Journal of Aquatic Food Product Technology
·
2018
·
IF 0.682
Fa-Wen Yin,Da-Yong Zhou,Yan-Fei Liu,Qi Zhao,Zhong-Yuan Liu,Liang Song,Xin Zhou,Jian-Run Zhang,Bei-Wei Zhu
Krill oils (KOs) were extracted from Antarctic krill using ethanol, hexane, or their mixture (1:2, v/v) with yields of 21.32%, 8.50%, and 18.75%, respectively. The total nitrogen content of the aforementioned oils was 2.76%, 1.06%, and 1.87%, respectively, indicating the presence of lipoprotein. All KOs contained a high proportion of phospholipid (PL) (30.20–64.82% of total lipids) and polyunsaturated fatty acids (PUFA) (30.00–34.94% of total FAs). Among PL, phosphatidylcholine was dominant (89.81–90.60 mol %). In contrast, KO extracted with the mixed solvent had the highest amount of glycerophosphocholine species containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
研究领域:
生物化学
·
海洋生物学
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Zheng Zhou,Mingxuan Liu,Haoyu You,Boyu Su,Yuxing Wu,Shilin Zhang,Tao Sun,Chen Jiang
Considering that currently used anti-epileptic drugs (AEDs) in clinical practice can only suppress abnormal discharges without intervening in the inflammatory microenvironment, combining anti-inflammatory and antioxidant agents with AEDs is probably an effective approach to overcoming the limitations of AEDs. Additionally, damaged neurons and the blood-brain barrier (BBB) in epileptic foci require corresponding repair to minimize the risks of triggering new epileptogenic events. Unfortunately, there are hardly any effective strategies that integrate inflammatory microenvironment regulation with epileptogenic focus restoration. Therefore, based on the conductive polymer polypyrrole (ppy), a multiple-stimuli-responsive macrophage membrane-coated drug delivery system has been designed, co-loaded with inflammation-regulating drug fingolimod (FTY) and lesion-repairing drug citicoline sodium (CTC). This biomimetic system enables selective accumulation and release of drugs in epileptic foci, exerting broad effects on various cells and damage factors within lesions. By comprehensively managing various pathological events in epileptic lesions, it holds promise for fully regulating and repairing the epileptic focus microenvironment.
研究领域:
生物医学工程
·
神经科学
·
药剂学
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材料科学
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纳米技术
·
免疫学
✓ 已验证
产品关联
DOI
高影响因子
Nature Biomedical Engineering
·
2021
·Vol. 5
·期 10
·1189-1201
·
IF 25.671
Xie Renjian,Yao Hang,Mao Angelina S.,Zhu Ye,Qi Dawei,Jia Yongguang,Gao Meng,Chen Yunhua,Wang Lin,Wang Dong-An,Wang Kun,Liu Sa,Ren Li,Mao Chuanbin
The early stages of progressive degeneration of cartilage in articular joints are a hallmark of osteoarthritis. Healthy cartilage is lubricated by brush-like cartilage-binding nanofibres with a hyaluronan backbone and two key side chains (lubricin and lipid). Here, we show that hyaluronan backbones grafted with lubricin-like sulfonate-rich polymers or with lipid-like phosphocholine-rich polymers together enhance cartilage regeneration in a rat model of early osteoarthritis. These biomimetic brush-like nanofibres show a high affinity for cartilage proteins, form a lubrication layer on the cartilage surface and efficiently lubricate damaged human cartilage, lowering its friction coefficient to the low levels typical of native cartilage. Intra-articular injection of the two types of nanofibre into rats with surgically induced osteoarthritic joints led to cartilage regeneration and to the abrogation of osteoarthritis within 8 weeks. Biocompatible injectable lubricants that facilitate cartilage regeneration may offer a translational strategy for the treatment of early osteoarthritis.
研究领域:
生物医学工程
·
骨科
·
材料科学
·
再生医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 3
·2073-2088
·
IF 4.682
Lin Jingjing,Song Xingying,Yin Hang,Song Nijia,Wang Yanchao,Li Zhen,Luo Feng,Tan Hong,He Xueling,Li Jiehua
Regulating the immune microenvironment around the central neurons is a difficult problem. To address this critical matter, drug-loading scaffolds are promising ways of releasing drugs directly to the surrounding cells and ignoring the influence of blood–brain barrier and blood–medullary barrier. Microglia are fundamental innate immune sentinels in the central nervous system, usually activated during neuroinflammation. Citicoline (CDPC), a neuroprotective agent on secondary injuries, is used in clinical treatment of central nervous system diseases. To overcome low efficiency of CDPC uptake and improve immune microenvironment of CDPC in central nervous system (CNS), in this work, double local drug delivery systems, hybrid CDPC–liposome and CDPC blending directly waterborne polyurethane scaffolds, were prepared. It shows that CDPC–liposome composite scaffolds are more conducive to inhibit the inflammatory response of microglia and promote axon elongation, which presents a certain prospect in the field of nerve repair. Graphical abstract
研究领域:
神经科学
·
生物材料
·
药学
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2023
·Vol. 13
·期 38
·26630-26639
·
IF 3.9
Jian Liu,Changchun Wen,Miaomiao Hu,Juan Long,Jing Zhang,Minzhe Li,Xiang-Cheng Lin
Chemodynamic therapy (CDT) has received more and more attention as an emerging therapeutic strategy, especially transition metals with Fenton or Fenton-like activity have good effects in CDT research, manganese dioxide nanosheets (MnO2 NSs) and their complexes have become one of the most favored nanomaterials in CDT of tumors. CDT is mainly based on the role of reactive oxygen species (ROS) in tumor treatment, which have clear chemical properties and produce clear chemical reactions. However, their mechanism of interaction with cells has not been fully elucidated. Here, we performed CDT on mouse breast cancer cells (4T1) based on MnO2 NSs, extracted the metabolites from the 4T1 cells during the treatment, and analyzed the differences in metabolites by using high-resolution liquid chromatography-mass spectrometry (LC-MS). Untargeted metabolomics studies were conducted using the relevant data. This study mainly explored the changes in MnO2 NSs on the metabolite profile of 4T1 cells and their potential impact on tumor therapy, in order to determine the mechanism of action of MnO2 NSs in the treatment of breast cancer. The results of the study showed the presence of 11 different metabolites in MnO2 NSs CDT for 4T1 tumor cells, including phosphoserine, sphingine, phosphocholine, and stearoylcarnitine. These findings provide a deeper understanding of breast cancer treatment, and are beneficial for the further research and clinical application of CDT.
研究领域:
癌症研究
·
纳米技术
·
药理学
·
代谢组学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）