ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2024
·
IF 0
Zheng Yang,Zhang Lin,Wang Xiaocong,Guo Fenghui,Xing Yi,Li Guoliang,Yue Tao
The substantial amount of mercury emissions from coal-fired flue gas causes severe environmental contamination. With the Minamata Convention now officially in force, it is critical to strengthen mercury pollution control. Existing activated carbon injection technologies suffer from poor desulfurization performance and risk secondary-release risks. Therefore, considering the potential industrial application of adsorbents, we selected cost-effective and readily available activated coke (AC) as the carrier in this study. Four metal selenides—copper, iron, manganese, and tin—were loaded onto the AC to overcome the application problems of existing technologies. After 120 min of adsorption, the CuSe/AC exhibited the highest efficiency in removing Hg 0 , surpassing 80% according to the experimental findings. In addition, the optimal adsorption temperature window was 30–120 °C, the maximum adsorption rate was 2.9 × 10 −2 mg·g −1 ·h −1 , and the effectiveness of CuSe/AC in capturing Hg 0 only dropped by 5.2% in the sulfur-containing atmosphere. The physicochemical characterization results indicated that the AC surface had a uniform loading of CuSe with a nanosheet structure resembling polygon and that the Cu-to-Se atomic ratio was close to 1:1. Finally, two possible Hg 0 reaction pathways on CuSe/AC were proposed. Moreover, it was elucidated that the highly selective binding of Hg 0 with ligand-unsaturated Se − was the key factor in achieving high adsorption efficiency and sulfur resistance in the selenium-functionalized AC adsorbent. This finding offers substantial theoretical support for the industrial application of this adsorbent. Graphical Abstract
研究领域:
环境科学
·
材料科学
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产品关联
DOI
PubMed
PROCESS BIOCHEMISTRY
·
2022
·
IF 4.885
Yaling He,Hui Chen,Ziyang Ye,Xinmiao Zhang,Hongling Ye,Ming Ye
To prepare zinc and selenium modified polysaccharides derivatives (ZnLEP-1a and SeLEP-1a), a novel polysaccharide (LEP-1a) isolated from Lachnum YM38 was chosen. Following that, the structural characterization and in vitro bioactivities of LEP-1, ZnLEP-1a and SeLEP-1a were investigated. Results revealed that LEP-1a had a molecular weight of 5.69 × 10 4 Da and was composed of mannose , galactose and glucose. The linkage types of LEP-1a were proved to be (1→)-α- D -Manp, (1→3)-α- D -Manp, (1→2)-α- D -Galp, (1→2)-α- D -Glcp, (1→2,6)-α- D -Manp. Zinc content of ZnLEP-1a was 0.69 mg/g, while selenium content of SeLEP-1a was 206.99 µg/g. Compared with LEP-1a, ZnLEP-1a and SeLEP-1a had a lower molecular weight, same monosaccharides in different molar ratios. The results of FT-IR, DSC , NMR, SEM and AFM suggested that there were obvious changes in structural characteristics after LEP-1a was modified with zinc and selenium. ZnLEP-1a and SeLEP-1a had stronger antioxidant, hypoglycemic, antitumor activities in vitro in comparison with LEP-1a. As a result, ZnLEP-1a and SeLEP-1a showed great potential to develop into a natural antioxidant, hypoglycemic and low-toxic antitumor drug.
研究领域:
生物化学
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药理学
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产品关联
DOI
高影响因子
Nanophotonics
·
2023
·
IF 7.5
Xiao Chen,Xiaopeng Ma,Gui Yang,Guan Huang,Haibing Dai,Nian Liu,Jianbo Yu
The unique optical properties of squaraine dyes make them promising for cancer phototheranostics, but the reported squaraines for in vivo treatments mainly rely on their photothermal effect, where monotherapy cannot achieve the desired therapeutic effect. Here we generated a type of squaraine capable of killing tumors through both photothermal and photodynamic effects. We optimized squaraine structure with selenium modulation and formulated it into nanoparticles that showed strong absorption of infrared light, negligible fluorescence, good photothermal conversion (66.6 %), and strong photodynamic effects even after several irradiation cycles. In addition, the nanoparticles could be tracked through their strong optoacoustic signal. In mice, the nanoparticles effectively accumulated in tumors and eliminated them upon irradiation, without causing adverse effects. Our work demonstrates the potential of selenium modulation of squaraine for precise cancer diagnosis and treatment through synergistic photothermal and photodynamic effects.
