SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Cuilian Wei,Haowei Tu,Pengcheng Zhang,Jiafeng Ouyang,Liyong Yuan,Zijie Li,Nannan Wang,Yanqiu Zhu,Kang Liu,Lin Wang,Weiqun Shi
The construction of novel MXene-based composites with superb abilities through functionalization is an effective strategy to enhance the potential of this emerging inorganic lamellar material for environmental adsorption applications. The present work systematically investigated the adsorption performance of Ti 3 C 2 T x MXene modified with phosphate functional groups that facilitate the capture of uranyl ions. After introducing phosphate groups via a two-step modification of 3-aminopropyltriethoxysilane (APTES) and phytic acid (PA), the synthesized Ti 3 C 2 -APTES-PA is significantly superior to pristine Ti 3 C 2 T x nanosheets in terms of adsorption capacity, adsorption selectivity and reusability for uranium. The maximum uptake capacity of Ti 3 C 2 -APTES-PA at pH = 5 reaches 323 mg/g, which is 2.5 times higher than that of unmodified MXene. Furthermore, the large selectivity coefficient (S U/M > 16.2) declares that Ti 3 C 2 -APTES-PA preferentially adsorbs uranium among substantial competing ions. Ti 3 C 2 -APTES-PA also shows good cycling performance that its adsorption capacity remained 92.3 % after 6 cycles. When it comes to treating simulated uranium tailings pond leachate and radioactive wastewater from mines, high U(VI) removal rates of 88.9 % and 96.8 % can be achieved by our ternary composite at a dosage of 0.05 g/L. The underlying adsorption mechanism was unraveled by spectroscopic analysis to be the formation of coordination complexes of uranyl ions with phosphate groups on PA and hydroxyl groups on Ti 3 C 2 T x substrate, as well as the reduction of a small amount of adsorbed U(VI) to U(IV) by MXene. The overall results imply that Ti 3 C 2 -APTES-PA is an effective uranium chelating scavenger for the treatment of environmental radioactive wastewater.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2020
·
IF 4.032
Shi-Lin Zeng,Cheng-Yuan Xing,Li Chen,Long Xu,Bang-Jing Li,Sheng Zhang
Flexible polyurethane (PU) foam is one of the most versatile materials, which has a widely range of applications. However, flexible PU foam it is easily ignitable and highly flammable. This study developed a kind of post-modification method to prepare inherent FR PU foam, which use β-CD as chain extender and introduce FR additive through a facile esterification between phosphoric acid and β-CD moiety in PU foams. The morphology and elasticity of PU still maintained after the modification of PU. β-CDs, as a bio-resources, can not only act as polyol carbon sources to promote carbon formation, but also crosslinked with phosphate ester and PU matrix through P–O–C bonds to form compact carbon layer during the combustion. This dense carbon layer effectively isolates the heat source of the flame, resulting in great improvement of combustion resistance. The time to ignition for 15% CD-H 3 PO 4 -PUF foam reached 152 s, which was over 10 times longer than that of pure PU foams. And the foam immediately self-extinguished when the flame was removed. The THR of 15% CD-H 3 PO 4 -PUF foam decreased by 70.43% compared to that of neat PU foam. The significant delay of TTI and reduction of THR can reduce the hazards of flame spread greatly.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Yingqin Hou,Yaoyi Wang,Ruijue Wang,Weier Bao,Xiaobo Xi,Yunlong Sun,Shengtao Yang,Wei Wei,Hua Lu
To improve the therapeutic index of cisplatin (CDDP), we present here a new paradigm of drug-induced self-assembly by harnessing phosphato-platinum complexation. Specifically, we show that a phosphato-platinum cross-linked micelle (PpY/Pt) can be generated by using a block copolymer methoxy-poly(ethylene glycol)-block-poly(l-phosphotyrosine) (mPEG-b-PpY). Coating of PpY/Pt with a R9-iRGD peptide by simple mixing affords a targeting micelle with near neutral-charged surface (iPpY/Pt). The micelles feature in well-controlled sizes below 50 nm and high stability under physiological conditions, and can withstand various environmental stresses. Importantly, the micelles demonstrate on-demand drug release profiles in response to pathological cues such as high ATP concentration and acidic pH. In vitro, the micelles are efficiently internalized and almost equally potent compared to CDDP. Moreover, iPpY/Pt induce greater cytotoxicity than PpY/Pt in a 3D tumor spheroid model likely due to its deeper tumor penetration. In vivo, the micelles exhibit prolonged circulation half-lives, enhanced tumor accumulation, excellent tumor growth inhibition in a xenograft HeLa model and an orthotropic mammary 4T1 model, and improved safety profiles evidenced by the reduced nephrotoxicity. Together, this work demonstrates for the first time that phosphato-platinum complexation can be exploited for effective delivery of CDDP, and suggests a paradigm shift of constructing nanosystems for other anticancer metallodrugs.
