ANALYTICA CHIMICA ACTA
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2026
·
IF 6
Jian-Ming Liu,Jian Liu,Tian-Tian Ma,Cheng-Xiong Yang
Background Microporous organic networks (MONs) are an emerging class of porous materials characterized by extremely large surface area, tunable topology, and superior stabilities, which have received increasing attention in sample pretreatment. However, their superhydrophobic nature has largely limited their application scope. The synthesis of functionalized MONs has proved to be a feasible strategy to broaden their utility. Nevertheless, this approach remains constrained by the limited variety and availability of functionalized monomers. Therefore, developing novel post-synthetic modification strategies is crucial for expanding the functionality and applications of MONs, particularly in trace analyte enrichment. Results Herein, we present a novel post-esterification strategy to synthesize a new carboxyl groups enriched magnetic MON (MMON-2COOH) for the highly efficient magnetic solid-phase extraction (MSPE) of four quaternary ammonium alkaloids (QAAs) from complex urine samples. The resulting MMON-2COOH not only retains the porous structure, excellent solvent and thermal stability, and rapid magnetic responsiveness of its precursor (hydroxyl-functionalized magnetic MON) but also incorporates conjugated networks and abundant carboxyl groups. This enables efficient extraction of QAAs through multiple interactions, including π-π stacking, hydrogen bonding, and electrostatic attraction. After optimization of extraction factors, an analytical method integrating MMON-2COOH-based extraction with HPLC-UV detection was established, achieving sensitive and selective determination of QAAs with low limits of detection of 0.05–0.5 μg L −1 and limits of quantification of 0.5–1.0 μg L −1 , wide linear range of 0.5–1000 μg L −1 , negligible matrix effect of 0.88–1.09, rapid extraction of 2 min, and less adsorbent consumption of 2 mg. Significance This is the first example of post-esterification preparation of carboxyl groups functionalized MON. The results demonstrate that MMON-2COOH is a highly effective adsorbent, and the developed method is suitable for accurate determination of QAAs in biological samples. This work highlights the significant potential of post-esterification as a versatile approach for designing high-performance adsorbents in sample pretreatment.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2026
·
IF 4.8
Siting Zhou,Shuyi Qin,Qin Zhang,Baizhen Yuan,Yan Pang,Jiali Liang,Jinqiu Yang,Hai-Bo Liu,Jing Wang
The increasing environmental contamination by tetracycline antibiotics (TCs) necessitates efficient detection and removal strategies. This study presents the development of a bifunctional material, Eu-NU-1000, which integrates ratiometric fluorescence detection and high-capacity adsorption of TCs. The material is constructed by doping europium ions (Eu 3+ ) into the zirconium-based metal-organic framework (MOF) NU-1000, offering a dual-channel fluorescence response for selective TCs detection and enhanced adsorption performance. Eu-NU-1000 enables highly sensitive and selective detection of TCs through ratiometric fluorescence at 617 and 472 nm, the detection mechanism was based on antenna effect and photoinduced electron transfer, with a low limit of detection (LOD): 22.14 nM for tetracycline and 11.83 nM for oxytetracycline. Furthermore, the material exhibits a high adsorption capacity of 440.6 mg·g −1 for tetracycline, surpassing several existing MOF-based adsorbents. The study also investigates the adsorption mechanisms, including electrostatic interactions, coordination chelation, and π-π stacking, which collectively contribute to the exceptional tetracyclin removal efficiency of Eu-NU-1000. The material maintains over 80% adsorption efficiency after five regeneration cycles, highlighting its reusability and practical applicability in environmental remediation.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Huiting Feng,Yuxin Yang,Ruiling Li,Yuting Yang,Zongwen Wang,FengFu Fu,Yue Lin
