Food Bioscience
·
2025
·
IF 5.9
Lei Chen,Zhuomin Zhang,Zihan Guan,Jing Sun,Yanhui Sun,Mengmeng Xu,Ka-Hing Wong,Guiyang Shi,Zhongyang Ding
Ergothioneine (EGT) production in Pleurotus tuber-regium was significantly enhanced through Na 2 SeO 3 -induced oxidative stress, in combination with optimized carbon sources and precursor amino acids. Initially, glucose and rhamnose (20 g/L each) as dual carbon sources increased EGT synthesis. Supplementation with 0.75 mM cysteine and 1 mM methionine further promoted EGT biosynthesis by providing essential precursors. Additionally, the introduction of 0.3 mM Na 2 SeO 3 induced oxidative stress, leading to an EGT accumulation of 4.68 mg/g dry weight (DW) in the mycelium and a yield of 35.27 mg/L, representing a 4.25-fold and 162% increases compared to the control, respectively. RNA-Seq analysis revealed that selenium exposure triggered the upregulation of genes involved in antioxidant defense, reinforcing redox homeostasis and driving EGT accumulation. This study highlights the mechanistic role of selenium in modulating antioxidant pathways, offering a promising strategy for enhancing EGT production in the nutraceutical and biotechnological fields.
研究领域:
生物技术
·
营养学
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2019
·
IF 3.621
Li Song,Bao Zhang,Ge Gao,Chunsheng Xiao,Gao Li
Herein, Pluronic F127 (PEO 99 -PPO 65 -PEO 99 ) end functionalized with α-lipoic acid (LA) (F127-LA) was synthesized and used for preparation of “single-component, multi-responsive” hydrogels through the photo cross-linking of LA components. The F127-LA hydrogels not only possessed thermo- and reduction- double responsiveness, but also demonstrated self-healing properties under UV irradiation due to the existence of dynamic disulfide bonds. The rheological and mechanical properties of the hydrogels can be adjusted by their concentration. The F127-LA hydrogels presented a swelling ratio decrease from 25 °C to 37 °C due to a lower critical solution temperature (LCST)-type thermo-responsive volume phase transition. The bovine serum albumin (BSA) was loaded into F127-LA hydrogels, and their drug release behavior can be regulated by surrounding temperature and reducing agent concentration. The volume shrinkage of the hydrogels promoted the sustained release of BSA above volume phase transition temperature. Cytocompatibility assay of L929 mouse fibroblasts showed that cellular metabolic activity were merely affected by F127-LA, even at concentrations up to 1000 mg L −1 . This study thus provided a very promising route for the preparation of multifunctional hydrogels.
研究领域:
材料科学
·
生物医学工程
·
药物递送
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Ruiming Liu,Xiaosen Pan,Zijun Xu,Lin Cheng,Dongsheng Ma,Lulu Cai,Xiao-Gen Xiong,Liyu Zheng,Qin Yue
Stretchable sensors have attracted an increasing interests in electronic skin, motion monitoring, medical care, and human-computer interaction. The traditional polymer-based elastomers possess excellent mechanical properties, however, are non-recyclable and difficult-to-degrade. Poly(thioctic acid) (PTA) offers recyclability through reversible disulfide bond polymerization, its poor resilience and conductivity limit practical applications. Herein, the synthesis of a recyclable polysulfide network has been pioneered with super-stretchability, remarkable resilience, electrical stability, and self-healing ability through molecular structure design. By modifying the thioctic acid (TA) repeating units with cationic chains to obtain cationic thioctic acid (C 15 H 25 N 2 O 2 S 2 Br, TAB), and subsequently co-polymerizing it with PTA, the recyclable and super-stretchable Poly(TA- co -TAB) are generated with high resilience and electronic stability. The resulting material achieves tunable stretchability (360–1700%), high sensitivity (GF = 16.2), fast response/recovery (117/108 ms), and stability (>1500 cycles at 100% strain). Notably, the material can be fully recycled via a simple alkaline dissolution-acid extraction process, showcasing its environmental sustainability.
