui,Zhao Qi,Ye Hua,Wu Kefeng
Optical transparency methods can facilitate biological tissue optical imaging, which enabled accurate three-dimensional (3D) signal visualization and quantification of complex biological structures. Unfortunately, existing optical clearing approaches present a compromise between maximizing clearing capability, the preservation of fluorescent protein emission and the speed of sample processing. To address this challenge, we synthesis of a 2-hydroxyethyl methacrylate (HEMA)-acrylamide (AAm) copolymer using antipyrine (ATP) and 2,2′-thiodiethanol (TDE) as solvent, which could embed tissue samples rapidly and highly transparent, and compatible with multiple fluorescence labeling. It can enable volumetric imaging of tissue up to the scale of mice organs, shrinkage duration of the clearing and preserve emission from fluorescent proteins and dyes. This copolymer with suitable toughness and plasticity allows the tissue of interest to be sectioned into thin slices, and histological techniques provide high-resolution two-dimensional (2D) images of cells and subcellular structures. Furthermore, HEMA-AAm copolymer -tissue transparent could distinguish cell structures between healthy and diabetic disease in dye-labeled liver tissues, which provides new insights into pathological diagnosis and analysis. Copolymer provides an environment to facilitate high-resolution 3D/2D fluorescence imaging, which enables the study of cellular and tissue morphology in experimental and clinical conditions of interest.
研究领域:
生物医学工程
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荧光成像
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组织光学
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病理诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Jingyi Hu,Yihua Xu,Xiaolu Ma,Weitong Hu,Yunting Zhang,Yuxian Ye,Shengfei Yang,Hangjuan Lin,Xiaoxia Sheng,Jiahe Wu,Tianyuan Zhang,Jianqing Gao
Hair-related disorders are currently widely concerned issues for not only the scientific society but also the public attentions. Microneedle-based drug delivery system has been regarded as a promise hair follicle-targeted drug delivery approach, largely because they can effectively penetrate the stratum corneum barrier and deliver drugs to hair follicles within dermis. However, the currently reported microneedles for treating hair-related disorders usually rely on rigid backings, showing poor adaptability to the curved scalp and thereby restricting their usability for hair follicles targeted drug delivery. To this end, this study utilized sodium alginate and polyvinylpyrrolidone to construct a scalp-curvature-conforming microneedle with flexible backing. Subsequently, Psoralea corylifolia extract (PE) was loaded into the microneedles to investigate its capability in delivering PE to the hair follicle site for treating leukotrichia associated with vitiligo. These PE-loaded microneedles can effectively conform to the curvature of skin, enhancing the efficiency of microneedle insertion and ensuring stable drug delivery. Moreover, animal studies demonstrate that the PE loaded microneedles can effectively penetrate the stratum corneum, benefiting the drug delivery to hair follicles located site, and consequently showing a successful inhibition of hair graying. In summary, the present study reports a design and preparation of scalp-curvature-conforming microneedle. This design may offer a potential solution for efficient drug delivery using microneedles to the curved skin.
研究领域:
药剂学
·
皮肤科
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）