A variety of sulfonamides (SAs) are extensively utilized in animal husbandry and aquaculture, necessitating the development of high-throughput methods for the rapid screening and accurate determination of multiple, ideally all commonly-applied SAs, in animal-derived foodstuffs. We herein developed a paper-based colorimetric aptasensor for the detection of eight different SAs employing a mixture of two broad-specific aptamers as bio-receptor, ascorbic acid (AA)-mediated gold nanobipyramids (AuNBPs) growth for generating color signals, and a paper-based analytical device (PAD) for stabilizing and enhancing color signals. The aptasensor exhibits target SAs concentration-corresponding multiple color changes and has excellent specificity. It can be used to visually screen eight SAs (either individually or collectively) with a visual detection limit (LOD) of 4.0 μM, and quantitatively detect these SAs (either individually or collectively) with a spectrometry LOD of 0.2 μM. Importantly, the signals of the aptasensor can be stably stored for one month for later verification, and the spectrometry LOD is lower than the maximum residue limit (MRL) of total SAs in animal-derived foodstuffs. The aptasensor was successfully applied to detect eight SAs (either individually or collectively) in milk samples with a recovery of 89% - 95% and a relative standard deviation (RSD, n = 5) < 8%. The results obtained with the aptasensor were consistent with those obtained using commercial ELISA kit. These findings demonstrated that the aptasensor simultaneously meets the requirement of instrument-free screening and quantitative determination of eight SAs in animal-derived foods, making it a promising approach for ensuring the consumption safety of animal-derived foodstuffs.
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Frontiers in Nutrition
·
2022
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IF 6.59
Tang Jiaming,Zheng Xiaoling,Jiang Shuang,Cao Mingdong,Wang Sixian,Zhou Zhaoyang,Nie Xunqing,Fang Yu,Le Tao
Herein, we developed a dual fluorescent aptasensor based on mesoporous silica to simultaneously detect sulfadimethoxine (SDM) and oxytetracycline (OTC) in animal-derived foods. We immobilized two types of aptamers modified with FAM and CY5 on the silica surface by base complementary pairing reaction with the cDNA modified with a carboxyl group and finally formed the aptasensor detection platform. Under optimal conditions, the detection range of the aptasensor for SDM and OTC was 3–150 ng/mL (R2 = 0.9831) and 5–220 ng/mL (R2 = 0.9884), respectively. The limits of detection for SDM and OTC were 2.2 and 1.23 ng/mL, respectively. The limits of quantification for SDM and OTC were 7.3 and 4.1 ng/mL, respectively. Additionally, the aptasensor was used to analyze spiked samples. The average recovery rates ranged from 91.75 to 114.65% for SDM and 89.66 to 108.94% for OTC, and all coefficients of variation were below 15%. Finally, the performance and practicability of our aptasensor were confirmed by HPLC, demonstrating good consistency. In summary, this study was the first to use the mesoporous silica-mediated fluorescence aptasensor for simultaneous detection of SDM and OTC, offering a new possibility to analyze other antibiotics, biotoxins, and biomolecules.
