JOURNAL OF PHYSICS D-APPLIED PHYSICS
·
2025
·Vol. 58
·期 13
·135207
·
IF 3.2
Liu Jinren,Wang Xiangni,Cui Yixin,Xu Guimin,Lu Jiajia,He Zhirou,Xu Yulin,Li Rongrong,Gao Lingge,Wang Hong,Gao Junhong,Wu Xili,Shi Xingmin,Zhang Guanjun
Cisplatin resistance coupled with adverse effects presents substantial hurdles in the treatment of ovarian cancer. Both cold atmospheric plasma and plasma-activated liquid (PAL) hold the ability to induce DNA damage, which is a primary target of cisplatin. In this study, we investigate the potential of PAL in augmenting cisplatin sensitivity or diminishing the necessary drug dosage by impairing the DNA of cisplatin-resistant cancer cells. We found that plasma irradiated medium exceeding 40 s could decrease the viability, induce DNA damage, trigger cell cycle arrest, and augment apoptosis and autophagy in two types of cisplatin-resistant ovarian cancer cells (A2780/DDP and SKOV3/DDP) after a 24 h incubation period. Notably, pre-treatment with 40 s plasma-activated medium (PAM) for 2 h significantly enhanced the anti-cancer effect of cisplatin administered at lower doses on these cell types. RNA-seq, quantitative real-time PCR and Western blotting analysis revealed that PAM treatment could downregulate the expression of several pivotal proteins involved in nucleotide excision repair (NER) and homologous recombination repair (HRR). The mouse xenograft tumor model demonstrated that plasma-activated saline and cisplatin synergistically inhibited tumor growth and significantly suppressed the expression of proteins related to HRR and NER pathways. We identified plasma-derived peroxide generation in PAM as crucial in these processes. These results pave the way for considering PAM as an adjuvant treatment for cisplatin-resistant ovarian cancer and other abdominal cancers. Additionally, the findings indicate the feasibility of reducing cisplatin dosage to alleviate side effects through sensitization.
研究领域:
肿瘤学
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分子生物学
·
医学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2024
·
IF 3.8
Yuanji Gao,Yijun Liu,Xingyu Li,Kaineng Huang
Herein, ambient electric arc ionization mass spectrometry was used to examine 16 plasticizers in various wrap films, demonstrating high sensitivity (detection limit: <0.2 ng/mg) and precision (intra-/inter-day precision: <12 %). The ease of operation helps in the identification of wrap film and plasticizer analysis. In addition, the introduction of a cold arc plasma treatment presents a practical and innovative method for effectively eliminating plasticizers. This innovative strategy has implications for both environmental protection and food safety.
研究领域:
环境科学
·
食品安全
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PLASMA SCIENCE & TECHNOLOGY
·
2019
·Vol. 22
·期 2
·025503
·
IF 1.193
Qunxia ZHANG,Cao FANG,Zhu CHEN,Qing HUANG
Fungal infection of human nails, or onychomycosis, affects 10% of the world's adult population, but current therapies have various drawbacks. In this work, we employed a self-made low-temperature plasma (LTP) device, namely, an atmospheric-pressure plasma jet (APPJ) device to treat the nails infected with Trichophyton rubrum (T. rubrum) with the aid of persulfate solution. We found that persulfate solution had a promoting effect on plasma treatment of onychomycosis. With addition of sodium persulfate, the APPJ therapy could cure onychomycosis after several times of treatment. As such, this work has demonstrated a novel and effective approach which makes good use of LTP technique in the treatment of onychomycosis.
