Journal of Materials Chemistry A
·
2014
·Vol. 3
·期 4
·1696-1702
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IF 0
Zhonghui Han,Gang Chen,Chunmei Li,Yaoguang Yu,Yansong Zhou
The one-dimensional (1D) cubic Cd0.8Zn0.2S solid-solution nanowires are first prepared by the “levelling effect” of thioglycolic acid (TGA) in a solvothermal process. It exhibits the enhanced transfer and separation efficiency of carriers to improve the photocatalytic H2-production activity. TGA not only serves as the sulphur source but also plays a template medium agent role. Furthermore, no TGA selectivity for diverse solvents to prepare 1D Cd0.8Zn0.2S solid solutions suggests that it also may be extended to the preparation of other 1D metal sulphide solid solutions in diverse solvents.
研究领域:
材料科学
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化学工程
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DOI
ANALYST
·
2021
·Vol. 146
·期 16
·5198-5203
·
IF 4.616
Shimeles Addisu Kitte,Fuad Abduro Bushira,Haijuan Li,Yongdong Jin
Thioacetamide (TAA) is a well-known hepatotoxic substance, so it is important to determine its presence and content in food and environmental samples. Herein, we report a highly sensitive determination method for TAA based on the electrochemiluminescence (ECL) of tris(2,2′-bipyridyl)ruthenium(II) (Ru(bpy)32+) for the first time by using TAA as a new coreactant for Ru(bpy)32+ ECL via an anodic route. The developed Ru(bpy)32+–TAA ECL system allows the determination of TAA with a good dynamic linear range and low limit of detection (LOD) of 0.1 μM to 1000 μM and 0.035 μM (3σ/m), respectively. In addition, the established ECL system can be applied to detect TAA in fruit juice and waste water samples with outstanding recoveries.
研究领域:
分析化学
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环境科学
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毒理学
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DOI
高影响因子
Metabolomics
·
2014
·Vol. 11
·期 3
·559-570
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IF 3.965
Wei Dan-Dan,Wang Jun-Song,Li Ming-Hui,Guo Ping-Ping,Dong Ge,Yang Ming-Hua,Kong Ling-Yi
Hepatic encephalopathy (HE) is a severe neuropsychiatric complication due to acute or chronic liver failure. In this work, an acute thioacetamide induced HE mice model was established to investigate the metabolic events in the onset of HE (OHE) and the protective role of taurine (TAU). Sera for biochemical evaluation, and livers and cortexes for histopathological inspection and NMR-based metabolomic investigation were collected. Principal component analysis and orthogonal partial least squares-discriminant analysis were performed to excavate differential metabolites of OHE, and explore the protective role of TAU. Metabolites pathway analysis was performed on significant metabolites selected based on loading/S-plots and fold change plots to identify biologically meaningful metabolic patterns and relevant pathways. The most affected pathways in OHE mice were those along the liver–brain axis: among them, the alanine, aspartate and glutamate metabolism was the most important. TAU showed better performance in improving the disturbed metabolism in the cortex than in the liver of OHE mice. This pilot study based on metabolomics approach and pathway analysis should help to understand HE systematically, and to develop new therapy for HE.
研究领域:
医学
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生物学
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DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2022
·
IF 6.633
Longjie Huang,Xiaofang Li,Runlin Han,Yajun Li,Lingfeng Xu,Zhaoyun Zeng,Kui Wu
The solubility of thioacetamide in fifteen pure solvents (methanol, ethanol, n -propanol, isopropanol, n -butanol, isobutanol, n -pentanol, isopentanol, ethyl acetate, 2-butanone, 2-pentanone, acetone, acetonitrile, ethyl formate and methyl acetate) was determined by a gravimetric method from 272.85 K to 323.95 K under ambient pressure. Four thermodynamic models, including the modified Apelblat equation, Buchowski-Ksiazaczak λh equation, non-random two-liquid (NRTL) model and the Wilson model were used to correlate the solubility data. And the NRTL model provides the best data fitting results among the four models. To elucidate the dissolution behavior of thioacetamide, the KAT-LSER model was introduced to analyze the solvent effect. The results revealed that hydrogen bond basicity and bipolarity/polarizability had a similar and significant favorable effect to the dissolution of thioacetamide. The mixing thermodynamic properties such as enthalpy, entropy and Gibbs free energy were calculated and the results indicated that the dissolution process of thioacetamide was spontaneous and favorable.
