Biomaterials Advances
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2026
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IF 6.7
Xiaomei Xia,Jianbo Wu,Vladimir Levchenko,Baoe Li,Ziyang Liu,Chunyong Liang
A novel Janus bilayer scaffold is designed for simultaneous prevention of cerebrospinal fluid leakage and bone regeneration in skull base defects. • It consists of two layers: a simvastatin-loaded chitosan-hydroxyapatite porous layer for bone growth and a polycaprolactone electrospun barrier for sealing. • In vitro tests show the osteogenic layer promotes mineralization, increases alkaline phosphatase activity, and exhibits good hemostatic properties. • In vivo studies confirm enhanced bone formation in mice and effective leakage prevention in rabbits. To address the critical scientific challenge of achieving synergistic repair of cerebrospinal fluid leakage prevention and bone regeneration in skull base defects, an innovative Janus-type bilayer scaffold with dual functions of “leakage prevention and osteogenesis” was designed and fabricated by electrospun and freeze-drying technology. The scaffold consists of a simvastatin-loaded chitosan-hydroxyapatite porous scaffold (CS-HA-SIM) as the osteogenic layer, and a polycaprolactone (PCL) electrospun fiber membrane as the watertight barrier, forming a structurally and functionally integrated three-dimensional repair system. In vitro studies demonstrate that the osteogenic layer exhibits excellent hemostatic capability, significantly promotes the deposition of calcium phosphate minerals, and markedly upregulates the expression of alkaline phosphatase (ALP) in osteoblasts. Meanwhile, in vitro leakage prevention experiments demonstrate that the PCL membrane can effectively prevent cerebrospinal fluid leakage under intracranial pressure. In vivo experiments also confirm that the scaffold system significantly enhances new bone formation in a mouse calvarial defect model and demonstrates reliable anti-leakage performance in a rabbit cerebrospinal fluid leakage model. This novel bilayer scaffold, combining biological functionality and clinical applicability, provides an innovative solution for the regenerative repair of skull base defects and holds significant potential for clinical translation. Download: Download high-res image (338KB) Download: Download full-size image
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EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
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2026
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IF 5
Jianmin Chen,Wanhui Wu,Baozhu Feng,Meilian Ning,Ziyan Cai,Qiulong Zhang,Liyang Du,Yunhua Gao
SPFX-SLNs were systematically optimized using BBD-RSM for infected wounds. • Optimized SLNs showed uniform spherical morphology with a size of ∼87 nm. • SPFX-SLNs exhibited 2-fold higher antibacterial potency than the free drug. • MNs enabled efficient skin penetration for targeted SLNs delivery. • Optimized MNs achieved a 98.61% wound closure rate by Day 14. The efficient management of infected skin wounds is severely limited by the thick bacterial biofilm within the lesion, the intractable stratum corneum barrier of the perilesional skin, and the high toxicities of potent antibiotics. Sparfloxacin (SPFX) was withdrawn from the market due to its severe systemic side effects and UV-induced phototoxicity, while its severe hydrophobicity causes localized crystalline cytotoxicity upon topical application. To safely rejuvenate this potent drug, an integrated transdermal system combining photoshielding, SPFX-loaded solid lipid nanoparticles (SPFX-SLNs) with dissolving microneedles (MNs) was developed. This study primarily focuses on the systematic screening, formulation development, and optimization of SPFX-SLNs via Box-Behnken Design-Response Surface Methodology (BBD-RSM). The optimized nanocarriers exhibited a uniform size (86.85 ± 1.89 nm) and a two-fold higher antibacterial potency against Escherichia coli ( E. coli ) than free SPFX. Mechanistically, the solid lipid core locked SPFX in a safe amorphous state to preclude crystal-induced irritation, while functioning as a physical photoshield against UV activation. By depositing