FOOD RESEARCH INTERNATIONAL
·
2025
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IF 8
Tingting Yang,Xinming Zhang,Chenhan Huang,Guanghua Xia,Haohao Shi,Xueying Zhang,Fan Wang,Liming Zhang,Jiamei Wang
With the increasing demand of consumers for food preservation materials, the development of high-performance active packaging films has become a research hotspot. This study constructed a novel chondroitin sulfate-zein nanoparticles system co-encapsulating curcumin and resveratrol (ZCRC NPs) for gelatin-based active packaging, modified by atmospheric cold plasma (ACP) to achieve multifunctional enhancement. The ACP-treated composite film exhibited significantly improved in physical properties, with opacity increasing to 1.15 ± 0.16, while mechanical strength and elongation at break improved by 168 % (from 0.025 ± 0.001 MPa to 0.067 ± 0.003 MPa, P < 0.05) and 105 % (from 25.76 ± 2.46 % to 52.81 ± 3.54 %), respectively. Barrier properties were simultaneously enhanced, with oxygen permeability reduced by 50 % (from 3.61 ± 0.05 to 1.82 ± 0.03 g/m·d) and water vapor permeability decreasing from (7.45 ± 0.76) × 10 −7 to (2.63 ± 0.86) × 10 −7 g/m·d·Pa. The scanning electron microscopy (SEM) exhibited that ZCRC NPs were uniformly dispersed in the gelatin-based film and exhibited good compatibility with the matrix. Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) analyses confirmed that ACP treatment enhanced NPs cross-linking in gelatin-based films by driving hydrogen bonding, hydrophobic interactions, and electrostatic forces, while also enhancing crystallinity. Moreover, differential scanning calorimetry (DSC) and thermogravimetry (TG) analysis demonstrated that the thermal stability of the composite film was significantly improved ( P < 0.05). Antioxidant capacity significantly increased ( P < 0.05), with DPPH inhibition (29.11 ± 1.34 % to 60.63 ± 1.05 %) and ABTS scavenging (45.25 ± 1.67 % to 76.80 ± 1.94 %), effectively delaying fish fillet deterioration. In summary, this study provides new insights into the application and preservation potential of ACP-modified NPs in active food packaging films.
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REACTIVE & FUNCTIONAL POLYMERS
·
2026
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IF 5.4
Lingling Zhang,Xin Wang,Guo Li,Lizhen Yan,Hu Jiang,Xiacong Zhang
Epoxy vitrimer was synthesized from resveratrol epoxy, dynamic disulfide lipoic acid and anhydride curing agent. • Resveratrol epoxy vitrimer as the matrix for carbon fiber composites exhibited well-balanced performance. • DMF/β-mercaptoethanol (1:1 v /v) at 100 °C for 48 h dissolved matrix and recovered carbon fiber. To enable the recycling of carbon fiber composites, this study developed a resveratrol-based epoxy vitrimer containing double dynamic covalent bonds (ester and disulfide bonds) by using bio-based polyphenolic resveratrol epoxy resin (RE), with dynamic disulfide-containing lipoic acid (LA) as a crosslinking agent and curing agent phthalic anhydride (PA). By adjusting the ratio of the crosslinking agent to the curing agent, the synergistic optimization of the thermal and mechanical properties of the epoxy vitrimer and its composite was achieved. A variety of testing methods were employed to systematically investigate the thermal properties, mechanical properties, and chemical degradation behavior of this epoxy vitrimer. Carbon fiber reinforced composites (CFRCs) based on this epoxy vitrimer were subsequently fabricated. The CFRC reached its optimal mechanical and recycled properties when the resin system had a molar ratio of RE (epoxy): LA (carboxyl): PA (carboxyl) = 5: 1: 4 and the composite resin content was 40% ± 2.7%. Finally, the composite was immersed in a mixed solution of DMF and β-mercaptoethanol (2-ME) (1: 1, v /v), which successfully dissolved the matrix resin and obtained relatively pure carbon fiber. Download: Download high-res image (294KB) Download: Download full-size image
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PHYTOMEDICINE
·
2026
·
IF 11.3
Minghui Zhao,Hongfang Mu,Qian Ji,Jiale Song,Fuyixuan Zheng,Tianlong Liu,Wenbin Li,Rong Wang
Background The effects of persistent hypoxic conditions in high-altitude regions on metabolic disorders remain poorly understood and in-depth investigation into its underlying molecular mechanisms is notably insufficient. As a metabolism-associated liver disease, the pathogenesis of non-alcoholic fatty liver disease (NAFLD) under hypoxic conditions urgently requires clarification. Previous studies have demonstrated that resveratrol (Rsv) possesses significant anti-inflammatory, antioxidant, and lipid metabolism-modulating properties, and it can act as an inhibitor of ferroptosis. Yet its precise therapeutic efficacy and mechanism in hypoxic NAFLD remain to be further explored. Objective This study aims to explore the potential mechanism by which Rsv improves