研究领域:
材料科学
·
高分子化学
·
柔性电子学
·
可持续技术
·
传感器技术
✓ 已验证
DOI
高影响因子
Antioxidants
·
2022
·Vol. 11
·期 8
·1530
·
IF 7.675
Qingxiu Liu,Wenxiang Li,Shimeng Huang,Lihong Zhao,Jianyun Zhang,Cheng Ji,Qiugang Ma
The development of single enantiomers with high efficiency and low toxic activity has become a hot spot for the development and application of drugs and active additives. The aim of the present study was to investigate the effectiveness of the application of α-lipoic acid with a different optical rotation to alleviate the inflammation response and oxidative stress induced by oxidized fish oil in laying hens. Sixty-four 124-week-old Peking Red laying hens were randomly allocated to four groups with eight replicates of two birds each. The normal group was fed basal diets supplemented with 1% fresh fish oil (FO), and the oxidative stress model group was constructed with diets supplemented with 1% oxidized fish oil (OFO). The two treatment groups were the S-form of the α-lipoic acid model with 1% oxidized fish oil (OFO + S-LA) and the R-form of the α-lipoic acid model with 1% oxidized fish oil (OFO + R-LA) added at 100 mg/kg, respectively. Herein, these results were evaluated by the breeding performance, immunoglobulin, immune response, estrogen secretion, antioxidant factors of the serum and oviduct, and pathological observation of the uterus part of the oviduct. From the results, diets supplemented with oxidized fish oil can be relatively successful in constructing a model of inflammation and oxidative stress. The OFO group significantly increased the levels of the serum inflammatory factor (TNF-α, IL-1β, IL-6, and IFN-γ) and the oxidative factor MDA and decreased the activity of the antioxidant enzyme (T-AOC, T-SOD, GSH-Px, GSH, and CAT) in the oviduct. The addition of both S-LA and R-LA significantly reduced the levels of serum inflammatory factors (TNF-α, IL-1β, IL-6, and IFN-γ), increased the activity of antioxidant indexes (T-AOC, T-SOD, GSH-Px, GSH, and CAT), and decreased the MDA contents in the serum and oviduct. Meanwhile, the supplementation of S-LA and R-LA also mitigated the negative effects of the OFO on the immunoglobulins (IgA and IgM) and serum hormone levels (P and E2). In addition, it was worth noting that the R-LA was significantly more effective than the S-LA in some inflammatory (IL-1β) and antioxidant indices (T-SOD, GSH, and CAT). Above all, both S-LA and R-LA can alleviate the inflammation and oxidative damage caused by oxidative stress in aged laying hens, and R-LA is more effective than S-LA. Thus, these findings will provide basic data for the potential development of α-lipoic acid as a chiral dietary additive for laying hens.Keywords:S-form of α-lipoic acid;R-form of α-lipoic acid;oxidized fish oil;antioxidant;laying hen
研究领域:
动物科学
·
营养学
·
免疫学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
POLYMER COMPOSITES
·
2025
·
IF 4.7
Che Zhao,Yuxuan Zeng,Yuhan Zhou,Tianyu Wu,Meng Song,Lei Duan,Jiamei Dong,Yanlong Luo
Cross-linked polymeric damping materials with efficient energy dissipation mechanisms have attracted significant attention in impact protection applications. However, conventional viscoelastic damping materials frequently encounter limitations in processability and operational durability. Herein, a novel high-dielectric CaCu 3 Ti 4 O 12 /poly(lipoic acid) dynamic covalent network composite was introduced. This advanced material demonstrated an exceptional self-healing efficiency of 89.7% after 24 h at ambient temperature and remarkable reprocessability through thermally activated bond exchange reactions. Upon damage, the material's mechanical strength and integrity can be restored via the reformation of cross-linking points within the polymer network, thereby extending its operational lifespan. Notably, the synergistic combination of interfacial polarization effects from CaCu 3 Ti 4 O 12 particles and the dynamic equilibrium of coordination bonds establishes multiple energy dissipation pathways. This unique architecture achieves broadband damping performance with loss factors (tan δ) exceeding 0.3 across an extended frequency spectrum (0.009–100 Hz), coupled with a substantial enhancement in dielectric constant. The energy dissipation capability was verified through a steel ball rebound experiment, which demonstrated an exceptionally low rebound rate of 3.0%. This research offers an innovative design concept for developing sustainable impact-resistant materials. Highlights A novel high-dielectric self-healing CaCu 3 Ti 4 O 12 /poly(lipoic acid) damping material was successfully synthesized. The CaCu 3 Ti 4 O 12 /poly(lipoic acid) films exhibit outstanding self-healing ability and reprocessability. The CaCu 3 Ti 4 O 12 /poly(lipoic acid) composites achieve a superior impact resistance and a significantly elevated dielectric constant.
