BIOSENSORS & BIOELECTRONICS
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2025
·
IF 10.5
Jian Luo,Yuli Wang,Junhong Yi,Zonglei Wang,Wenqing Yan,Jiawei Yang,Leqi Li,Xinyuan Ye,Mingzhe Wang,Pengcheng Zhou,Qingyuan Sun,Yi Liu,Zichong Ji,Zongman Zhang,Zhihui Pan,Yan Wang
Robust, long-term electrophysiological monitoring demands epidermal electrodes that breathe like skin, adhere to demand, and survive the repetitive strains of daily life. Here, we present a 2.4 μm-thick, transparent, and gas-permeable epidermal electrode that adheres to human skin upon brief wetting with saline solution. The electrode is fabricated through a simple, scalable method using a gelatin matrix composed of gelatin, glycerol, citric acid, and water, reinforced by an electrospun polyurethane nanomesh. This construction yields an interfacial adhesion energy of 1.7 mJ cm −2 and excellent breathability with a water vapor transmission rate of 1339.3 g m −2 day −1 . The film withstands more than 1500 cycles of 60 % uniaxial strain and still exhibits an adhesion energy of 0.8 mJ cm −2 after 48 h of skin attachment. The skin-electrode interface maintains a low contact impedance of 36.7 kΩ at 100 Hz even after 48 h of continuous wear. These properties enable stable and high-fidelity recording of electroencephalogram, electromyogram, and continuous electrocardiogram signals for over 36 h under daily activities, including lab work, commute, meal, nap/sleep, and desk work. The electrode performance remains consistent even after 30 days of ambient storage. We further demonstrate wireless electroencephalogram and electrocardiogram signals acquisition during one full night of sleep, enabling accurate and automatic sleep stage classification based on electroencephalogram spectral features and heart rate dynamics. Together, these results establish the ultrathin gelatin film as a practical platform for real-world, long-term electrophysiological monitoring and point toward its broader use in personalized healthcare wearables.
研究领域:
生物医学工程
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柔性电子
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可穿戴设备
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生理信号监测
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睡眠医学
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产品关联
DOI
PubMed
高影响因子
Advanced Materials Technologies
·
2025
·
IF 6.2
Qing Dang,Xuan Ling,Qian Zhang,Shipai Song,Xiaoran Hu
The safety incidents caused by the thermal runaway of lithium-ion batteries (LIBs) have motivated people to develop sensing technologies to monitor the temperature and pressure for safety warnings. However, current external sensors face challenges such as low accuracy and high latency. Internal sensors are limited by device size, which usually allows for monitoring only a parameter and significantly impacts the capacity and cycle characteristics of LIBs. The present work designs an implantable integrated sensor (TPS) capable of real-time monitoring of the temperature and pressure inside the 6Ah LIB. The TPS is composed of a PT1000 temperature-sensitive alloy and a polydimethylsiloxane/ carbon nanotubes piezoresistive composite. The TPS offers a temperature measurement range of −50–80 °C with an accuracy of 0.30 °C; and a pressure measurement range of 0–2 MPa with an accuracy of 0.11 MPa, and shows significant accuracy when compared with external sensors. Furthermore, the TPS has a rather low impact on the battery capacity with a retention rate of 92.80% after 300 cycles, which is only 0.75% lower than normal batteries, and a maximum Coulombic efficiency difference of 0.04%. The proposed TPS holds promise for monitoring the temperature and pressure of LIBs and promotes its safe utilization.
研究领域:
材料科学
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能源工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 16
·2626-2633
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IF 5.047
Nan Pan,Juanrong Qin,Pingping Feng,Zeke Li,Botao Song
Real-time monitoring of wound pH may provide information about the wound healing status and potential bacterial infection. Herein, we integrated the biocompatible color changing substance curcumin into a fibrous material, capable of in situ real-time visually monitoring the wound pH. The results indicate that the curcumin-loaded fibrous mat exhibits an obvious pH-dependent color change from yellow to red brown with a change in pH from 6.0 to 9.0, which can be easily detected by the human naked eye. Moreover, the wound pH conditions can be determined with the aid of a smart phone App after image analysis. Due to their flexibility, the fibrous materials have been further processed into various shapes from 1D to 3D for fitting the irregular wounds. It is believed that smart fibrous materials that can simultaneously real-time monitor the wound pH and repair the wound may change wound management to a convenient and comfortable way.
