JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Tao Ai,Mingling Yu,Yicheng Dai,Ruipu Yao,Ling N. Jin,Yuanyuan Yu,Xinbin Qiu,Peixin Huang,Xifen Zhu,Jianteng Sun,Lizhong Zhu
This study investigates the uptake, biotransformation, and phytotoxicity of sulfadiazine (SDZ) and its acetyl derivative N4-acetylsulfadiazine (NASDZ) in rice. Results showed that rice was more tolerant to NASDZ, with lower malondialdehyde and reactive oxygen species levels but higher antioxidant enzyme activities (SOD, POD, and CAT). The maximum accumulations of SDZ in roots and shoots were 19.3 ± 1.0 and 3.6 ± 1.1 μg/g, while NASDZ were 18.6 ± 2.5 and 3.5 ± 1.4 μg/g, respectively. SDZ exposure generated more metabolic intermediates, including deamination, hydroxylation, glycosylation, acetylation, and formylation products, while NASDZ metabolism was documented for the first time. Key genes involved in biotransformation include cytochrome P450, acetyltransferase, glycosyltransferases, and methyltransferase. Density functional theory calculations showed structural differences affecting reactive sites and intermediates. SDZ disrupted lipid metabolism, while NASDZ altered carbohydrate and amino acid pathways, highlighting their selective effects on rice metabolism. Our data help understand sulfonamide biotransformation and phytotoxicity in rice.
研究领域:
环境科学
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植物生理学
·
毒理学
✓ 已验证
DOI
PubMed
高影响因子
Polymers
·
2018
·Vol. 10
·期 2
·190
·
IF 2.935
Sa Liu,Chunting Zhong,Weiwei Wang,Yongguang Jia,Lin Wang,Li Ren
As a drug carrier, polyrotaxane (PR) has been used for targeted delivery and sustained release of drugs, whereas silver sulfadiazine (SD-Ag) is an emerging antibiotic agent. PR was synthesized by the use of α-cyclodextrin (CD) and poly(ethylene glycol) (PEG), and a specific antibacterial material (PR-(SD-Ag)) was then prepared by loading SD-Ag onto PR with different mass ratios. The loading capacity and the encapsulation efficiency were 90% at a mass ratio of 1:1 of PR and SD-Ag. SD-Ag was released stably and slowly within 6 d in vitro, and its cumulative release reached more than 85%. The mechanism of PR loading SD-Ag might be that SD-Ag attached to the edge of α-CD through hydrogen bonding. PR-(SD-Ag) showed a higher light stability than SD-Ag and held excellent antibacterial properties againstEscherichia coli(E. coli) andStaphylococcus aureus(S. aureus).Keywords:polyrotaxane;silver sulfadiazine;mechanism;antibacterial
研究领域:
药学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2014
·
IF 4.058
Xiaoli Zou,Tao Zhou,Juan Mao,Xiaohui Wu
In this study, a novel ultrasound-enhanced heterogeneous Fe 0 /persulfate (US/Fe 0 /PS) system was developed and investigated for the degradation of an antibiotic sulfadiazine (SD). It was demonstrated that the US/Fe 0 /PS system could achieve a significant synergy in the degradation efficiency of SD, as compared to its corresponding comparative systems. The SD degradation in the US/Fe 0 /PS system could be applied by the pseudo-first-order kinetic with a k obs (SD) value of 3.4 ± 0.20 h −1 . Affecting factors such as initial pH, dosage ratio of [Fe 0 ]:[PS], US input power and reaction temperature were further studied. SD could be effectively degraded with a relatively low PS dosage at a broad pH range of 3–7. Simultaneous evolution of soluble iron species and PS was evaluated in three comparative systems (US/Fe 0 , Fe 0 /PS and US/Fe 0 /PS) during the reaction. It could be concluded that the promotional role of US would be dual in the US/Fe 0 /PS system, i.e. enhancement in the heterogeneous iron corrosion reactions and acceleration in the bulk radical reactions. Identification of the degradation intermediates indicated that sulfate radical (SO 4 − ) oxidation was the main SD degradation pathway. Attacking of the amine group in the benzene ring would be its first step, followed by cleavage of C–N bonds in the heterocyclic ring. Another degradation pathway, i.e. direct cleavage of the S–N bond should be also present.
