Applied Sciences-Basel
·
2023
·Vol. 13
·期 20
·11593
·
IF 2.7
Bin Jiang,Xin Li,Bozhi Yang,Shujie Yang,Xinyi Chen,Junhong Chen,Minghao Fang,Zhaohui Huang,Xin Min,Xiaozhi Hu
The occurrence of fractures has emerged as one of the most prevalent injuries in the human body. In bone reconstruction surgery, after the implantation of porous hydroxyapatite materials, there is an initial infiltration of body fluids into the porous implant, followed by biomineralization-mediated apatite crystal formation and the subsequent ingrowth of bone cells. Despite extensive research efforts in this field, previous investigations have primarily focused on the formation of apatite crystals on exposed surfaces, with limited literature available regarding the formation of apatite crystals within the internal microstructures of bone implants. Herein, we demonstrate the occurrence of dynamic biomineralization within a three-dimensional porous hydroxyapatite/wollastonite (HA/WS) skeleton, leading to the abundant formation of nano-sized apatite crystals across diverse internal environments. Our findings reveal that these apatite nanocrystals demonstrate distinct rates of nucleation, packing densities, and crystal forms in comparison to those formed on the surface. Therefore, the objective of this study was to elucidate the temporal evolution of biomineralization processes by investigating the microstructures of nanocrystals on the internal surfaces of HA/WS three-dimensional porous materials at distinct stages of biomineralization and subsequently explore the biological activity exhibited by HA/WS when combined with cell investigation into apatite crystal biomineralization mechanisms at the nanoscale, aiming to comprehend natural bone formation processes and develop efficacious biomimetic implants for tissue engineering applications. The simultaneous examination of bone cell attachment and its interaction with ongoing internal nanocrystal formation will provide valuable insights for designing optimal scaffolds conducive to bone cell growth, which is imperative in tissue engineering endeavors.Keywords:hydroxyapatite;biomineralization;apatite crystal;bone tissue
研究领域:
生物材料学
·
组织工程学
✓ 已验证
产品关联
DOI
高影响因子
SURFACE & COATINGS TECHNOLOGY
·
2020
·
IF 3.784
Cong Wu,Yufei Tang,Bobo Mao,Kang Zhao,Siyue Cao,Zixiang Wu
Coatings with piezoelectric characteristics were prepared on the titanium alloy's surface to improve its biological properties, so that the titanium alloy possessed a piezoelectric effect similar to that of bones, thereby promoting bone growth and shortening bone repair time. Compared with other piezoelectric ceramic coatings , PVDF bio-piezoelectric coatings have better piezoelectric properties. However, the PVDF coating is hydrophobic, which is not conducive to calcium deposition. In this study, HA/PVDF coating was obtained on the titanium surface, which indicated a piezoelectric effect. The hydrophilicity of the coating has been improved with the increase of HA content. Corona poling gives the HA/PVDF coating piezoelectric characteristics, and also effectively reduces the contact angle. Moreover, the contact angle of the polarized HA/PVDF coating decreased by 66.9%. The synergistic effect of the introduction of HA and the high piezoelectric coefficient promotes the coating's mineralization. Surprisingly, the poled 20HA/PVDF coating surface was entirely covered by apatite after soaking in simulated body fluids (SBF) for 1 day with physiological loading. Additionally, the coating with rapid apatite deposition ability allows titanium alloy implants to obtain excellent biological activity, which has potential application value in the rapid repair of bone defects.
