JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Bin Yang,Wan-Zhong Yin,Jin Yao,Zhang-Lei Zhu,Hao-Ran Sun,Ke-Qiang Chen,Li-Ying Wang
Different adsorption behaviors of the collector on the mineral surface play a crucial part in the flotation separation of different minerals by selectively modifying the wettability of mineral surfaces. In this investigation, to effectively remove quartz from hematite via reverse flotation, decaethoxylated stearylamine (DEOSA) was first introduced as a high-performance collector for quartz. The selective collecting performance and differential adsorption mechanisms of DEOSA for both hematite and quartz were studied by flotation experiments and surface analysis. Flotation results suggested that DEOSA displayed excellent collecting capacity for quartz against hematite and the effective removal of quartz from hematite was achieved. Adsorption capacity measurements and surface wettability analysis demonstrated that much larger amounts of DEOSA adsorbed onto quartz than hematite significantly enhanced the quartz surface hydrophobic whether the depressant starch was present or not, which resulted in the excellent flotation performance of quartz. Surface electrical characterization and Fourier transform infrared (FTIR) analysis further proved that the combination of hydrogen bonding and electrostatic attracting force enhanced the strong adsorption of DEOSA onto the quartz, achieving the efficient collection performance of DEOSA for quartz. Based on these findings, DEOSA can be used potentially as a strong-collection and high-performance quartz collector for recovering hematite from quartz via reverse flotation.
研究领域:
矿物加工工程
·
界面化学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Bin Yang,Wanzhong Yin,Jin Yao,Qiuyue Sheng,Zhanglei Zhu
This investigation focused on the collection performance and sorption mechanisms of decaethoxylated stearylamine (DSA) applied as a new high-selectivity hornblende collector, to further extend the use of DSA for efficiently recovering siderite from hornblende. The collecting ability of DSA to both minerals was explored via a series of flotation experiments. Flotation results illustrated that in comparison with DDA, DSA displayed an excellent collection performance for the hornblende flotation, whereas it hardly collected siderite. With 0.18 mM DSA, siderite could be efficiently separated from hornblende at pH 6.30 through reverse flotation. The selective collection mechanisms of DSA for hornblende were uncovered via surface wettability, X-ray photoelectron spectroscopy (XPS), surface electrical properties, infrared spectrum (IR) characterizations, and molecular dynamics (MD) simulations. Contact angle detection indicated that DSA strengthened the surface hydrophobicity of hornblende instead of siderite, which promoted the strong collection of hornblende. Besides, surface electrical detection and IR analyses suggested that the intense DSA sorption toward the hornblende was due to the combination of electrostatic adsorption and hydrogen bonding interaction. It was demonstrated by XPS results that larger amounts of DSA were adsorbed onto hornblende than siderite, and the O sites of hornblende were involved in electrostatic attraction and hydrogen bonding interaction. Furthermore, MD simulations further revealed that compared with siderite, the intense adsorption of DSA on the hornblende was due to the hydrogen bond and electrostatic interactions between its amino group and the hornblende surface, as evidenced by a much smaller interaction distance and very negative electrostatic energy. Therefore, DSA can be utilized as an efficient collector for collecting hornblende to achieve the desiliconization of the siderite flotation.
研究领域:
矿物加工工程
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表面化学
✓ 已验证
产品关联
DOI
高影响因子
MOLECULAR PHARMACEUTICS
·
2013
·
IF 4.57
Zhiwen Zhang,Zeying Liu,Li Ma,Shijun Jiang,Yixin Wang,Haijun Yu,Qi Yin,Jingbin Cui,Yaping Li
Multidrug resistance (MDR) remains one of the major challenges for successful chemotherapy. Herein, we tried to develope a mitochondria targeted teniposide loaded self-assembled nanocarrier based on stearylamine (SA-TSN) to reverse MDR of breast cancer. SA-TSN was nanometer-sized spherical particles (31.59 ± 3.43 nm) with a high encapsulation efficiency (99.25 ± 0.21%). The MDR in MCF-7/ADR cells was obviously reduced by SA-TSN, which mainly attributed to the markedly reduced expression of P-gp, increased percentages in G2 phase, selectively accumulation in mitochondria, decrease of mitochondrial membrane potential, and greatly improved apoptosis. The plasma concentration of teniposide was greatly improved by SA-TSN, and the intravenously administered SA-TSN could accumulate in the tumor site and penetrate into the inner site of tumor in MCF-7/ADR induced xenografts. In particular, the in vivo tumor inhibitory efficacy of SA-TSN in MCF-7/ADR induced models was more effective than that of teniposide loaded self-assembled nanocarrier without stearylamine (TSN) and teniposide solution (TS), which verified the effectiveness of SA-TSN in reversal of MDR. Thereby, SA-TSN has potential to circumvent the MDR for the chemotherapy of breast cancer.
研究领域:
药学
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肿瘤学
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纳米技术
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药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano Research
·
2018
·Vol. 11
·期 8
·4245-4264
·
IF 7.994
Aouameur Djamila,Cheng Hao,Opoku-Damoah Yaw,Sun Bo,Dong Qiuling,Han Yue,Zhou Jianping,Ding Yang
Engineered stimuli-responsive drug delivery devices hold vast promise in biological applications for disease treatment due to their maximized therapeutic efficacy. In this study, a novel, stably cross-linked, and pH-sensitive biodegradable gel-micelle was constructed with amphiphilic conjugates of trimethylene dipiperidine-methacrylic anhydride-hyaluronic acid-stearylamine (TMDP-MA-HA-SA, TMHS) to improve tumor-targeting with flexible intracellular delivery of paclitaxel (PTX).The cross-linked methacrylate bonds significantly improved the biostability of TMHS gel-micelle (~ 200 nm) over the non-cross-linked under physiological conditions, while hyaluronic acid plays an important role in active tumor targetability. The gradual degradation of cross-linked hyaluronic acid shell was triggered by the concentrated hyaluronidase. Meanwhile, under acidic conditions (pH < 6.5), the tertiary amines of pH-sensitive TMDP moieties were protonated and thereby solubilized the gel-micellar core-portions. The resultant pH-triggered inner-core spaces rapidly prompted PTX release in the presence of multiple cytosolic enzymes that mainly degraded the remaining hydrophobic stearylamine core. During the in vitro cytotoxicity assay, PTX-loaded TMHS gel-micelles (CLTMHSPTX) revealed anticancer efficacy against human hepatocellular carcinoma HepG2 cells with IC 50 of 1.42 μg/mL (PTX concentration), significantly lower than other groups. In parallel, the in vivo anti-tumor efficacy of CL TMHS PTX gel-micelles against BALB/c xenograft tumor animal model demonstrated the greater tumor growth inhibition capacity of 72.06%, compared to other treatment groups at a safe concentration. Consequently, the cross-linked and stimuli-responsive CL TMHS PTX gel-micelles hold a great potential for flexible modulation of intracellular delivery of hydrophobic anticancer drugs with maximized antitumor efficacy.
研究领域:
药学
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生物医学工程
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癌症研究
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）