RSC Advances
·
2025
·Vol. 15
·期 7
·5117-5123
·
IF 4.6
Huizhou Ye,Jiayin Cai,Zhihao Shen,Qiuping Qian,Chunxia Zhang
Polyphenols exhibit strong antioxidant, and anti-inflammatory but are limited by chemical instability and low bioavailability. To address these challenges, we developed polyphenol–amino acid conjugates that self-assemble into stable nanospheres, enhancing their stability and bioavailability. These nanoparticles demonstrate significantly improved ROS scavenging efficiency and promote cell proliferation in vitro. The incorporation of amino acids enhances biocompatibility and facilitates effective ROS elimination. The polyphenol–amino acid nanoparticles offer a multifaceted therapeutic strategy to mitigate oxidative stress, overcoming traditional antioxidant limitations through advanced nanotechnology. This approach contributes to the development of next-generation wound care solutions with enhanced efficacy and safety profiles.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2024
·Vol. 31
·期 32
·44759-44769
·
IF 0
Wu Rui,Song Xi,Tian Guanghui
Highly active Fe 3 O 4 /GO/Au composite nanomaterial was fabricated as a substrate of surface-enhanced Raman spectroscopy (SERS) and applied for pesticide residue detection. The three-layer multifunctional Fe 3 O 4 /GO/Au nanoparticles (NPs) were designed by facile method, with high hotspots, and were characterized by various techniques, including ultraviolet spectrophotometry (UV), X-ray diffraction (XRD), infrared absorption spectrometer (IR), and transmission electron microscopy (TEM). The performance of Fe 3 O 4 /GO/Au was evaluated by Raman spectroscopy with R6G as a probe molecule to verify its enhancement effect. It exhibited a strong Raman signal with 10 −6 M of R6G. Furthermore, the presence of Fe 3 O 4 /GO/Au nanohybrid enabled the SERS-based method to detect mancozeb and showed an excellent linear relationship in the range of 0.25–25 ppm, with a low limit of detection (0.077 ppm), satisfactory EF, stability, and repeatability. In addition, the mechanism of SERS enhancement with electromagnetic mechanism (EM) and chemical mechanism (CM) was discussed in detail. Therefore, the proposed SERS approach holds promise as an auxiliary technique for screening contaminated agricultural products, environmental sample, and food in the future.
✓ 已验证
产品关联
DOI
PubMed
Desalination and Water Treatment
·
2026
·
IF 3.4
Hao Li,Minru Su,Chen Shi,Rouyi Wang,Anqi Xu,Xiaolan Shen
High catalytic activity and long-term stability of particle electrodes are key to three-dimensional electro-activated peroxydisulfate (3D-E-PDS). This study developed the Fe-based reduced graphene oxide (Fe/rGO) hydrogel particle electrodes prepared using a low-temperature hydrothermal method, demonstrating a 9.77-fold increase in tetracycline hydrochloride (TCH) degradation rate compared with conventional two-dimensional (2D) E-PDS system. The structural properties and catalytic activities of the Fe/rGO hydrogel particles clearly depended on the iron precursor, with the Fe 3 + -derived hydrogel exhibiting the highest catalytic activity. After systematically optimizing the operational parameters (PDS concentration, current density, particle dosage, initial solution pH, TCH concentration, and agitation rate), the 3D-E-PDS system achieved a TCH degradation efficiency of 94.44% and total organic carbon removal efficiency of 46.62% within 2 h. In water matrices, Cl − promoted TCH degradation, whereas SO 4 2− , PO 4 3− , and especially CO 3 2− inhibited the degradation. Radical quenching experiments identified SO 4 · − , ·OH, 1 O 2 , and ·O 2 − as the primary reactive species. After six cycles, the 3D-E-PDS maintained a TCH degradation efficiency of 82.56%, with a degradation rate 2.56 times higher than that of the 2D-E-PDS system, validating its stability and reusability. Overall, this study establishes a one-step hydrothermal synthesis protocol for Fe/rGO hydrogel particle and demonstrates the efficacy of 3D-E-PDS in TCH degradation.
