International Journal of Nanomedicine
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2022
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IF 7.033
Yuetian Wang,Chun Liu,Huiling Liu,Haoyong Fu,Chunde Li,Lei Yang,Haolin Sun
Purpose To evaluate the effect of cement augmentation of cortical bone trajectory (CBT) screws using a novel calcium phosphate–based nanocomposite (CPN).Material and Methods CBT screws were placed into cadaveric lumbar vertebrae. Depending on the material used for augmentation, they were divided into the following three groups: CPN, polymethylmethacrylate (PMMA), and control. Radiological imaging was used to evaluate the cement dispersion. Biomechanical tests were conducted to measure the stability of CBT screws. A rat cranial defect model was used to evaluate biodegradation and osseointegration of the CPN.Results After cement augmentation, the CPN tended to disperse into the distal part of the screws, whereas PMMA remained limited to the proximal part of the screws (P < 0.05). As for cement morphology, the CPN tended to form a concentrated mass, whereas PMMA arranged itself as a scattered cement cloud, but the difference was not significant (P > 0.05). The axial pullout test showed that the average maximal pullout force (Fmax) of CPN-augmented CBT screws was similar to that of the PMMA group (CPN, 1639.56 ± 358.21 N vs PMMA, 1778.45 ± 399.83 N; P = 0.745) and was significantly greater than that of the control group (1019.01 ± 371.98 N; P < 0.05). The average torque value in the CPN group was higher than that in the control group (CPN, 1.51 ± 0.78 N∙m vs control, 0.97 ± 0.58 N∙m) and lower than that in the PMMA group (1.93 ± 0.81 N∙m), but there were no statistically significant differences (P > 0.05). The CPN could be biodegraded and gradually replaced by newly formed bone tissue after 12 weeks in a rat cranial defect model.Conclusion The biocompatible CPN could be a valuable augmentation material to enhance CBT screw stability.
研究领域:
骨科
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生物医学工程
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材料科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2024
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IF 2.7
Chaobi Chen,Defu Lyu,Wenjing Xi,Lichao Chen,Shijie Cai,Yonggang Yan,Xiaodan Li,Haohao Ren,Rong Xing
In this work, semi-aromatic polyamide containing ether bond (PAE10T) was synthesized through nucleophilic substitution reaction using 1, 10-N, N′- bis (4-fuorobenzamide) decane (BFBD) and hydroquinone (HQ) as the raw materials. And then the composites hydroxyapatite/semi-aromatic polyamide (40%HA-PAE10T and 60%HA-PAE10T) were prepared by chemical precipitation method. Mechanical, SEM, FT-IR, XRD, DSC, TGA and bioactivity tests were performed to characterize the structure, morphology, thermal and mechanical properties of PAE10T and its composites. Mechanical tests revealed that the difference of HA in weight played an important role in mechanical performance of the composites. Furthermore, in comparison with PAE10T, the 60%HA-PAE10T showed the highest enhancement in compressive strength (133 MPa) at 75.9%, and the 40%HA-PAE10T given expression to the best increase in bending strengths (97 MPa) at about 18.4%. The 40%HA-PAE10T and 60% HA-PAE10T exhibited the mechanical performances closed to the cortical bone of human. After 28 days of dip in the phosphate buffer saline (PBS), PAE10T, and its composites showed satisfactory stability. The cell culture results showed all composites gad good cytocompatibility, cells attached on the materials well with excellent morphology. All the experimental results showed that the composites were expected to have a good application in the field of compact bone repair.