研究领域:
生物材料学
·
骨科医学
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Xueni Zhao,Guowen Shi,Linlin Ma,Jinxin Guan,Zhipeng Zhu
Carbon fiber (CF) is one of ideal reinforcements to hydroxyapatite (HA) owing to its unique structure, excellent biocompatibility and high mechanical properties. However, the mechanical property of CF reinforced HA (CF/HA) composites cannot be effectively improved due to the mismatch in surface properties and thermal expansion coefficients between CF and HA. In order to solve the problems, nano-hydroxyapatite (nHA) coating with different thickness was fabricated on the CF surface. The effect of the coating thickness on mechanical property of nHA-coated CF/HA composites was studied by finite element analysis. The CF with proper nHA coating thickness was subsequently used to reinforce HA. The compressive strength of nHA-coated CF/HA composites was approximately 97.3 % and 164.6 % higher than those of the uncoated CF/HA composites and pure HA ceramics, respectively. The interface properties and crack propagation were analyzed by cohesive element in the finite element analysis. The toughening mechanism of the composites included interfacial debonding, crack deflection, crack branching, and crack bridging. The mechanical properties of nHA-coated CF/HA composites were enhanced due to the strong interfacial bonding strength and reducing cracking in HA matrix. The prepared nHA-coated CF/HA composites satisfy the requirement of the mechanical properties of human load-bearing bone. It can be used to prepare cages, plates, screws, pins and other compact bone substitute parts in bone grafting. The study provided a method for construction of nHA-coated CF/HA composites with the designed properties by adjusting the nHA coating on the fiber and can be used to design other fibers reinforced ceramic matrix composites.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Qingguo Chen,Xiaofeng Zhao,Yuancheng Teng,Weipeng Wang,Hang Liu,Kuibao Zhang,Junjie Wen,Zhengjun Zhang
LnPO 4 ·nH 2 O rhabdophane/monazite is an important actinide-bearing material in the back end of the nuclear fuel cycle. In this work, using Nd 3+ to simulate trivalent actinides, Ce 0.5 Nd 0.5 PO 4 ·0.667H 2 O rhabdophane was synthesized by the wet-chemistry method in 90 °C and pH = 1 solution. The sintering behavior of associated Ce 0.5 Nd 0.5 PO 4 monazite ceramics was investigated by pressureless sintering and spark plasma sintering (SPS), along with appraising their chemical stability. The results reveal that Ce 3+ is successfully replaced by Nd 3+ in the rhabdophane lattice, and rhabdophane can transform to monazite with a temperature over 750 °C. SPS can compact the ceramic sample at a lower temperature compared to pressureless sintering even if the grain size is smaller. Adding a pre-sintering process of 900 °C before SPS and pressureless sintering will further improve the density and Vickers hardness of ceramics. For the chemical stability of Ce 0.5 Nd 0.5 PO 4 monazite ceramics, Ce is more likely to be leached compared to Nd, and the ceramics prepared by SPS with a pre-sintering process have the lowest normalized leaching rates, associated with the values of 2.03 × 10 −5 g·m −2· d −1 and 0.75 × 10 −5 g·m −2 ·d −1 for Ce and Nd, respectively.
研究领域:
材料科学
·
核燃料循环
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2022
·
IF 6.364
Xueni Zhao,Mingyue Liu,Pengfei Wang,Jinxin Guan,Xianxian Wang
An electrostatic splitting device was self-designed and manufactured for highly efficient preparation of multi-angle continuous carbon fibre (CF)-reinforced ceramic-based composites and was used to prepare multi-angle continuous CF and nano-hydroxyapatite (nHA)-coated CF reinforced HA composites with improved CF dispersion and content. The compressive strength of sintered [0°/90°] CF reinforced hydroxyapatite (CF/HA) composites is more than two and a half times that of hydroxyapatite and is superior to that of cortical bone (26.42–110.7%). Compared with hydroxyapatite, fracture toughness of [0°/0°], [0°/90°] and [− 45°/+ 45°] CF/HA composites increase by 28.83%, 66.32% and 115.95%, respectively. The strength and fracture toughness (30.2 MPa·m 1/2 ) of [− 45°/+ 45°] CF/HA bioceramics display synchronously improving. Micromechanical property and crack propagation process of the composites were simulated in depth. Based on optimised dispersion and arrangement of CF, the introduction of nHA coating enhances the mechanical properties of nHA-coated CF reinforced HA composites because nHA coating can block the generation and propagation of cracks.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Minerals
·
2022
·Vol. 12
·期 12
·1633
·
IF 2.818
Jingkun Zhang,Zhiyun Xiao,Hongbo Zhang