研究领域:
生物医学工程
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材料科学
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医学
✓ 已验证
DOI
PubMed
高影响因子
ACS Photonics
·
2022
·
IF 7.077
Meihua Chen,Yongcheng He,Haohua Liang,Hongyou Zhou,Xin Wang,Xiaobo Heng,Zhishen Zhang,Jiulin Gan,Zhongmin Yang
A stretchable fluorescent optical fiber provides a flexible platform for wearable functional devices due to its stretchability and immunity to electromagnetic interference. However, for wearable applications, stretchable fiber sensors suffer from severe body movement-induced strain interference. Here, we report a stretchable optical sensor with strain-decoupling ability. The stretchable core-clad structured optical fiber is prepared with fluorescent nanoparticles and silicone-based elastomers that enable both efficient excitation light delivery and fluorescence collection. The excitation light loss and fluorescence intensity exhibit a linear response to the sensing variables and strain change, which have been utilized as the sensing parameters to decouple the strain from the sensing variables. Our strain-decoupled scheme is widely applicable to other stretchable fluorescent optical fiber sensors that are simultaneously subject to strain. In the experiment described here, the temperature-sensitive fluorescent nanoparticle-doped stretchable fluorescent optical fiber exhibits stable temperature-sensing in the range −10 to 60 °C, with an uncertainty as low as ±0.23 °C and a relative sensitivity of 1.3% °C–1, even when it is subjected to large strain up to 40%. We demonstrate sensor-integrated wearable masks and gloves, which can simultaneously measure physiological thermal changes and the movement of the wrist joint. Our sensor shows great promise as a technology for wearable health monitoring.
研究领域:
生物医学工程
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材料科学
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光学工程
✓ 已验证
产品关联
DOI
高影响因子
BMEMat
·
2024
·
IF 0
Xinxin He,Zhiyuan Li,Xingcan Huang,Qiang Zhang,Yuyang Zeng,Jialin Li,Chun Ki Yiu,Yawen Yang,Jingkun Zhou,Guoqiang Xu,Jiachen Wang,Jian Li,Zitong Xu,Zhenlin Chen,Yiming Liu,Yuyu Gao,Binbin Zhang,Guangyao Zhao,Zhan Gao,Pengcheng Wu,Rui Shi,Yuze Qiu,Hehua Zhang,Lung Chow,Denglin Ye,Ya Huang,Xinge Yu
The importance of continuous healthcare management has significantly accelerated the development of wearable devices for monitoring health-related physical and biochemical markers. Despite extensive research on wearable devices for physiological and biochemical monitoring, critical issues of power management and device/skin interfacial properties restrict the advancement of personalized healthcare and early disease detection. Here, we report a multimodal sweat monitoring device featuring a real-time display and long-term data analysis based on self-powered format of sweat-activated batteries (SABs). The polyvinyl alcohol-sucrose (PVA-Suc) hydrogel serves as the key component for the SAB, offering not only great long-term adhesive properties for conformable wearability but also significant power generation capabilities. A maximum current density of 44.06 mA cm −2 and a maximum power density of 21.89 mW cm −2 can be realized for the hydrogel based SAB. The resulting device integrates an advanced colorimetric and electrochemical sensor array to measure pH levels, glucose concentrations, and chloride ion levels in human sweat, with data wirelessly transmitted by Near Field Communication. The self-powering features and multiple mode sensing function offer sufficient power to support real-time monitoring of metabolic biomarkers in sweat, with the ability to visually observe changes in the colorimetric sensors for long-term data monitoring.