研究领域:
生物医学工程
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肿瘤学
·
纳米医学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Guanghui Jiang,Haoyue Kong,Yuwen Wang,Yufei Wang,Junjie Zhou,Zhezhi Wang,Junfeng Niu
Liver fibrosis is a significant precursor to cirrhosis and liver cancer, yet effective treatments remain elusive. Our previous studies demonstrated that Bletilla striata polysaccharide (BSP) has therapeutic effects, though it performed poorly at medium concentrations. To address this limitation, BSP underwent selenization modification. In this study, selenized BSP (Se-BSP) was structurally characterized, and its in vivo activity in alleviating liver fibrosis was evaluated. The results showed that the molecular weight of Se-BSP increased, its in vitro antioxidant activity improved, and it exhibited enhanced efficacy in alleviating liver fibrosis at medium concentrations (150 mg/kg) compared to BSP. These findings provide a theoretical basis for the potential application of Se-BSP as an anti-liver fibrosis agent.
研究领域:
药理学
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生物化学
·
肝脏疾病研究
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Ju Liu,Danna Yan,Qianying Chen,Huayong Peng,Lu Jin,Chong Feng,Lixia Zhang,Guomin Zhao,Depo Yang,Zhimin Zhao
In this study, a homogeneous polysaccharide, named YDOP-1 was isolated form Dendrobium officinale using hot water extraction and ethanol precipitation method. YDOP-1 was characterized to be a typical O -acetyl-glucomannan with the molecular wight was 13,456 Da. Cell viability and colony forming assay showed that YDOP-1 possess moderate anti-gastric cancer effects. In order to further improve the anti-gastric cancer effects of YDOP-1, a selenium modification on YDOP-1 was performed. Energy dispersive spectrometer (EDS) and X-ray photoelectron spectroscopy (XPS) analysis demonstrated that the Se was successfully introduced into YDOP-1 by forming Se O bonds. Se modification significantly enhanced the anti-gastric cancer effects of YDOP-1, which could effectively inhibit the proliferation of MGC-803 cells via suppressing colony and inducing apoptosis by regulating the apoptosis proteins of Bax, Bcl-2, and Caspase-7. Our results indicated that the Se modified O -acetyl-glucomannan, YDOP-Se, was expected to be useful in the biomedicine field for the gastric cancer treatment.
研究领域:
药用植物学
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肿瘤生物学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CATALYSIS
·
2024
·
IF 6.5
Ting-Ting Mao,Zhen Wei,Jun Cai,Yan-Xia Chen,Juan M. Feliu,Enrique Herrero
Se-modified platinum single-crystal surfaces in the [ 01 1 ¯ ] zone have been used as model electrocatalysts for the oxygen reduction reaction (ORR). The results show that: (1) the Pt(hkl)-[n(111)×(100)] electrodes display enhanced ORR electrocatalytic activity with Se modification. (2) Se adatoms have a double effect on the ORR kinetics at model Pt electrodes: they enhance the activity on the neighboring sites and inhibit the reaction on the sites in direct contact with the Se adatoms. (3) The hydrophobicity and the altered electronic properties are probably the reasons for the enhanced electrocatalysis for ORR with Se modification. The positive shift of the potential of zero free charge of Pt(hkl)@Se electrodes compared to that of un-modified Pt(hkl) are in agreement with these interpretations. (4) At very low coverages, the promotion effect of Se modification on ORR activity at (100) sites is stronger than that at (111) sites, which is probably due to the more pronounced hydrophobicity of the former.
研究领域:
电化学
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材料科学
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产品关联
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2025
·
IF 4.8
Xutao Wen,Qin Zhou,Sihan Lin,Huaming Mai,Ling Zhang
Introduction Head and neck squamous cell carcinoma (HNSCC) frequently invades the jaw, and surgical treatment often leads to bone defects requiring reconstruction with titanium plates. To enhance the anti-tumor and bone regeneration properties of titanium, a selenium-modified hydroxyapatite coating was developed on titanium surfaces. Methods Selenium-modified hydroxyapatite coatings was fabricated using micro-arc oxidation (MAO). The coating properties were characterized by SEM, XPS, AFM, Contacting angle test and ICP-OES. Cell proliferation assays were performed using rBMSCs and Cal27 cells. The osteogenic potential of the materials was assessed via ALP and OCN immunofluorescence staining and quantitative polymerase chain reaction (qPCR). Apoptosis in Cal27 cells was analyzed through flow cytometry, and ROS levels in rBMSCs and Cal27 cells were measured using ROS fluorescent probes. Results A coating was successfully formed on the surface of titanium with a porous structure via MAO. The atomic percentages of calcium, phosphorus and selenium on the coating surface were 42.47%, 45.43% and 12.3%, respectively, and the ion components could be released steadily and slowly. In vitro , 0.2 µg/mL selenium had toxic effects on Cal27 and promoted osteogenic differentiation of rBMSCs. PCR showed that selenium increased the expression of genes related to osteogenic differentiation of rBMSCs by 3–5 times. ROS detection found differences in intracellular ROS content between Cal27 and rBMSCs. Discussion By incorporating selenium-modified coatings, titanium implant materials can simultaneously promote osteogenesis and inhibit tumor growth, offering a promising strategy for postoperative functional recovery in HNSCC patients.