the nanomedicine exclusively into infected dermis, the MN platform minimized systemic drug exposure. In a rat model of E. coli -infected biofilm wounds, the formulated SPFX-SLNs MNs achieved over 50% (58.44%) wound closure within 3 days and near-complete re-epithelialization by day 11, and a 98.61% final closure rate by day 14. Ultimately, this work establishes a comprehensive formulation development strategy for a safety-enhanced, biofilm-penetrable nanomedicine-MN hybrid that successfully repurposes a clinically restricted antibiotic for advanced wound regeneration. Download: Download high-res image (242KB) Download: Download full-size image
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高影响因子
APPLIED SURFACE SCIENCE
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2026
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IF 6.6
Xuyang Qin,Wenqiang Xu,Ning Wang,Peng Chen,Huanyu Zhu,Mildred Quintana,Hongqiang Li,Shaoxian Song
A magnetic Zr-MOF@Fe 3 O 4 material for rapid phosphorus removal was developed. • A maximum phosphate uptake of 141.0 mg P g −1 was achieved. • Phosphate adsorption mainly involved ion exchange and inner-sphere coordination. • DFT calculation elucidated the orbital hybridization between Zr and O atoms. Environmental remediation of phosphorus-containing wastewater is crucial for ecological protection and sustainable resource development. However, existing adsorbents generally suffer from slow phosphate uptake kinetics, limited adsorption capacity and difficult solid-liquid separation. Here, a magnetic Fe 3 O 4 -modified zirconium-based metal–organic framework (Zr–MOF@Fe 3 O 4 ) was synthesized via a simplified hydrothermal process for highly selective phosphate adsorption. Outperforming most reported adsorbents, Zr–MOF@Fe 3 O 4 –1.0 with the porous framework and abundant active sites significantly enhanced phosphate adsorption kinetics, achieving an adsorption rate of 173.3 mg P g –1 h −1 within 0.5 h and a maximum adsorption capacity of 141.0 mg g −1 . Experimental results and density functional theory calculations indicated that the efficient phosphate capture was primarily attributed to synergistic effects of electrostatic adsorption, ion exchange with surface hydroxyl groups, and inner-sphere complexation via Zr–O–P bonds. Excellent anti-anion interference performance, coupled with robust cycling stability and rapid magnetic separation, collectively highlight the application potential of Zr–MOF@Fe 3 O 4 for phosphate removal from complex wastewaters. Download: Download high-res image (225KB) Download: Download full-size image
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ADVANCED MATERIALS
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2026
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IF 29.1
Ziyu Shao,Zhihui Dong,Zijian Xu,Zeye Wang,Mingrui Wu,Nifang Zhao,Meng Li,Weiwei Gao,Hao Bai
Fatigue failure remains a critical challenge for soft materials used in biomedical implants and soft robotics. Existing strategies, including stiff reinforcement and microstructural alignment, can suppress crack growth but often introduce anisotropy and poor resistance to multidirectional loading. In addition, a persistent orders-of-magnitude disparity remains between fracture toughness and fatigue threshold of synthetic soft materials. Here, the fish bladder of silver carp, characterized by a multilayered hierarchical fibrous architecture, is shown to exhibit extraordinary isotropic fatigue resistance (∼6000 J·m − 2 ) approaching its fracture toughness. This behavior originates from a “compliance for resistance” mechanism that couples dynamic fiber straightening and rotation, sacrificial bond breakage and reassociation, and layer-specific fiber reorientation with the resulting interfacial sliding to dissipate energy under cyclic loading. Guided by these principles, a biohybrid hydrogel is designed to reproduce this multiscale anti-fatigue mechanism, achieving a high fatigue threshold (>3000 J·m − 2 ) together with robust antifouling performance. These results uncover fundamental design principles of fatigue-resistant biological soft tissues and provide a general strategy for engineering durable soft materials.