In the reverse flotation of fluorapatite and dolomite, high-efficiency depressors of fluorapatite have received considerable attention. In this paper, the depression mechanism of hydroxy ethylene diphosphonic acid (HEDP) was studied for the first time as a novel fluorapatite depressant on the surface of fluorapatite. The effect of HEDP on the flotation behavior of the two minerals was studied by single and mixed minerals in flotation tests. HEDP exhibited an excellent depression effect on fluorapatite flotation, whereas its adsorption on dolomite surface was minimal. Fluorapatite and dolomite were effectively separated by applying sodium oleate as a collector and HEDP as a depressant at pH 6.0. The depression mechanism of HEDP on fluorapatite was further analyzed via contact angle measurement, zeta potential and X-ray photoelectron spectroscopic (XPS) analysis. We found that HEDP seriously hindered the adsorption of sodium oleate (NaOL) on the fluorapatite surface and had a minimal effect on the dolomite surface. XPS analysis results indicate that the strong adsorption of HEDP on the fluorapatite surface can be attributed to the strong chelation between the electron-rich groups of HEDP and Ca ions on the fluorapatite surface. Therefore, HEDP is used as a selective depressant of fluorapatite in the fluorapatite–dolomite flotation–separation process.Keywords:HEDP;fluorapatite;flotation;depression mechanism
研究领域:
矿物加工工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Materials
·
2019
·Vol. 12
·期 11
·1769
·
IF 2.972
Wenchao Chi,Jiawei Zou,Fanrong Ai,Yanjun Lin,Wenchao Li,Chuanliang Cao,Kang Yang,Kui Zhou
Copper is an indispensable micronutrient in human health, which has important effects on the promotion of angiogenesis and thus contributes to bone formation and antimicrobial activity. We used ion exchange and pneumatic printing methods to prepare hydroxyapatite (HA) microspheres with different copper content. The microspheres were characterized by scanning electron microscope (SEM), X-ray diffractometry (XRD) and X-Ray photoelectron spectroscopy (XPS). Considering the resistance of hydroxyapatite to biodegradation in vivo, the degradation rate of microspheres in modified simulated body fluids was studied. In addition, cell proliferation and antibacterial experiments were carried out to study the biological properties of microspheres. HA-1.5MCu microbeads treated by 1.5 mol/L CuSO4curing solution have good performance on degradation, antibacterial properties and cell survival rate on day 7. The results showed that HA-1.5MCu microbeads may be used as a good repair material for bone defects.Keywords:hydroxyapatite;microbeads;copper;biological performance
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MINERALS ENGINEERING
·
2023
·
IF 4.8
Bingqiao Yang,Zhiwen Guan
Sodium polymer [(Naphthalene formaldehyde) sulfonate] (PNFS) was selected as an efficient dolomite depressant to upgrade phosphate ores in this work. The depression ability and selectivity were tested through micro-flotation and batch flotation, and the depression mechanism was revealed via Fourier transform infrared spectroscopy (FTIR), Zeta potential, adsorption capacity and X-ray photoelectron spectroscopy (XPS) measurement. Flotation tests proved that PNFS was able to depress dolomite effectively, but hardly influenced the flotation of apatite, which also exhibited high selectivity for raw head ores. FTIR, zeta potential, adsorption capacity and XPS results proved that -SO 3 - groups of PNFS complexed with Ca and Mg atoms on dolomite by means of single layer, while PNFS physically adsorbed on apatite surface in the form of multilayer. The pre-adsorbed PNFS could be replaced by NaOL for apatite, while it couldn’t be substituted by NaOL in the case of dolomite. PNFS had good prospective to be applied as an eco-friendly alternative for apatite depressant with good selectivity and low toxicity.
研究领域:
矿物加工工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2019
·
IF 2.442
Xiaojun Sun,Zhaoyang Li,Zhenduo Cui,Shuilin Wu,Shengli Zhu,Yanqin Liang,Xianjin Yang
In this study, an injectable dopamine-modified alginate hydrogel combined with nano-hydroxyapatite or strontium hydroxyapatite was cross-linked via the in situ slow release of divalent ions from the hydrolysis of D-glucono-δ-lactone (GDL). The cross-linking mechanism involved the chelation of an alginate with divalent ions and the hydrogen-bonding interaction between alginate and catechol groups. As the GDL concentration at 0.5% (w/v) regulated the release of the divalent ions, which enhanced the chelation effect, it was investigated, and inorganic nanoparticles were homogeneously distributed into the hydrogel system to improve the mechanical properties and stabilize the hydrogel network. Furthermore, the effects of dopamine on the improvement of the mechanical properties were investigated. Results demonstrated that the compressive strength of this injectable hydrogel is enhanced by 4.6 times compared with that of the hydrogel without the addition of GDL, and the compressive strength is enhanced by 4.0 times compared with that of the unmodified alginate hydrogel at strain values ranging from 10% to 50%. The hydrogels combined with strontium hydroxyapatite exhibited a more compact, suitable pore size, with a three-dimensional network structure, and the particle size was 50–100 μm; this range of values is considered as optimal for the growth of bone tissues. In addition, the gelation time can be adjusted from a few minutes to a few seconds by adjusting experiment variables. Our study provides a potential method for improving the mechanical properties of bone tissue engineering materials. 1HNMR, FTIR, and UV–vis spectroscopy measurements; XRD and SEM; and pH, ion release, and mechanical tests were carried out.
