ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Linghui Song,Panpan Chen,Baimei Shi,Aihua Qu,Chuanlai Xu,Hua Kuang,Maozhong Sun
Autophagy is a key regulator in a diverse range of human diseases. Here, chiral copper sulfide (CuS) nanoparticles (NPs) modified with penicillamine are fabricated, which exhibited a circular dichroism (CD) spectrum between 300 and 1000 nm and a fluorescence peak at 680 nm. The experimental data showed that D -CuS NPs exhibited chirality-dependent autophagy induction, outperforming L -CuS NPs, and targeted breast cancer cells with 228.4 times higher affinity for CD81 receptor. The mechanism is revealed that chiral NPs specifically bound to CD81 receptor to open mechanosensitive calcium channels and motivated the calmodulin-dependent protein kinase kinase β (CaMKKβ)/AMPK pathway, which enhanced Atg1/Unc-51-like autophagy activating kinase 1 (ULK1) activity to promote autophagy. In vivo experiments confirmed the selective accumulation of D -CuS NPs in tumors, induction of autophagy, and successful treatment of the tumor. Therefore, chiral CuS NPs show great potential for modulating biological processes and improving tumor treatment.
研究领域:
纳米医学
·
肿瘤学
·
分子生物学
·
细胞自噬
·
生物材料
·
转化医学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2022
·
IF 5.999
Lihua Li,Xinyu Sun,Mengna Dong,Hui Zhang,Jiao Wang,Tong Bu,Shuang Zhao,Li Wang
Nature-derived bioactive components and photothermal synergistic therapy bring potential strategies for fighting bacterial infection and accelerating would healing by virtue of their excellent therapeutic efficiencies and ignorable side effects, where photothermal property not only acts as sterilization energy but also as a doorkeeper to control the natural component release. Herein, by integrating the excellent antibacterial property of cinnamaldehyde (CA) and the outstanding photothermal performance of copper sulfide nanoparticles (CuS NPs), a multifunctional nanoplatform of SiO 2 @CA@CuS nanospheres (NSs) is constructed with silica nanosphere (SiO 2 NSs) as carrier. SiO 2 @CA@CuS NSs exhibit photothermal property, bacterial absorption capacity, extraordinary antibacterial activity and antioxidant property. Mechanism characteriazation and antibacterial experiment indicate that positive charged SiO 2 @CA@CuS can adhere to the negative charged surface of bacteria, and quickly kill bacteria through the synergistic action of the released CA and heat produced under near infrared light (NIR) irradiation at 980 nm. The sterilization efficiencies for Escherichia coli ( E. coli ) and S. aureus reach 99.86% and 99.84%, respectively. Furthermore, NIR-regulated SiO 2 @CA@CuS perform great biocompatibility, as well as effective effects for accelerating S. aureus -infected wound healing at a low photothermal temperature (45 °C) relying on synergistic sterilization and anti-oxidation.
研究领域:
生物医学工程
·
纳米医学
·
感染与伤口愈合
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2016
·
IF 2.265
Yimin Wu,Ilia Korolkov,Xvsheng Qiao,Xianghua Zhang,Jun Wan,Xianping Fan
A rapid injection approach is used to synthesize the copper selenide nanoparticles and two-dimensional single crystal nanoplates . This technique excludes the use of toxic or expensive materials, increasing the availability of two-dimensional binary chalcogenide semiconductors. The structure of the nanocrystals has been studied and the possible formation mechanism of the nanoplates has been proposed. The optical absorption showed that the nanoplates demonstrated wide and tuneable absorption band in the visible and near infrared region . These nanoplates could be interesting for converting solar energy and for nanophotonic devices operating in the near infrared .