研究领域:
物理化学
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药物化学
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产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2021
·Vol. 10
·期 5
·1718-1726
·
IF 7.393
Zhenyu Hu,Longhui Deng,Tingjun Wu,Jing Wang,Feiyan Wu,Lie Chen,Qikai Li,Weishu Liu,Shui-Yang Lien,Peng Gao
The preparation of high-performance thermoelectric thin films can be challenging. Herein, we report the preparation, characterization, and thermoelectric performance of morphology-controlled bismuth sulfide (Bi2S3) thin films using a single-source precursor, namely bismuth(III) ethylxanthate. Using this precursor, room-temperature thermoelectric thin-films could be prepared quickly and cost-effectively. We acquired the intrinsic Bi2S3 thin films with electrical conductivity of 14.23 S cm−1 and Seebeck coefficient of −388.33 μV K−1 at room temperature, which are comparable to that of the bulk Bi2S3. Furthermore, a higher Seebeck coefficient could be achieved by adopting a composition engineering method to achieve an antimony (Sb)-doping solid solution, in which the phonon scattering and dislocation density could be manipulated. By tuning the mole fraction of Sb in the films, we further improved the Seebeck coefficient to −516.35 μV K−1 and the power factor to 170.10 μW m−1 K−2 with a solid solution of (Bi0.97Sb0.03)2S3. Thus, the chalcogenide composition engineering protocol can be a universal methodology to fabricate target semiconductors for thin-film thermoelectric applications, which may broaden the application of thermoelectric films in the field of microelectronic devices.
研究领域:
材料科学
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热电技术
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DOI
高影响因子
ACS Applied Materials & Interfaces
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2020
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IF 8.758
Xuping Liu,Jihuai Wu,Guodong Li,Qiyao Guo,Zeyu Song,Yuqian Yang,Xiaobing Wang,Zhang Lan,Jianming Lin
Titania (TiO2) has wide applications in the realm of perovskite solar cells (PSCs). Because high-temperature processing severely limits the application of flexible and tandem devices, it is significant to develop a high-quality electron-transport layer (ETL) by low-temperature processing. Here, we design a new strategy by introducing a bifunctional molecule (thioacetamide, TAA) in the TiO2 ETL. During the low-temperature annealing, the N and S atoms in TAA can bond with the Ti atom in the ETL and the Pb atom in the perovskite (PVK) layer, respectively. The formation of coordinate bonds is beneficial to increase the crystallinity and reduce the roughness of TiO2 ETLs and PVK layers, which effectively passivate the defects. Meanwhile, the energy level matching between the ETL and PVK is optimized. The structure characterization and electrochemical measurement demonstrate the design. Compared with precursor doping, surface spin-coating is a more effective method for introducing TAA into TiO2. Significantly, the PSC based on the surface spin-coated TAA TiO2 ETL achieves the best power conversion efficiency (PCE) of 21.17%. Nevertheless, the PSC fabricated with the pristine TiO2 ETL offers a PCE of 19.52% under the same conditions. The results demonstrate a novel method for optimizing the properties of PSCs.
研究领域:
材料科学
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能源技术
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光伏器件
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DOI
高影响因子
CHEMICO-BIOLOGICAL INTERACTIONS
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2022
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IF 5.168
Rongrong Zhao,Huajun Zhao,Quanjuan Guo,Yongliang Mu,Jian Zhang,Yuhang Su,Qiuju Han
Edaravone (EDA), a strong novel free radical scavenger, have been demonstrated to exert neurovascular protective effects clinically. Furthermore, EDA can suppress the lung injury, pulmonary fibrosis and skin fibrosis , while the precise effects and mechanisms of EDA on liver injury and fibrosis remain unclear. The effects of EDA on the Thioacetamide (TAA)-induced liver fibrosis were evaluated by sirius red staining, α-SMA immunohistochemistry. The percentages of immune cell subsets were analyzed by flow cytometry. Immunofluorescence assay was performed to identify the fibrotic properties of hepatic stellate cells (HSCs). Western blot and qPCR were used to detect the levels of liver fibrosis-related molecules and IL-1β. EDA displayed a hepatic protective role in TAA-induced chronic liver fibrosis via inhibiting monocyte/macrophages recruitment and IL-1β production of macrophages. Mechanically, EDA inhibited of NF-κB signal pathway and reactive oxygen species (ROS) production in macrophages. Moreover, EDA treatment indirectly suppressed the activation of HSCs by decreasing the IL-1β secretion of macrophages. Together, EDA protects against TAA-induced liver fibrosis via decreasing the IL-1β production of macrophages, thereby providing a feasible solution for clinical treatment of liver fibrosis.