研究领域:
材料科学
·
高分子化学
·
力学
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2020
·
IF 4.469
Cong Huang,Nan Zhang,Qiang Wang,Ping Wang,Yuanyuan Yu,Man Zhou
Extensive research and practice on anti-crease of cotton fabric has been made in the past few decades because of its easy creasing properties. However, it has not achieved a good balance between anti-crease performance, strength loss, hydrophilicity and formaldehyde release until now. In this study, for the first time, α-lipoic acid (ALA) which contains bifunctional groups, carboxyl group and disulfide bond, has been successfully used as an innovative cross-linking agent in the anti-crease functionalization to prepare high crease resistant and hydrophilic cotton fabric without strength loss and formaldehyde release. The mechanism between ALA and cellulose through esterification, disulfide breaking and reconstruction, and anti-crease mechanism based on topological disulfide bridges among cellulosic molecules were illustrated in terms of the characterization analyses of cross-linked ALA and poly(α-lipoic acid). This study provides a completely different idea for the preparation of anti-crease cotton fabric with high strength and hydrophilic without negative environmental impact.
研究领域:
纺织科学
·
材料化学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2013
·Vol. 3
·期 46
·24618-24624
·
IF 2.562
Dongyue Su,Xin Yang,Qingdong Xia,Fang Chai,Chungang Wang,Fengyu Qu
This paper describes the sensing application of water-dispersible thioctic acid functionalized gold nanoparticles (TA-GNPs) as sensors for the colorimetric detection of Hg2+ ion in water samples. The state and stability of thioctic acid decorated gold nanoparticles in pH range (pH = 4–11) were evaluated by UV/vis spectra. The thioctic acid modified GNPs could be induced to aggregate quickly in the presence of Hg2+, especially after adding a solution of 0.05 M NaCl. The detection of Hg2+ by TA-GNPs at different pH values (pH = 5, 7, 9, 11) was also investigated to optimize the experimental conditions in detail. The result indicated that the TA-GNPs at pH 5 were the most optimal choice for detecting Hg2+. The detection results of Hg2+ could be determined by the naked eye or a UV-vis spectrophotometer. The detection of Hg2+ could be realized with a detection limit of 10 nM over a long range (10 nM to 20 μM). Additionally, the selectivity of this method has been investigated using other metal ions. The TA-GNPs can selectively bind Hg2+ over other metal ions (Pb2+, Mg2+, Zn2+, Ni2+, Cu2+, Co2+, Ca2+, Mn2+, Fe2+, Cd2+, Ba2+, Ag+ and Cr3+), leading to prominent color change. This will provide a simple and effective colorimetric sensor (no DNA) for on-site and real-time Hg2+ ion detection. More importantly, this probe was also applied to determine the Hg2+ in lake samples, and the results demonstrate low interference and high sensitivity.
研究领域:
分析化学
·
环境科学
·
纳米技术
✓ 已验证
DOI
高影响因子
POLYMER
·
2025
·
IF 4.5
Xinlong Liu,Xitong Shang,Xiaofeng Zhu,Longmeng Du,Qifan Yang,Liping Ren,Zaixing Jiang,Wenhui Zheng,Wei Li
Growing interest in conductive organohydrogels for wearable flexible strain sensors has significantly increased the demand for their stability and versatility. In this work, stable, and 3D-printed organohydrogels were prepared by utilizing the dynamic hydrogen bonding interaction between Gelatin and dl -Thioctic acid (TA), along with the Hofmeister effect between gelatin and ammonium sulfate. This double network structure endows the hydrogel with outstanding mechanical robustness, excellent low-temperature stability, and rapid gelation behavior suitable for 3D printing. After 200 compression loading-unloading cycles, the organohydrogel retained a remarkably high stress level, maintaining 96 % of its initial stress, and displayed a consistent electrical signal throughout each cycle. Furthermore, even after 7 days at room temperature, the organohydrogel preserved excellent stress (maintained at 92 %), electrical performance, and sensitivity in pressure signal recognition during extended cycle tests. The organohydrogel also supported 3D printing and was used to construct sensor arrays. Its excellent stability and versatility enhanced the potential applications in wearable pressure sensors.