研究领域:
环境科学
·
化学工程
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产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2015
·
IF 7.435
Tao Zhou,Xiaoli Zou,Juan Mao,Xiaohui Wu
Effective decomposition of antibiotic sulfadiazine (SD) in a Fe 0 -catalyzed sonochemical Fenton like system (Sono-FL) was demonstrated. By using the response surface methodology (RSM), an optimized experimental condition of pH 7.00, 0.94 mM Fe 0 , 1.90 mM persulfate (PS) and 20 W ultrasound (US) power was concluded, which could reach the predicted SD degradation efficiency of 90%. Afterwards, effects of wastewater matrix (five inorganic anions and two chelating agents) on the SD degradation were investigated in the system, respectively. It was found that the SD degradation could be inhibited by SO 4 2− , NO 3 − , HCO 3 − /CO 3 2− and H 2 PO 4 − to different extents. Cl − would lead to an enhancement with a low dosage (5 mM), but an inhibition with a high dosage (100 mM). Unexpectedly, chlorinated organic intermediates were also found as SD decomposed. Appropriate dosages of oxalic acid (OxA) or EDTA could benefit the SD degradation in the Sono-FL system, while excessive chelating agents would play as competitive pollutants. It was summarized that inorganic anions would mainly react with SO 4 − and/or OH to form sub-radicals of less oxidative potential. OxA and EDTA would not only participate in complexing dissolution of Fe 0 but also provide additional oxidants such as H 2 O 2 and [Fe IV O] 2+ , through the electron transfer reactions caused by the iron-ligands species.
研究领域:
环境科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Environmental Science and Technology
·
2023
·Vol. 20
·期 11
·11865-11876
·
IF 3.1
Xin X.,Liu H.,Sun J.,Gao K.,Jia R.
The composite material based on N- , S- , and Fe-doped TiO 2 (NSFe-TiO 2 ) synthesized by wet impregnation was used as a photocatalyst to rapidly degrade sulfadiazine. The photocatalytic degradation behavior and mechanism of sulfadiazine on NSFe-TiO 2 were investigated for revealing the role of degradation under ultraviolet light. The results showed that compared with TiO 2 , NSFe-TiO 2 markedly improved the efficiency in photocatalytic degradation of sulfadiazine: more than 90% of sulfadiazine could be removed within 120 min by NSFe-TiO 2 dosage of 20 mg L −1 . The process conformed to first-order reaction kinetics model. The parameters such as loaded amount of NSFe-TiO 2 , solution pH value, humic acid concentration and recycle numbers on removal efficiency were also studied. Compared to neutral and alkaline conditions, acidic condition was not conducive to the photocatalysis. HA, Ca 2+ , Cu 2+ and Zn 2+ in the actual water body had mild inhibition on sulfadiazine degradation in UV/NSFe-TiO 2 system. Fragments screened by high-resolution mass spectrometry were conducted to explore the oxidation mechanism and pathways of sulfadiazine degradation. On the whole, UV/NSFe-TiO 2 photocatalysis has a good effect on sulfadiazine removal.
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
Biosensors-Basel
·
2023
·Vol. 13
·期 6
·613
·
IF 5.4
Xiaoling Zheng,Lulan Yang,Qi Sun,Lei Zhang,Tao Le
The monitoring of sulfadiazine (SDZ) is of great significance for food safety, environmental protection, and human health. In this study, a fluorescent aptasensor based on MnO2and FAM-labeled SDZ aptamer (FAM-SDZ30-1) was developed for the sensitive and selective detection of SDZ in food and environmental samples. MnO2nanosheets adsorbed rapidly to the aptamer through its electrostatic interaction with the base, providing the basis for an ultrasensitive SDZ detection. Molecular dynamics was used to explain the combination of SMZ1S and SMZ. This fluorescent aptasensor exhibited high sensitivity and selectivity with a limit of detection of 3.25 ng/mL and a linear range of 5–40 ng/mL. The recoveries ranged from 87.19% to 109.26% and the coefficients of variation ranged from 3.13% to 13.14%. In addition, the results of the aptasensor showed an excellent correlation with high-performance liquid chromatography (HPLC). Therefore, this aptasensor based on MnO2is a potentially useful methodology for highly sensitive and selective detection of SDZ in foods and environments.Keywords:aptamer;MnO2;aptasensor;sulfadiazine
研究领域:
食品安全检测
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环境科学
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生物化学
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产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2015
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IF 3.088
Ping Li,Longlong Wu,Binjie Li,Yanbao Zhao,Peng Qu
Highly water-dispersible silver sulfadiazine (SSD) was prepared by liquid phase method with polyvinyl pyrrolidone (PVP) as a surface modification agent. The structure and morphology of the PVP-modified silver sulfadiazine (P-SSD) were investigated by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and Fourier-transform infrared (FT-IR) spectrometry. The produced particles are ginkgo leaf-like architecture with the sizes of micron-nanometer. Due to hydrophilic PVP decorated on the surface, the P-SSD has excellent dispersion in water over a period of 24 h, which is obviously stable by comparison to that of the commercial silver sulfadiazine (C-SSD). In addition, the P-SSD exhibits good antibacterial activities against Escherichia coli ( E. coli ), Pseudomonas aeruginosa ( P. aeruginosa ) and Staphylococcus aureus ( S. aureus ).