研究领域:
药理学
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肝病学
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免疫学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF PROTEOME RESEARCH
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2018
·
IF 3.95
Xiao-Nan Yang,Xue-Mei Liu,Jian-He Fang,Xu Zhu,Xiu-Wei Yang,Xue-Rong Xiao,Jian-Feng Huang,Frank J. Gonzalez,Fei Li
Nutmeg is a Traditional Chinese Medicine used to treat gastrointestinal diseases. Some reports have indicated that nutmeg has hepatoprotective activity. In this study, a thioacetamide (TAA)-induced acute liver injury model in mice was used to explore the mechanism of the protective effects of nutmeg extract (NME), including its major bioactive component myrislignan. The results indicated that NME could effectively protect TAA-induced liver damage as assessed by recovery of increased serumtransaminases, decrease in hepatic oxidative stress, and lower hepatic inflammation. Metabolomics analysis further revealed that treatment with NME led to the recovery of a series of lipids including lysophosphatidylcholines that were decreased and a lowering of acylcarnitines that were increased in mouse plasma and liver after TAA exposure. Gene expression analysis demonstrated that the hepatoprotective effect of NME was achieved by modulation of the peroxisome proliferator-activated receptor alpha (PPARα) as well as the decrease in oxidative stress. NME could not protect from TAA-induced liver injury in Ppara-null mice, suggesting that its protective effect was dependent on PPARα. Myrislignan, a representative neolignan in nutmeg, showed potent protective activity against TAA-induced liver toxicity. These data demonstrate that nutmeg alleviates TAA-induced liver injury through the modulation of PPARα and that the lignan compounds in nutmeg such as myrislignan partly contributed to this action.
研究领域:
药理学
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肝病学
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中药
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分子生物学
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产品关联
DOI
PubMed
高影响因子
Journal of Cell Communication and Signaling
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2023
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IF 4.1
Zhao Ye,Wang Huiling,He Tianhua,Ma Bo,Chen Guoguang,Tzeng Chimeng
Liver fibrosis is an aberrant wound healing response to tissue injury characterized by excessive extracellular matrix deposition and loss of normal liver architecture. Hepatic stellate cells (HSCs) activation is regards to be the major process in liver fibrogenesis which is dynamic and reversible. Both Hippo signaling core factor Yap and Hedgehog (Hh) signaling promote HSCs transdifferentiation thereby regulating the repair process of liver injury. However, the molecular function of YAP and the regulation between Yap and Hh during fibrogenesis remain uncertain. In this study, the essential roles of Yap in liver fibrosis were investigated. Yap was detected to be increased in liver fibrotic tissue by the thioacetamide (TAA)-induced zebrafish embryonic and adult models. Inhibition of Yap by both embryonic morpholino interference and adult’s inhibitor treatment was proved to alleviate TAA-induced liver lesions by and histology and gene expression examination. Transcriptomic analysis and gene expression detection showed that Yap and Hh signaling pathway have a cross talking upon TAA-induced liver fibrosis. In addition, TAA induction promoted the nuclear colocalization of YAP and Hh signaling factor GLI2α. This study demonstrates that Yap and Hh play synergistic protective roles in liver fibrotic response and provides new theoretical insight concerning the mechanisms of fibrosis progression. Graphical abstract
研究领域:
分子生物学
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肝病学
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细胞信号传导
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Yu-Chen Jiang,Jia-Yi Dou,Mei-Yan Xuan,Chong Gao,Zhao-Xu Li,Li-Hua Lian,Zhen-Yu Cui,Ji-Xing Nan,Yan-Ling Wu
Hepatic fibrosis is a compensatory response to chronic liver injury and inflammation, and dietary intervention is recommended as one of the fundamental prevention strategies. Raspberry ketone (RK) is an aromatic compound first isolated from raspberry and widely used to prepare food flavors. The current study investigated the hepatoprotection and potential mechanism of RK against hepatic fibrosis. In vitro, hepatic stellate cell (HSC) activation was stimulated with TGF-β and cultured with RK, farnesoid X receptor (FXR), or peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) agonist or inhibitor, respectively. In vivo, C57BL/6 mice were injected intraperitoneally with thioacetamide (TAA) at 100/200 mg/kg from the first to the fifth week. Mice were intragastrically administrated with RK or Cur once a day from the second to the fifth week. In activated HSCs, RK inhibited extracellular matrix (ECM) accumulation, inflammation, and epithelial–mesenchymal transition (EMT) process. RK both activated FXR/PGC-1α and regulated their crosstalk, which were verified by their inhibitors and agonists. Deficiency of FXR or PGC-1α also attenuated the effect of RK on the reverse of activated HSCs. RK also decreased serum ALT/AST levels, liver histopathological change, ECM accumulation, inflammation, and EMT in mice caused by TAA. Double activation of FXR/PGC-1α might be the key targets for RK against hepatic fibrosis. Above all, these discoveries supported the potential of RK as a novel candidate for the dietary intervention of hepatic fibrosis.
