ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Deke Li,Yufeng Fan,Guocai Han,Zhiguang Guo
Superwetting surfaces that repel various liquids have been exciting for biomimetic research and have displayed versatile potential applications. Generally, superhydrophobic coatings can allow for droplet rolling off and antifouling, whereas it is a challenge to achieve superomniphobic surfaces with transparency, flexibility, and conductivity. Here, we adopt an effective and simple method to fabricate a superomniphobic, transparent, and flexible smart silk fibroin (SF) membrane by spray-coating long AgNWs dispersed in polydimethylsiloxane (PDMS), followed by treatment with vacuum drying. The resulting SF/AgNWs membranes are super-repellent to different liquids with low surface tension and water, and demonstrate high contact angles (CAs) more than 150° and low rolling-off angles (RAs) even less than 10°. Moreover, the obtained membranes display superior sensitivity under stretching and bending, as well as intact stability of high transparency, which can be considered as promising flexible sensing electronics to detect human motions under wet conditions.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2021
·
IF 4.952
Chan Zhong,Peng-Fei Hou,Ya-Xing Li,Wen-Yu Yang,Mei Shu,Guo-Ping Wu
A novel active packaging gelatin film incorporated with protocatechuic acid (PCA) was prepared and characterized. After addition of PCA from 0.1 to 1.0%, gelatin films showed the improved extensibility and barrier properties with better elongation at break, lower water vapor permeability and UV light transmission compared with control group. Meanwhile, the higher thickness and total color difference, weaker tensile strength of these films were also found in gelatin-PCA composite films. The molecular interaction of these films between PCA and gelatin were non-covalent linkages, including hydrogen bond, hydrophobic interaction and electrostatic interaction, contributing to homogenous and smooth microstructures observed in SEM morphologies of gelatin films containing PCA of 0.1–1.0%. In addition, gelatin-PCA composite films presented the obvious antioxidant capability to scavenge DPPH radicals and the significant inhibitory effect on total viable counts of beef in chilled storage condition. Furthermore, they also exhibited strong antibacterial effects against E. coli O157:H7 and S. aureus both in vitro as well as the challenge of beef preservation in 4 °C simulation tests. These results suggested that fish gelatin-PCA composite film, as a novel active packaging film with good functional property and high biological activity, has promising application on foods preservation.
研究领域:
食品科学
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包装工程
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生物化学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Fen Ao,Changyu Yin,Xiaomin Luo,Wen Shen,Xuemei Ge,Yan Zheng
Skin wound repair is a complex dynamic process. Current dual-drug delivery systems struggle to adapt to the process of wound healing. Therefore, the construction of a dual-drug delivery system with intelligent responsiveness, controllable release, and understanding the repair mechanisms, is a current research challenge. This study described the design of a new gelatin-based dual-drug delivery system (PGDMD) using electric field stimulation to achieve a controlled drug release. In vitro drug release experiments demonstrated PGDMD completed the transition from a fiber membrane state to a gel state during the release process. Quercetin released with a rapid release within the first 60 min and amikacin released over 24 h. The amount of drug released in the same release time was increased mainly through electrostatic action under the effect of the electric field and accelerated the movement of drug molecules. The non-targeted metabolomics analysis revealed that PGDMD mainly reduced inflammation and oxidative stress responses by upregulating the expression of antioxidant-related metabolites, thereby improving the therapeutic effect of rat traumatic skin. In conclusion, the dual-drug delivery system might be potentially applied to high-performance medical devices, pharmaceuticals and other industry products, and provides research ideas and reference for exploring the interaction between biomaterials and the organism.
