RSC Advances
·
2015
·Vol. 5
·期 89
·72736-72744
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IF 3.84
Jinku Xu,Weiyue Zhu,Lijuan Jiang,Jing Xu,Yongchun Zhang,Yuezhi Cui
The refractive index (RI) is an important parameter for intraocular lens biomaterials. In this paper, a novel carbazole-grafted methacrylic polysiloxane macromonomer (MA-CZ-PDMS) with a high RI value was synthesized and its structure was confirmed by proton nuclear magnetic resonance (1H NMR). The polysiloxane macromonomer can copolymerize with monomers of 3-methacryloxypropyl tris(trimethylsiloxy) silane (TRIS) and N,N-dimethylacrylamide (DMA) to prepare transparent high RI silicone hydrogel. Increasing MA-CZ-PDMS macromonomer content in the silicone hydrogels improved its water content, RI value, and mechanical properties, however decreased slightly glass transition temperature (Tg) and transmittance of blue light. The carbazole-grafted silicone hydrogel possessed good cytocompatibility and in vivo biocompatibility in rabbit eyes. The results demonstrate that the carbazole-grafted silicone hydrogel has a potential application as high RI ocular refractive correction biomaterial.
研究领域:
材料科学
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眼科医学
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高分子化学
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产品关联
DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2019
·Vol. 297
·期 9
·1233-1243
·
IF 1.906
Zhang Xueqin,Wang Lu,Tao Huiwen,Sun Ying,Yang Hong,Lin Baoping
Two series of multicomponent silicone hydrogels based on poly (ethylene glycol)- polydimethylsiloxane-poly (ethylene glycol) (PEG-PDMS-PEG) triblock oligomers were prepared by copolymerization of silicon-containing monomers methacrylate-terminated PEG-PDMS-PEG (MTSM), tris (trimethylsiloxy)-3-methacryloxpropylsilane (TRIS), and hydrophilic monomers such as N,N-dimethylacrylamide (DMA), N-vinylpyrrolidone (NVP), and hydroxypropyl-methacrylate (HPMA). The influences of PEG chain length on hydrophilicity, oxygen permeability, and mechanical properties of silicone hydrogels were explored. The hydrophilic properties of silicone hydrogels were characterized by water contact angle, equilibrium water content, and swelling-dehydration process. The results showed that the water contact angles of dry samples decreased while the swollen ones increased with the increase of PEG chain length. The equilibrium water content decreased first and then increased as the length of the PEG chain increased. The results of swelling and dehydration process showed that PEG chains improved the water-retaining capacity of silicone hydrogels. Moreover, the protein adsorption of samples with PEG chains decreased. The surface morphologies of silicone hydrogels were characterized by scanning electron microscope (SEM), and a reconstruction model was proposed. In addition, the oxygen permeability and mechanical properties of silicone hydrogels also varied with the length of the PEG chain. These results could provide a theoretical reference for the design and modification of new hydrogels.
The properties of silicone hydrogels obtained by copolymerization of MTSM with hydrophilic monomers vary with the chain length of PEG, when PEG chains are presented as a segment of MTSM.
研究领域:
材料科学
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聚合物化学
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生物材料
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DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2014
·Vol. 132
·期 5
·
IF 1.64
Jinku Xu,Pengfei Yang,Leilei Zhang,Guanghua Huo
Transparent silicone hydrogels with interpenetrating hydrophilic/hydrophobic networks were simultaneously synthesized on the basis of the radical polymerization of the methacrylic monomer of 3-methacryloxypropyl tris(trimethylsiloxy) silane (TRIS)/ N,N -dimethylacrylamide (DMA) and the addition polymerization of hydroxyl-grafted polysiloxane (HPSO)/isophorone diisocyanate. The curing temperature was set at 80°C by a differential scanning calorimetry study. The polymerization process was studied by in situ Fourier transform infrared spectroscopy. The results indicate that the curing time was about 4.5 min, and the addition polymerization had a faster rate than radical polymerization. Then, the radical polymerization rate increased rapidly, and this led to instant curing. The interpenetrating polymer network (IPN) silicone hydrogels were characterized by swelling kinetics and dynamic mechanical thermal analysis. The results show that all of the hydrogels reached swelling equilibrium at about 4 h in water, and the IPN silicone hydrogels with a hydrophobic network of HPSO indicated a slower water transport than that of the copolymerization hydrogel of DMA and TRIS. The hydrophobic network was finely dispersed in the hydrophilic network, and the increasing hydrophobic network of HPSO decreased the glass-transition temperature of the IPN silicone hydrogels. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 41399.