研究领域:
医学
·
微生物学
✓ 已验证
DOI
高影响因子
Analytical Methods
·
2019
·Vol. 11
·期 42
·5421-5430
·
IF 2.378
Yaliang Wang,Li Xu,Hui Zhu,Junguo Dong,Ping Cheng,Zhen Zhou
The unique ionization characteristics of plasma can be used in multimodal ion sources, which have expanded plasma-based ambient ionization mass spectrometry rapidly to accommodate a range of analytical applications. In this work, microwave plasma torch (MPT) and low-temperature plasma (LTP) ion sources coupled with an atmospheric-pressure interface linear ion trap time-of-flight spectrometry (LIT-TOFMS) instrument, respectively, were developed. Instead of desorption sampling, spray-inlet sampling was used for MPT- and LTP-LIT-TOFMS instruments, respectively, to analyze agrochemicals, and the results were compared to those obtained from traditional ESI-TOFMS. For the methanol solutions of eight reference samples (atrazine, chlorpyrifos, dimethoate, diphenylamine, imazalil, imidacloprid, isoprocorb, and triazophos), spray-inlet MPT and LTP exhibited similar high sensitivity with limits of detection at parts-per-billion, which was comparable to or higher than that exhibited by ESI. However, the spectra obtained from ambient mass spectrometric analysis of the pesticide residues in apple and grape peel extracts using MPT and LTP were comparable, and showed much higher ion measurements than those from the ESI spectra. In order to verify the stability of this method, eight agrochemicals were added to the apple peel extract at concentrations of 0.1 ng mL−1 for atrazine, diphenylamine, imazalil, isoprocorb, and triazophos, and 1 ng mL−1 for chlorpyrifos, dimethoate, and imidacloprid. The determined recovery rates for MPT-, LTP-, and ESI-LITMS are 61.7–83.3%, 60.0–97.5%, and 19.3–61.9%, respectively, probably due to ionization suppression caused by the matrix effect. This study shows that spray-inlet coupled MPT- and LTP-LIT-TOFMS can be effectively used for direct and rapid identification of various compounds with high sensitivity and high reproducibility in a very complex matrix, and are more suited for food quality control for contamination, fraud or authenticity checks, and even environmental quality assessment for pollutant screening, etc.
研究领域:
分析化学
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食品科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Jie Wang,Changrui Xing,Ji Xia,Hongjuan Chen,Jianhao Zhang,Wenjing Yan
Dielectric barrier discharge (DBD) cold plasma, as a new nonthermal technology, has attracted increasing attention in pesticide degradation. In this study, DBD plasma was used to degrade carbendazim (MBC) in aqueous solution. Under the optimal conditions (160 kv, 50 Hz), MBC solution (0.5 μg/mL) was degraded by 89.04% after plasma treatment for 10 min. Four MBC degradation products were identified, one of which was a common oxidative degradation product (5-hydroxycarbendazim, m / z 208.07); the others were identified ( m / z 118.06, m / z 132.08 and m / z 104.05) to have formed by the cleavage of the benzimidazole heterocyclic ring. The degradation pathways were obtained by analysis of degradation products at different treatment times. The toxicity of the degradation products was estimated based on the survival rate of yeast, indicating much lower toxicity levels compared to that of MBC. This study provides a theoretical basis for the application of DBD plasma in the degradation of benzimidazole pesticides in foods.
研究领域:
环境科学
·
食品科学
·
农药化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
OPTICAL MATERIALS
·
2025
·
IF 4.2
Shiya Rong,Pengfei Cheng,Weiming Song,Xuyan Zhang,Jieming Huang,Guofu Zhou,Zhang Zhang,Junming Liu
Core-shell nanostructures have attracted the interest of many researchers due to their unique structural features and suitable band structure match. However, the fabricated core-shell nanostructures generally have only one core, which makes it challenging to explore the collective effect of multiple cores. Herein, two kinds of multicore-shell Au@ZIF-8 and Au@ZnO were synthesized, focusing on the effect of Au concentration on the optical and photocatalytic properties of the latter. By controlling the concentration of Au precursor, different quantities of Au NPs can be encapsulated in one ZIF-8 nanocrystal. Consequently, the hybridization effect and its localized surface plasmon resonance effect of Au NPs could also be accordingly regulated, with Au-0.4@ZnO showing the best photocatalytic activity. This work offers a new inspiration on regulating the plasmonic properties of the multicore-shell nanostructure, which holds an appealing prospect in plasmonic photocatalysis, surface-enhanced Raman scattering detection, and intermediates identification in catalytic reactions.
