Nanoscale
·
2022
·Vol. 15
·期 4
·1835-1848
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IF 8.307
Wenjing Xie,Han Li,Houqiang Yu,Hongfu Zhou,Anran Guo,Qing Yao,Ling Zhang,Yongsheng Zhao,Hongan Tian,Ling Li
Iodized oil has an excellent X-ray imaging effect, but it shows poor embolization performance. When used as an embolic agent, it is easily washed off by the blood flow and eliminated from the body. Therefore, it is essential to use iodized oil in combination with solid embolic agents such as gelatin sponge or to perform multiple embolization procedures to achieve the therapeutic effect. In the present study, a poly(N-isopropyl acrylamide)-co-acrylic acid (PNCAA) temperature-sensitive nanogel was synthesized by emulsion polymerization; the nanogel was then emulsified with iodized oil to prepare a thermosensitive iodized oil Pickering gel emulsion (TIPE). The oil–water (O/W) ratio of an O/W emulsion system can reach 4 : 6. When injected into the body, TIPE transforms into a nonflowing coagulated state at physiological temperature; the iodized oil is locked in the emulsion structure, thereby achieving local embolization and continuous imaging effects, which not only retain the X-ray imaging effect of the iodized oil but also improve its embolization effect. Subsequently, we further evaluated renal artery embolization in a normal rabbit renal artery model, and the results showed that TIPE shows a long-term conformal embolization performance and excellent long-term X-ray imaging ability.
研究领域:
医学材料学
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介入放射学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Superconductivity and Novel Magnetism
·
2021
·Vol. 34
·期 4
·1165-1176
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IF 1.506
Sun Xiaoning,Song Kun,Wang Song,Sun Kangning
Fe 3 O 4 nanoparticles/iodized oil magnetic fluids (FIOMFs) have showed potential in targeted hyperthermia for liver tumors; in this paper, FIOMFs were simply and conveniently prepared by dispersing the synthesized hydrophobic Fe 3 O 4 nanoparticles (FNPs) in iodized oil; the stability, magnetothermal effects, and the biotoxicity of FIOMFs were evaluated. The results showed that the stability of FIOMFs was mainly influenced by the morphology and the size of FNPs. FNPs prepared with FeCl 3 ·6H 2 O, oleylamine (OAm), ethylene glycol (EG), and stearic acid exhibited the best suspension stability, which could suspend in iodized oil stably for a long time. Depending on the FNP content and the parameters of the alternating magnetic field (AMF), the temperature of FIOMF in AMF can reach up to more than 70 °C within 60 s, exhibited excellent magnetothermal effects. The in vitro cytotoxicity tests indicated the cytotoxicity of FNPs is mainly influenced by its concentration in cells.
研究领域:
医学
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材料科学
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生物医学工程
✓ 已验证
DOI
高影响因子
ADVANCED MATERIALS
·
2024
·
IF 27.4
En Ren,Jing Hu,Ziyang Mei,Lin Lin,Qian Zhang,Pan He,Junqing Wang,Tao Sheng,Hu Chen,Hongwei Cheng,Tiantian Xu,Shiyao Pang,Yang Zhang,Qixuan Dai,Xing Gao,Hui Liu,Hongjun Li,Yang Zhao,Zhen Gu,Xiaohui Yan,Gang Liu
Magnetic microrobots, designed to navigate the complex environments of the human body, show promise for minimally invasive diagnosis and treatment. However, their clinical adoption faces hurdles such as biocompatibility, precise control, and intelligent tracking. Here a novel formulation (referred to water-stable magnetic lipiodol micro-droplets, MLMD), integrating clinically approved lipiodol, gelatin, and superparamagnetic iron oxide nanoparticles (SPION) with a fundamental understanding of the structure-property relationships is presented. This formulation demonstrates multiple improved properties including flowability, shape adaptability, efficient drug loading, and compatibility with digital subtraction angiography (DSA) imaging in both in vitro and in vivo experiments. This enables the MLMD as a versatile tool for image-guided therapy, supported by a close-looped magnetic navigation system featuring artificial intelligence (AI)-driven visual feedback for autonomous control. The system effectively performs navigational tasks, including pinpointing specific locations of MLMD, recognizing and avoiding obstacles, mapping and following predetermined paths, and utilizing magnetic fields for precise motion planning to achieve visual drug delivery. The MLMD combines magnetic actuation with an AI-directed close-looped navigation, offering a transformative platform for targeted therapeutic delivery.