研究领域:
材料科学
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高分子化学
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DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2013
·
IF 1.7
Jinku Xu,Leilei Zhang,Yongchun Zhang,Tianduo Li,Guanghua Huo
Hydrogels with interpenetrating network (IPN) can overcome thermodynamic incompatibility and obtain transparent materials with limited phase separation. In this report, hydroxyl-grafting polysiloxane (HPSO) was synthesized and transparent silicone hydrogels with interpenetrating network were simultaneously prepared based on radical polymerization of methacrylic monomer of 3-methacryloxypropyl tris(trimethylsiloxy)silane/N,N-dimethylacrylamide and addition polymerization of HPSO/isophorone diisocyanate. The silicone hydrogels were characterized by dehydration kinetics, tensile tester, light transmittance, ion permeability, oxygen permeability, and lysozyme deposition. The results show that increasing the proportion of hydrophobic network of HPSO in the IPN silicone hydrogel decreases equilibrium swelling ratio, ion permeability, Young’s modulus, and lysozyme deposition; on the contrary, increased tensile strength, elongation at break and oxygen permeability. Puerarin and ketoconazole were used as models to evaluate the drug loading and in vitro release behavior of the silicone hydrogels. It is revealed that the amount of loaded drugs in the hydrogel decreases with the increase of HPSO network in the hydrogels. All the silicone hydrogels exhibit extended release behavior, especially for ketoconazole, the in vitro release is divided into two phases corresponding to the rapid release at initial 24 h and relatively slow release from 125 to 360 h.
研究领域:
材料科学
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药剂学
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眼科学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Xuemei He,Haiyan Mao,Shuzhen Wang,Zhongliang Tian,Tianchi Zhou,Lu Cai
Due to the growing demand for self-health and safety, eco-friendly health textile products with natural colors and pharmacological functionalities have gained considerable popularity. Rapid adsorption and controlled release of active molecules are important issues for functional health textiles. In this study, a functionalized chitosan-based hydrogel composite silk fabric was prepared using chitosan, 3-carboxyphenylboronic acid, and 3-(2, 3-epoxypropyl oxygen) propyl silane by dip-pad and vacuum freeze-drying techniques. The results showed that the incorporation of chitosan/phenylboronic/SiO 2 hydrogel into silk fibers improved the UV protection capacity, mechanical properties, and adsorption properties of silk fabrics. The effects of various parameters on the luteolin adsorption properties of silk fabrics were discussed, including metal salt types, salt dosage, pH value, dyeing temperature, initial luteolin concentration, and dyeing time. Under the dyeing temperature of 60 °C and pH of 6.8, the luteolin exhaustion of the composite silk was more than that of the untreated silk, and the adsorption process followed the quasi-second-order kinetic model and the Langmuir adsorption isotherm model. Furthermore, the luteolin-dyed composite silk materials exhibited strong antioxidant activity and controllable release behavior with various pH levels. The as-prepared chitosan-hydrogel composite silk could be a promising material for the sustained release of drugs in medical and healthcare textiles.
研究领域:
材料科学
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纺织工程
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生物医学
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产品关联
DOI
PubMed
高影响因子
Materials
·
2025
·Vol. 18
·期 4
·827
·
IF 3.2
Yamin Chen,Dianyang Li,Yougen Chen,Hui Fang
Four kinds of silicone hydrogel transparent contact lenses (CLs) with different formulations were prepared by the free radical photocuring polymerization. By mixing polyethylene glycol diacrylate (PEGDA) of 1000 Da with ethylene glycol dimethacrylate (EGDMA) and adding other silicone monomers and hydrophilic monomers, the transparency and flexibility of the material were successfully achieved. By optimizing the weight percentage of each component, the best balance of optical performance can be achieved. The photocuring properties of the materials were characterized by electronic universal test, double-beam UV-visible spectrophotometer, Atomic Force Microscope (AFM), Scanning Electron Microscope (SEM) and Fourier Transform Infrared Spectroscopy (FTIR). The results showed that the addition of higher PEGDA content reduces the elastic modulus, improves curing efficiency, improves equilibrium water content (EWC), and enhances light transmission. Hydrogels containing only high PEGDA but no EGDMA showed similar curing rates, water content, and elastic modulus, but had the worst optical transparency, far inferior to the materials mixed with PEGDA and EGDMA. Additionally, imaging performance of the CLs was further evaluated through simulation analysis using Ansys Zemax OpticStudio2024 software. This research provides a new choice of material consideration to improve the performance and wearing comfort of CLs.