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CHEMICAL PAPERS
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2022
·Vol. 77
·期 3
·1423-1432
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IF 2.146
Li Gang,Wu Ming-Huo,Liu Yan,Hu Yu-Feng
A facile fluorescent probe (FFP) based on single-excitation/dual-emission detection system for the simultaneous sensing of fluoroquinolones (FQs) and copper was prepared via sol–gel polymerization using graphene carbon dots (GCDs) and CdTe quantum dots (CdTe QDs) as fluorescent units. FQs were detected by GCDs fluorescence enhancement, and copper (II) [Cu(II)] was detected by fluorescence quenching of the CdTe QDs in the FFP. If only one FQ co-existed with Cu(II), simultaneous quantitative analysis could be performed. The norfloxacin (NOR) was used as an example to investigate the working conditions of FFP. Under optimal conditions, the FFP could linearly recognize NOR with its concentration over the range 0–50 µM, with a detection limit of 1.6 nM. Meantime, the FFP could linearly detect the concentration of copper over the range of 0–10 µM, with a detection limit of 48.4 nM. NOR and Cu(II) were then detected simultaneously in tap water, drinking water, seawater, and milk with good recoveries. When multiple FQs co-existed with Cu(II), the FFP could discriminate among four different FQs via linear discriminant analysis. Therefore, this facile fluorescent probe can be used for simultaneous detection of various types of compounds in liquid samples.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2022
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IF 9.136
Yawen Wang,Jingwen Huang,He Guo,Chendong Puyang,Jiangang Han,Yan Li,Yunxia Ruan
The present study focused on pulse dielectric barrier discharge (DBD) plasma activated persulfate (PS) for sulfamethoxazole (SMZ) degradation in water. The results showed that PS addition could enhance removal efficiency of SMZ in pulse DBD plasma system. The highest removal efficiency, kinetic constant and energy efficiency reached 93.4%, 0.084 min −1 and 0.353 g/kWh respectively with the PS dosage of 40:1 and input power of 85 W. With increase of imput power and pulse frequency, the removal efficiency of SMZ was also increased. The removal efficiency was firstly enhanced and then declined as raising duty cycle and liquid flow rate. SMZ degradation was promoted in alkaline solution conditions. Active species including ·OH, e - , ·O 2 – , 1 O 2 and ·SO- 4 play a certain role in the degradation of SMZ. The decline of O 3 and enhancement of ·OH and H 2 O 2 were found after PS addition. In process of SMZ degradation, the overall conductivity increased but pH decreased. PS addition accelerated the removal of COD and TOC. The degradation process was explored by UV–Vis spectra, three-dimensional fluorescence and LC-MS. Three degradation pathways were deduced based on the indentified intermediates. SMZ degradation in the system was considered as a toxicity-attenuation process. The water matrix including Cl - , HCO 3 – , SO 4 2- and HA have some impact on SMZ degradation. This study presented that pulse DBD plasma could activate PS efficiently, which finally improved pollutant removal efficiency and energy utilization.
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Journal of Environmental Sciences
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2022
·
IF 6.796
Jie Du,Zhijun An,Yufeng Hu,Xianliang Yi,Hao Zhou,Jingjing Zhan,Minghuo Wu
Sulfonamides (SAs) are one of the most widely used antibiotics and their residuals in the environment could cause some negative environmental issues . Advanced oxidation such as Fenton-like reaction has been widely applied in the treatment of SAs polluted water. Degradation rates of 95%-99.7% were achieved in this work for the tested 8 SAs, including sulfisomidine, sulfameter (SME), phthalylsulfathiazole, sulfamethoxypyridazine, sulfamonomethoxine, sulfisoxazole, sulfachloropyridazine, and sulfadimethoxine, in the Fe 3 O 4 /peroxodisulfate (PDS) oxidation system after the optimization of PDS concentration and pH. Meanwhile, it was found that a lot of unknown oxidation products were formed, which brought up the uncertainty of health risks to the environment, and the identification of these unknown products was critical. Therefore, SME was selected as the model compound, from which the oxidation products were never elucidated, to identify these intermediates/products. With liquid chromatography-high resolution tandem mass spectrometry (LC-HRMS/MS), 10 new products were identified, in which 2-amino-5-methoxypyrimidine (AMP) was confirmed by its standard. The investigation of the oxidation process of SME indicated that most of the products were not stable and the degradation pathways were very complicated as multiple reactions, such as oxidation of the amino group, SO 2 extrusion, and potential cross-reaction occurred simultaneously. Though most of the products were not verified due to the lack of standards, our results could be helpful in the evaluation of the treatment performance of SAs containing wastewater.