研究领域:
生物医学工程
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纳米技术
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医疗机器人
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药学
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成像技术
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人工智能
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2024
·
IF 5.4
Zhihua Li,Xiaoya Liu,Jingyu Xiao,Hang Jiang,Le Ma,Yucheng Luo,Meijuan Wang,Yuwei Zhu,Hongliang Jiang,Hanyang Yao,To Ngai,Qiongyu Guo
Tumor hypoxia-associated drug resistance presents a major challenge for cancer chemotherapy. However, sustained delivery systems with a high loading capability of hypoxia-inducible factor-1 (HIF-1) inhibitors are still limited. Here, we developed an ultrastable iodinated oil-based Pickering emulsion (PE) to achieve locally sustained codelivery of a HIF-1 inhibitor of acriflavine and an anticancer drug of doxorubicin for tumor synergistic chemotherapy. The PE exhibited facile injectability for intratumoral administration, great radiopacity for in vivo examination, excellent physical stability (>1 mo), and long-term sustained release capability of both hydrophilic drugs (i.e., acriflavine and doxorubicin). We found that the codelivery of acriflavine and doxorubicin from the PE promoted the local accumulation and retention of both drugs using an acellular liver organ model and demonstrated significant inhibition of tumor growth in a 4T1 tumor-bearing mouse model, improving the chemotherapeutic efficacy through the synergistic effects of direct cytotoxicity with the functional suppression of HIF-1 pathways of tumor cells. Such an iodinated oil-based PE provides a great injectable sustained delivery platform of hydrophilic drugs for locoregional chemotherapy.
研究领域:
药学
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癌症研究
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生物医学工程
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药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2024
·
IF 3.7
Jin Long Zhang,Bing Yuan,Xiao Wei Zhang,Heng Zhang,Hao Wang,Xing Zhi Wang,Hong Wei Zhao
Drug-eluting microspheres are commonly used as a local drug delivery system for interventional therapy. However, current drug-eluting microspheres have poor X-ray visibility, which can hinder tracking and postembolization evaluation. In the current study, X-ray-visible poly(acrylic acid) drug-eluting beads loaded with iodized oil (IO-PAA-DEBs) ranging from 100–300 μm were prepared and evaluated both in vitro and in vivo. Iodized oil served as the radiopaque agent, and X-ray and computed tomography scanning confirmed that the microspheres exhibited excellent X-ray-visible properties. The drug-loading capacities of bleomycin hydrochloride, doxorubicin hydrochloride, and oxaliplatin were also investigated. IO-PAA-DEBs exhibited sustained drug release properties, accompanied by a cumulative drug release rate that reached approximately 60% after 120 h. In vitro and in vivo experiments revealed that IO-PAA-DEBs had good biocompatibility. Collectively, these results demonstrated that IO-PAA-DEBs could facilitate transarterial embolization and sustained drug delivery.
研究领域:
药学
·
介入放射学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2024
·
IF 10
Zhihua Li,Man Huang,Yingnan Li,Yongchao Wang,Yutao Ma,Le Ma,Hongliang Jiang,To Ngai,Jianbo Tang,Qiongyu Guo
Microsphere-based embolic agents have gained prominence in transarterial embolization (TAE) treatment, a critical minimally invasive therapy widely applied for a variety of diseases such as hypervascular tumors and acute bleeding. However, the development of microspheres with long-term, real-time, and repeated X-ray imaging as well as ultrasound imaging remains challenging. In this study, emulsion-based dual-modal imaging microbeads with a unique internal multi-interface structure is developed for TAE treatment. The embolic microbeads are fabricated from a solidified oil-in-water (O/W) emulsion composed of crosslinked CaAlg-based aqueous matrix and dispersed radiopaque iodinated oil (IO) droplets through a droplet-based microfluidic fabrication method. The CaAlg-IO microbeads exhibit superior X-ray imaging visibility due to the incorporation of exceptionally high iodine level up to 221 mgI mL −1 , excellent ultrasound imaging capability attributed to the multi-interface structure of the O/W emulsion, great microcatheter deliverability thanks to their appropriate biomechanical properties and optimal microbead density, and extended drug release behavior owing to the biodegradation nature of the embolics. Such an embolic agent presents a promising emulsion-based platform to utilize multi-phased structures for improving endovascular embolization performance and assessment capabilities.