研究领域:
材料科学
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生物医学工程
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眼科研究
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产品关联
DOI
PubMed
高影响因子
COLLOID AND POLYMER SCIENCE
·
2021
·Vol. 299
·期 8
·1327-1335
·
IF 1.931
Wu Shu,Zhang Xueqin,Sun Ying,Yang Hong,Lin Baoping,Han Xuelian,Chen Ping
Abstract To investigate the influence of crosslinking density and free polysiloxane chain length on oxygen permeability and hydrophilicity of multicomponent silicone hydrogels, two kinds of silicone macromonomers, single methacrylate terminated silicone macromonomers (PDMS-1) and double methacrylate terminated silicone macromonomers (PDMS-2), were synthetized, respectively. Then, a series of multicomponent silicone hydrogels with different crosslinking densities and free polysiloxane chain lengths were prepared by copolymerization of obtained silicone macromonomers, silicone monomer tris(trimethylsiloxy)-3-methacryloxpropylsilane (TRIS), and hydrophilic monomers. The oxygen permeability coefficient (Dk), equilibrium water content (EWC), light transmittance, and mechanical properties of silicone hydrogels were characterized. The results indicated that the longer free polysiloxane chain was beneficial to the increase of Dk values and EWC of silicone hydrogels. With the increase of crosslinking density, the Dk values and EWC of the silicone hydrogels decreased. This work provided a new idea for the preparation of high-permeability silicone hydrogels in the future. Graphical abstract
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
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2013
·
IF 5.437
Zi-Xue Yang,Bao-An Chen,Heng Wang,Guo-Hua Xia,Jian Cheng,Xiao-Ping Pei,Fei Wang,Wen Bao
Malignant tumor has become the leading cause of death worldwide; however, multiplex detection technology could provide great assistance in large-scale population screening of diseases which could effectively reduce the mortality of malignant tumors. Here a microbeads array chip, which could be a perfect alternative method for the early screening, was developed. Silica–hydrogel hybrid bead (SHHB) with photonic encoding, which consists of both silica and hydrogel materials, was manufactured as the carrier of microbeads array for the first time. The SHHB has the advantages of the beads made of silica or hydrogel, but does not have their limitations. Reaction conditions of SHHBs array were optimized and then the fluorescent concentration curves of two widely-used tumor markers, human alpha fetoprotein and carcinoembryonic antigen, were constructed. The accuracy of SHHBs array has been proven according to the comparison between the results obtained by detecting 50 clinical samples with SHHBs array and chemiluminescence immunoassay . A cassette like chip device has also been developed to standardize operational processes and benefit automization in the next work. Hence it is concluded that SHHBs array chip is a handy, rapid and multiplex immunoassay technology, which could imply its practical application in clinical immunoassay in the near future.
研究领域:
生物医学工程
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免疫学
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临床检验
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
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2024
·
IF 2.3
Xuefang Guo,Ying Sun,Jing Qiao,Ben Fan,Xueqin Zhang
Silicone contact lenses (SCL), as an emerging ocular drug delivery system, achieve controlled drug release. However, the existing drug loading methods have limitations such as low drug uptake, complicated operation process, poor welling rate and transmittance of the lens after drug loading. In this study, an effective microemulsion soaking method was proposed to increase the drug-loading capacity of silicone contact lenses. Levofloxacin (LVF) was encapsulated into the microemulsion by direct agitation, then the microemulsion was loaded into silicone contact lenses using the immersion method. The adsorption capacity of levofloxacin and its effect on drug release kinetics were explored. The results showed that the particle size of the microemulsion was approximately 160 nm. The levofloxacin microemulsion soaking method (LVF-ME-SCL) significantly enhanced the drug loading of levofloxacin in the silicone contact lenses, achieving a maximum drug loading of 216.32 ± 1.15 μg/lens (p > 0.05). The total release rate of levofloxacin was 95.96% when the sustained release time was 10 h, and the drug leakage observed after 10 h was negligible. The survival rate of E. coli and S. aureus in LVF-ME-SCL-1 (LVF concentration was 4.8 mg/mL) group was 0 and 19.33 ± 0.02% (p < 0.0001), with a significant difference, indicating that the drug-loaded silicone contact lenses exhibited effective bactericidal properties against E. coli and S. aureus. Following the addition of maximum levofloxacin, the surface contact angle of silicone contact lenses decreased significantly to 32.88 ± 1.19° (p > 0.05), while the swelling, mechanical properties, and oxygen permeability remained relatively unchanged. There was no significant decrease in the transmittance of the contact lenses after the addition of levofloxacin, which remained above 95%. In conclusion, these results show that the microemulsion impregnation method effectively improves the drug loading and sustained release time of levofloxacin, and maintains lens performance stability before and after drug loading, so it is expected to be used in ophthalmic treatment.