研究领域:
药剂学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2019
·Vol. 323
·期 1
·641-649
·
IF 1.186
Kou Ying,Zhang Ling,Liu Bo,Zhu Lin,Duan Tao
Abstract In this work, a composite of phosphonate-functionalized MoS 2 supported on carbon cloth, MoS 2 -IP6 NRA/CC, was prepared by the hydrothermal method to effectively remove U(VI). Results showed that the saturated adsorption capacity of MoS 2 -IP6 NRA/CC for uranium was 183.3 mg g −1 . The adsorption process was in good agreement with Langmuir model and pseudo-second-order kinetics model. Besides, MoS 2 -IP6 NRA/CC showed good adsorption on uranyl ions under acidic conditions, and the material was recyclable, indicating that the material can be used as a potential radioactive nuclear processing material. Graphic abstract
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
Science Advances
·
2025
·Vol. 11
·期 6
·
IF 12.5
Feng Liu,Jianyu Dong,Ruofei Cheng,Shuang-Feng Yin,Lang Chen,Lebin Su,Renhua Qiu,Yongbo Zhou,Li-Biao Han,Chao-Jun Li
Reductive functionalization of aldehydes and ketones is one of the most challenging but ultimately rewarding areas in synthetic chemistry and related sciences. We report a simple and extremely versatile carbonyl reductive functionalization strategy achieving direct, highly selective, and efficient reductive amination, etherification, esterification, and phosphinylation reactions of (hetero)aryl aldehydes and ketones, which are extremely challenging or unattainable to achieve by traditional strategies, using only diphenylphosphine oxide and an inorganic base. It enables modular synthesis of functionally and structurally diverse tertiary amines, ethers, esters, phosphine oxides, etc., as well as related pesticides, drug intermediates, and pharmaceuticals. Compared to phosphorus-mediated name reactions, this strategy firstly transformed C═O bonds into C-element single bonds. Mechanistically, phosphinates are formed as intermediates, which undergo unconventional nucleophilic substitution at the C atom within their C─O─P unit. Thus, this work provides important strides in the field of reductive functionalization of aldehydes/ketones, phosphorus-mediated transformation, and various fundamental reactions.
研究领域:
有机化学
·
合成化学
✓ 已验证
DOI
PubMed
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2025
·Vol. 36
·期 1
·e70063
·
IF 3.4
Yawen Li,Guoyang Ma,Shaohong Xu,Zaheer Ahmad,Muhammad Ali,Saad Ahmed,Naveed Ahmed
In the present study, hexagonal boron nitride (h-BN) nanosheets were first functionalized with hydroxyl groups (h-BN-OH), and then phosphonic acid groups were grafted onto the h-BN surface (BNP) using aminotris(methylenephosphonic acid) (ATMP) through a condensation reaction. The BNP was then incorporated into a polyvinyl chloride (PVC) matrix to prepare PVC/BNP composites. Thermogravimetric analysis showed an increase in thermal stability, with BNP/PVC composites exhibiting greater resistance to degradation at elevated temperatures. The addition of BNP improved the dispersion and interfacial adhesion within the PVC matrix, as confirmed by Scanning Electron Microscopy (SEM). Furthermore, the PVC/BNP composites exhibited a 22.5% increase in tensile strength (21.2 MPa) and an 82% improvement in elongation at break (464%) compared to pristine PVC composites, which showed a tensile strength of 17.3 MPa and an elongation at break of 255%. Moreover, the addition of BNP notably improved the thermal conductivity from 0.18 to 1.50 W/m K as the BNP content increased from BNP-0 to BNP-4. These improvements in thermal stability and mechanical strength, as well as excellent migration resistance, make BNP/PVC composites highly promising for advanced applications.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2021
·
IF 10.588
Yao Tian,Lijia Liu,Fuqiu Ma,Xiying Zhu,Hongxing Dong,Chunhong Zhang,Fangbo Zhao