研究领域:
生物材料学
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药剂学
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医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2017
·Vol. 98
·期 7
·2632-2641
·
IF 2.463
Junsheng Ding,Xiaomeng Wu,Xiaona Qi,Heng Guo,Anjun Liu,Wenhang Wang
BACKGROUND In this paper, two kinds of commonly used vegetable carbon black (VCB, 3000 mesh; nano) at 50 g kg −1 concentration (based on dried gelatin) were added to 48 g kg −1 of fish gelatin (GEL) solutions and their effects on mechanical, barrier and anti-photooxidation properties of GEL films were investigated. RESULTS From the SEM images, it was shown that compared with 3000 mesh VCB (1–2 μm), nano VCB (100–200 nm) made the microstructure of GEL film more compact and more gelatin chains were cross-linked by nano VCB. The addition of nano VCB significantly increased gelatin film strength with the greatest tensile strength of 52.589 MPa and stiffness with the highest Young's modulus of 968.874 MPa, but led to the reduction of film elongation. Also, the VCB presence significantly improved water vapour and oxygen barrier properties of GEL film. Importantly, nano VCB increased GEL film with better UV barrier property due to its stronger UV absorption nature when compared with micron VCB. This property could help in the preservation of oil samples in the photooxidation accelerated test. CONCLUSION With improved properties, the nano VCB-reinforced GEL film may have great potential for application in the edible packaging field, especially for the anti-photooxidation property. © 2017 Society of Chemical Industry
研究领域:
食品科学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
KEY ENGINEERING MATERIALS
·
2017
·
IF 0
Fang Yu Zhan,Kun Yan Wang,Miao Miao Niu
Glutaraldehyde cross-linked silk sericin films were successfully prepared. FTIR was applied to characterize the chemical structure of films. Compared to pure silk sericin, cross-linked silk sericin film with 3% glutaraldehyde was found a new peak at 1620 cm-1 and the peak intensity of cross-linked film decreased markedly, which indicating cross-linking reaction has been occurred. Thermal and swelling behavior of cross-linked films was investigated. The cross-linking reaction increased the thermal decomposition temperature. The swelling ratio of glutaraldehyde cross-linked silk sericin films went up with increasing glutaralehyde loading to 3wt%.
研究领域:
生物材料学
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生物化学
✓ 已验证
DOI
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2020
·
IF 4.006
Mingyu Ji,Jiulin Wu,Xinyu Sun,Xiaoban Guo,Wenjin Zhu,Qingxiang Li,Xiaodan Shi,Yongqi Tian,Shaoyun Wang
In this paper, the natural antibacterial agent cinnamaldehyde (CA) was made into nanoemulsions to improve its water solubility. Subsequently, the active gelatin (GL-CA-Vc) films with antibacterial and antioxidant activities were prepared by combining silver carp skin gelatin with CA nanoemulsions and vitamin C (Vc). Compared with the gelatin control (GL-Control) film, the thickness, roughness and water vapor permeability (WVP) of active films increased significantly. In addition, the elongation at break (EAB) and light barrier property of active films were also enhanced. The antibacterial and antioxidant activities of active films were related to the content of active additives. The film containing 100 mg of CA and 50 mg of Vc (GL-100CA-50Vc) had good light barrier property and a high EAB (158.00 ± 12.51%). What's more, the inhibition rate of GL-100CA-50Vc film against Pseudomonas aeruginosa was 55.97 ± 4.25%, and the free radical scavenging rate of the film to ABTS and DPPH was 96.26 ± 0.72% and 95.74 ± 0.20% respectively, which indicated that the film had good antibacterial and antioxidant activities.
研究领域:
食品科学
·
生物材料学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2018
·
IF 4.439
Renxuan Liu,Tao Sha,Qiuhong Zhou,Bei Nie
By employing copper grid as a surrogate agent, we present a facial, reagent-free and cost-effective approach to imprint the exquisite silver dendroid nanostructures on flexible silk fibroin membrane, which double roles as both optical enhancers and catalytic-active sites over many chemical reactions. Unlike the conventional rigid substrates, this hybrid Ag/protein composite exhibits many previous-inaccessible properties of flexibility, transparency, biocompatibility, molecular permeability and optical manipulation. The galvanic displacement was facilitated by a high pressure uv-lamp illumination (365 nm), shortening the dendroid growth time to be within a few minutes. The resulting substrate was characterized by microscopic image, revealing a decent 3D Ag dendrite architecture and interpenetrated crystal network, which arguably enlarged the entire surface area and keenly regulated the optical/electric property of fibrillated protein film. The underlying principle of copper-initiated silver reduction and growth of crystal structure was discoursed and verified with in-situ spectroscopic interrogation. Moreover, our comprehensive study supports that sub-dividable substrate enables to perform catalytic reaction under a wide range of conditions. This exploration renders a thrust to expand biopolymeric membrane into a wide breadth of applications of bendable devices through chemical modifications, exhaustively and economically.