研究领域:
药学
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眼科医学
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材料科学
✓ 已验证
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
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2025
·
IF 12.4
Yan Wen,Yan Zhang,Na Lü,Zehui Xuan,Lili Lu
D-tagatose is an attractive functional sweetener, and its production via enzymatic synthesis is simple and environmentally friendly; however, it faces challenges related to enzyme and substrate costs. In this study, a novel and cost-effective method for synthesizing D-tagatose was established using L-arabinose isomerase (L-AI) immobilized within a sodium alginate (SA) composite hydrogel, with the low-cost guar gum as the starting material. Eight inorganic or organic materials were individually combined with SA to encapsulate L-AI. The immobilized enzyme prepared with SA and 50-nm SiO 2 particles demonstrated superior properties, including enhanced mechanical strength and improved reusability, compared to enzymes immobilized with other carriers. The structure of the immobilized enzyme was characterized by scanning electron microscopy, Fourier-transform infrared spectroscopy, and X-ray diffraction. The D-tagatose synthesis reaction using the immobilized enzyme was optimized through both single-factor and statistical methods. The maximum yield of D-tagatose reached 30.12% from 1 M D-galactose at 68°C, with a productivity of 6.78 g/L/h. The immobilized enzyme was reusable for 20 cycles of reaction at 60°C, retaining over 55% of its initial activity and accumulating a high amount of 863.74 g/L D-tagatose. Furthermore, it efficiently converted guar gum hydrolysate into D-tagatose, retaining over 50% enzyme activity and yielding 114.32 g/L of D-tagatose after 10 cycles. The excellent enzyme reusability and the exploration of an economic substrate would significantly reduce production costs in large-scale D-tagatose synthesis in the future.
研究领域:
生物化学
·
食品科学
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产品关联
DOI
高影响因子
Journal of Nanomaterials
·
2022
·
IF 3.791
Wenke Xiao,Xiaojuan Zhang,Lingyun Hao,Yuan Zhao,Qing Lin,Zhao Wang,Wenli Song,Dong Liang
It is essential to design multifunctional contact lenses for selective recognition and utilization of the eye drop ofloxacin (OFL). Modified silicone hydrogel (MSL) contact lenses were firstly synthesized via ultraviolet curing by using (hydroxymethyl)methyl aminomethane, polydimethylsiloxane, methacryloxypropyl terminated polydimethylsiloxane, and N,N-dimethylacrylamide as monomers and N-vinyl-2-pyrrolidinone (NVP) as a modifier. The synthesized MSL contact lenses were characterized via Fourier transform infrared spectroscopy, scanning electron microscopy, and contact angle and mechanical property tests. The results showed that compared with silicone hydrogel (SL) contact lenses, the MSL contact lenses had a more porous structure and good swelling and mechanical properties. The molecularly imprinted polymer/ofloxacin-modified silicone hydrogel (MIP/OFL-MSL) contact lenses were firstly synthesized via free radical polymerization, using ofloxacin (OFL) as the template molecule. Moreover, compared with chlorogenic acid and myricetin molecule, the MIP/OFL-MSL contact lenses exhibited an adsorption capacity for OFL that reached 2.86 mg/g. The antibacterial test showed that the MIP/OFL-MSL contact lenses displayed an inhibition ring size of 15.2 mm and 17.8 mm for Staphylococcus aureus and Escherichia coli, respectively.
研究领域:
材料科学
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药学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2024
·
IF 4
Xueze Zhang,Yu Xiao,Shuqi Guo,Huifang Wang,Xianghua Gao,Baolong Niu,Wenfeng Li
This study designed a pH-sensitive carrier regulated by zinc oxide nanoparticles for the delivery of the hydrophobic drug curcumin (Cur). Carboxymethyl cellulose (CMC) was used as a stabilizer and dispersant to synthesize CMC-ZnO nanoparticles via an in situ reaction. These nanoparticles were then mixed with sodium alginate (SA) and immersed in a tetraethyl silicate (TEOS) hydrolysis solution to form sodium alginate/silica-zinc oxide (Ss/CMC-ZnO) composite hydrogel beads. XRD, FTIR, SEM, and UV-vis analyses confirmed the successful synthesis and incorporation of ZnO nanoparticles into the hydrogel beads. Swelling experiments demonstrated that as the concentration of CMC-ZnO increased, when the TEOS molar concentration was 0.205 M, the maximum swelling ratio decreased from 39.83 to 14.03, with the time to reach the maximum swelling ratio extending from 4 to 6 hours. At a TEOS concentration of 0.375 M, the swelling ratio decreased from 26.77 to 12.10, with the swelling time extending from 6 to 7 hours. Hemolysis and cytotoxicity tests confirmed the hydrogel beads' good biocompatibility. Cur was incorporated using a blending method, and in vitro release experiments revealed that the Ss/CMC-ZnO hydrogel beads exhibited excellent pH sensitivity. The addition of CMC-ZnO NPs effectively prolonged the release time of curcumin, indicating potential for applications in controlled drug delivery.
研究领域:
材料科学
·
药学
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纳米技术
·
药物递送系统
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）