Uranium (U) is hazardous and radioactive, wastewater containing U(VI) should be treated before being discharged. Here, two novel uranium adsorbents, phosphorylated hyper-cross-linked bisphenol A (PHCP-1) and fluorene-9-bisphenol (PHCP-2) were separately synthesized via Friedel-Crafts reaction followed by phosphorylation using phosphorus oxychloride. PHCPs had a BET surface area (up to 564 m 2 /g) with pore sizes of 2.2–2.8 nm. These adsorbents were used for the first time for uranium adsorption from water and demonstrated outstanding adsorption performance. PHCP-2 had a great uranium adsorption capacity (297.14 mg/g) and a very fast sorption rate (85% removal rate within 5 min). The adsorption data were well fitted with Freundlich isotherm and the pseudo-second-order kinetic model. PHCPs displayed selective adsorption capacity for U(VI) from solution that including a variety of competing metal ions . The reusability was confirmed through three regeneration cycles. Based on a series of spectroscopic analyses, the mechanism of action between PHCPs and U(VI) is primarily derived from the complex between phosphate functional groups and U (VI). The sorption performance of PHCPs is attributed to their huge specific surface area and the strong complex between phosphate groups and U(VI). These findings suggest that PHCPs could be useful in the effective adsorption of uranium from water.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
·
2021
·
IF 9.127
Boyang Huang,Haiming Hua,Longqing Peng,Xin Wang,Xiu Shen,Ruiyang Li,Peng Zhang,Jinbao Zhao
In lithium-ion batteries (LIBs), benefiting from various functional components, functional separators can possess different capabilities to cope with the risks in complex application scenarios. In this work, a functional separator based on the phosphonate-modified nano-scale silica ceramic particles is fabricated to reduce the safety risks in LIBs. Through an anhydrous polymerization process, dimethyl vinylphosphonate (DMVP), a kind of widely used flame retardants , is grafted on silica (SiO 2 ). Then the modified SiO 2 (mSiO 2 ) is coated on the pristine polyethylene separator by a typical coating process . Combining the function of the ceramic and phosphonate , the modified ceramic separator displays substantially enhanced thermal stability, without visual thermal shrink up to 200 °C. The flame resistances of separator itself and pouch cells are also significantly improved, even though flammable electrolyte is added. Different from the case when the phosphonate is used as an additive in electrolyte, the phosphonate is fixed firmly on the separator and not easy to be embedded in carbon anode after battery cycles. The coin cells assembled with the modified separators are away from the irreversible loss of discharge capacity and low Coulombic efficiency for the first cycle, which can be attributed to the firm immobilization of organic phosphonate.
研究领域:
材料科学
·
能源存储技术
✓ 已验证
DOI
高影响因子
Catalysis Science & Technology
·
2023
·Vol. 13
·期 5
·1501-1511
·
IF 5
You Zi,Songrui Wei,Zhihui Huang,Jun Zhu,Yi Hu,Mengke Wang,Han Zhang,Weichun Huang
Organophosphorus compounds display excellent chemical and biological properties that the S–P(O) bonds afford utility in various fields. Herein, we report for the first time on the utilization of zero-dimensional (0D) monoelemental bismuth (Bi) quantum dots (QDs) as photocatalysts for direct dehydrogenative phosphonylation under visible light irradiation. A tiny amount of 0D Bi QDs (1.5 mol%) show high photocatalytic efficiency in the direct formation of S–P(O) between thiols and H–P(O) compounds under visible light with simple protocol, amenable gram-scale synthesis and good reusability. The mechanism study and density functional theory (DFT) calculation demonstrate the sulfide radial generated on the surface of 0D Bi QDs. The DFT study also indicates that the as-synthesized 0D Bi QDs exhibit suitable adsorption energy and sufficient charge transfer to effectively promote phosphonylation. We believe that such unique transformation can pave the way to more sustainable organic photocatalytic transformations based on high-efficiency QDs or QD-related nanocomposites.