研究领域:
材料科学
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生物医学工程
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化学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Nina Gui,Xiaoxia Zhang,Chun Yang,Ruimin Ran,Changkai Yang,Xingling Zeng,Guoying Li
In this study, a UV-cured collagen-based film (C-P-H film) with high mechanical strength and antimicrobial properties was developed by riboflavin-mediated ultraviolet irradiation of collagen solution containing histidine-modified ε-polylysine. Fourier transform infrared analysis indicated that covalent cross-linking was formed between the collagen molecule and the histidine-grafted ε-polylysine. Compared with the pure collagen film, the C-P-H film containing 5 wt% histidine-modified ε-polylysine showed higher tensile strength (145.98 MPa), higher thermal denaturation temperature (76.5 °C), lower water vapor permeability (5.54 × 10 −11 g m −1 s −1 Pa) and excellent antimicrobial activities against Escherichia coli and Staphylococcus aureus . In addition, the wrapping of the C-P-H film effectively inhibited bacterial growth of pork during storage time, successfully prolonging the shelf-life of pork by approximately 4 days compared to that of plastic wrap. These results suggested that collagen-based film grafted with histidine-modified ε-polylysine via riboflavin-mediated ultraviolet irradiation process had a great potential for pork preservation.
研究领域:
食品科学
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生物材料学
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微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2019
·
IF 4.916
Muhammad Muhammad,Guohua Yao,Jie Zhong,Kuanglin Chao,Muhammad Hammad Aziz,Qing Huang
Fipronil is a phenylpyrazole insecticide commonly used in agriculture and residential applications. In this paper, we reported a novel label-free surface-enhanced Raman spectroscopy (SERS) method for detection of fipronil residues in chicken eggs (mostly accumulated on the egg membrane). We fabricated the SERS substrates composed of the SiO 2 @Au core/shell nanoparticles and probed the contamination of fipronil residue on the egg membrane. The identification of the characteristic Raman bands of fipronil was achieved with the aid of density functional theory (DFT) calculation, with which we could analyzed the trace amount of fipronil in a quantitative way. As such, this work may provide a practical solution to quick inspection of fipronil contamination in chicken eggs or other foods.
研究领域:
食品安全检测
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分析化学
·
环境科学
✓ 已验证
DOI
高影响因子
Scientific Reports
·
2023
·Vol. 13
·期 1
·1-12
·
IF 4.6
Li Tao,Tian Yuan,Zhong Quliang,Chen Peng,Zhang Junhao,Du Guangshi,Li Lei,Jiang Yiting,Jiang Kehua
Penile size is closely concerned and short penis contributes serious sexual dysfunction and tremendous psychological problems to couples. Androgen is essential for penile development and testosterone replacement is recommended to patients with micropenis. We previously proved that inhibiting activity of lysyl oxidase (Anti-lysyl oxidase, Anti-LOX) combined with vacuum erectile device (VED) lengthened penis by remodeling tunica albuginea. We thus explored whether HCG supplement could accelerate tunica albuginea remodeling (induced by Anti-LOX + VED) to promote penile growth. Forty-two SD male rats (4 weeks old) were purchased and divided into 7 groups: control, Anti-LOX, HCG, VED (with a negative aspirated pressure of − 300 mmHg), Anti-LOX + VED, HCG + VED, and Anti-LOX + HCG + VED. After an intervention for 4 weeks, all rats’ penile length, exposed penile length, and erectile function were measured. Serum samples were collected to detect hormone levels and penile corpus cavernosum were harvested for histo-pathological analysis. All intervention groups showed significantly longer penis than controlled rats. Anti-LOX sharply increased penile length and exposed length by 15% and 9% respectively, this lengthening effect was more obvious in Anti-LOX + VED group (26% and 19%, respectively). Although HCG promoted penile length by 8%, this effect was slight for exposed length (3%). Moreover, Anti-LOX + HCG + VED dramatically increased penile length and exposed length by 22% and 18%, respectively, which was similar with that in Anti-LOX + VED (26% and 19%, respectively). HCG dramatically stimulated testosterone and dihydrotestosterone secretions than control group, whether with or without Anti-LOX and VED; while it induced more AR expression than other groups. Finally, all procedures did not improve or deteriorate normal erectile function. Although we verified that Anti-LOX + VED lengthened penis by inducing tunica albuginea remodeling, however, HCG supplement did not synergize with Anti-LOX + VED to accelerate albuginea remodeling to facilitate penile growth.