研究领域:
材料科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Environmental Research and Public Health
·
2022
·Vol. 19
·期 24
·16945
·
IF 4.614
Yang Liu,Jianlei Chen,Haiyan Hu,Keming Qu,Zhengguo Cui
As the concept of green development spreads worldwide, environmental protection awareness for production and life has been continuously strengthened. Antibiotic residues in aquaculture wastewaters aggravate environmental pollution and threaten human health. Therefore, the detection of residual antibiotics in wastewater is crucial. In this paper, a new, simple, and low-cost method based on the glassy carbon electrode electrochemical sensor for the detection of sulfadiazine in aquaculture wastewater was developed without using complex materials to modify the electrode surface, to detect sulfadiazine which electrochemically oxidizes directly. The electrochemical performance of the sensor was studied and optimized with differential pulse voltammetry and cyclic voltammetry in the three-electrode system. The optimal electrolyte was acetic acid-sodium acetate buffer, and the optimal pH was 4.0. Finally, based on the optimized conditions, the newly established method showed satisfactory results for detecting sulfadiazine in aquaculture wastewater. The concentration of sulfadiazine and the peak current intensity showed a linear relationship in the range of 20 to 300 μmol/L, and the limit of detection was 6.14 μmol/L, the recovery rate of standard addition was 87–95%, with satisfactory reproducibility and low interference.Keywords:antibiotics;sulfadiazine;electrochemical sensors;aquaculture;wastewater
研究领域:
环境科学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Cheng Chen,Li Liu,Yuxin Li,Wei Li,Lixiang Zhou,Yeqing Lan,Ying Li
CuCo 2 O 4 was synthesized via the calcination of a copper-cobalt bimetallic oxalate precursor and was used as a heterogeneous catalyst of peroxymonosulfate (PMS) for the degradation of sulfamethazine (SMZ). The results demonstrated that the CuCo 2 O 4 had higher catalytic activity than the monometallic CuO and Co 3 O 4 . The degradation efficiency of SMZ (50 mg/L) by PMS (1 mmol/L) activated with CuCo 2 O 4 (0.1 g/L) was above 98% within 30 min at initial pH 5. Electron paramagnetic resonance (EPR) and radical quenching experiments proved that both sulfate radicals (SO 4 − ) and singlet oxygen ( 1 O 2 ) were responsible for the efficient removal of SMZ, especially 1 O 2 . The superoxide radicals (O 2 − ) produced from the reaction improved the generation of SO 4 − and 1 O 2 . Cyclic voltammograms (CV), electrochemical impedance spectroscopy (EIS) and hydrogen temperature- programmed reduction (H 2 -TPR) investigations revealed that the synergy of Cu and Co species in PMS activation resulted from higher electroconductibility, more electron transfer, and better redox potential of the CuCo 2 O 4 . The synergy between the Co(III)/Co(II) and the Cu(II)/Cu(I) couples enhanced the turnover frequency (TOF) of CuCo 2 O 4 . The possible degradation pathways are further proposed according to the identification of the SMZ degradation products and the theoretical calculations of the frontier electron densities (FEDs) of the SMZ molecule.