研究领域:
材料科学
·
化学工程
·
光化学
·
催化
✓ 已验证
产品关联
DOI
高影响因子
ACS Catalysis
·
2025
·
IF 13.1
Chen Hsu,Hsin-Ya Tsai,Sheng-Dong Chen,Chi-Fon Chang,Nan-Wei Su
Dikinases function in multiple biological roles, including energy metabolism and antibiotic resistance, as shown by pyruvate phosphate dikinase and rifampin phosphotransferase. Despite their functional importance, the substrate scope and synthetic potential of dikinases remain elusive. Here, we identified a dikinase from Bacillus subtilis, namely phenolic phosphate synthetase (BsPPS), which regioselectively monophosphorylates a broad spectrum of polyphenols, including flavonoids, stilbenoids, curcuminoids, chalcones, anthraquinones, coumarins, and coumestans. BsPPS catalyzes ATP-dependent phosphorylation via a ping-pong mechanism, featuring autophosphorylation at His795 and the formation of a transient phosphohistidine intermediate. This enzyme defines a PPS-like protein family characterized by a conserved catalytic tetrad (Asp627, His629, His630, and His795) and a distinctive motif (DDHHFYIDAMLDAKAR) in the unprecedented substrate-binding domain. While most members of this family remain uncharacterized, the prevalence of PPS homologs in Bacillus spp. suggests a potential role in phenolic xenobiotic metabolism. Furthermore, PPS and its widespread homologs belong to a largely unexplored superfamily of phosphotransferases with diverse apparent functions and EC classifications. Although these enzymes share a conserved domain architecture, they display significant variation in their substrate-binding domains, indicating a vast unexplored biocatalytic toolbox. Our findings unveil a biocatalytic route for synthesizing diverse polyphenol monophosphates, opening avenues for phosphate prodrug development.
研究领域:
生物化学
·
酶学
·
结构生物学
·
生物催化
·
微生物学
·
分子生物学
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Microbiology
·
2021
·
IF 5.64
Huang Maoxi,Yan Yunlong,Wang Li,Chen Jun,Liu Tao,Xie Xin,Li Xiangyang
Amino-phosphonate derivative R-diphenyl-1-(4-methylbenzothiazole-2-amino)-1-(thiphene-2-yl)-methylphosphonate (Q-R) has a high protective anti-tobacco mosaic virus (TMV) activity. However, the mechanism responsible for Q-R’s effect on TMV infection is largely unknown. Here, we studied the expression levels of harpin-binding protein 1 (HrBP1) and pathogenesis-related protein-1a (PR-1a) in TMV-infected tobacco plants by using reverse transcription quantitative real-time PCR. Then, we verified the interactions between Q-R and the HrBP1 protein from Escherichia coli using isothermal titration calorimetry and studied the Q-R-associated assembly of HrBP1 using size-exclusion chromatography. The results showed that the expression levels of HrBP1 and PR-1a genes were significantly increased by Q-R at the transcriptional level in TMV-infected tobacco plants, and the E. coli-expressed HrBP1 protein was assembled into oligomers by Q-R via binding to HrBP1 with a dissociation constant of 1.19 μM. We, therefore, concluded that Q-R activated the HrBP1 and PR-1a genes and enhanced the ability of HrBP1 to assemble in tobacco plants.
研究领域:
植物病理学
·
分子生物学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2019
·
IF 7.149
Jian Zhou,Zhengshuang Yang,Qing Liu,Yiman Liu,Menglin Liu,Tiecheng Wang,Lingyan Zhu
As emerging alternatives of legacy perfluoroalkyl substances, perfluorophosphinates (PFPiAs) and perfluorophosphonates (PFPAs) are widely applied in industrial and agricultural fields and are supposed to be large partitioned to soil and highly persistent. It is of particular interest to understand their transfer from roots to shoots and transformation in plants, such as wheat. The results of hydroponic experiments indicated that C6/C6 PFPiA, C8/C8 PFPiA, perfluorooctanophosphonic acid (PFOPA), and perfluorohexaphosphonic acid (PFHxPA) were quickly adsorbed on the epidermis of wheat root (Triticum aestivum L.), which was driven by their hydrophobicity. A small fraction of the accumulated PFPiAs and PFPAs in the wheat root was subjected to absorption via an active process dependent on H+-ATPase. PFHxPA, which has the smallest molecular weight and medium hydrophilicity (log Kow < 4), displayed the strongest absorption efficiency via the water and anion channels and had the highest translocation potential from roots to shoots in wheat. C6/C6 and C8/C8 PFPiAs experienced phase I metabolism in wheat, although at a low rate, to form more persistent PFHxPA and PFOPA, respectively, as well as 1H-perfluorohexane (1H-PFHx) and 1H-perfluorooctane (1H-PFO), which were regulated by cytochrome P450 in wheat root. As a result, exposure to PFPiAs in roots ultimately caused the accumulation of more persistent PFPAs in the above-ground parts of plants, raising concerns on their potential risks on human health.
研究领域:
环境科学
·
植物生理学
·
毒理学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）