研究领域:
泌尿学
·
内分泌学
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性医学
✓ 已验证
DOI
PubMed
高影响因子
DENTAL MATERIALS
·
2025
·
IF 6.3
Zhao Li,Ying Kong,Qun Zhang,Jing Han,Kezheng Chen,Baojin Ma
Traditional guided bone regeneration (GBR) membranes face challenges in balancing mechanical strength, bioactivity, and osteoconductivity for effective periodontal bone regeneration. While collagen-based GBR membranes dominate clinical use, the weak mechanical properties and lack of osteoinductive capacity limit regeneration efficacy. Here, we presented a gas diffusion-mediated single-sided mineralization strategy to fabricate silk fibroin (SF)-based GBR membranes with dual barrier/osteoinductive functions. SF was dissolved in formic acid with Ca 2 + and, optionally, other bioactive metal ions (BMIs, such as Sr 2+ , Cu 2+ , or Mg 2+ ), and a colloid was formed after the evaporation of formic acid. Followed by gradient mineralization under CO 2 /NH 3 atmosphere and β-sheet induction via ethanol treatment, SF-Ca/X (X refers to other BMIs) membranes were prepared. Mineralized SF membranes featured a dense, mineral-free side for mechanical support and barrier, and an osteoinductive side by releasing BMIs. Interestingly, the calcium phosphate layer formed on the mineralized side, and the phase of CaCO 3 changed from calcite to vaterite, which helps phosphate mineralization. In vitro results demonstrated that the SF-Ca/Sr membrane enhanced osteogenic differentiation by upregulating BMP2/SMAD1 expression. In a rat mandibular defect model, the SF-Ca/Sr membrane significantly promotes new bone regeneration and collagen formation. Overall, this gas diffusion-mediated single-sided gradient mineralization approach integrates barrier properties with localized bioactivity, allowing for the required barrier/osteoinduction functions in the GBR process in one membrane.
研究领域:
生物材料学
·
组织工程
·
口腔颌面外科
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再生医学
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生物矿化
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2024
·Vol. 25
·期 17
·9263
·
IF 4.9
Xiang Chen,Jiaqi Liu,Yaru Lu,Huijun Liu,Lan Cheng,Zhi Li,Fangyin Dai
The use of biodegradable materials combined with natural metabolites in wound dressings has received much attention. Flavonoids (FLs) from green cocoons, as metabolites, have antibacterial, antioxidant, anti-inflammatory, and other pharmacological effects. In this study, composite membranes of FL-loaded polylactic glycolic acid (PLGA)/silk fibroin (SF) were prepared by an electrospinning method. The prepared membranes, including SF, exhibited a good slow-release effect and cytocompatibility. An in vitro evaluation of the FL-loaded PLGA/SF membranes demonstrated good antioxidant, antibacterial, and anti-inflammatory properties. Animal experiments showed that the wound healing rate of PLGA/SF-2.5FL membranes within 15 days was 97.3%, and that of the control group was 72.5%. The PLGA/SF-2.5FL membranes shortened the inflammatory period of a full-layer wound model and promoted skin regeneration and wound healing by downregulating expression of the pro-inflammatory cytokines IL-1β and TNF-α and promoting expression of the growth factors VEGF, TGF-β, and EGF. In summary, the PLGA/SF-2.5FL composite nanofibre membrane with anti-inflammatory properties is an ideal wound dressing to promote acute wound healing.
研究领域:
生物医学工程
·
药理学
·
材料科学
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）