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International Journal of Analytical Chemistry
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2026
·Vol. 2026
·期 1
·3877339
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IF 2.8
Feifei Liu,Jing Li,Wenna Jiang,Jing Pang,Shuo An,Yue Shi,Li Ren
Human epidermal growth factor receptor 2 (HER2) is a critical biomarker for targeted therapy of gastric cancer. Tissue-based HER2 testing via immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) remains the clinical gold standard, while serum HER2 represents a potential complementary circulating biomarker for disease monitoring. However, conventional serum HER2 assays often suffer from limited sensitivity. Herein, we develop a highly sensitive fluorescence assay for serum HER2 detection using nonlinear hybridization chain reaction (NHCR) coupled with a HER2-specific aptamer (HB5). Unlike linear hybridization chain reaction (HCR), NHCR enables branching-mediated exponential amplification, in which each trigger initiates multiple independent HCR cascades, leading to nonlinear signal growth. The method exhibited a good linear relationship ( R 2 = 0.993) in the HER2 concentration range of 0.5–90 ng·mL −1 , with a detection limit as low as 38 pg·mL −1 . The sensor demonstrated excellent specificity for HER2, good reproducibility, and reliable stability. Clinical serum sample detection results indicated that the method was highly correlated with the clinically commonly used chemiluminescence immunoassay (CLIA), with spiked recoveries ranging from 95.4% to 109.6%. The NHCR-based fluorescent detection strategy established in this study provides a new tool for accurate and noninvasive detection of serum HER2, featuring simple operation and controllable cost.
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Food Bioscience
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2026
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IF 6.2
Lei Dong,Yongmin Wu,Hao Wang,Qingqing Xiao,Zexin Zhao,Jun Cai
Crayfish shell protein is an abundant but underutilized resource for developing peptide-based prebiotics to support gut health. However, systematic evidence linking protease selection to peptide structure and subsequent probiotic responses remains limited. This study evaluated five hydrolysis treatments (papain, trypsin, pepsin, alkaline protease, and neutral protease) to identify structure–function determinants for promoting Bifidobacterium animalis subsp. lactis 3296. Papain and trypsin hydrolysates (CSPe-P and CSPe-T) achieved moderate hydrolysis (16.87–22.24% and 17.14–20.39%), balanced molecular weights (7409–7445 Da), semicrystalline organization (48.12–50.60%), and relatively high β-turn and random-coil proportions. These hydrolysates also contained higher total amino acid contents (610.39–625.34 mg/g) and were enriched in Glu, Asp, Arg, and Lys. Functionally, CSPe-P and CSPe-T increased Bifidobacterium animalis subsp. lactis 3296 with final OD 600 values of approximately 1.8–1.9 and maximum specific growth rates at 12 h of 5.14 h −1 and 4.83 h −1 compared with 4.00 h −1 in control. At 12 h, viable counts in the fructooligosaccharides (FOS), CSPe-P, and CSPe-T reached 59.94–64.19 × 10 8 CFU/mL, whereas the control reached 50.0 × 10 8 CFU/mL. CSPe-P and CSPe-T performed comparably to commercial FOS in this in vitro growth assay. In contrast, alkaline and pepsin hydrolysates presented disordered structures and inferior probiotic promotion. Overall, this study provides preliminary in vitro evidence that structure-guided enzyme selection can identify crayfish shell peptides with probiotic-supporting potential.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Yinuo Liu,Zhengyuan Dai,Ying Wang,Shanshan Fu,Xiaoyu Yang,Jingcui Huang,Li Li,Yaping Ding
Ratiometric probe (blue/yellow CDs) offers visual color change and improved accuracy. • Molecularly imprinted polymers provide high selectivity against food interferents. • Smartphone with Color Picker App enables on-site visual quantitative detection. • Successfully applied to milk and ice cream with recoveries of 95.6–104.2%. A ratiometric fluorescence sensor (B-CDs@MIPs/Y-CDs) based on blue/yellow dual-emission carbon dots and molecularly imprinted polymers was constructed for visual detection of vanillin. The addition of vanillin resulted in selective quenching of the blue fluorescence of B-CDs at 438 nm via static quenching, whereas the yellow emission at 542 nm stayed constant, leading to a progressive color shift from blue to green and ultimately to yellow. Under optimized conditions, the linear range was 2.0–120.0 μM with a detection limit of 0.22 μM. Recoveries from spiked milk and ice cream samples ranged from 95.6% to 104.2% (RSD < 1.77%). Combined with a smartphone using the Color Picker App for RGB analysis, rapid visual detection was achieved. This method is low-cost, easy to operate, and sensitive, showing great potential for food safety monitoring. Download: Download high-res image (125KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Zhimo Fang,Zhou Zhou,Xiaomeng Li,Dongyang Li,Bin Hu,Haoyu Wang,Lin Zhang,Qin Dai,Kai Li,Yao Kong,Shiguan Yang,Qiang Lu