研究领域:
纳米材料科学
·
光催化
·
材料化学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2017
·
IF 9.446
Hongqing Gao,Peng Zhang,Jiangtao Zhao,Yongshang Zhang,Junhua Hu,Guosheng Shao
Direct evidence of plasmon for enhanced H 2 production is observed in photocatalytic water reduction by using TiO 2 /WO 3 electrospun nanofibers decorated with Au nanoparticles. The H 2 production rate of the as-prepared composite nanofibers was greatly enhanced compared with pure TiO 2 nanofibers (S0) and TiO 2 /WO 3 nanofibers (S1). The enhanced activities were mainly attributed to the Schottky effect and Z-scheme photosynthetic heterojunction system, in this system, WO 3 as a hole collector and Au as an electron collector, promoting effective charge separation. More importantly, Surface Plasmon Resonance (SPR) effect of Au further promoted charge separation and absorption of visible light. On the basis of the Z-scheme photosynthetic heterojunction system, the synergistic effect of Schottky and SPR effect further improve the performance of photocatalytic H 2 production, which were directly evidenced by photocurrent, electrochemical impedance spectroscopy (EIS) and ultraviolet Photoelectron Spectrometer (UPS) analysis. Besides, the synthesis route delivered three-dimensional sheets on the basis of interwoven nanofibrous networks, which can be readily recycled for the circular application of a potent photocatalyst system.
研究领域:
材料科学
·
光催化
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Kaijie Ma,Le Liu,Pengfei Zhang,Yonghong He,Qing Peng
An angular plasmonic sensor based on optimized angle-pixel resolution to detect antibody-antigen binding process is presented. Owing to discrete resonance curves by the CCD pixels, the pixel sensitivity and detection noise of the plasmonic sensors need to be balanced. The angle-pixel resolution is adjusted by changing the distance between the sensor chip and the CCD to obtain the optimal refractive index (RI) resolution for three plasmonic sensors, which are surface plasmon resonance (SPR), long range surface plasmon resonance (LRSPR) and plasmon waveguide resonance (PWR) sensors. Each plasmonic sensor can achieve its optimal RI resolution at the optimal distance, and the LRSPR sensor has the best RI resolution. Attributing to the reference channel and temperature control module in the sensor system, the RI resolution can achieve 4.37 × 10 −7 RIU at Normal mode and 1.13 × 10 -7 RIU at a slow response Extreme mode. The Protein A-IgG binding reaction experiment indicates that the plasmonic sensor has linear response to IgG concentration in a wide range and the limit of detection (LOD) is 5.45 pM at Extreme mode. The procedure and result of this work are helpful to the optimization of other angular plasmonic sensors.
研究领域:
生物传感
·
等离子体学
·
光学传感
·
分析化学
·
生物物理学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Environmental Sciences
·
2023
·
IF 6.9
Yongqi Yan,Xinyu Yang,Ping Ning,Chi Wang,Xin Sun,Fei Wang,Peng Gao,Kai Li
In this study, non-thermal plasma (NTP) was employed to modify the Cu/TiO 2 adsorbent to efficiently purify H 2 S in low-temperature and micro-oxygen environments. The effects of Cu loading amounts and atmospheres of NTP treatment on the adsorption-oxidation performance of the adsorbents were investigated. The NTP modification successfully boosted the H 2 S removal capacity to varying degrees, and the optimized adsorbent treated by air plasma (Cu/TiO 2 -Air) attained the best H 2 S breakthrough capacity of 113.29 mg H 2 S/g adsorbent , which was almost 5 times higher than that of the adsorbent without NTP modification. Further studies demonstrated that the superior performance of Cu/TiO 2 -Air was attributed to increased mesoporous volume, more exposure of active sites (CuO) and functional groups (amino groups and hydroxyl groups), enhanced Ti-O-Cu interaction, and the favorable ratio of active oxygen species. Additionally, the X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) results indicated the main reason for the deactivation was the consumption of the active components (CuO) and the agglomeration of reaction products (CuS and SO 4 2− ) occupying the active sites on the surface and the inner pores of the adsorbents.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Mingyu Cheng,Xiangxin Lin,Xinyi Chen,Chong Chen,Gang Zhang,Bin Ai
Heterogeneous multilayer configurations are discussed to enhance plasmonic hydrogen sensors (PHSs). Five sensor designs─pure Pd, Pd/Ag, Ag/Pd, Ag/Pd/Ag, and Pd/Ag/Pd─were developed by sequentially depositing Ag and Pd on nanosphere arrays. The Pd/Ag/Pd configuration demonstrated maximum 10, 2.7, and 1.69 times superior performances in rapid hydrogen sensing, signal detection, and reduced limit of detection (LOD) compared to pure Pd sensors. The impact of material composition, ambient interactions, intermaterial coupling, and surface morphology on sensitivity and response time was quantitatively analyzed using one-hot encoding and linear regression. Finite-difference time-domain (FDTD) calculations were employed to reveal the near-field surface plasmon resonance (SPR) effects. This study would offer theoretical insights and guiding principles for future PHS advancements, particularly in enhancing sensor performance through a heterogeneous multilayer configuration.