the deterioration of NAFLD under hypoxia exposure. Methods Herein, we performed concurrent interventions in both in vivo and in vitro models of NAFLD, comprehensively detecting biochemical indicators (inflammatory factors, oxidative stress markers, liver function), liver histopathological changes, and nucleic acid levels to assess the effects of Rsv. By introducing ferroptosis modulators, we measured core ferroptosis parameters (mitochondrial ultrastructure, Fe²⁺, 4-HNE, LPO levels, and key protein expressions) to define disease progression patterns. By HIF-1α silencing was employed to verify its regulatory roles in ferroptosis-related factors and NAFLD pathogenesis. Co-Immunoprecipitation assays and immunofluorescence co-localization were used to explore protein interactions among ACSL4, TfR1, and HIF-1α. Conclusion Our results demonstrated that high-altitude hypoxia exacerbates NAFLD via inducing ferroptosis; HIF-1α upregulates the expression of key ferroptosis mediators (ACSL4, TfR1), and HIF-1α silencing attenuates ferroptosis. Rsv exerts therapeutic effects against hypoxia-related NAFLD by targeting the HIF-1α-mediated ferroptosis pathway. This study elucidates the pivotal role of HIF-1α-dependent ferroptosis in hypoxia-aggravated NAFLD, identifies the therapeutic targets and mechanisms of Rsv, and provides novel theoretical foundations and potential intervention strategies for clinical management of hypoxia-related NAFLD in high-altitude areas.
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Advanced Healthcare Materials
·
2026
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IF 11
Xiaohui Wang,Xinran Wang,Yuechen Li,Qu Tang,Rui Xia,Yuling Qin,Li Wu
Persistent bacterial infections and oxidative stress-induced inflammatory responses present significant challenges to wound healing. Conventional wound care approaches frequently prioritize bacterial eradication while overlooking the critical need to modulate inflammation. To address this limitation, we have innovatively developed carrier-free nano-aggregates through the co-precipitation of natural polyphenols (resveratrol and piceatannol) and a porphyrin-based photosensitizer, which function as antibacterial and anti-inflammatory agents, respectively. Significantly, rather than forming a simple mixture, the two components co-assemble via microstructure regulation into a highly ordered architecture exhibiting characteristic J-aggregate features. Specifically, the piceatannol-based aggregates (designated T 4 PIC NPs) achieved an exceptional photothermal conversion efficiency (PCE) of 51.1% under 730 nm irradiation, accompanied by an 86 nm spectral redshift, surpassing most previously reported porphyrin-based nanoparticles. These properties enable highly effective sterilization even at low doses. Notably, the natural polyphenols not only enhance phototherapeutic efficacy but also, owing to their multi-hydroxyl structures, effectively scavenge reactive oxygen species and modulate inflammatory responses, thereby accelerating wound healing. This study establishes a straightforward strategy for delivering natural polyphenolic drugs while concurrently constructing highly efficient porphyrin-based photothermal formulations, demonstrating unique advantages for advanced wound management.
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高影响因子
Crystals
·
2026
·Vol. 16
·期 2
·126
·
IF 2.9
Yuhang Liu,Ziqing Wu,Fenghua Chen,Yongming Liu,Rongrong Xue
In the organic biomineralization of guanine (GUA), amorphous GUA is utilized to enhance its solubility, facilitating its transport for the formation of biominerals, and GUA nanocrystals are employed to protect tissues from ultraviolet damage. These principles of GUA biomineralization inspire us to improve the solubility and photostability of trans-resveratrol (RES) using bio-purines, which limits its bioavailability. Bio-purines, such as GUA, hypoxanthine (HYP), and adenine (ADE), were used as co-formers in the amorphous systems of RES. Amorphous RES-2Purines with a 1:2 molar ratio were prepared via the neat ball-milling method and confirmed by powder X-ray diffraction, Raman spectroscopy, and diffuse reflectance spectroscopy. The stability, dissolution profiles, and photostability of RES-2Purines were comprehensively compared. RES-2Purines show high amorphous-to-crystalline transformation temperatures (>100 °C), confirmed by the differential scanning calorimetry-thermogravimetric analysis. Both RES-2HYP and RES-2ADE show an enhanced RES solubility (about 1.6-fold that of raw RES) in water and the simulated gastric fluid (pH 1.2). RES-2Purines can recrystallize quickly after being dispersed in water, which limits the solubility enhancements of RES-2Purines. RES-2Purines have better photostability than raw RES. Bio-purines are promising co-formers for amorphous systems to enhance the solubility and photostability of poorly water-soluble compounds.