研究领域:
药理学
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肝病学
·
细胞生物学
·
分子生物学
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DOI
PubMed
高影响因子
WORLD JOURNAL OF GASTROENTEROLOGY
·
2021
·
IF 5.742
Qiu-Ju Han,Yong-Liang Mu,Hua-Jun Zhao,Rong-Rong Zhao,Quan-Juan Guo,Yu-Hang Su,Jian Zhang
BACKGROUND Fasudil, as a Ras homology family member A (RhoA) kinase inhibitor, is used to improve brain microcirculation and promote nerve regeneration clinically. Increasing evidence shows that Rho-kinase inhibition could improve liver fibrosis. AIM To evaluate the anti-fibrotic effects of Fasudil in a mouse model of liver fibrosis induced by thioacetamide (TAA). METHODS C57BL/6 mice were administered TAA once every 3 d for 12 times. At 1 wk after induction with TAA, Fasudil was intraperitoneally injected once a day for 3 wk, followed by hematoxylin and eosin staining, sirius red staining, western blotting, and quantitative polymerase chain reaction (qPCR), and immune cell activation was assayed by fluorescence-activated cell sorting. Furthermore, the effects of Fasudil on hepatic stellate cells and natural killer (NK) cells were assayed in vitro . RESULTS First, we found that TAA-induced liver injury was protected, and the positive area of sirius red staining and type I collagen deposition were significantly decreased by Fasudil treatment. Furthermore, western blot and qPCR assays showed that the levels of alpha smooth muscle actin (α-SMA), matrix metalloproteinase 2 (MMP-2), MMP-9, and transforming growth factor beta 1 (TGF-β1) were inhibited by Fasudil. Moreover, flow cytometry analysis revealed that NK cells were activated by Fasudil treatment in vivo and in vitro . Furthermore, Fasudil directly promoted the apoptosis and inhibited the proliferation of hepatic stellate cells by decreasing α-SMA and TGF-β1. CONCLUSION Fasudil inhibits liver fibrosis by activating NK cells and blocking hepatic stellate cell activation, thereby providing a feasible solution for the clinical treatment of liver fibrosis.
研究领域:
药理学
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肝病学
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免疫学
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产品关联
DOI
PubMed
高影响因子
SEPARATION SCIENCE AND TECHNOLOGY
·
2022
·
IF 2.799
Yu Zhang,Yun Jia,Yaoguo Huang,Linlin Chen,Ming Wang,Yali Zhang
In this study, thioacetamide (TAA) was used as the precipitant to selectively precipitate Cu2+, Cd2+, and Pb2+ in acidic solution. The effect of temperature, time, and pH conditions on the selective precipitation of metal ions were investigated. Meanwhile, the thermodynamic process of single metal precipitation was studied by Avrami equation. By continuously and accurately controlling pH, Cu2+, Cd2+, and Pb2+ were successfully precipitated at pH 2.5, 4.0, and 6.5, respectively. Traditional inorganic sulfide precipitator Na2S was also used to compare with TAA under the same conditions, and the results showed that compared with Na2S, TAA could be better to achieve the goal of selective precipitation of Cu2+, Cd2+, and Pb2+. The metal sulfide precipitation was measured by field emission scanning electron microscopy (FE-SEM) and X-ray diffraction (XRD).
研究领域:
环境化学
·
分析化学
·
材料科学
✓ 已验证
DOI
高影响因子
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