研究领域:
生物材料学
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肿瘤学
·
再生医学
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产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2017
·
IF 3.833
Yongmin Zhang,Shuang Guo,Xiaofei Ren,Xuefeng Liu,Yun Fang
Herein, we described for the first time a CO2 and redox dual responsive paraffin oil-in-water Pickering emulsion stabilized by the modified silica nanoparticles with Se-containing tertiary amine, SeTA, in which the tertiary amine serves as a CO2-sensitive group, and the Se atom serves as a redox-sensitive center. The Pickering emulsion can be reversibly switched between stable and unstable states by bubbling CO2 and N2 in the reduced state, or with the addition of H2O2 and Na2SO3 in the absence of CO2, because of the adsorption and desorption of SeTA on the silica surface. The former is mainly attributed to a CO2-controllable electrostatic attraction, resulting from the transition of molecules between cationic and nonionic states; whereas, the latter is ascribed to a redox-tunable hydrogen bonding, originating from the transition of molecules between selenide and selenoxide. However, in the presence of CO2, redox can only induce a change in the droplet size, not demulsification. These interesting and unique multiresponsive behaviors endow the Pickering emulsion with a capacity for intelligent control of emulsification and demulsification, as well as the droplet size, which may be an asset for a myriad of technological applications in biomedicine, microfluidics, drug delivery, and cosmetics.
研究领域:
材料科学
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化学工程
·
生物医药
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-11
·
IF 10.2
Yang Lele,Gao Yijian,Wei Jinchao,Cheng Zehua,Wu Sijia,Zou Liang,Li Shengliang,Li Peng
Second near-infrared (NIR-II) fluorescence imaging in the range of 1000–1700 nm has great prospects for in vivo imaging and theranostics monitoring. At present, few NIR-II probes with theranostics properties have been developed, especially the high-performance organic theranostics material remains underexploited. Herein, we demonstrate a selenium (Se)-tailoring method to develop high-efficient NIR-II imaging-guided material for in vivo cancer phototheranostics. Via Se-tailoring strategy, conjugated oligomer TPSe-based nanoparticles (TPSe NPs) achieve bright NIR-II emission up to 1400 nm and exhibit a relatively high photothermal conversion efficiency of 60% with good stability. Moreover, the TPSe NPs demonstrate their photothermal ablation of cancer cells in vitro and tumor in vivo with the guidance of NIR-II imaging. It is worth noting that the TPSe NPs have good biocompatibility without obvious side effects. Thus, this work provides new insight into the development of NIR-II theranostics agents.
研究领域:
生物医学工程
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材料科学
·
癌症研究
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL IMMUNOPHARMACOLOGY
·
2022
·
IF 5.714
Shaomin Liu,Qiufang Chen,Liang Yan,Yuehong Ren,Jun Fan,Xingwang Zhang,Shiping Zhu
Inflammation mediates a variety of physiological and pathological events, prompting an importance of inflammation management for prevention and treatment of inflammatory diseases. This study formulated tripterine (Tri) into selenized phytosomes in an attempt to attenuate its cytotoxicity and potentiate its inflammation-regulating effect with selenium. Tri-loaded phytosomes (Tri-PTs) with selenium modification were prepared by a melting-hydration followed by in situ reduction technique. Then, selenized Tri-PTs ( [email protected] ) were characterized by particle size, entrapment efficiency, and transmission electron microscope. The in vitro drug release and cellular uptake were performed to examine the formulation performance of [email protected] The cytotoxicity and anti-inflammatory efficacy through inhibiting NLRP3 inflammasome activation and pyroptosis were appreciated in murine J774A.1 macrophage cell line, respectively. The resultant [email protected] presented a particle size of 125 nm around. [email protected] exhibited attenuated cytotoxicity and improved cellular uptake in macrophages compared with free Tri or Tri-PTs. Also, [email protected] inhibited the releases of caspase-1p20 and mature IL-1β, resulting in restriction of NLRP3 inflammasome activation that inhibits the formation of GSDMD-NT whereby to initiate pyroptosis. Altogether, our findings suggest that [email protected] can inhibit inflammatory response by regulating the NLRP3/caspase-1 pathway, which in turn reduces pyroptosis via suppressing the cleavage of GSDMD.
研究领域:
药剂学
·
免疫学
·
炎症研究
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）