研究领域:
材料科学
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生物材料
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生物医学工程
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DOI
高影响因子
Materials
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2022
·Vol. 15
·期 23
·8398-8398
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IF 3.748
Ze Wang,Zhiqiang He,Bohua Duan,Xinli Liu,Dezhi Wang
Porous NiTi alloys are widely applied in the field of medical implant materials due to their excellent properties. In this paper, porous NiTi alloys were prepared by non-aqueous gel-casting. The influence of solid loading on the process characteristics of slurries and the microstructure and mechanical properties of sintered samples were investigated. The viscosity and the stability of slurry significantly increased with the growth of solid loading, and the slurry had better process characteristics in the solid loading range of 40-52 vol.%. Meanwhile, the porosity and average pore diameter of the sintered NiTi alloys decreased with a rise in the solid loading, while the compressive strength increased. Porous NiTi alloys with porosities of 43.3-48.6%, average pore sizes of 53-145 µm, and compressive strengths of 87-167 MPa were fabricated by gel-casting. These properties meet the requirements of cortical bone. The results suggest that the pore structure and mechanical properties of porous NiTi products produced by gel-casting can be adjusted by controlling the solid loading.
研究领域:
材料科学
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生物医学工程
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机械工程
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产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
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2025
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IF 26.8
Yajun Shuai,Tao Yang,Meidan Zheng,Li Zheng,Jie Wang,Chuanbin Mao,Mingying Yang
Assembling natural proteins into large, strong, bone-mimetic scaffolds for repairing bone defects in large-animal load-bearing sites remain elusive. Here this challenge is tackled by assembling pure silk fibroin (SF) into 3D scaffolds with cortical-bone-like lamellae, superior strength, and biodegradability through freeze-casting. The unique lamellae promote the attachment, migration, and proliferation of tissue-regenerative cells (e.g., mesenchymal stem cells [MSCs] and human umbilical vein endothelial cells) around them, and are capable of developing in vitro into cortical-bone organoids with a high number of MSC-derived osteoblasts. High-SF-content lamellar scaffolds, regardless of MSC inoculation, regenerated more bone than non-lamellar or low-SF-content lamellar scaffolds. They accelerated neovascularization by transforming macrophages from M1 to M2 phenotype, promoting bone regeneration to repair large segmental bone defects (LSBD) in minipigs within three months, even without growth factor supplements. The bone regeneration can be further enhanced by controlling the orientation of the lamella to be parallel to the long axis of bone during implantation. This work demonstrates the power of oriented lamellar bone-like protein scaffolds in repairing LSBD in large animal models.
研究领域:
生物医学工程
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组织工程
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再生医学
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生物材料科学
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产品关联
DOI
PubMed
高影响因子
Biomaterials Advances
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2024
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IF 5.5
Xueni Zhao,Yu Zhang,Pengfei Wang,Jinxin Guan,Dexin Zhang
Drawing on the structure and components of natural bone, this study developed Mg-doped hydroxyapatite (Mg-HA) bioceramics, characterized by multileveled and oriented micro/nano channels. These channels play a critical role in ensuring both mechanical and biological properties, making bioceramics suitable for various bone defects, particularly those bearing loads. Bioceramics feature uniformly distributed nanogrooves along the microchannels. The compressive strength or fracture toughness of the Mg-HA bioceramics with micro/nano channels formed by single carbon nanotube/carbon fiber (CNT/CF) (Mg-HA(05-CNT/CF)) are comparable to those of cortical bone, attributed to a combination of strengthened compact walls and microchannels, along with a toughening mechanism involving crack pinning and deflection at nanogroove intersections. The introduction of uniform nanogrooves also enhanced the porosity by 35.4 %, while maintaining high permeability owing to the capillary action in the oriented channels. This leads to superior degradation properties, protein adsorption, and in vivo osteogenesis compared with bioceramics with only microchannels. Mg-HA(05-CNT/CF) exhibited not only high strength and toughness comparable to cortical bone, but also permeability similar to cancellous bone, enhanced cell activity, and excellent osteogenic properties. This study presents a novel approach to address the global challenge of applying HA-based bioceramics to load-bearing bone defects, potentially revolutionizing their application in tissue engineering.
研究领域:
材料科学
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生物医学工程
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组织工程
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生物材料
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产品关联
DOI
PubMed
高影响因子
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