研究领域:
生物医学工程
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可穿戴设备
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电化学传感
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健康监测
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能源收集
✓ 已验证
DOI
FIBERS AND POLYMERS
·
2024
·
IF 2.2
He Xia,Liu Qingchun,Pan Lianjun,Zhou Ying,Xu Le,Zhou Shiyu,Ma Yixin
Wearable electronics based on natural biocompatible fibers have attracted considerable interests due to the promising use for healthcare monitoring, human–machine interactions, and smart clothing. However, crucial challenges to design robust, flexible, and highly sensitive fiber sensors remain, to meet various requirements for practical application. Herein, Fischer esterification and in situ polymerization technologies were employed to produce conductive nanocelluloses (CNC–PEDOT), which possessed excellent mechanical stiffness and high conductivity (238 μS/cm). Then, silk yarns as supporting materials were functionalized by as-prepared conductive units to construct all-in-one fiber sensor (SCP) for multiple signals monitoring. Surprisingly, the resulted SCP fiber showed impressive mechanical performances (422.86 MPa at 18.44%), due to the strong hydrogen-bond interaction between SY substrate and CNC–PEDOT conductive units. More importantly, SCP fiber was employed a dual-function sensor for real-time monitoring of strain and temperature, illustrating remarkable sensitivities, i.e., gauge factor = 4.28 in a large strain range of 0–16%, and sensitivity = 1.55%/℃ in a broad temperature range of 25–60 ℃. The SCP fiber sensor with impressive mechanical performances and high sensitivity, can be applied for real-time health monitoring in wearable biosensors, smart healthcare, and on-demand therapy.
研究领域:
材料科学
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生物医学工程
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可穿戴技术
✓ 已验证
产品关联
DOI
高影响因子
eTransportation
·
2024
·
IF 15
Anyu Su,Shuoyuan Mao,Languang Lu,Xuebing Han,Minggao Ouyang
The current battery management system is limited to testing external characteristics, leaving the battery's internal status as a “black box”. Advanced characterization techniques and battery sensing technologies are needed to assess the battery's internal state. However, due to their short lifespan, low sensitivity, invasive nature, and high cost, these technologies face challenges in practical applications and commercialization. Here, we propose a smart battery implanted with a potential sensor for in-situ measurement of anode potential, enabling the recognition of severe side reactions and abnormal Li plating behavior. Specifically, the potential sensing material is directly integrated into the battery separator, which provides a reliable potential reference and serves as a sensing terminal . The porous structure of the separator facilitates lithium-ion transport while simultaneously enabling high-accuracy monitoring with non-destructive implantation. Additionally, the potential sensing separator can detect pre-existing or latent defects in the battery at an early stage, which are difficult to discern from the battery's external characteristics in a timely manner. Furthermore, we have developed a multi-point potential sensor monitoring system that can not only monitor the distribution of anode potential but also pinpoint the location of battery defects.
研究领域:
材料科学
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能源技术
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传感技术
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Zhe Li,Xiaohui Wang,Xiuli Fu,Jinhua Liu,Yuanan Liu,Hongxin Zhang
The pH and O 2 are the two important parameters to evaluate environmental conditions, healthcare, and industrial processes. Herein, we developed a ratiometric fluorescent capillary-based dual-functional sensor for simultaneous monitoring of pH and O 2 fluctuations. The fluorescent sensor consists of a pH sensing unit and an O 2 sensing unit on both ends of the capillary inner wall. The ratiometric fluorescent pH sensing unit includes pH-sensitive probe HPTS and the reference dye Ce6, while the O 2 sensing unit is composed of O 2 -sensitive probe RuDP and the reference dye C6. Under single-wavelength excitation at 430 nm, the ratiometric fluorescent dual-functional sensor exhibits highly sensitive, selective and reproducible responses to both pH and O 2 . As for practical aqueous samples, the results about pH and O 2 levels obtained by our sensor are considerable consistent with commercial devices. Meanwhile, the dynamic changes of pH and O 2 levels during glucose catalysis by glucose oxidase can be detected in real-time and accurately. The dual-functional ratiometric fluorescent capillary transducer provides a significant potential platform for environmental monitoring and medical diagnosis.