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GIANT
·
2026
·
IF 6.1
Yong Liu,Shi Hao Zheng,Fang Zhou,Hao Yuan
With an increasing focus worldwide on protecting the environment and developing in a sustainable way. Developing halogen-free, environmentally benign flame retardants is of critical relevance. To enhance the fire-safety performance of epoxy resins while simultaneously mitigating their environmental impacts. The bio-derived flame retardant DOPR was prepared in a single-step, one-pot process using resveratrol and DOPO as the key starting materials. The resulting product was subsequently incorporated into an epoxy matrix to obtain EP/DOPR composites. Despite encompassing only 0.35 wt % phosphorus, the EP/5DOPR composite exhibited an increased LOI of 28.19 % and secured the top-tier V-0 grade in the UL-94 flammability evaluation. Compared with neat EP, its pHRR, THR and TSP were lowered by nearly 15.65 %, 33.13 % and 9.62 %, respectively. Furthermore, the residual char yield of the composite was improved from 14.78 % to 17.88 %. The mechanical properties of the composite material were enhanced following the addition of 3wt % and 5wt % flame retardant, indicating a more favourable balance between flame retardancy efficiency and additive loading. The relevant research findings may provide a potential fundamental approach for the application of bio-based flame retardants to enhance the high performance of epoxy resins.
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Drug Design Development and Therapy
·
2026
·
IF 6.1
Chao Song,Xiaofei Wu,Chaoqi Chen,Baoxin Shen,Yuheng He,Fei Liu,Feng Chen,Zhijiang Fu,Zongchao Liu
Background: Intervertebral disc degeneration (IVDD), characterized by inflammation, cell death, and matrix dysregulation, involves ferroptosis and autophagy interactions, though the role of ferritinophagy remains unclear.Methods: This study integrated bioinformatics analysis of clinical transcriptomes, single-cell sequencing, and experimental models to identify molecular targets linking ferritinophagy to IVDD progression.Results: Multi-omics analysis revealed 10 ferroptosis-related hub genes (eg, NCOA4, TP53, SLC7A11) enriched in hypoxia, autophagy, and ferroptosis pathways. Single-cell profiling demonstrated dynamic shifts in nucleus pulposus cell (NPCs) phenotypes during degeneration, with increased pro-inflammatory monocyte/macrophage infiltration. Clinical and experimental validation showed elevated NCOA4 and ACSL4 (ferroptosis drivers) alongside reduced GPX4 and FSP1 (anti-ferroptotic factors) in degenerated discs. Mechanistically, NCOA4-mediated ferritinophagy promoted iron overload and lipid peroxidation by degrading ferritin, exacerbating oxidative damage. Resveratrol, a natural anti-inflammatory compound, mitigated IVDD in rat models by restoring disc height, suppressing IL1β, TNF-α, and IL6, and reversing ferroptosis/autophagy imbalance via NCOA4 downregulation. Cellular studies confirmed that resveratrol attenuated LPS-induced NPCs degeneration by blocking NCOA4-dependent ferritinophagy, reducing lipid peroxidation and cell death.Conclusion: This work identifies NCOA4 as a critical nexus coordinating ferroptosis-autophagy crosstalk in IVDD and establishes ferritinophagy as a novel pathological mechanism. Resveratrol’s therapeutic efficacy, mediated through multi-target modulation of inflammatory and iron homeostasis pathways, provides a promising strategy for IVDD treatment. The findings advance precision medicine approaches by elucidating ferritinophagy’s role and proposing resveratrol as a targeted intervention to disrupt this self-amplifying cycle of oxidative damage in disc degeneration.