研究领域:
材料科学
·
纳米科技
·
半导体材料
·
光电子学
·
能源材料
✓ 已验证
DOI
高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Rui Cai,Jiayu Zhao,Peirong Zhou,Xuemin Ma,Chuankai Zhang,Zhaodan Wu,Liyu Hu,Yajuan Hu,Yongcen Chen,Chenglong Huang,Gang Tao
Bacterial infections often hinder the wound-healing process. Antibiotics are commonly used to eradicate bacteria, but long-term use can lead to the development of drug-resistant bacteria. Photothermal therapy (PTT) is a promising technology that utilizes a photothermal agent (PTA) to convert near-infrared radiation into heat, which can eliminate bacteria and has the advantages of being highly effective, controllable, and low drug resistance. In this study, we obtained silk fibroin-copper sulfide nanoparticles(SF/CuS NPs) in situ with excellent photothermal responsive properties by a green synthesis strategy using silk fibroin proteins as biological templates. Then, the SF/CuS NPs were mixed with PVA solution, and the photothermal nanofiber membrane (PVA-SF/CuS) was prepared using the electrostatic spinning technique. The synthesized SF/CuS NPs endowed the nanofiber membrane with excellent photothermal sterilization properties. In addition, the constructed PVA-SF/CuS nanofibrous membranes had good cytocompatibility and haemocompatibility. Meanwhile, in vivo experiments confirmed that PVA-SF/CuS nanofibrous membrane could inhibit the expression of pro-inflammatory factor (IL-6), promote the expression of angiogenic factor (VEGF), and accelerate collagen deposition and neovascularization under near-infrared light irradiation, which could then promote the healing of infected wounds. Thus, the PVA-SF/CuS nanofiber membrane provides a new candidate material for treating bacterially infected wounds.
研究领域:
生物医学材料
·
纳米医学
·
伤口愈合研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2020
·Vol. 10
·期 1
·178
·
IF 4.324
Yanping Wang,Fuchuan Jiang,Jiafu Chen,Xiaofeng Sun,Tao Xian,Hua Yang
Herein, a coprecipitation method used to synthesize CuS nanostructures is reported. By varying the reaction time and temperature, the evolution of the CuS morphology between nanoparticles and nanoflakes was investigated. It was found that CuS easily crystallizes into sphere-/ellipsoid-like nanoparticles within a short reaction time (0.5 h) or at a high reaction temperature (120 °C), whereas CuS nanoflakes are readily formed at a low reaction temperature (20 °C) for a long time (12 h). Photodegradation experiments demonstrate that CuS nanoflakes exhibit a higher photodegradation performance than CuS nanoparticles for removing rhodamine B (RhB) from aqueous solution under simulated sunlight irradiation. Carbon nanotubes (CNTs) were further used to modify the photodegradation performance of a CuS photocatalyst. To achieve this aim, CNTs and CuS were integrated to form CNT/CuS hybrid composites via an in situ coprecipitation method. In the in situ constructed CNT/CuS composites, CuS is preferably formed as nanoparticles, but cannot be crystallized into nanoflakes. Compared to bare CuS, the CNT/CuS composites manifest an obviously enhanced photodegradation of RhB; notably, the 3% CNT/CuS composite with CNT content of 3% showed the highest photodegradation performance (η= 89.4% for 120 min reaction,kapp= 0.01782 min−1). To make a comparison, CuS nanoflakes and CNTs were mechanically mixed in absolute alcohol and then dried to obtain the 3% CNT/CuS-MD composite. It was observed that the 3% CNT/CuS-MD composite exhibited a slightly higher photodegradation performance (η= 92.4%,kapp= 0.0208 min−1) than the 3% CNT/CuS composite, which may be attributed to the fact that CuS maintains the morphology of nanoflakes in the 3% CNT/CuS-MD composite. The underlying enhanced photocatalytic mechanism of the CNT/CuS composites was systematically investigated and discussed.Keywords:CuS nanoparticles/nanoflakes;morphology tailoring;CNT/CuS composites;photodegradation performance
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2018
·Vol. 10
·期 39
·18520-18530
·
IF 7.233
Xiaomei Dai,Yu Zhao,Yunjian Yu,Xuelei Chen,Xiaosong Wei,Xinge Zhang,Chaoxing Li
The chronic infection of humans by antibiotic-resistant bacteria and their related biofilm have, so far, not been properly addressed. In the present work, we developed a novel antibacterial nanoplatform showing the most efficient antibiotic-resistant bacteria inhibition and biofilm eradication. This particular formulation contains tobramycin-conjugated graphene oxide, for efficiently capturing bacteria through electrostatic interactions and eliminating bacteria as a “nano-knife”, and copper sulphide nanoparticles for enhancing the photothermal and photodynamic properties. This novel formulation can selectively eliminate bacteria over NIH 3T3 cells, and the biofilm eradication capacity was up to 70%. Importantly, the nanoplatforms can inhibit bacterial growth and promote the repair of antibiotic-resistant bacteria-infected wounds on rats without non-specific damage to normal tissue. This work provides an effective, simple, and rapid method for the design and fabrication of near-infrared light-induced nanoplatforms that offer possibilities to treat biofilm-related infections.
