SENSORS AND ACTUATORS B-CHEMICAL
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2018
·
IF 5.667
Hongli Zheng,Huan Yi,Hong Dai,Dandan Fang,Zhensheng Hong,Danmei Lin,Xiangqin Zheng,Yanyu Lin
Herein, an effective integrated electrochemiluminescence (ECL) bioprobe was constructed based on F-couSiPc as co-reaction accelerator of tris (2,2′-bipyridine-n,n’)-, dichloride, hexahydrate (II) (Ru(bpy) 3 2+ ) and TiO 2 MOFs as carrier for developing a competitive-type ECL strategy for the sensing of deoxynivalenol (DON). Initially, TiO 2 MOFs with high specific surface area and regular pore structure was employed to immobilize Ru(bpy) 3 2+ and Mercapto-beta-cyclodextrin (β-CD), then sensitizer of F-couSiPc was introduced into the system by encapsulating into the cup-shaped cavity of β-CD, which mainly ascribed to the supermolecular self-assembly behavior, perfectly avoiding the aggregation of F-couSiPc. Due to the shortened electronic transmission distance, reduced energy loss and less reagent consumption, the integrated ECL reaction pattern between the luminescent Ru(bpy) 3 2+ and sensitizer of F-couSiPc has shown improved luminous efficiency compared with the common intermolecular ECL reactions. Meanwhile, the (3-Aminopropyl) triethoxysilane (APTES), perylene-3,4,9,10-tetracarboxylic acid (PTCA) and carbon nanohorn (CNHs) nanohybrid (APTES-PTCA@CNHs), combing the remarkable advantages of CNHs with the desirable electronic and optical properties of PTCA, served as matrix to immobilize antigen (DON) with an increasing amount, and on account of the high affinity between the APTES and DON, a stable ECL performance was obtained. Based on the competitive immunoreactions, a facile and sensitive ECL immunosensor was constructed for the detection of DON, with excellent linear range from 0.1 pg/mL to 20 ng/mL and a detection limit of 0.03 pg/mL (S/N = 3).
研究领域:
分析化学
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食品科学
·
生物传感技术
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Dandan Fang,Xiangqin Zheng,Huan Yi,Hong Dai,Zhensheng Hong,Yiru Peng,Yanyu Lin
A highly sensitive electrochemiluminescence (ECL) immunosensor was fabricated for the quantitative analysis of deoxynivalenol (DON) based on an effective all-in-one bioprobe that composed of TiO 2 -B with Fluoro-coumarin silicon phthalocyanine (F-couSiPc) and luminol. Herein, TiO 2 -B with large specific area was served as a favorable carrier, greatly increased the loading of enhancer F-couSiPc and luminophore luminol, resulting in the tremendous enhancement of ECL signal. Specifically, F-couSiPc as coreaction accelerator could facilitate the decomposition of dissolved O 2 to generate substantial reactive oxygen species (ROS) to participate in the ECL reaction of luminol. Additionally, the prepared PEDOT/HA@mp MnO 2 was employed as the sensing platform of biosensor, which can not only capture substantial antibody to improve the sensitivity, but also could expedite the electronic transmission rate to make the ECL intensity further amplified. Ultimately, the proposed immunosensor presented favorable performance for the determination of DON, such as high sensitivity, good stability, wide liner range (from 1.0*10 −6 ng/mL to 10 ng/mL) and a low detection limit of 3.3*10 -7 ng/mL.