Superexchange-mediated dual-acceptor sites enable spatial charge separation. • Synergistic single-atom and vacancy engineering creates multifunctional sites. • Cu SA -TO-O V delivered excellent corresponding turnover frequencies of 177.52 h −1 . • The photo-Fenton system exhibited wide pH adaptability and anti-interference. Synchronously and efficiently utilizing photogenerated electrons and holes remains a significant challenge in Fenton-like reaction. Herein, the Cu single-atom (Cu SA ) and oxygen vacancy (O V ) co-modified TiO 2 nanoflake-like catalyst is successfully synthesized. O V modulate the electronic coupling interaction, which is proposed to trigger superexchange -mediated electron transfer from Cu 3 d x 2 − y 2 to Ti 3 d xy via O 2 p y orbitals. Specifically, Cu SA serves as the hole-accepting site for 1 O 2 generation, while O V and Ti 3+ functions as the electron-accepting site for •OH production and contaminant adsorption. The substrate enrichment effect and the free radical/non-radical coupling interaction significantly enhances photo-Fenton catalytic performance, achieving superior sulfanilamide removal efficiency across a broad pH range (3–11) and a high turnover frequency of of 177.52 h −1 . This work not only highlights the potential of active site engineering in designing photo-Fenton catalysts but also advances the development of efficient and sustainable water purification solutions.
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Chem
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2026
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IF 19.1
Shuxia Liu,Jixian Hu,Jiarui Liu,Zijie Lin,Shuo Wang,Hao Sun,Yinghe Zhao,Qing Li,Tanyuan Wang
Developing a Cu-free electrocatalytic system for CO 2 reduction toward a multi-carbon product remains challenging due to the limited understanding of C–C coupling. Herein, an Ag/Cr 2 O 3 heterostructure is reported to achieve selective ethanol electrosynthesis from CO 2 with anions to modulate the electrocatalytic interfaces. The performance of Ag/Cr 2 O 3 follows the trend of ClO 4 − > NO 3 − > NO 2 − > HCO 3 − /HPO 4 2− /SO 4 2− for different anions, which is similar to the tendency of Hofmeister anions to disrupt water’s structure. Notably, Ag/Cr 2 O 3 exhibits a faradaic efficiency (FE) ethanol of 51.8% with a stable response at ∼160 mA cm −2 in a flow cell containing ClO 4 − . In situ characterizations and theoretical calculations demonstrate that ClO 4 − reduces the number of interfacial hydrogen bonds, thus inhibiting hydrogen evolution. While the Ag-Cr asymmetric sites stabilize the C–C coupling intermediates and favor the ethanol pathway over ethylene, this enables selective ethanol generation. This work extends the approach for multi-carbon generation from CO 2 .
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MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Jiahui Liu,Xiaorui He,Yue Wang
One-step MXene/CNTs-COOH/CS/IL sensing interface was constructed. • CNTs-COOH alleviated MXene restacking and promoted electron transport. • CS and ionic liquid enhanced metal-ion enrichment and ionic transport. • The sensor simultaneously determined Cd 2+ , Pb 2+ , Cu 2+ , and Hg 2+ . • Real-water results agreed well with ICP-MS measurements. Rationally coordinating ion accessibility, electron transport, metal-ion enrichment, and film stability within a facile electrode architecture remains challenging for multiplex electrochemical analysis. Herein, an MXene-based multicomponent sensing interface was constructed through the one-step integration of carboxylated carbon nanotubes (CNTs-COOH), chitosan (CS), and an ionic liquid (IL) with Ti 3 C 2 T x nanosheets. CNTs-COOH act as conductive nano-spacers that alleviate MXene restacking and improve electronic connectivity, while CS provides coordination-active amino and hydroxyl groups for metal-ion enrichment and contributes to film stability. The incorporation of IL improves component dispersion and ionic transport and partially mitigates the interfacial transport limitation associated with the