研究领域:
医学
·
材料科学
·
感染病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 48
·27382-27389
·
IF 2.936
Chengwan Xia,Diya Xie,Lang Xiong,Qian Zhang,Yang Wang,Zezheng Wang,Yuxin Wang,Bin Li,Chao Zhang
Herein, we reported nitroxide radical-modified CuS nanoparticles (CuS–NO˙ NPs), and they exhibited a typical absorption peak at 1182 nm. Due to such a long wavelength absorbance, CuS–NO˙ NPs exhibited excellent therapeutic outcome and low damage to normal tissues. Besides, we simultaneously achieved CuS–NO˙ NPs for MRI and CT dual-modal imaging, which successfully provided a new strategy for imaging-guided tumor treatment, thus increasing potential clinical applications for cancer treatment.
研究领域:
纳米医学
·
癌症治疗
·
成像技术
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
·
2024
·
IF 4.2
Haozhe Wang,Dan Li,Qingyao Meng,Xue Li,Kangle Guo,Zehua Zou,Jinsong Peng,Yuan Sun,Tiedong Sun
Bacterial infection of wound surfaces has posed a significant threat to human health and represents a formidable challenge in the clinical treatment. In this study, a novel antimicrobial hydrogel utilizing POM is synthesized as the primary component, with gelatin and sodium alginate as the structural framework. The resultant hydrogel demonstrates exceptional mechanical properties and viscoelasticity attributed to the hydrogen-bonded cross-linking between POM and gelatin, as well as the ionic cross-linking between sodium alginate and Ca 2+ . In addition, the integration of CuS nanoparticles conferred photothermal properties to the hydrogel system. To address the concerns regarding the potential thermal damage to the surrounding normal cells, this study employs a LT-PTT combined with CDT approach to achieve the enhanced antimicrobial efficacy while minimizing the inadvertent harm to the healthy cells. The findings suggested that POM-based hydrogels, serving as an inorganic–organic hybrid material, will represent a promising antimicrobial solution and offer valuable insights for the development of the non-antibiotic materials.
研究领域:
材料科学
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Therapeutics
·
2021
·Vol. 4
·期 7
·2100043
·
IF 0
Shaohua Zhang,Guangzhi Li,Dashi Deng,Yizhi Dai,Zhuang Liu,Song Wu
The emergence of near-infrared-II (NIR-II) light activated photomedicines has extended the penetration depth for noninvasive theranostics, especially for photothermal nanomedicines. Intravesical instillation therapy of bladder cancer (BCa) is restricted greatly due to the short residence time and the low penetration ability of therapeutic agents in clinic. Therefore, improving the mucoadhesiveness and penetration of therapeutic agents are crucial factors in treatment of BCa. The development of NIR-II light triggered photothermal transduction agents for enhanced penetration and photothermal ablation of BCa post-intravesical instillation has not yet been investigated. Herein, Cu 2- x Se biocompatible particles are prepared through a fluorinated chitosan (FCS)-mediated one-pot aqueous approach, which possesses enhanced penetrating ability and high photothermal conversion capability for effective NIR-II photothermal therapy (PTT). Owing to the outstanding transmucosal ability of FCS, FCS capped Cu 2- x Se nanoparticles exhibit much better transmucosal and penetration performance than their non-fluorinated counterparts to significantly improve the therapeutic efficacy of NIR-II PTT to ablate orthotopic bladder tumors. This study presents a promising phototherapy agent based on Cu 2- x Se modified with FCS for efficient NIR-II PTT for BCa treatment post-intravesical instillation.