✓ 已验证
产品关联
DOI
高影响因子
Biochemistry and Biophysics Reports
·
2026
·
IF 3.3
Wenyuan Wan,Yuntao Zhang,Xiaotong Yang,Jinyao Li,Jun Lu,Yu Zhao
This study investigated the reparative effects of Brassica rapa L. ethanolic extract (BREE) on H 2 O 2 -induced oxidative injury in PC-12 cells. Brassica rapa L. , a cruciferous plant rich in bioactive flavonoids, exhibits potent antioxidant and neuroprotective properties against oxidative stress, a key pathological driver in neurodegenerative diseases. This study investigated the reparative effects of Brassica rapa L. ethanolic extract (BREE) on H 2 O 2 -induced oxidative injury in PC-12 cells, employing a multi-omics approach integrating LC-MS/MS metabolite profiling, molecular docking, and transcriptomic validation. BREE demonstrated robust radical-scavenging activity. Molecular docking identified direct interactions among flavonoids within BREE, suggesting a role in redox modulation. Subsequent experiments confirmed the activation of the PI3K/Akt, Keap1-Nrf2, and cell cycle pathways. Functionally, BREE significantly restored cell viability to 162.3% ± 6.9% of that in the control group. These findings validate BREE's dual action in scavenging ROS and reprogramming redox signaling networks, positioning it as a candidate for combating oxidative stress-associated neurodegeneration and as a potential functional food for age-related cognitive decline.
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2026
·
IF 11
Xiaoling Liu,Run Huang,Ling Zou,Lu Yang,Yonghui Wu,Dandan Li,Jinbao Li,Jian He,Xiaochao Yang
Oxidative stress caused by the excessive accumulation of reactive oxygen species (ROS) plays a critical role in the development of acute respiratory distress syndrome (ARDS). Current antioxidant therapies using organic ROS scavengers fail in decreasing mortality due to the low ROS scavenging activity and fast metabolic rate. Inorganic ROS scavenging nanoparticles provide potential options for investigating ARDS antioxidant therapy. However, previous studies mainly focus on the ROS scavenging activity of these nanoparticles, while their capability to modulate the endogenous antioxidant system remains largely unexplored. Herein, mesoporous Ce–Mn–O bimetallic oxide nanoparticles (NP CeMn ) are designed and synthesized to activate the endogenous antioxidant system for ARDS therapy. Morphologically similar ceria nanoparticles (NP Ce ) and manganese oxide nanoparticles (NP Mn ) are used for comparison. In vivo and in vitro results demonstrate that NP Ce and NP Mn can promote the expression of SOD1 and SOD2, respectively, while NP CeMn can promote the expression of both SOD1 and SOD2. Mechanism studies establish a Keap1/Nrf2/SOD axis through which NP CeMn acts to activate the endogenous antioxidant system. Based on this property, NP CeMn can effectively alleviate oxidative stress and inflammation in the lung of the murine ARDS model. These findings suggest that activating the endogenous antioxidant system via inorganic nanoparticles is a promising ARDS therapeutic strategy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 8.8
Yixin Wang,Tiegen Guo,Erqiang Yang,Ruofei Gao,Bin Hu,Junfen Li,Jiandang Xue,Nanwen Li
Anion exchange membrane water electrolysis (AEMWE) has garnered significant attention due to its potential for low cost and high efficiency, with the anion exchange membrane (AEM) serving as its core component. However, the trade-off between stability and ionic conductivity remains a key challenge hindering the advancement of AEMs. In this work, we introduce a novel twisted multi-directional branching agent, hexaphenylbenzene (HPB), to poly(terphenyl piperidinium) (PTP) and employ a block-branching synthetic strategy. Specifically, the block poly(terphenyl-HBPB-piperidium) (B-PTHP) membrane achieved low swelling (14.2% at 80 °C) and high ionic conductivity (183.6 mS cm -1 at 80 °C), alongside excellent oxidative stability (retained 88.1% of its mass after 96 h in Fenton reagent) and alkaline stability (retaining 97.2% of OH - conductivity after 1500 h in 1 M KOH). Consequently, the B-PTHP membrane reached a current density of 1.06 A cm -2 at 2 V and running over 740 h at 0.25 A cm -2 in a pure-water-fed AEMWE. Meanwhile, it also achieved a current density of 8.26 A cm -2 at 2 V and stable operation for over 2500 h at 0.5 A cm -2 and 60 °C in a 1 M KOH-fed AEMWE. Therefore, our work contributes to addressing the critical challenges of oxidative stability and pure-water-fed AEMWE.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2026
·
IF 9.2
Yuce Zhang,Chuanmin Ding,Yan Lv,Yanwen Guo,Mengtao Liu,Zekai Ren,Junwen Wang