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ACS Nano
·
2026
·
IF 17.3
XuanLin Zhao,Tao Wang,QiLong Zhou,ZeLiang Wei,Ying Zhang,XiaoYi Wu,YuDa Zhu,XiuXian Yu,HongLi Jiang,XinRui Xu,Kun Zhang,Guang Xin,Wen Huang
Acute pancreatitis (AP) is a common and potentially fatal inflammatory disorder lacking effective targeted therapies. Mitochondrial dysfunction, marked by ATP depletion and excessive ROS production, lies at the heart of disease initiation and progression. This study presents a hierarchically targeted nanotherapeutic, Cu-CDs/Kyna@RM (RMCK), in which copper-doped, mitochondria-targeting carbon dots (Cu-CDs) are grafted with kynurenic acid (Kyna) and encapsulated within red blood cell-macrophage hybrid membranes. Upon systemic administration, RMCK homes to inflamed pancreatic tissue, where it sequentially releases Cu-CDs to target mitochondria, scavenge ROS, liberate Kyna, and restore mitochondrial function. It markedly improves survival, lowers serum amylase/lipase, attenuates pancreatic edema and necrosis, and prevents secondary lung injury, outperforming free Kyna therapy. In vitro, RMCK significantly reduces sodium taurocholate (STC)-induced acinar cell injury, measured by decreased cell necrosis and LDH release. Mechanistic studies including transcriptomics, immunohistochemistry, and functional assays reveal that RMCK amplifies GPR35-NF-κB inhibition to curb cytokine storms, prevents mtDNA-driven inflammasome activation, and alleviates hypoxia to downregulate HIF-1α and upregulate PPARγ for restored fatty acid oxidation. By integrating organ- and organelle-level targeting with ROS scavenging and mitochondrial energy remodeling, RMCK delivers synergistic, precision therapy for AP and offers a versatile platform for other inflammatory diseases characterized by mitochondrial dysfunction.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.7
Nesma S. Abdelaty,Mostafa Gouda,Amel Thanina Amrouche,Cheng Chen,Baiyi Lu
Casein-based gel delivery systems often exhibit limited loading efficiency and functional performance under conventional formulation approaches. We present a novel UV-induced photo-crosslinking strategy for generating porous casein–polyethylene glycol gels, enhancing resveratrol stabilization and enabling controlled delivery during processing and storage. Structural characterization by FTIR and 13 C NMR supported the formation of an enhanced covalent network via ester and amide linkages. Formulation optimization showed that 10% casein achieved a crosslinking degree of 93.32 ± 0.43% ( p < 0.05), accompanied by rapid gelation (18 s) and a sixfold increase in storage modulus compared with the control, while gel electrophoresis profiles supported controlled degradation behavior. Resveratrol was efficiently encapsulated at 96.31 ± 1.40%, as evidenced by reduced fluorescence intensity in the cross-linked matrix, and the optimized gel retained 86% of the drug during storage. The optimized formulation exhibited enhanced antioxidant performance, with 27.03% higher DPPH radical-scavenging activity and 46.12% higher ABTS response compared to the non-crosslinked system, highlighting that structurally engineered casein-based gels can significantly enhance encapsulation efficiency and the controlled release of sensitive bioactives in pharmaceutical applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Chunjing Guo,Yuxin Cao,Yiyang Sun,Zhongqiang Sun,Xiaopeng Tong,Xiangzhen Tan,Yuxiu Chen,Xuemei Wang,Xinxin Wang,Xiaowei Liu,Weili Yang,Xiaoping Zhang,Daquan Chen
Ulcerative colitis (UC) is a chronic inflammatory bowel disease that primarily affects the colon and rectum and is characterized by diffuse, superficial inflammation of the colonic mucosa. The excessive production of reactive oxygen species (ROS) plays a pivotal role in immune dysregulation and the pathogenesis of UC. However, current treatment options are limited by poor absorption, rapid metabolism, and systemic side effects due to the lack of targeted delivery. Therefore, there is an urgent need for therapies capable of specifically scavenging ROS. In this study, we developed a ROS-responsive nanoscavenger system, Fucoidan-TK-Resveratrol@Curcumin (FTR@Cur), based on the marine-derived polysaccharide fucoidan, and loaded with the natural compound curcumin (Cur) for the treatment of UC. The nanoscavenger was constructed using fucoidan (Fuc) as the hydrophilic backbone, while resveratrol (Res) was conjugated via a ROS-sensitive thioketal (TK) linker, enabling targeted ROS clearance. The resulting FTR@Cur nanoparticles had a mean particle size of 92.17 nm, a zeta potential of −22.2 mV, and an encapsulation efficiency and drug loading of 69.0% and 5.5%. FTR@Cur exhibited excellent ROS-scavenging ability and biocompatibility, effectively modulating the inflammatory and immune microenvironment in the colon. This system enhanced colonic barrier function, reduced inflammation, and offers a promising therapeutic strategy for UC.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Huiyong Zeng,Lifeng Chen,Tianmeng Lei,Mingchen Shi,Feifan Liu
