INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2024
·Vol. 25
·期 8
·4276
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IF 4.9
Chenyang Li,Xinxin Qi,Lei Xu,Yuan Sun,Yan Chen,Yuhan Yao,Jun Zhao
This study aimed to investigate the preventive effects of the total polyphenols fromNymphaea candida(NCTP) on LPS-induced septic acute lung injury (ALI) in mice and its mechanisms. NCTP could significantly ameliorate LPS-induced lung tissue pathological injury in mice as well as lung wet/dry ratio and MPO activities (p< 0.05). NCTP could significantly decrease the blood leukocyte, neutrophil, monocyte, basophil, and eosinophil amounts and LPS contents in ALI mice compared with the model group (p< 0.05), improving lymphocyte amounts (p< 0.05). Moreover, compared with the model group, NCTP could decrease lung tissue TNF-α, IL-6, and IL-1β levels (p< 0.05) and downregulate the protein expression of TLR4, MyD88, TRAF6, IKKβ, IκB-α, p-IκB-α, NF-κB p65, p-NF-κB p65, NLRP3, ASC, and Caspase1 in lung tissues (p< 0.05). Furthermore, NCTP could inhibit ileum histopathological injuries, restoring the ileum tight junctions by increasing the expression of ZO-1 and occludin. Simultaneously, NCTP could reverse the gut microbiota disorder, restore the diversity of gut microbiota, increase the relative abundance of Clostridiales and Lachnospiraceae, and enhance the content of SCFAs (acetic acid, propionic acid, and butyric acid) in feces. These results suggested that NCTP has preventive effects on septic ALI, and its mechanism is related to the regulation of gut microbiota, SCFA metabolism, and the TLR-4/NF-κB and NLRP3 pathways.
研究领域:
药理学
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免疫学
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微生物学
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病理学
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分子生物学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Tianzong Jiang,Shili Gai,Yanqi Yin,Zewei Sun,Bingchen Zhou,Yubo Zhao,He Ding,Anees Ahmad Ansari,Piaoping Yang
Inspired by the natural stimulus–response of plants and animals, a range of soft equipment has been extensively developed and used in intelligent human–computer interaction, editable remote drives, and machine learning. Poly(N-isopropyl acrylamide) (PNIPAM) hydrogels have gained popularity thanks to their low phase transition temperature and excellent flexibility. However, the PNIPAM hydrogels suffer from poor mechanical properties, low electrical conductivity, and lack of self-responsiveness. Herein, a bilayer light/thermal cascaded-driven anisotropic poly acrylamide/poly(N-isopropylacrylamide-co-acrylamide)-polyvinyl alcohol-MXene (P/PP-M) actuator was prepared by a simple two-step polymerization method. The unique bionic light/thermal response mechanism enables rapid conversion of energy forms and the construction of remote editable actuators. Concretely, the mechanical properties of hydrogels (strain: 1014 %, stress: 94 KPa) have been greatly improved by copolymerizing MXene nanosheets and multiplex hydrogels through two-by-two interpenetrating molecular chains. MXene nanosheets formed dynamic networks conferring the hydrogel system with high conductivity and light/thermal conversion efficiency. The P/PP-M soft actuator features high sensitivity (Gauge factor = 3.62), fast response time (400 ms), and cycling durability (>500 cycles). Finally, the energy transfer mechanism from light to thermal energy to kinetic energy was corroborated by preparing a series of bionic equipment. Manual clips were prepared on this basis, which enables the transportation of objects and realizes the real-time reflection of the operating status of remotely driven soft manual clips through changes in electrical signals. Thus, the proposed efficient editable remote-driven machine recognition soft equipment provides new insights for developing intelligent flexible robots and wearable smart devices.
研究领域:
材料科学
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机器人技术
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生物医学工程
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机械工程
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纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）