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JOURNAL OF HAZARDOUS MATERIALS
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2019
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IF 7.65
Yang Wang,Xueyan Liu,Lei Zhang
The excessive accumulation of sulfonamides (SAs) drugs makes it imperative to develop novel materials for boosting simultaneously efficient removal and precise monitoring of multiple SAs. Herein, three-dimensional hollow flower-like Ni@nitrogen-doped graphitic carbon (3DHFNi@NGC) was designed/fabricated via a facile one-pot hydrothermal route and subsequent pyrolysis. The resultant 3DHFNi@NGC exhibits a unique 3D hollow hierarchical architecture assembled by a layer-by-layer interlacing of corrugated nanosheets subunits, thereby affording numerous interconnected channels, available internal/external surfaces as well as suitable interior cavities. By virtue of its special architecture and in-situ generated N-doped graphitic carbon along with good magnetism, the 3DHFNi@NGC demonstrates superior sorption performance towards SAs, accompanied by high total saturated adsorption capacity, fast sorption rate and easy magnetic recycling. It is noteworthy that as-constructed 3DHFNi@NGC also exhibits high-sensitive/simultaneous detection of trace multiple SAs combined high performance liquid chromatography (HPLC), together with a low detection limit (0.035–0.071 ng mL -1 ) and a broad linear range (0.2–100 ng mL -1 ) as well as high enrichment factors (252 < EFs < 291). These indicate that the smart 3DHFNi@NGC could be a promising candidate for the synchronous remediation and sensitive detection of multiple SAs in aqueous systems, presenting a viable option for sewage treatment and water quality monitoring.
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Journal of Environmental Sciences
·
2022
·
IF 6.796
Ligui Wu,Mingyu Wang,Lingling Rong,Wenbiao Wang,Linwei Chen,Qiaofeng Wu,Haoyu Sun,Xiangfeng Huang,Xiaoming Zou
Antibiotic resistance genes (ARGs) can be easily promoted by antibiotics, however, the structural effects of antibiotics on the proliferation of ARGs dynamic and the associated mechanisms remain obscure in, especially, activated sludge sequencing batch reactors. In the present study, the effects of 9 sulfonamides (SAs) with different structures on the proliferation dynamic of sulfonamide resistance genes ( Sul s) in the activated sludge sequencing batch reactors and the corresponding mechanisms were determined (30 days), and the results showed that the largest proliferation value (∆ A R ) of Sul s dynamic for SAs (sulfachloropyridazine) was approximately 2.9 times than that of the smallest one (sulfadiazine). The proliferation of Suls was significantly related to the structural features ( minHBint6, SssNH, SHBd and SpMax2_Bhm ) that represent the biological activity of SAs. To interpret the phenomenon, a mechanistic model was developed and the results indicated that the biodegradation of SAs ( T 1/2 ) rather than conjugative transfer frequency or mutation frequency tends to be the key process for affecting Sul s proliferation. T 1/2 was proved to be dependent on the interactions between SAs and receptors ( E binding ), the cleavage mode (bond dissociation energy), and the site of nucleophilic assault. Besides, the metagenomic analysis showed that SAs posed significant effect on antibiotic resistome and Tnp31 played a vital role in the proliferation of Suls . Overall, our findings provide important insight into a theoretical basis for understanding the structural effects of SAs on the proliferation of ARGs in SBR systems.
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JOURNAL OF CHROMATOGRAPHY A
·
2023
·
IF 4.1
Jiana Lin,Zenghui Xie,Yuling Hu,Gongke Li,Qisheng Zhong
Supramolecular macrocycle-based covalent organic frameworks (COFs) are promising adsorbents for adsorption of hazards due to their host-guest recognition property. However, most supramolecular macrocycles are conformationally flexible, making them challenging to introduce into COFs. In this work, a calix[6]arene-based COF (CX6-BD COF) was fabricated with a unique flower-like morphology and high crystallinity. Especially, the cavity of CX6 exhibited host-guest inclusion interaction for sulfonamides (SAs), which was verified by quantum chemistry calculation. The integration of the porosity of COFs with the recognition cavity of CX6 made CX6-BD COF display excellent enrichment performance for SAs, with good enrichment factors (EFs) between 77 and 96. The material was employed as an adsorbent for COF membrane filter extraction, coupled with ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) to simultaneously enrich and determine seven SAs in animal-derived food. The analytical method showed a wide linear range (0.01–100 µg/L and 0.05–100 µg/L) and low detection limits (3–10 ng/L). The established method was successfully applied to sensitively determine SAs in chicken, pork and beef samples, which achieved satisfactory recoveries (73.8–113%). These results demonstrated CX6-BD COF has good application potential in determination of trace and ultra-trace SAs in complex food matrices as an adsorbent.