研究领域:
医学工程
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生物材料
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成像科学
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介入放射学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Pharmaceutical Analysis
·
2024
·
IF 6.1
Ling Li,Anran Guo,Haixia Sun,Yanbing Zhao,Qing Yao,Ling Zhang,Peng Shi,Hongan Tian,Min Zheng
Transcatheter arterial embolization (TAE) is the mainstay for treating advanced hepatocellular carcinoma (HCC), and the performance of the embolization material is crucial in TAE. With the development of medical imaging and the birth of “X-ray-free” technologies, we designed a new dual-mode imaging material of dimethoxy tetraphenyl ethylene (DMTPE) via emulsification by mixing poly ( N- isopropylacrylamide -co- acrylic acid) (PNA) with lipiodol and fluorocarbons, which was evaluated for temperature sensitivity, stability, and dual-mode visualization in vitro . Additionally, blood vessel casting embolization and renal artery imaging were assessed in healthy rabbits. In a rabbit model with a VX2 tumor, the effectiveness of transarterial embolization (TAE) for treating HCC was examined, with an emphasis on evaluating long-term outcomes of embolization and its effects on tumor growth, necrosis, and proliferation through imaging techniques. In vitro experiments confirmed that the temperature-sensitive dual-oil-phase Pickering emulsion had good flow, stable contrast, and embolism when the oil-to-oil ratio and water-to-oil ratio were both 7:3 (V/V ) and stabilized with 8% PNA. Similarly, in vivo , arterial embolization confirmed the excellent properties of DMTPE prepared at the abovementioned ratios. It was observed that DMTPE not only has an antitumor effect but can also achieve dual imaging using X-rays and ultrasound, making it a promising excellent vascular embolization material for TAE in tumor treatment.
研究领域:
医学影像
·
癌症治疗
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材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Aggregate
·
2024
·
IF 13.9
Xiaoliu Liang,Hui Liu,Hu Chen,Xuqi Peng,Zhenjie Li,Minglei Teng,Yisheng Peng,Jiwei Li,Linyu Ding,Jingsong Mao,Chengchao Chu,Hongwei Cheng,Gang Liu
The efficacy of transarterial chemoembolization (TACE) has been limited by insufficient embolization and a high incidence of tumor recurrence. Herein, we identified that aberrant metabolic reprogramming and immunosuppression contribute to TACE refractoriness and Rhein, as a potential glycolytic metabolism inhibitor and immunoactivation inducer, was optimized to sensitize tumors to TACE therapy. To achieve efficient embolization, we developed an oil-in-water lipiodol embolic emulsion by stabilizing the self-assembled Rhein nanogel. The assembled Rhein exhibited a nanofiber network, and its integration enhanced the mechanical stability and viscoelasticity of the lipiodol embolic agent. With the synergistic advantages of solid and liquid embolic agents, this carrier-free Pickering emulsion exhibits efficient embolization and sustained drug release in models of unilateral renal artery embolization, rabbit ear tumor embolization, rabbit orthotopic liver cancer, and rat orthotopic liver cancer. Compared to conventional three-way catheter mixing methods, multimodal imaging corroborates a marked enhancement in local drug retention and tumor suppression. Importantly, the incorporation of Rhein-mediated synergistic immunoembolization in this strategy achieved efficient embolization while robustly activating anti-tumor immune responses, including inducing immunogenic cell death, dendritic cell activation, and major histocompatibility complex class I presentation to CD8 + T cells for tumor killing. Together, these findings reveal a novel strategy for the application of self-assembled Rhein nanofiber-stabilized lipiodol emulsion to control metabolic signaling and immunoactivation in TACE.
研究领域:
肿瘤学
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药学
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生物医学工程
·
免疫学
·
代谢学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）