CS-containing layer. Structural and electrochemical characterization results collectively support complementary roles of the four components in regulating interfacial accessibility, analyte accumulation, and charge-transfer behavior. Under the optimized conditions, the resulting electrode enabled the simultaneous determination of Cd 2+ , Pb 2+ , Cu 2+ , and Hg 2+ by differential pulse anodic stripping voltammetry over linear ranges of 0.5–22.5, 0.5–60, 0.5–87, and 0.5–62 μM, respectively. The corresponding detection limits were 0.1539, 0.0746, 0.2279, and 0.0931 μM. The sensor also exhibited satisfactory selectivity, reproducibility, and long-term stability, retaining approximately 92–95% of its initial response after 30 days. Recoveries of 92.2–96.0% were obtained in spiked tap-water and river-water samples, and the measured concentrations were consistent with those obtained by ICP-MS. These results demonstrate a functionally coordinated interface-engineering strategy for the simultaneous electrochemical determination of multiple heavy metal ions. Download: Download high-res image (139KB) Download: Download full-size image
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MEASUREMENT
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2026
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IF 6.1
Yang Liu,Changyuan Xu,Yuqin Zhu,Jianxin He,Quanhua Xie,Yuanyuan He,Lei Wu,Dong Lai,Fei Fu,Qiongyao He,Bowen Jing,Guoqing Zhang,Nianbing Zhong
Moss-induced biocorrosion of stone heritage is a slow yet persistent deterioration process that alters the physicochemical conditions within porous stones, leading to structural damage and loss of cultural value. To conduct in-situ decoding of the pathogenic mechanism of mosses on sandstone, we developed a fiber Bragg grating (FBG)–based multi-parameter sensing system. The sensing system integrates three types of FBGs—temperature-sensing (T-FBG), strain-sensing (S-FBG), and polyacrylic acid–polyvinyl alcohol (PAA-PVA) coated pH-sensing FBG (H-FBG). The sensitivities and resolutions of T-FBG, S-FBG and H-FBG are 9.69 pm/℃ (0.01 ℃), 1.23 pm/με (0.1 με) and 38.63 pm/pH (0.02 pH units), respectively. A decoupling model based on a 3 × 3 sensitivity matrix was established to eliminate cross-sensitivity effects. During 60 days of Funaria hygrometrica colonization, the system captured dynamic variations including a maximal pH decrease of 0.5, a temperature fluctuation of 3.2 ℃, and an internal microstrain increase of 11.3 με. Microscopic and porosity analyses further confirmed the dual biochemical–mechanical degradation caused by metabolite secretion and rhizoid penetration. This work provides quantitative insights into moss-induced biocorrosion mechanisms and indicates the feasibility of optical fiber sensing as an early-warning strategy for preventive conservation of stone relics.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Huanhuan Liu,Xiaolei Fan,Jingyan Huang,ZiXu Wang,Runli Li,Ruoyu Li,Bo Yang,Yan Wang
Dentin hypersensitivity is a globally oral dilemma arising from the exposure of dentinal tubules (DTs), which elicits discomfort upon external stimulation. Due to the complex dentin structure and oral environment, developing a multifunctional repair strategy that combines dentin remineralization, antibacterial properties, and DT occlusion remains highly challenging. Herein, we propose a biomimetic remineralization approach utilizing glycosaminoglycan chondroitin sulfate (CS) to mimic the bioactivity of proteoglycans (GAGs) for modifying collagen fibrils, in conjunction with a zwitterionic poly(carboxybetaine acrylamide) (PCBAA) to stabilize amorphous calcium phosphate (ACP), CS modification not only increases the negative charge density on the collagen but also provides additional nucleation sites, facilitating the binding of calcium phosphate precursors and thereby promoting collagen mineralization. Both in vitro and in vivo experiments demonstrate that the CS-based biomimetic mineralization strategy achieves dense occlusion of DTs and effective remineralization of demineralized dentin. The remineralized dentin exhibits significant antibacterial activity against cariogenic bacteria (e.g., Streptococcus mutans and Lactobacillus acidophilus ), and its mechanical properties can be restored to level comparable to that of sound dentin. Thus, this strategy integrates three key functions, dentin matrix remineralization, effective tubular occlusion, and antibacterial surface modification, offering substantial clinical potential for the effective treatment of dentin hypersensitivity.
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