研究领域:
环境科学
·
催化化学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Dongmei Ma,Yang Yang,Bingfeng Liu,Guojun Xie,Chuan Chen,Nanqi Ren,Defeng Xing
Zero-valent iron and biochar composite (ZVI/BC) is a prospective catalyst for activating persulfate and specific surface area (SSA) of ZVI/BC is one of the most important factors affecting its efficacy in the removal of environmental contaminants. However, the green fabrication of ZVI/BC with large SSA remains a challenge. In this study, ZVI/BC with a highly porous structure and large SSA fabricated by co-pyrolysis of K 2 FeO 4 and bamboo was prepared and characterized. The large SSA stemmed from the catalytic and corrosive functions of K and the oxidation of K 2 FeO 4 onto bamboo. ZVI/BC fabricated with 0.05 mol/L K 2 FeO 4 (BC-Fe 0.05 ) showed optimal sulfadiazine (SDZ) removal performance in the peroxydisulfate (PDS) activation system with complete removal after 10 min, as it showed the highest adsorptive ability of SDZ. Moreover, BC-Fe 0.05 was able to remain stable after four cycles or 80 days of storage. Higher temperature, lower pH, and Cl − were beneficial to SDZ removal efficiency, whereas CO 3 2– and HPO 4 2− had inhibitory effects. Non-radical species ( 1 O 2 ) and radical species (SO 4 − , OH, and O 2 − ) both contributed to SDZ degradation, and 1 O 2 was the most important reactive oxygen species. Four degradation pathways were proposed based on ten identified intermediates. Potential eco-toxicity analysis by ECOSAR suggested that most intermediates were less toxic than their parent compound. Overall, this study describes a green fabrication method for ZVI/BC with large SSA using K 2 FeO 4 as the iron precursor. Generally, ZVI/BC with large SSA is an effective catalyst for activating persulfate to degrade antibiotics.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Environmental Research
·
2022
·Vol. 17
·期 1
·1-18
·
IF 3.229
Huang Wen,Tang Yaxin,Zhang Xueping,Chen Jiao,Lu Yixin,Luo Jinqi,Zhang Jianqiang
Biochar could be used as a green and efficient carbon-based material for activation of PMS to degrade antibiotics. In this study, different carbon structured bio-chars were prepared from sheep manure by varying the pyrolysis method and conditions. The biochar was characterized by Brunauer–Emmett–Teller, electron microscopy scanning, elemental analysis and N 2 adsorption–desorption isotherms to establish the conformational relationships between different carbon structures and the degradation of sulfadiazine (SDZ) by activated PMS. The results showed that the pyrolysis temperature accelerates the generation of biochar pore structures, the nitrogen atmosphere facilitates the generation of mesoporous structures, and the appropriate residence time effectively reduces the polarity and enhances the aromaticity of the biochar. When the dosages of G600-1.0 h and PMS were 0.6 and 0.5 g·L −1 , respectively, 10 mg·L −1 of SDZ could be completely removed within 50 min and still had good activation efficiency after 3 cycle tests. The results of the radical quenching test, electron paramagnetic resonance analysis and X-ray photoelectron spectroscopy indicated that the defective structure on the surface of G600-1.0 h activates the radical pathway of PMS (SO 4 ·− , ·OH and O 2 ·− ), while the C=O group and graphitic nitrogen promote the production of the non-radical pathway ( 1 O 2 ). In the degradation of SDZ, the radical pathway was dominated by the production of SO 4 ·− . In summary, a new biochar-based PMS activator was designed and prepared by optimizing the pyrolysis conditions, with a view to providing new technological support for a green, efficient and low-cost treatment method for antibiotic wastewater, as well as a new option for the resource utilization of manure sources. Graphical Abstract
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2018
·
IF 6.434
Feilong Dong,Cong Li,John Crittenden,Tuqiao Zhang,Qiufeng Lin,Guilin He,Weiqiu Zhang,Jinming Luo
Sulfadiazine (SDZ) has been frequently detected in surface waters in recent years. We evaluated the kinetics, mechanisms, intermediate products and bacterial community structure that result from the reaction of SDZ with free chlorine (HOCl/OCl − ). We examined this in a pilot-scale water distribution system. Neutral pH had the fastest rate of destruction of SDZ. A second-order reaction constant for the destruction of SDZ by chlorine increased with increasing concentration of free chlorine (FC). For different pipe materials, the rate of SDZ degradation decreased as follows: stainless steel (SS) pipe > polyethylene (PE) pipe > ductile iron (DI) pipe. Based on the less complex bacterial diversity and more chlorine-resistant by 16S ribosomal ribonucleic acid (rRNA) gene analysis, SS pipe and PE pipe were more suitable in SDZ degradation in water distribution system (WDS) than DI pipe. In addition, the transformation products from SDZ chlorination were identified by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry, and the products included SO 2 extrusion products, haloacetic acids and trihalomethanes. Toxicity tests further confirmed that the toxicity of SDZ chlorination was higher both in low FC (0.7 mg/L) and high FC (1.3 mg/L) in WDS.
研究领域:
环境工程
·
水处理
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）