Advanced Materials Technologies
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2025
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IF 6.2
Li Mi,Qian Yang,Qindong Pu,Yicheng Jiang,Adric Ru Khiing Hii,Zhenghong Wu,Xiaole Qi
Diabetic wounds, a common complication of diabetes, pose significant challenges in clinical management. Proactively targeting bacterial biofilms in chronic wounds can enhance anti-inflammatory efficacy, accelerate the transition from inflammation to tissue proliferation, and promote more efficient healing. In this study, a bilayer hydrogel patch (NIM@UP/CuS@BT gel) is developed for diabetic wound management. This innovative system comprises a glucose-responsive bottom layer containing copper sulfide (CuS) to deliver transient antibacterial and antibiofilm activity during the initial infection phase, and a stable upper layer incorporating nimesulide (NIM) to provide sustained anti-inflammatory effects throughout the subsequent healing phase. This results demonstrate that the upper layer of the hydrogel patch exhibits enhanced mechanical strength of 146.3 ± 18.9 kPa, offering robust physical protection similar to a plaster. Additionally, the patch exhibits satisfied antibacterial performance, achieving over 95% bactericidal efficacy against both Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ), with an in vivo bactericidal rate of 78.7%. Furthermore, the downregulation of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) and the upregulation of the anti-inflammatory cytokine interleukin-10 (IL-10) confirms its potent anti-inflammatory properties. In summary, the bilayer hydrogel system exhibits high biocompatibility, antibacterial and anti-inflammatory capabilities, addressing the distinct needs of different stages in the wound healing process.
研究领域:
生物医学工程
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药剂学
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伤口愈合
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材料科学
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传染病
✓ 已验证
产品关联
DOI
高影响因子
CELLULOSE
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2025
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IF 4.8
Sun Yanyan,Natsuki Jun,Zhou Wanyu,Zou Lihua,Wang Zhen,Li Bingbing,Gao Yamin,Chu Changliu,Natsuki Toshiaki
Wearable electronics have gained considerable attention in recent years owing to their softness, flexibility, and compatibility with the human body. However, most conventional multifunctional smart textiles are developed by integrating various fibers or fabrics with single functionalities, facing challenges such as high integration complexity and poor stability, and struggling to meet the demands of wearable electronics. In this study, we present a simple and scalable method involving dip-coating and spray-coating to produce multifunctional, wearable, high-performance MXene/CuS/cotton fabrics. Leveraging the conductive networks formed by synergistic MXene/CuS and the porous structure of the fabrics, these MXene/CuS/cotton fabrics demonstrate impressive electromagnetic interference (EMI) shielding effectiveness (51.1 dB at a thickness of 335 μm) and notable Joule heating performance (approximately 60 °C at a voltage of 6 V). Moreover, when pressure is applied, MXene/CuS/cotton fabrics exhibit negative piezoresistivity, high sensitivity (− 18.2 kPa −1 for 1–4 kPa pressures), rapid response and recovery times (0.4 s), along with exceptional long-term durability and stability (over 2000 cycles). These remarkable properties suggest that MXene/CuS/cotton fabrics are highly promising for future applications in human motion detection, EMI shielding, thermal management, and other applications.
研究领域:
材料科学
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纳米技术
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柔性电子学
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纺织工程
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电磁兼容性
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Xiaotong Mu,Xinxin Zeng,Zhiwei Xu,Hongpeng Zhang,Chenzhao Bai,Yucai Xie,Yu Liu
Solar-powered steam generation and thermoelectric generation, as sustainable green technologies, have emerged as effective strategies to tackle the worldwide issues of water and energy scarcity. However, existing photothermal interfacial evaporation materials generally suffer from low evaporation efficiency and poor energy utilization, significantly limiting its practical applications. Therefore, developing high-performance three-dimensional (3D) solar-driven interfacial evaporation materials is crucial for advancing the construction of photothermal-thermoelectric evaporation systems. Herein, inspired by the multiscale array structure of Roman broccoli, an MXene-CuS@CF interfacial evaporator based on a multiscale pyramid photothermal structure was designed and fabricated by mimicking the optical enhancement and pore transport mechanisms observed in Roman broccoli photosynthesis. Under 1 kW m −2 illumination, the evaporator achieved an evaporation rate of 3.25 kg m −2 h −1 , five times higher than pure water. The maximum output power density reached 1.52 W m −2 . After 50 evaporation cycles in simulated seawater, MXene-CuS@CF demonstrated good evaporation stability. Under outdoor sunny conditions with 8 h of natural sunlight exposure, the freshwater output reached 9.1 kg m −2 . The bionic MXene-CuS@CF interfacial evaporator significantly enhances evaporation performance and energy utilization through its multiscale structural design and efficient photothermal synergy. This research provides a novel ideas for constructing efficient and stable photothermal-thermoelectric hybrid systems in the future.
研究领域:
材料科学
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可再生能源
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仿生学
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光热转换
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海水淡化
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热电发电
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
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2024
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IF 10.5
Hong Zhang,Xiao Wang,Xiaorong Yang,Zehua Wu,Qin Chen,Qiaolin Wei,Yong Guo,Quan Hu,Jia-Wei Shen
Recent advancements in cancer treatment have underscored the inadequacy of conventional monotherapies in addressing complex malignant tumors. Consequently, there is a growing interest in synergistic therapies capable of overcoming the limitations of monotherapies, leading to more personalized and effective approaches. Among these, the combination of photothermal therapy (PTT) and chemotherapy has emerged as a promising avenue for tumor management. In this study, we present a novel approach utilizing thermoresponsive mesoporous silica nanoparticles (MSN) as a delivery system for the chemotherapeutic drug doxorubicin. By incorporating photothermal agent copper sulfide (CuS) nanoparticles into the MSN, the resulting composite material exhibits potent photothermal properties. Furthermore, the integration of an upper critical solution temperature (UCST) polymer within the silica outer layer serves as a “gatekeeper”, enabling precise control over drug release kinetics. This innovative nanomaterial effectively merges thermoresponsive behavior with PTT, thereby minimizing the collateral damage associated with traditional chemotherapy on healthy tissues. Moreover, in both in vitro studies using mouse breast carcinoma cells (4 T1) and in vivo experiments utilizing a 4 T1 tumor-bearing mouse model, our nanomaterials demonstrated synergistic effects, enhancing the anti-tumor efficacy of combined PTT and chemotherapy. With its remarkable photothermal conversion efficiency, robust stability, and biocompatibility, the UCST-responsive nanoplatform holds immense potential for clinical applications.
研究领域:
纳米技术
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癌症治疗
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）