Thermocatalytic water splitting to produce hydrogen at low temperature was of great significance. In this study, a series of efficient and stable FeO x and FeO x S x catalysts were synthesized via a liquid precipitation method using ferrous sulfate, sodium hydroxide, and thiourea as precursors. The study focused on investigating the effects of sulfur introduction and preparation atmosphere on the catalytic performance. These catalysts were characterized by SEM, XRD, FT-IR, XPS and H 2 -TPR, which confirmed the successful preparation of sulfur-doped catalysts (denoted as FeO x S x -Air and FeO x S x -O 2 ). Under reaction conditions of 350 °C and water vapor (space velocity: 0.3 mL min −1 ), the sulfur-doped catalysts demonstrated superior activity, with FeO x S x -Air and FeO x S x -O 2 achieving H 2 production rates of approximately 0.0523 mmol (mL g) −1 and 0.04092 mmol (mL g) −1 , respectively, outperforming their undoped counterparts (FeO x -Air and FeO x -O 2 ). Meanwhile, FeO x S x -Air with the higher activity was more beneficial for the reaction than FeO x S x -O 2 , which indicated that a lower oxygen partial pressure facilitated the formation of unsaturated Fe coordination environments. The performance enhancement was attributed to the synergistic effect of sulfur doping and low oxygen partial pressure, which optimized the Fe 2+ /Fe 3+ ratio and accelerated the Fe + /Fe 3+ redox cycle, thereby improving charge transfer efficiency and optimizing hydrogen production. These findings highlighted the critical role of sulfur incorporation under low-oxygen conditions in boosting the catalytic activity of iron oxide-based for low-temperature water splitting.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2026
·Vol. 16
·期 12
·11158
·
IF 6.1
Wenli Qin,Xinyi Zhang,Gaofeng Chen,Zhaoting Ji,Zengling Ma
The increasing influx of nutrients ( e.g. , nitrogen and phosphorus) into freshwater systems is exacerbating eutrophication in natural waterways. To address this issue, a novel magnetic photocatalyst composed of a carbon nanotube core and a titanium dioxide coating (denoted as C–TiO 2 –Fe 3 O 4 and C–TiFe 2 O 4 ) is successfully synthesized. Microcystis aeruginosa and microcystin-LR (MC-LR) in eutrophicated water can be efficiently inactivated by the composite via visible light photocatalysis. The incorporation of magnetic Fe significantly enhances cyanobacteria capture and improves the photocatalytic efficiency for algal inactivation and MC-LR breakdown. C–TiFe 2 O 4 exhibits the highest adsorption-photocatalysis performance with an inactivation efficiency of 77.9% after 7 hours. Under optimal conditions (7 h of reaction time, a catalyst dosage of 0.39 g L −1 , and an initial algae density of 1 × 10 6 cells per mL), the MC-LR removal rate is 89.1%. Notably, C–TiFe 2 O 4 maintains exceptional stability and reusability even after five cycles. The composite demonstrates promising potential for treating harmful algal blooms (HABs) across diverse environmental conditions. These findings highlight the viability of C–TiFe 2 O 4 as a sustainable and scalable technology to mitigate HABs and degrade MC-LR in contaminated water systems. The prepared magnetic photocatalysts, C–TiO 2 –Fe 3 O 4 and C–TiFe 2 O 4 , are sustainable and scalable technologies to mitigate HABs and degrade MC-LR in contaminated water systems.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2026
·
IF 18.1
Wu Zenglong,Zhang Haimin,Yin Huajie,Zhao Huijun
Electrochemical energy conversion reactions are central to sustainable energy technologies, yet their efficiency at industrially relevant current densities is often constrained by mass-transfer limitations. Here, we introduce a periodic flow field strategy for enhancing mass transfer based on a geometrically periodic microstructure that induces spatially varying velocity fields and wall shear oscillations within the pores, generating a coherent convective contribution to otherwise diffusion-dominated transport. To implement this concept, we design hierarchical ordered interconnected porous nickel electrodes with long-range order, tunable structural periods and scalable centimeter-scale fabrication, serving as a general electrocatalyst support. The resulting architecture alleviates mass-transfer constraints across multiple electrochemical reactions. As a representative example, the NiFe-modified electrode delivers a current density of 7 A cm −2 for the oxygen evolution reaction at 25 °C with an overpotential of 393 mV, while an anion-exchange-membrane water electrolyzer sustains 1 A cm −2 at 1.68 V for 1083 h at 60 °C. We also construct a lightweight flexible device for portable oxygen and hydrogen production with efficient operation under fluctuating solar power.