研究领域:
生物材料学
·
组织工程学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2023
·Vol. 15
·期 20
·4144
·
IF 5
Yisu Wang,Yan Wang,Shuai Qiu,Chongyang Wang,Hong Zhang,Jing Guo,Shengfa Wang,Huixia Ma
Chitosan/Hydroxyapatite composites, enriched with relatively active -NH2and -OH groups, have emerged as promising adsorbents for heavy metal removal. In this study, we harnessed the potential of CS/HAP composites by developing monolithic PLA@CS/HAP filters utilizing 3D printing and freeze-drying techniques. These filters possess both macroscopic and microscopic porous structures, endowing them with exceptional capabilities for removing heavy metals from water. The adsorption properties of CS/HAP composites were explored by varying the dosage, duration, and initial concentrations of copper ions. The maximum adsorption capacity for Cu2+was determined to be approximately 119+/−1 mg/g at the natural pH and 298 K. Notably, the monolithic PLA@CS/HAP filters demonstrated remarkable efficiency in the removal of copper ions, with 90% of copper ions effectively removed within a mere 2-h period in a cyclic adsorption experiment. Furthermore, the PLA@CS/HAP filters exhibited a robust dynamic Cu2+removal capacity (80.8% or even better in less than 35 min) in a dynamic adsorption experiment. Importantly, all materials employed in this study were environmentally friendly. In summary, the PLA@CS/HAP filter offers advantages such as ease of preparation, eco-friendliness, versatility, and broad applicability in diverse wastewater treatment scenarios, thereby presenting a significant potential for practical implementation.Keywords:chitosan;hydroxyapatite;3D printing;adsorption
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL PAPERS
·
2021
·Vol. 75
·期 5
·1949-1958
·
IF 2.097
Zou Heng,Cao Qin-bo,Liu Dian-wen,Chen Xiu-min,Jiao Yong
Abstract Improving the collecting ability of a collector is a crucial issue in phosphate flotation. In this work, ricinoleic acid (RA) was used as a collector for fluorapatite (FA, Ca 5 (PO 4 ) 3 F) flotation. There is an OH group in the middle of the RA molecule, and thus, hydrogen bonds (H-bonds) can be formed between RA species. The role of the H-bond between RA molecules in FA flotation was revealed by experimental and theoretical calculation methods. The flotation results suggested that RA was more efficient than oleic acid for FA flotation at pH 9. The RA − anion was chemisorbed onto the negative FA surface, forming calcium ricinoleate (Ca(RA) 2 ) precipitates. The crystallization of Ca(RA) 2 on the FA surface was aided by the H-bonds between RA species. On the other hand, the results of quantum chemistry calculations showed that the H-bond in Ca(RA) 2 resulted in the close packing of RA − anions. Such a packing structure may occur on the FA surface, which favors the formation of Ca(RA) 2 on the surface and FA flotation. Moreover, Ca(RA) 2 was more stable than calcium dioleate in solution, also contributing to the better flotation efficiency of RA. These theoretical calculation results clarified the beneficial effect of the H-bond between RA species on FA flotation at the atomic level. Graphic abstract
研究领域:
矿物加工工程
·
物理化学
✓ 已验证
DOI
高影响因子
Journal of Biomedical Nanotechnology
·
2016
·Vol. 12
·期 4
·602-618
·
IF 3.929
Deng Yi,Sun Yuhua,Bai Yanjie,Gao Xiang,Zhang Huan,Xu Anxiu,Huang Enyi,Deng Feng,Wei Shicheng
Enhancing the biocompatibility and osteogenic activity of nano-apatite for applications in bone graft substitutes and bone tissue engineering have been the current challenge in regeneration of lost bone. Inspired by mussels, here we have developed facile biomimetic approaches for preparation
of two types of peptide-conjugated apatite nanocompsoties assisted by polydopamine (pDA). We exploited polydopamine chemistry for the modification of nano-apatite crystals: polydopamine coated apatite (HA-c-pDA) and polydopamine template-mediated apatite (HA-t-pDA), on which bone forming peptide
was subsequently immobilized under weakly basic conditions to obtain peptide-conjugated apatite nanocomposites (HA-c-pep and HA-t-pep, respectively). TEM images revealed that HA-c-pDA displayed typically rod-like morphology, while HA-t-pDA was sponge-like structure where pDA sheets were decorated
by needle-like apatite crystals with low degree of crystallinity. In the cell culture experiments, HA-t-pep nanocomposite exhibited higher cell proliferation, spreading, and alkaline phosphatase activity as well as calcium nodule-formation, compared with pristine nano-HA and HA-c-pep nanocomposite.
We then implanted the peptide-decorated apatite into rabbit calvarial defects and analyzed bone formation after 2 months. The data revealed that HA-t-pep group exhibited remarkably enhanced bioactivity and bone formation in vivo. Based on these results, our biomimetic approach could
be a promising tool to develop peptide-conjugated apatites for bone regeneration. Meanwhile, the excellent biocompatibility and high osteogenesis of the peptide-conjugated apatite nanocomposite might confer its great potentials in bone repair, bone augmentation, as well as coating of biomedical
implants.
研究领域:
生物材料
·
组织工程
·
生物医学工程
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）