MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2021
·Vol. 222
·期 8
·2000461
·
IF 2.527
Yushi Wang,Jiyu Dong,Jiahong Jin,Yong-Guang Jia
As an effective alternative to suture in wound closure, tissue adhesives often need to have excellent biocompatibility and suitable bioadhesion. To achieve long-term adhesion on moist tissue, polyrotaxane (PR) crosslinked self-healing hydrogels have been prepared by the introduction of dynamic borate bonds between PR bearing phenylboronic acid moieties (PR-PBA) and dopamine grafted poly(vinyl alcohol) (PVA-DOP). Synthesis of these precursor polymers PR-PBA and PVA-DOP is quite simple and the hydrogels combine dynamic borate bonds with the sliding motion of the phenylboronic acid moieties on PR. The sliding nature of the crosslinking points along the axle in the PR is thought to enhance the mechanical properties and adhesion ability of the resultant hydrogels. Meanwhile, catechol groups on dopamine units have been protected by borate bonds under alkaline conditions to avoid oxidation, and they then are released to react with various functional groups on tissue surface to ensure the switchable tissue adhesion. The self-healing test and adhesion of hydrogels on pigskin demonstrate the ability to restore the original performance after repeated strain cycles and maintain strong tissue adhesion. The components of these hydrogels have satisfying biocompatibility. These results indicate that these self-healing hydrogels have great potentials in tissue adhesion.
研究领域:
材料科学
·
生物医学工程
·
组织工程
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Wenfeng Yan,Junmao Li,Wei Long,Yulin Feng,Mingzhen He,Weifeng Zhu,Meiying Liu,Hui Ouyang,Xiaoyong Zhang,Yen Wei
In this paper, a simple method that relied on direct chain transfer free radical polymerization was reported to synthesize MSNs based polymeric composites (named as MCM-41-SH-poly (PEGMA- co -VPA)) using poly (ethylene glycol) monomethyl ether (PEGMA) and 4-vinyl phenylboric acid (VPA) as monomers. The utilization of MCM-41-SH-poly (PEGMA- co -VPA) to load and delivery curcumin (CUR) was also evaluated in detail. The structure, properties, drug loading and release behaviors were evidenced by various characterization techniques. The results from biological studies have shown that CUR can be effectively loaded on MCM-41-SH-poly (PEGMA- co -VPA) with high drug loading rate through formation of borate bond between CUR and VPA. More importantly, resultant drug-loading complexes displayed excellent water dispersibility and CUR could be released from complexes with pH responsiveness. Taken together, we have developed a simple method for surface modification MCM-41 and resultant composites could display improved properties for intracellular controlled drug delivery applications.
研究领域:
材料科学
·
纳米医学
·
药物递送系统
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER SCIENCE
·
2025
·
IF 3.6
Yumei Luo,Jingya Yu,Hua Hu,Moubo Wang,Xiaoqian Dong,Qingguo Shang,Xiaodong Bai
Borehole wall instability is one of the most serious problems in drilling and completion, and the most common way to solve the problem is to stabilize the borehole wall with sealing materials. This work reports the synthesis, characterization, and evaluation of the double network self-healing hydrogel containing acrylamide (AM), 2-acrylamide-2-methylpropane sulfonic acid (AMPS), polyvinyl alcohol (PVA) and borax to use as a plugging agent for drilling fluids. The experimental results show that P (AM-co-AMPS-co-LMA)/PVA DN hydrogel has good temperature and salt resistance. There are a large number of holes in the interior, and the swelling ratio is as high as 217.33%. The mechanical properties test showed that the hydrogel had a high tensile strength of 0.57 MPa and elongation at break of 464.63%. The recovery efficiency of elongation at break is over 87%. Through the pressure plugging test, the steel model with crack widths of 0.5 mm and 1 mm was adopted. 0.8% P(AM-co-AMPS-co-LMA)/PVA DN hydrogel could withstand the pressure of 5 MPa at 70°C. This kind of hydrogel with good mechanical properties and certain self-healing properties can be a new material to control leakage. Graphical
研究领域:
材料科学
·
石油工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2022
·
IF 6.76
Lijie Tang,Yan Ma,Caixia Yang,Enxiang Liang,Hong Yin,Qiong Wan,Jiance Zhang,Wei Wang
Flexible energy storage devices are susceptible to damage, which might result in safety issues. In this paper, a self-healing flexible P(AAPBA-co-P4-AC) gel electrolyte based on dynamic borate bond cross-linking strategy is reported. On the one hand, it is simple to process into complicated shapes or patterns, and on the other hand, it could rapidly return to its original state after stress damage. Even after ten times self-healing, the gel has the same mechanical properties as the non-damaged gel. Furthermore, this gel can also be applied in all-solid-state supercapacitors without the need of extra electrolytes. Because the gel has a large number of hydroxyl groups, it has a high affinity for the activated carbon electrode, and the supercapacitors can maintain 100% initial performance under various angles or strains. After ten thousand times cycles charge–discharge, the supercapacitors using the gel after twenty times self-healing process can retain 90% of its initial capacity, which is only 4% lower than the non-damaging supercapacitors, demonstrating high self-healing ability.
研究领域:
材料科学
·
能源存储
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2020
·
IF 4.845
Lei Liu,Shuaichao Wang,Peilan Qi,Shiyong Song,Yanwei Yang,Jiahua Shi,Guang Han
Poly(ethylene glycol)-poly(ε-caprolactone) (PEG-b-PCL) micelles have been widely used as drug delivery vehicles for cancer therapies. Because of the lack of functional groups, the use of PEG-b-PCL in drug delivery system is greatly limited and structural modifications is needed. In this work, chemical modification at the terminus of PEG-b-PCL was performed via the “grafting from” polymerization method. A poly(dopamine methyl acrylamide) segment was introduced containing multiple catechol groups, which could attach bortezomib (BTZ) to the chain of the polymer through the formation of a pH-sensitive borate bond. This method greatly enhanced the loading capacity of BTZ into the micelles. Additionally, the controlled release of BTZ in response to the acidic environment of a tumor was realized. High loading capacity, stimuli-responsiveness, biodegradability, and compatibility were integrated in the PEG-b-PCL-based system. In vitro and in vivo studies demonstrated that superior tumor inhibition without obvious side effects can be achieved by the BTZ-loaded PEG-b-PCL-b-PDMA micelles.
研究领域:
药学
·
材料科学
·
纳米技术
·
肿瘤学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）