研究领域:
分析化学
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食品安全检测
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
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IF 8.2
Wanyu Tian,Lele Qiu,Shuhui Zhou,Jian Xiao,Jing Liang,Fangjing Liu,Yunpeng Zhao
Passivation treatment for perovskite films has constituted an indispensable process in fabricating high-performance perovskite solar cells (PSCs), yet the degradation or dynamic evolution of passivation layers under external stimuli persists as a critical bottleneck impeding commercialization. Here, we develop a silicon phthalocyanine-engineered ammonium cation (SiPc(4HTy)2) that enables perovskite films to resist degradation under thermal stress and meanwhile reinforces the related heterointerfaces in PSCs. The surface passivation strategy based on SiPc(4HTy)2 efficiently reduces surface defects of perovskite films, optimizes energy level alignment, and suppresses ion diffusion, without relying on the formation of two-dimensional perovskite passivation layers. The superior passivation efficacy originates from the solution-processable bulky cation engineering achieved by axially coordinating three-dimensional silicon phthalocyanine. Under the passivation treatment of SiPc(4HTy)2, the power conversion efficiency of PSCs reaches a maximum of 23.55%, mainly due to the improvement of the open-circuit voltage and fill factor. Furthermore, benefiting from the maintenance of the morphology and optoelectronic properties of perovskite films, the related devices still maintain more than 80% of their initial performance after over 1000 h at 85 °C in an inert atmosphere.
研究领域:
材料科学
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光伏技术
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纳米技术
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化学工程
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固态物理
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产品关联
DOI
PubMed
高影响因子
Pharmaceutics
·
2024
·Vol. 16
·期 9
·1166
·
IF 4.9
Kadireya Aikelamu,Jingya Bai,Qian Zhang,Jiamin Huang,Mei Wang,Chunhong Zhong
The combination of photodynamic therapy (PDT) and pneumatotherapy is emerging as one of the most effective strategies for increasing cancer treatment efficacy while minimizing side effects. Photodynamic forces affect nitric oxide (NO) levels as activated photosensitizers produce NO, and NO levels in the tumor and microenvironment directly impact tumor cell responsiveness to PDT. In this paper, 3-benzenesulfonyl-4-(1-hydroxy ether)-1,2,5-oxadiazole-2-oxide NO donor–silicon phthalocyanine coupling (SiPc–NO) was designed and prepared into self-assembled nanoparticles (SiPc–NO@NPs) by precipitation method. By further introducing arginyl-glycyl-aspartic acid (RGD) on the surface of nanoparticles, NO-photosensitizer delivery systems (SiPc–NO@RGD NPs) with photo-responsive and tumor-targeting properties were finally prepared and preliminarily evaluated in terms of their formulation properties, NO release, and photosensitizing effects. Furthermore, high reactive oxygen species (ROS) generation efficiency and high PDT efficiency in two breast cancer cell lines (human MCF-7 and mouse 4T1) under irradiation were also demonstrated. The novel SiPc–NO@RGD NPs show great potential for application in NO delivery and two-photon bioimaging-guided photodynamic tumor therapy.
研究领域:
癌症治疗
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纳米技术
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药学
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生物医学工程
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光化学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2021
·
IF 9.229
Wenxiong Cao,Yuan Liu,Pan Ran,Jie He,Shuang Xie,Jie Weng,Xiaohong Li
Antithrombosis therapy is confronted with short half-lives of thrombolytic agents, limited therapeutic effects, and bleeding complications. Drug delivery systems of thrombolytic agents face challenges in effective penetration into thrombi, which are characterized by well-organized fibrin filled with abundant activated platelets. Herein, Janus rod (JR)-shaped micromotors are constructed by side-by-side electrospinning and cryosection, possessing advantages in controlling the Janus structure and aspect ratio of microrods. Silicon phthalocyanine (Pc) and CaO2 nanoparticles (NPs) are loaded into the separate sides of JRs, and Arg-Gly-Asp (RGD) peptides are grafted on the surface to obtain Pc/Ca@r-JRs for the sonodynamic therapy (SDT) of thrombosis without using any thrombolytic agents. Decomposition of CaO2 NPs ejects O2 bubbles from one side of JRs, and ultrasonication of O2 bubbles produces the cavitation effect, both generating mechanical force to drive the thrombus penetration. The integration of ultrasonication-propelled motion and RGD mediation effectively increases the targeting capabilities of r-JRs to activated platelets. In addition to mechanical thrombolysis, ultrasonication of the released Pc produces 1O2 to destruct fibrin networks of clots. In vitro thrombolysis of whole blood clots shows that ultrasonication of Pc/Ca@r-JRs has a significantly higher thrombolysis rate (73.6%) than those without propelled motion or RGD-mediated clot targeting. In a lower limb thrombosis model, intravenous administration of Pc/Ca@r-JRs indicates 3.4-fold higher accumulations at the clot site than those of JRs, and ultrasonication-propelled motion further increases thrombus retention 2.1 times. Treatment with Pc/Ca@r-JRs and ultrasonication fully removes thrombi and significantly prolongs tail bleeding time. Thus, this study has achieved precise and prompt thrombolysis through selective targeting to clots, efficient penetration into dense networks of thrombi, and SDT-executed thrombolysis.