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Chemosensors
·
2023
·Vol. 11
·期 7
·386
·
IF 4.2
Meiling Ping,Wenchao Lv,Chen Yang,Qian Chen,Zongwen Wang,Fengfu Fu
It is crucial that simple and high-throughput methods for determining multiple, or groups of, sulfonamides (SAs) be developed since they are widely used in animal husbandry and aquaculture. We developed a paper-based multicolor colorimetric aptasensor to detect 3 SAs: sulfaquinoxaline (SQ), sulfamethoxypyridazine (SMP) and sulfamethoxydiazine (SMD). Using a broad-specificity aptamer as a bioreceptor, we reduced the growth of nicotinamide adenine dinucleotide I (NADH)–ascorbic acid (AA)-mediated gold nanobipyramids (AuNBPs) to generate a multicolor signal. We also used a paper-based analytical device (PAD) system to deposit AuNBPs for a sensitive color signal read out. The aptasensor can detect more color changes corresponding to the concentrations of SQ, SMP and SMD and has higher sensitivity, better specificity and stability. It can also be used to determine SQ, SMP and SDM individually, or collectively, or any two together with a visual detection limit of 0.3–1.0 µM, a spectrometry quantification limit (LOQ) of 0.3–0.5 µM and a spectrometry detection limits (LOD) of 0.09–0.15 µM. The aptasensor was successfully used to determine SQ, SMP and SDM in fish muscle with a recovery of 89–94% and a RSDn= 5) < 8%, making it a promising method for the rapid screening of total SQ, SMP and SDM residue in seafood.Keywords:aptasensor;antibiotics residue;seafood;sulfonamides;visual detection
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ACS Omega
·
2023
·
IF 4.1
Jing Wang,Yong Zhang,Fubin Liu,Ying Liu,Litao Wang,Guihua Gao
A multifunctional cylindrical hybrid foam column, referred to as the chitosan/cyclodextrin/MIL-68(Al) (CS/CD/MIL-68(Al)) foam column, was prepared for the first time. The prepared foam column could be used for the adsorption/removal of hydrophilic and hydrophobic contaminants by different forms. Here, it was placed in hydrophilic dye solutions to investigate the adsorption behavior of methylene blue and trypan blue. The adsorption process followed the pseudo-second-order kinetic model with R2 ranging from 0.9983 to 0.9998 for methylene blue and from 0.9993 to 1.0000 for trypan blue, and the adsorption process was consistent with the Langmuir isothermal model with R2 greater than 0.96. The RL values for methylene blue and trypan blue were 0.8871 and 0.5366, respectively, which were present between 0 and 1, indicating that the adsorption behaviors of the two dyes onto the CS/CD/MIL-68(Al) foam column were favorable. The maximum adsorption capacities (Qm) of methylene blue and trypan blue were 60.61 and 454.55 mg/g at 298 K, respectively. Also, the CS/CD/MIL-68(Al) foam column was spun into a syringe and used to adsorb trace hydrophobic sulfonamides from water in the form of filtration. The porous structure impeded the need for any external force and equipment, allowing the water sample to pass through the foam column smoothly. The conditions of the CS/CD/MIL-68(Al) foam column were optimized. The adsorption was carried out under the condition of pH = 4, the amount of the adsorbent was two foam columns, and no salt was added. It was found that the removal rate of the CS/CD/MIL-68(Al) foam column for six sulfonamides was 100%, and it could be reused at least five times. Therefore, this CS/CD/MIL-68(Al) foam column had a simple preparation method, offered a flexible and diverse form of use, was nonpolluting, biodegradable, and reusable, and could have a wider application in the field of environmental pollutant removal and adsorption.
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