研究领域:
纳米技术
·
生物医学工程
·
癌症治疗
·
材料科学
·
药学
✓ 已验证
产品关联
DOI
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2025
·
IF 4.9
Xueling Long,Siyi Li,Yuxiang Ma,Yuting Cao,Shaoping Sun
Transdermal delivery is considered as a promising convenient and painless approach for the delivery of insulin. In this study, an amphiphilic peptide derivative of oleic acid modified octaarginine (R8-OA) and a photothermal nanomaterial of hyaluronic acid modified CuS (CuS-HA) were successfully synthesized. Using both materials as carriers, CuS-HA enveloped R8-OA@insulin nanocomplexes (HERNCs) were prepared. In vitro studies demonstrated that R8-OA could chemically enhance the penetration of insulin through the stratum corneum. In vivo laser activation studies suggested that CuS-HA in HERNCs could ablate the stratum corneum, thus facilitating the insulin penetration through physical enhancement. The hypoglycemic effect study revealed that blood glucose level in diabetic mice decreased to 42.3% within 4 h, and the value was maintained at 75.1% after 24 h. These results underscored the potential of the enveloped nanocomplexes for enhanced transdermal delivery of insulin.
研究领域:
纳米医学
·
药物递送
·
透皮治疗
·
糖尿病治疗
·
生物材料
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2025
·
IF 9.5
Yueling Lai,Jingying Luo,Xianglong Zhao,Hao Chen,Qianqian Song,Kanghui Zheng,Xin Tong,Ruilin Wang,Yufeng Zhou
In the realm of imaging and optoelectronic devices, near-infrared (NIR) light has garnered significant attention due to its unique properties of deep tissue penetration and anti-interference capability. Among various NIR materials, silver telluride (Ag2Te) colloidal quantum dots (QDs) have emerged as promising candidates due to their low toxicity and broad absorption/emission range. However, the photoluminescence quantum yield (PL QY) and photostability of Ag2Te QDs are relatively low, which poses a considerable challenge to their practical application. We herein report a novel strategy to enhance their optical properties by leveraging the localized surface plasmon resonance (LSPR) effect of non-noble metallic Cu2−xS1−ySey nanoparticles (NPs). Experimental results demonstrate that the core@shell@shell Cu2−xE@SiO2@Ag2Te (E = Se, S) nanostructures (NSs) exhibit a remarkable fluorescence enhancement factor of up to 2.72, with the PL QY increasing from 9.52% to 14.46% and the fluorescence lifetime being significantly prolonged with respect to those of bare Ag2Te QDs. Furthermore, the optimized NS-based photodetectors show a 4.18-fold enhancement in responsivity compared to bare QD-based devices, highlighting the effectiveness of LSPR in optimizing carrier dynamics.
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2020
·Vol. 12
·期 23
·12508-12521
·
IF 6.895
Qian Li,Junjie Ren,Qiubing Chen,Weiwei Liu,Zhigang Xu,Yang Cao,Yuejun Kang,Peng Xue
Hollow mesoporous copper sulfide nanoparticles (HMCuS NPs) are advantageous for loading small-molecule therapeutic drugs coupled with photothermal ablation for synergistic tumor therapy. However, treatment efficacy mediated by HMCuS NPs is not always satisfactory owing to their insensitivity toward the tumor microenvironment (TME), and unpredictable drug leakage may also result in deleterious systemic toxicity. Here, a novel HMCuS@MnO2-based core–shell nanoplatform was developed as a highly efficient TME modulator, which could alleviate tumor hypoxia, deplete the level of intracellular glutathione (GSH) and trigger the dissolution of Mn2+. Moreover, MnO2, in situ grown on the surface of HMCuS, may act as a gatekeeper by forming a stimulus-responsive plug within the mesoporous structure, which effectively prevented the premature release of encapsulated photosensitizer chlorin e6 (Ce6) and was responsive to the acidic TME for demand-based drug release. Under the condition of 660/808 nm dual-wavelength laser irradiation, hyperthermia-mediated photothermal therapy (PTT) and reactive oxygen species (ROS)-mediated photodynamic therapy (PDT) can be triggered for tumor eradication, which were further enhanced upon the modification of the TME. In the meantime, splendid photoacoustic (PA)/fluorescence (FL)/magnetic resonance (MR) imaging properties of HMCuS@MnO2/Ce6 (CMC) NPs could enable the realization of more precise, reliable and on-demand combination therapy. In a word, this study illustrated a promising approach to strengthen the efficacy of HMCuS-based nanotherapeutics, which would definitely promote the further exploitation of smarter nanoplatforms for synergistic disease management.
研究领域:
纳米医学
·
癌症治疗
·
生物医学工程
·
材料科学
·
成像技术
✓ 已验证
DOI
PubMed
高影响因子
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