Journal of Materials Chemistry B
·
2024
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IF 6.1
Zitong An,Enguang Lin,Zhiguang Wu,Yongming Kang
Recent advances in synthetic micro/nanomotors in numerous biofluids have garnered widespread hobby because of their capability biomedical programs. However, present micro/nanomotor systems for shipping inside the gastrointestinal (GI) tract are inefficient in propulsion. Here, we present a micromotor-tableted tablet that achieves lively retention in the GI tract in vivo. The drug-loaded magnesium-based totally absolutely Janus micromotors, enveloped in an enteric polymer-protected magnetic tablet, stay sturdy within the stomach. The movement of the micromotor tablets (MPs) is facilitated by means of the use of an outside low-frequency gradient magnetic difficulty, directing them to focused regions inside the intestines. A excessive-frequency alternating magnetic concern induces water-powered propulsion of the micromotors via the magnetocaloric effect, attaining lively retention in GI tissue. The integration of this newly evolved MP tool lets in energetic retention of micromotors in vivo, promising more suitable drug transport for GI treatment.
研究领域:
生物医学工程
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药剂学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 68
·63704-63710
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IF 3.289
Aihua Li,Hongjing Ma,Jingquan Liu
A novel GO coated porous magnetic NPs (Fe3O4@mSiO2@GO) for bioimaging was synthesized. First, Fe3O4 magnetic NPs were prepared through a solvothermal reaction. Second, through a surfactant-templating approach with cetyltrimethylammonium bromide (CTAB) as a template, a mesostructured CTAB/SiO2 composite was deposited on Fe3O4 NPs surfaces. Third, CTAB templates were removed to form a mesoporous SiO2 shell, resulting in mesoporous magnetic (Fe3O4@mSiO2) NPs. Forth, the magnetic NPs surfaces were functionalized with amino groups by (3-aminopropyl)triethoxysilane (APTES). Finally, the dye rhodamine B (RB) was loaded inside porous magnetic NPs, and the magnetic NPs surfaces were then wrapped with graphene oxide (GO) nanosheets. SEM analysis revealed that GO sheets have been successfully coated on magnetic NPs surfaces. The hysteresis loops analysis indicated that these magnetic NPs still retained strongly magnetic property. Furthermore, Fe3O4@mSiO2@GO NPs could efficiently protect the loaded dye from releasing. In addition, MTT assay revealed that the RB loaded Fe3O4@mSiO2@GO NPs exhibited insignificant cytotoxicity at moderate concentrations and the RB loaded Fe3O4@mSiO2@GO NPs could undergo target-directed move under the action of a magnetic field. The noncytotoxic magnetic hybrids presented significant potential for applications in cell imaging.
研究领域:
材料科学
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生物医学工程
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纳米技术
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Rong-Kun Liu,Jia Jia,Qian Sun,Hong Zhao,Jie-Xin Wang
Janus-microswimmers, as efficient self-propelled materials, have garnered considerable attention, particularly for their potential applications in nonagitated liquids, like natural aquatic systems. However, current microswimmers face challenges such as unconfined diffusion areas and small-scale production. Herein, we propose a scalable spray-drying-assisted strategy for the efficient production of Janus-microswimmers. The Janus structures are fabricated by the assembly of polystyrene microparticles and SiO2/polydopamine nanoparticles in the microdroplets, and the single-side propulsion microswimmers are subsequently obtained by loading MnO2. By catalyzing the decomposition of H2O2 to produce oxygen, the speed of these microswimmers is much faster than those of other reported continuous-motion microswimmers. Interestingly, the microswimmers are self-propelled and gather in the proximity of water surface, and the extent of the confined area is controllable. This range-confined motion, distinct from the traditional irregular motion, offers a novel perspective on the behavioral patterns of Janus-microswimmers. Furthermore, by in situ loading of Fe3O4 nanoparticles, the microswimmers can be sensitively induced and controlled in their movement direction by a magnetic field. As a proof-of-concept, by harnessing the hydrophobic components of the microswimmers, we successfully recover floating oil films in a simulated natural water body, offering a promising approach for the remediation of petroleum pollution in the environment.
研究领域:
材料科学
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环境科学
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纳米技术
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DOI
高影响因子
Nanoscale
·
2025
·
IF 5.1
Hanye Xing,Xingyu Liu,Ju Wang,Tao Zhou,Xiangxiang Jin,Rui Qiu,Yang Lu,Changhong Liu,Yonghong Song
The effectiveness of orally delivered probiotics in treating gastrointestinal diseases is restricted by inadequate gut retention. In this study, we present a magnetically controlled strategy for probiotic delivery, which enables controlled accumulation and residence of probiotics in the intestine. The magnetically controlled probiotic is established by attaching amino-modified iron oxide (Fe3O4–NH3+ NPs) to polydopamine-coated Lacticaseibacillus rhamnosus GG (LGG@P) through electrostatic self-assembly and named as LGG@P@Fe3O4. In a simulated gastrointestinal environment, LGG@P@Fe3O4 maintains both structural stability and probiotic viability. Furthermore, the LGG@P@Fe3O4 clusters can be easily manipulated by an external magnetic field, inducing directional movement and aggregation. In vitro simulations demonstrated significant accumulation and retention of LGG@P@Fe3O4 under a magnetic field, with the optical density (OD) value of the suspension decreasing from ∼1.17 to ∼0.29. In contrast, the OD value of the suspension without a magnetic field remained at its original level (∼1.15). In a mouse model with intragastrically administered LGG@P@Fe3O4, the group exposed to a magnet exhibited stronger gut fluorescence after 24 h. The magnetically controlled probiotic delivery strategy offers an easy manufacturing and feasible method to enhance the effectiveness of probiotics in treating gastrointestinal diseases.
研究领域:
生物医学工程
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微生物学
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药物递送
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2023
·
IF 4.7
Ziwei Yang,Shaobo Jin,Chuanyu Zhang,Juan Ren,Weixuan Jing,Xueyong Wei
Using one microfluidic device integrating acoustic and magnetic control, we propose a novel preparation method of magnetic fluorescent polyacrylamide hydrogel microspheres and calcium alginate hydrogel microparticles in this paper. The effect of the two interdigital transducers in different position on the droplets generation is studied. By tuning the input parameters of the two focused interdigital transducers (FIDTs), the excited focused surface acoustic wave (FSAW) can induce the generation of magnetic droplets with different sizes flexibly. Then the prepared magnetic droplets are cross-linked after crossing the continuous phase into the laminar flow induced by magnetic force. This method can avoid the direct reaction between the dispersed phase and the continuous phase in the channel, and enable the synthesis of magnetic fluorescent polyacrylamide hydrogel microspheres and calcium alginate hydrogel microparticles more easy and simple.
研究领域:
生物材料学
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化学工程
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微纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）