研究领域:
生物材料
·
柔性电子器件
·
传感器技术
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2022
·Vol. 10
·期 13
·2171-2182
·
IF 7.571
Yamei Gao,Xiang Zhan,Shaohu Huo,Ling Fu,Zhen Tang,Keke Qi,Chunchun Lv,Chengyuan Liu,Yulin Zhu,Shenggang Ding,Yongmei Lv
Bacterial infections remain a major concern during wound healing and tissue bonding. The excessive proliferation of bacteria will seriously hinder the repair of the wound and even lead to death. Generally, surgical sutures might cause damage to the surrounding tissues and inevitable infection due to the unfixed shape of the wound. Thus, it is urgent to develop novel antibacterial skin dressing with self-healing and strong adhesion properties. Herein, we prepared an antibacterial and self-healable hydrogel with strong adhesion activity through natural small molecules, including thioctic acid TA and gentamicin (GM). The rapid ring-opening-polymerization of the TA (PTA) forms the backbone of macromolecules, and the functional hydrogel was constructed with the crosslinking of GM, termed as G-PTA, which offers hydrogen bonding interactions between the amino and hydroxyl groups of GM and carboxylic group side chains of poly(TA). The synthesized hydrogel exhibited rapid self-healing ability and strong tissue adhesion due to the internal dynamic disulfide bonds and multiple hydrogen bonds. Importantly, the introduction of GM enabled the G-PTA hydrogel to sustainably release antibiotics and exhibit a durative antibacterial effect with the degradation of PTA, which further shorten the therapeutic time and enhance tissue regeneration in a wound infection model. The in vitro and in vivo experiments demonstrate that the G-PTA hydrogel has potential as a surgical antibacterial biological adhesive, especially for bacterial wound infections.
研究领域:
生物材料学
·
医学
·
药剂学
✓ 已验证
DOI
PubMed
高影响因子
Metabolites
·
2025
·Vol. 15
·期 1
·45
·
IF 3.7
Zhe Liu,Fengxu Xiao,Yupeng Zhang,Jiawei Lu,Youran Li,Guiyang Shi
Purpose: This study aimed to utilize genetically engineeredBacillus licheniformisfor the production of ergothioneine (EGT). Given the value of EGT and the application ofBacillus licheniformisin enzyme preparation production, we cloned the key enzymes (EanA and EanB) fromChlorbium limicola. Through gene alignment, new ergothioneine synthase genes (EanAN and EanBN) were identified and then expressed inBacillus licheniformisto construct strains. Additionally, we investigated the factors influencing the yield of EGT and made a comparison withEscherichia coli. Methods: The relevant genes were cloned and transferred intoBacillus licheniformis. Fermentation experiments were conducted under different conditions for yield analysis, and the stability of this bacterium was also evaluated simultaneously. Results: The constructed strains were capable of producing EGT. Specifically, the yield of the EanANBN strain reached (643.8 ± 135) mg/L, and its stability was suitable for continuous production. Conclusions: Genetically engineeredBacillus licheniformisdemonstrates potential in the industrial-scale production of EGT. Compared withEscherichia coli, it has advantages, thus opening up new possibilities for the application and market supply of EGT.
研究领域:
微生物学
·
生物技术
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Dongdong Wang,Feifei Sun,Chunbo Lu,Peng Chen,Zhaojie Wang,Yuanhao Qiu,Haibo Mu,Zehong Miao,Jinyou Duan
Colorectal cancer is one of the most common types of tumor in the world. Here we developed a lipoic acid esterified polysaccharide (inulin) delivery system for tanshinone IIA to treat colorectal cancer in vitro . The release of tanshinone IIA in the system was highly responsive to glutathione , which is commonly abundant in cancer cells. In addition, this drug delivery system was proliferative to Bifidobacterium longum , the common inhabitant of human intestine. Thus, this strategy might be useful to improve colon cancer therapy efficacy of anticancer drugs and meanwhile promote the growth of beneficial commensal flora in the gut.
研究领域:
药剂学
·
肿瘤学
·
肠道微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 20
·3691
·
IF 5.719
Lin Wang,Hang Liu,Xinsong Li,Chen Yao
In this research, we constructed a novel engineered tripeptide modified with lipoic acid (LA-RWR), followed by crosslinking of lipoic acid to form nanoparticles (c-LA-RWR). LA-RWR was also modified with phenethylamine (PEA) on the C-terminus to achieve better antibacterial activities. The as-prepared c-LA-RWR and LA-RWR-PEA were effective againstE.coli,S.aureus,C.albicans, and methicillin-resistantStaphylococcus aureus, with minimum inhibitory concentration values ranging from 2 to 16 µg/mL, which greatly improved the performance of LA-RWR. Similar antibacterial activities were demonstrated in anti-biofilm activity; there was no matter on the biofilm that was already established or forming. Moreover, c-LA-RWR/LA-RWR-PEA remarkably induced cytoplasmic membrane depolarization and outer membrane permeabilization, resulting in varying degrees of damage to the bacterial morphology, which were consistent with the results obtained via electron microscopy. Thus, our results show that c-LA-RWR/LA-RWR-PEA exhibited excellent efficacy against a variety of microorganisms with good biosafety, providing new strategies by which to improve the performance of antimicrobial peptides.Keywords:antimicrobial peptides;lipoic acid;biofilm;crosslink;nanoparticles;phenethylamine
研究领域:
药学
·
微生物学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）