研究领域:
生物医学工程
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环境科学
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化学传感
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Materials Technologies
·
2023
·Vol. 8
·期 22
·2300949
·
IF 6.8
Zhiping Feng,Qiang He,Jing Qiu,Xue Wang,Yinggang Lin,Yufen Wu,Jin Yang
Long-term surveillance records of cardiac activity are essential for people at potential risk of cardiovascular disease. However, the existing mainstream technologies for cardiac monitoring, such as electrocardiography (ECG) and photoplethysmography (PPG), are inconvenient and prone to skin allergies due to contact measurements. Ballistocardiography (BCG) is a vibration signal related to cardiac activity, which can be monitored in an unconstrained way. Herein, an iontronic textile-type flexible capacitive pressure sensor (i-TFCPS) based on ionic liquid doped hollow-porous fiber is developed to monitor physiological signals. With a high sensitivity of 7.26 kPa −1 , a wide pressure range (10 Pa–600 kPa), a fast response time of 30 ms, and decent durability over 3500 cycles, the i-TFCPS is simultaneously capable of detecting and tracking the static and dynamic changes of sitting posture, and subtle physiological information, such as respiration and BCG signals. Benefits from the iontronic textile as sensitive dielectric, the capacitive pressure sensor is able to monitor the subtle BCG signal under high static pressure in an unconstrained state, showing great potential for unobtrusive cardiac monitoring in home, office and hospital.
研究领域:
生物医学工程
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材料科学
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医学信号处理
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Qiyu Wang,Qingzhou Liu,Geng Zhong,Tailin Xu,Xueji Zhang
Ketogenic diets have attracted substantial interest in the treatment of chronic diseases, but there are health risks with long-term regimes. Despite the advancements in diagnostic and therapeutic methods in modern medicine, there is a huge gap in personalized health management of this dietary strategy. Hence, we present a wearable microneedle biosensor for real-time ketone and glucose monitoring. The microneedle array possesses excellent mechanical properties, allowing for consistent sampling of interstitial biomarkers while reducing the pain associated with skin puncture. Vertical graphene with outstanding electrical conductivity provides the resulting sensor with a high sensitivity of 234.18 μA mM–1 cm–2 and a low limit detection of 1.21 μM. When this fully integrated biosensor was used in human volunteers, it displayed an attractive analytical capability for tracking the dynamic metabolite levels. Moreover, the results of the on-body evaluation established a significant correlation with commercial blood measurements. Overall, this cost-effective and efficient sensing platform can accelerate the application of a ketogenic diet in personal nutrition and wellness management.
研究领域:
生物医学工程
·
营养学
·
传感技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2016
·
IF 5.886
Hailong Yan,Li Zhang,Ping Yu,Lanqun Mao
Real-time monitoring of respiratory rate (RR) is highly important for human health, clinical diagnosis, and fundamental scientific research. Exhaled humidity-based RR monitoring has recently attracted increased attention because of its accuracy and portability. Here, we report a new design of an exhaled humidity sensor for the real-time monitoring of the RR based on a synthetic redox conducting supramolecular ionic material (SIM). The humidity-dependent conducting SIM is prepared by ionic self-assembly in aqueous solutions of electroactive 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,10-bis(3-methylimidazolium-1-yl) decane (C10(mim)2). By taking full advantage of the high hygroscopicity and water stability arising from the ionic and hydrophobic interactions between two building blocks (i.e., ABTS and C10(mim)2), the SIM-based humidity sensor exhibits both high sensitivity (less than 0.1% relative humidity) and fast response time (∼37 ms). These excellent properties allow this humidity sensor to noninvasively monitor the RRs of not only humans but also rats that have a much faster RR and much smaller tidal volume than humans. Moreover, this sensor could also be efficiently used for the real-time monitoring of the recovery process of rats from anesthesia.
研究领域:
生物医学工程
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材料科学
·
临床诊断
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF FLUORESCENCE
·
2025
·
IF 3.1
Guo Yangyang,Wang Chaoyue,Liu Ying,Zheng Guangjin,Meng Juan
Monitoring the hydrazine (N 2 H 4 ) level is essential for environmental and health safety, while traditional detection methods face challenges including low sensitivity, complex sample handling, and sophisticated operation. In this study, a novel fluorescent probe, ZNP , was designed and synthesized for tracking hydrazine in soils and river water. It was used for in situ monitoring of hydrazine generation in living cells. The optical performance guaranteed the high selectivity and reliable anti-interference. The most significant merit was a practical dynamic range for intuitive visualization. Additionally, the develop probe predominantly accumulated in lysosomes. Notably, ZNP integrated the fluorescent and visual signals, which enabled the naked-eye observation. This work acted as a significant step towards the practical tools for environmental toxicology applications.
研究领域:
环境毒理学
·
分析化学
·
生物成像
·
化学传感
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）