Improving the consolidation strength of unconsolidated sandstone while reducing permeability impairment during sand consolidation is important for the long-term stable development of sand-producing reservoirs. To mitigate the conflict between strength enhancement and pore-throat damage in conventional resin-based sand consolidation, a bio-based reactive Pickering emulsion sand-consolidation system based on oil–water interfacial regulation was developed in this work. N-(n-butyl)-3-aminopropyltrimethoxysilane (EB-1189)-modified nano-SiO 2 (EBS) was used as the particulate stabilizer at the oil–water interface. First, EBS particles with different degrees of surface modification were prepared. Their surface structure, thermal behavior, wettability, and emulsion-stabilizing ability were evaluated by FT-IR, TGA, XPS, contact-angle measurements, and droplet-size analysis. The results showed that EBS-6 had a water contact angle of 70.7 ± 0.8°. It provided a good balance between aqueous dispersibility and oil-water interfacial adsorption. The emulsion stabilized by EBS-6 showed smaller droplets and a narrower droplet-size distribution. Then, Pickering emulsions with different particle loadings, denoted as EBSR, were prepared using epoxidized linseed oil (ELO) and 1,3-bis(aminomethyl)cyclohexane-methyl isobutyl ketone ketimine (1,3-BAC-MIBK) as the core reactive components. The chemical structure and high-temperature stability of EBSR were confirmed by FT-IR, TGA, and XPS. Emulsion stability and rheological tests showed that EBSR-3 had better injectivity and stability at 80 ℃. Its gel time and initial curing time were about 11.8 h and 15.2 h, respectively. Core flooding tests using field unconsolidated sandstone cores showed that EBSR-3 achieved permeability retention values of 89.86% after curing and 90.28% after long-term water flooding. Its compressive strength reached 6.83 MPa after curing and remained at 5.98 MPa after long-term water flooding, with a strength retention ratio of 87.55%. Micro-CT results showed that EBSR-3 better preserved pore-throat connectivity and main flow channels. SEM observations further showed coating-like cured products on sand-grain surfaces and intergranular cementation bridges at grain-contact regions. These results suggest that EBS-mediated oil–water interfacial stabilization and the resulting regulation of curing behavior may help reduce extensive accumulation of cured products within the main pore-throat space while promoting effective intergranular cementation, thereby contributing to the balance between consolidation strength and permeability retention. This system provides a new bio-based Pickering-emulsion strategy based on oil–water interfacial regulation for low-damage sand consolidation in unconsolidated sandstone reservoirs. Download: Download high-res image (251KB) Download: Download full-size image
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ACS Applied Bio Materials
·
2025
·
IF 4.7
Qi Meng,Chenyu Li,Jiayi Jiang,Fengzhen Guo,Yang Fu,Shuchen Gu,Tianyi Jiang,Jialu Pan,Yichun Zeng,Lei Sun,Shaohua Wu
Constructing fibrous dressings integrating innovative physical cues with appropriate biological cues is crucial for enhancing wound healing and reducing patient’s discomfort. In this study, a series of nanomicro conjugated fibrous dressings (NCFDs) were constructed via conjugated electrospinning, comprising poly(caprolactone) (PCL) microfibers (diameter >2 μm) with/without zinc oxide (ZnO) nanoparticles and PCL nanofibers (diameter <100 nm) with/without resveratrol (Res). ZnO-loaded NCFDs exhibited dramatically high antibacterial rates exceeding 99% against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Additionally, all NCFDs, regardless of ZnO and Res loading, demonstrated excellent biocompatibility for human dermal fibroblasts (HDFs) and superior hemostatic performance in a mouse liver bleeding model. The in vivo experiments revealed that the incorporation of ZnO and Res significantly promoted the wound healing process. Specifically, the wound closure rate of mPCL + 0.5%ZnO/nPCL + 8%Res NCFD reached 93.7 ± 0.6% after 10 days of treatment. The regenerated skin tissues displayed enhanced collagen deposition, improved epithelial regeneration, and neovascularization. The mPCL + 0.5%ZnO/nPCL + 8%Res NCFD was also found to significantly stimulate macrophage polarization toward the M2 phenotype, thereby reducing inflammation levels at the injury site. This study provides a novel routine to develop mPCL + ZnO/nPCL + Res NCFDs with innovative structure and appropriate biofunctions, demonstrating potential in wound treatment and skin tissue engineering.
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