研究领域:
生物医学工程
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治疗学
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纳米技术
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药学
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产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
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2025
·
IF 9.6
Ailin Wu,Gaoqiang Ma,Yanhua Chen,Houda Gui,Baiyu Sun,Bing Zhang,Yingxue Liu,Sen Zhang,Guixue Lian,Dawei Song,Dongjiao Zhang
Bone defects caused by fractures and diseases often do not heal spontaneously. They require external agents for repair and regeneration. Bone tissue engineering is emerging as a promising alternative to traditional therapies like autografts and allografts. Nanobiomaterials enhance osteoblast resistance to harsh environments by promoting cell differentiation. Black phosphorus (BP), a novel 2D material in biomedicine, displays unique osteogenic and antimicrobial properties. However, BP nanosheets still face clinical limitations like rapid degradation and high-dose cytotoxicity. To address these, the introduction of amino-silicon phthalocyanine (SiPc-NH 2 ) is investigated to see if it can enhance BP dispersion, reduce BP oxidation, and improve stability and safety for better osteogenesis and antibacterial effects through noncovalent interactions (van der Waals, π–π stacking and electrostatic interactions). Here, the self-healing hydrogel is successfully designed using a step-by-step co-assembly of BP and SiPc-NH 2. SiPc-NH 2 as a “structural stabilizer” of BP nanosheets reconstructed well-dispersed BP-SiPc-NH 2 nanosheets, which improves the biocompatibility of BP, reduces oxidation and enhances photothermal conversion, guaranteeing osteogenic and antimicrobial properties. Furthermore, findings show BP-SiPc-NH 2 -induced mitochondrial changes support osteogenesis by regulating the crosstalk between Hippo and Wnt signaling pathways-mediated mitochondrial homeostasis, and boosting cellular bioenergetics. Overall, this mitochondrial morphology-based BP-SiPc-NH 2 strategy holds great promise for bone repair applications.
研究领域:
组织工程
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纳米生物材料
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再生医学
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生物医学工程
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细胞生物学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Innovative Optical Health Sciences
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2022
·
IF 2.396
Yiming Zhou,Wenlong Zeng,Mengxuan Wang,Rui Li,Xiuli Yue,Zhifei Dai
Targeted photodynamic therapy (TPDT) based on the photosensitizers responsive for tumor microenvironment is promising because of the better anti-tumor effect and less phototoxicity against normal tissue than the traditional PDT. Nanoparticle-based stimuli-responsive photosensitizers have been widely explored for TPDT. Based on the acidic microenvironments in solid tumors, an ultrasmall pH-responsive silicon phthalocyanine nanomicelle (PSN) (smaller than 10 nm) was designed for selective PDT of tumor. PSN had high drug loading efficacy (more than 28%) and exhibited morphological transitions, enhanced fluorescence and improved singlet oxygen yield under acidic environments. PSN was renal clearable and could rapidly accumulate and be retained at tumor sites, achieving a tumor-inhibiting effect better than phthalocyanine micelle without pH response. Tumors of mice treated with PSN for PDT were completely ablated without recurrence. Thus, we have developed a phthalocyanine-based pH-responsive micelle with excellent tumor targeting ability, which is expected to realize the selective PDT of tumor.