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Zhiyuan Wang,Libo Wang,Shihao Cui,Dejian Xu,Hui Wang,Honghao Liu,Haipeng Zhang,Ning Gong,Qingshan Zhao,Mingbo Wu
Pd-based catalysts play a pivotal role in nitroaromatic hydrogenation for fine chemical synthesis, yet their intrinsic overactivity often undermines target selectivity. In this study, we develop a highly efficient and magnetically recoverable Pd/Fe3O4–rGO catalyst for nitroaromatic hydrogenation through dual-support interfacial engineering, realized by precisely anchoring Pd nanoparticles at the heterojunctions of ferrosoferric oxide and reduced graphene oxide (Fe3O4–rGO). The dual-support modulation effect not only ensures uniform Pd distribution via strong interfacial interaction but also drives directional charge transfer from Pd to the Fe3O4–rGO composite support, synergistically enhancing nitro group adsorption and optimizing H2 dissociation kinetics. The prepared Pd/Fe3O4–rGO catalyst achieves exceptional catalytic performance with 99% conversion and >97% selectivity for the chemoselective hydrogenation of diverse nitroaromatics under mild conditions while maintaining remarkable activity/selectivity over multiple cycles. Notably, the integrated Fe3O4 component facilitates efficient magnetic separation (<2 min), demonstrating industrial viability for continuous processes. This work provides a rational dual-support strategy that simultaneously regulates spatial configuration and electronic states of active sites to overcome the activity-selectivity trade-off in hydrogenation catalysis.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Jianjun Guo,Liang Yao,Hang Li,Xianqing Wang,Mingzhi Yu,Guohua Wu
Free radicals, generated in the living system through diverse biochemical pathways, can damage biomolecules, thereby causing oxidative stress, impairing tissue function, and delaying wound healing. This has stimulated increasing interest in antioxidant-based strategies to neutralize free radicals and protect biological structures. Gallic acid (GA), a plant-derived polyphenol, is well-known for its potent free-radical scavenging activity. However, its poor solubility and instability under physiological conditions limit its practical applications. In this work, GA was coordinated with ferric ions to form ultrasmall Fe-GA nanoscale coordination polymers (Fe-GA NCPs), designed to enhance its stability and maintain antioxidant activity. To provide a biocompatible and mechanically stable carrier, silk fibroin (SF) from silkworm cocoons, an FDA-approved biomaterial widely used in medical applications, was selected as the carrier. The resulting RSF/Fe-GA NCPs exhibited strong hydroxyl and DPPH radical scavenging abilities, improved mechanical strength and flexibility, and excellent biocompatibility. In vivo studies confirmed accelerated wound closure, enhanced tissue regeneration, and reduced inflammatory marker expression, demonstrating the potential of these antioxidant fibers as multifunctional materials for wound healing and other bio-based applications.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Dong-Wei Shao,Tong Xie,Ya-Tao Wang
Osteoarthritis (OA) is a widespread chronic degenerative joint disease, for which new treatment strategies are urgently needed. In this study, we developed an injectable, pH-responsive hydrogel (HA-TA-CS) aimed at improving joint drug delivery by enhancing retention within the joint cavity, while exhibiting excellent biocompatibility. The hydrogel was loaded with celecoxib for localized, in situ release (HA-TA-CS@Cel). OA is characterized by elevated levels of reactive oxygen species (ROS), which promote oxidative stress, inflammatory cytokine production, and further exacerbate the inflammatory response. HA-TA-CS@Cel effectively mitigates inflammation by scavenging excess ROS through the sustained release of TA and celecoxib. Our results demonstrate that HA-TA-CS@Cel significantly alleviates OA progression. In a mouse OA model, the system reduced pro-inflammatory factors and alleviated disease severity. Furthermore, HA-TA-CS@Cel promoted the polarization of macrophages from the M1 to the M2 phenotype, suggesting its ability to modulate the immune microenvironment and thereby attenuate joint inflammation and slow OA progression. These findings indicate that the injectable HA-TA-CS@Cel hydrogel system holds great promise for treating OA through enhanced cartilage protection and macrophage polarization, with potential applications in other inflammatory diseases.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）