研究领域:
材料科学
·
传感器技术
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2019
·
IF 6.35
Xin Yan,Chang Xia,Bin Chen,Yuan Fang Li,Peng Fei Gao,Cheng Zhi Huang
Plasmon resonance energy transfer (PRET), as a new form of energy transfer first discovered in 2007, has been widely applied for the biomolecular recognition, detection of ions, cellular physiological status monitoring, and energy conversion. It occurs between noble metal nanoparticles (donor) and conjugated molecules or nanoparticles (acceptor). In this study, we used urchin-like gold nanoplasmonics (UGPs) and oxTMB as a new donor–acceptor pair to establish a novel PRET coupling system, avoiding trivial modification. PRET from UGPs to conjugated redox-active oxTMB leads to resonant quenching in the localized surface plasmon resonance (LSPR) spectra. However, when the acid phosphatase (ACP) was introduced, the hydrolyzate ascorbic acid (AA) converted from 2-phospho-l-ascorbic acid trisodium salt (AAP) could be capable of reducing oxTMB into TMB, thereby preventing the occurrence of PRET. The recovery of the scattering spectral intensity of UGPs was linearly related to the concentration of ACP in the range of 0.1 to 5.0 U/L, and the ACP with a detection limit of 0.076 U/L could be measured. In addition, this method also showed good selectivity attributed to the substrate specificity of enzyme.
研究领域:
纳米技术
·
生物医学工程
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2024
·
IF 7.1
Guangzhao Zhou,Ziyu Wang,Xiaochao Wang,Yiran Zhang,Xuteng Zhao,Qi Chen,Ting Chen,Zhen Huang,He Lin
Nonthermal plasma catalysis offers the potential to synthesize ammonia on a distributed scale under ambient pressure by consuming renewable electricity. Clarifying the relationship between plasma discharge and the role of catalysts is beneficial to the performance improvement of nonthermal-plasma-catalytic ammonia synthesis (NTPCAS). In this study, the plasma discharge was enhanced using CeO2 and Fe2O3/CeO2 (Fe/Ce) mechanically mixed with dielectric Al2O3, recorded as Ce@Al and Fe/Ce@Al, respectively, and the promoting effect of plasma discharge enhancement on the catalytic role of Fe/Ce and CeO2 in NTPCAS was investigated in a dielectric barrier discharge reactor under atmospheric pressure. The results indicate that the concentration of ammonia synthesized using Fe/Ce was only 2.7% higher than that synthesized using CeO2 and that synthesized using Fe/Ce@Al was 36.5% higher than that synthesized using Ce@Al and 102.6% higher than that synthesized using Fe/Ce at maximum. In addition, the ammonia production rate of Fe/Ce in Fe/Ce@Al with the optimum Al2O3 mixing ratio was 8.8 times that in pure Fe/Ce. U–I curves, U–Qc curves, and self-luminous optical imaging results of the discharge region packed with the catalysts indicated that Al2O3 mixing effectively strengthened the plasma discharge. Catalyst characterization showed that Fe/Ce had better catalytic properties than CeO2, explaining the better performance of Fe/Ce@Al than that of Ce@Al in the NTPCAS. In situ N2 and H2 adsorption, desorption, and reaction behaviors over catalysts revealed that significantly improved N2 adsorption and activation over Fe/Ce@Al under plasma conditions were the key to NTPCAS. The strategy of mixing highly active ammonia synthesis catalysts with discharge-enhanced materials can significantly improve the performance of NTPCAS catalysts, thus providing a novel approach to designing catalysts for NTPCAS.
研究领域:
化学工程
·
催化
·
等离子体科学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）