研究领域:
癌症研究
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纳米技术
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诊疗学
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药学
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生物医学工程
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产品关联
DOI
高影响因子
Small
·
2022
·Vol. 18
·期 21
·2200813
·
IF 15.153
Zhanlin Zhang,Hui Yan,Bo Qiu,Pan Ran,Wenxiong Cao,Xinwei Jia,Kun Huang,Xiaohong Li
External light irradiation is usually required in bacterial infection theranostics; however, it is always accompanied by limited light penetration, imaging interference, and incomplete bacterial destruction. Herein, a feasible “image-launching therapy” strategy is developed to integrate real-time optical imaging and simultaneous photodynamic therapy (PDT) of bacterial infections into persistent luminescence (PL) nanoparticles (NPs). Mesoporous silica NPs are used as a substrate for in situ deposition of PL nanodots of ZnGa 2 O 4 :Cr 3+ to obtain mPL NPs, followed by surface grafting with silicon phthalocyanine (Si-Pc) and electrostatic assembly of cyanine 7 (Cy7) to fabricate mPL@Pc-Cy NPs. The PL emission of light-activated mPL@Pc-Cy NPs is quenched by Cy7 assembly at physiological conditions through the fluorescence resonance energy transfer effect, but is rapidly restored after disassembly of Cy7 in response to bacterial infections. The self-illuminating capabilities of NPs avoid tissue autofluorescence under external light irradiation and achieve real-time colorimetric imaging of bacterial infections. In addition, the afterglow of mPL NPs can persistently excite Si-Pc photosensitizers to promote PDT efficacy for bacterial elimination and accelerate wound full recovery with normal histologic features. Thus, this study expands the theranostic strategy for precise imaging and simultaneous non-antibiotic treatment of bacterial infections without causing side effects to normal tissues.
研究领域:
纳米技术
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生物医学工程
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药学
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传染病学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2021
·
IF 9.229
Rui Zou,Yifan Gao,Yong Zhang,Ju Jiao,Ka-Leung Wong,Jing Wang
Featured with a zero-autofluorescence background, superior signal-to-noise ratio, high sensitivity, and deep penetration ability, near-infrared persistent luminescence nanoparticle (NIR-PLNP)-based multimodal nanoprobes show great potential for full-scale noninvasive cancer diagnosis. However, direct synthesis of NIR-PLNP-based multimodal nanoprobes with high drug loading capacity to meet growing cancer theranostic demands remains a challenge. In this work, multifunctional hybrid mesoporous nanoparticles (HMNPs) that integrate NIR-PLNPs (Ga2O3:Cr3+, Nd3+), magnetic nanoparticles (Gd2O3), and radionuclides (68Ga) are designed and constructed via a large-pore (mesoporous silica nanoparticle) MSN-templated strategy. The ingenious composition design endows HMNPs with rechargeable NIR-PL, superior longitudinal relaxivity, and excellent radioactivity, making these versatile nanoparticles available for long-term in vivo NIR-PL imaging, magnetic resonance imaging (MRI), and positron emission tomography (PET) imaging. More importantly, the application of large-pore MSN templates maintains the mesoporous structure of HMNPs, promising excellent drug loading capacity of these nanoparticles. As a proof-of-concept, HMNPs loaded with a high dose of DOX (chemotherapy agent) and Si-Pc (photosensitizer) are rationally designed for chemotherapy and NIR-PL-sensitized photodynamic therapy (PDT), respectively. Studies with mice tumor models demonstrate that the DOX/Si-Pc-loaded HMNPs possess excellent cancer cell killing ability and an outstanding tumor suppression effect without systemic toxicity. This work shows the great potential of HMNPs as an “all-in-one” nanotheranostic tool for multimodal NIR-PL/MR/PET imaging-guided chemotherapy and NIR-PL-sensitized photodynamic cancer therapy and provides an innovative paradigm for the development of NIR-PLNP-based nanoplatforms in cancer theranostic.
研究领域:
癌症诊疗学
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材料科学
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纳米医学
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医学成像
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放射学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）