MATERIALS CHEMISTRY AND PHYSICS
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2019
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IF 2.781
Li-li Lu,Wen-ya Xiong,Jun-bin Ma,Tian-fang Gao,Si-yuan Peng,Wang Xiao
Pores and framework dual responsive controlled release systems with high drug loading capacity based on HMONs (DOX@HMONs/CD) have been prepared. The DOX@HMONs/CD show high loading capacity (1060 mg/g) for anticancer drug. The cumulative release of drug diffusing from pore channels or degraded framework could be tuned by varying the pH or the concentration of dithiothreitol (DTT), and the systems exhibited an obvious enhanced release capacity in the combination of two stimulus.
研究领域:
生物材料学
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药物递送系统
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肿瘤治疗
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2025
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IF 11.3
Yu Wu,Linna Shao,Cai Cheng,Xianyong Kou,Shi Huang,Liexiong Zhang,Jie Yu,Xuehan Xu,Xingyu Xiang,Xiaoliang Guo,Lingling Feng
Harmful Microcystis blooms (HMBs) and their hepatotoxic metabolites microcystins (MCs) pose escalating threats to aquatic biodiversity and public health due to their recalcitrance to conventional remediation approaches. To address this dual challenge, mesoporous silica (MSN) and hollow mesoporous organosilica (HMON) nanostructures were engineered via structure-guided design principles, enabling the development of the crude extract microcystinase A (CMlrA)-tailored immobilized platform (CMlrA@MSN and CMlrA@HMON) for synchronized HMBs suppression and MCs detoxification. Systematic optimization of carrier physicochemical properties (including specific surface area, hydrophilicity, and pore size) significantly enhanced the immobilization efficiency and catalytic durability of CMlrA. Kinetic modeling revealed 201.3% and 44.1% K cat / K m enhancements in MC-LR degradation for CMlrA@MSN and CMlrA@HMON relative to free CMlrA. Immobilized enzyme systems achieved 77.06% and 83.03% growth inhibition rates in Microcystis aeruginosa FACHB-905 after six-day treatment. This biocatalytic immobilization strategy establishes an eco-efficient framework for synergistic HMB suppression and MC degradation, providing the technical groundwork for practical water remediation systems.
研究领域:
环境科学
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生物技术
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生态毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2020
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IF 10.652
Dejian Li,Tao Zhang,Chuwei Min,Hui Huang,Denghui Tan,Wenguang Gu
Benefit from the integration of therapeutic and diagnostic functions, theranostic nanoplatforms have attracted widespread attention in preclinical research. Herein, a biodegradable theranostics nanoplatform based on hollow mesoporous organosilica nanoparticles (HMONs) is designed for highly efficient photoacoustic (PA) imaging guided chemo-photothermal therapy (PTT) of human osteosarcoma cancer. In this design, HMONs with intrinsic tumor microenvironment-responsive biodegradability were served as carrier for doxorubicin (DOX) loading. Then, biocompatible nanocomposites (CuS@BSA) with excellent photothermal conversion efficiency and inherent biocompatibility were prepared via a facile biomineralization strategy and are first decorated on the surface of HMONs through a GSH-sensitive disulfide bond (denoted as CuS@BSA-HMONs-DOX). The obtained CuS@BSA-HMONs provides a high DOX loading capacity of 42.9%. The fabricated theranostic nanosystems exhibit GSH-responsive breakage of the incorporated disulfide bonds in the framework of HMONs and the linker between HMONs and BSA, which leads to the release of loaded DOX and tumor-specific biodegradation. With the strong absorbance in near-infrared (NIR) region, CuS@BSA-HMONs-DOX nanoparticles show excellent diagnostic performance on the PA imaging modalities. Upon NIR laser irradiation, the introduction CuS endows the nanotheranostics have high photothermal conversion efficiency of 51.5% for hyperthermia. Also, the resulting CuS@BSA-HMONs-DOX exhibited pH-, NIR- and GSH-sensitive drug release, realizing synergistic chemo-phototherapy functions. Besides, the NIR laser-triggered mild hyperthermia can significantly enhance the cell uptake of nanoparticles. As validated by in vivo and in vitro assays, our CuS@BSA-HMONs-DOX can effectively delivers drug to tumor sites/cancer cells and induce the mild hyperthermia, resulting in an enhanced suppression of tumor growth. Combined with the excellent biocompatibility and biodegradability, the presented “all-in-one” nanotheranostics may provide an innovative paradigm for imaging guided and synergistic treatments.
研究领域:
纳米医学
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肿瘤学
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生物材料学
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2021
·
IF 5.161
Chunling Li,Xiyu Zhao,Cheng Meng,Tengfang Zhang,Shuangqing Sun,Songqing Hu
The stimuli-responsive release could reduce the waste of the corrosion inhibitor and realize the accurate repair of corroded region. In this work, hollow mesoporous organosilica nanoparticles (HMON) were first synthesized by silica-etching chemistry tailoring method. Then, HMON were encapsulated with 2-mercaptobenzothiazole (MBT) corrosion inhibitor molecules to build an intelligent corrosion inhibitor system, i.e., MBT@HMON. The microstructure and frame composition of the synthesized HMON were characterized. After the successful encapsulation of MBT into HMON, the release kinetics of MBT from HMON under different dithiothreitol (DTT) concentration and pH conditions were investigated. Finally, the corrosion inhibition performance of MBT@HMON for copper alloy was evaluated in 3.5 wt% NaCl solution by weight loss test and electrochemical impedance spectroscopy (EIS). The results show that the controlled release of corrosion inhibitor MBT from HMON could be realized by tuning the redox and pH conditions of corrosion medium. When the appropriate concentration of MBT@HMON was added into the corrosion medium (1.6 g·L −1 in this work), the corrosion of cooper alloy was greatly inhibited. This simple and general strategy of introducing corrosion inhibitors loaded HMON directly into the corrosion medium offers a new prospect for the application of nanocontainers in the intelligent corrosion protection of metallic materials.
研究领域:
材料科学
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腐蚀科学
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纳米技术
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化学工程
✓ 已验证
DOI
高影响因子
LANGMUIR
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2023
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IF 3.9
Kang Wang,Jia-Qing Li,Shun He,Jun Lu,Dan Wang,Jie-Xin Wang,Jian-Feng Chen
Extremely inefficient utilization of pesticides has prompted a study of low-cost, sustainable, and smart application systems. Herein, as a promising pesticide nanocarrier, hollow mesoporous organosilica nanoparticles (HMONs) were first synthesized by using inexpensive CaCO3 nanoparticles as the hollow templates. A redox/near-infrared light dual-triggered pesticide release system was further achieved via loading avermectin (AVM) into the HMONs and coating a layer of polydopamine (PDA). The as-prepared AVM@HMONs@PDA displays a favorable pesticide load capability (24.8 wt %), outstanding photothermal performance, and high adhesion to leaves. In addition, with glutathione (GSH), the AVM cumulative release from AVM@HMONs@PDA was 3.5 times higher than that without GSH. Under ultraviolet light irradiation, the half-life of AVM@HMONs@PDA was prolonged by 17.0-fold compared to that of the AVM technical. At day 21 after treatment in the insecticidal activity, the median lethal concentrations (LC50) values displayed that the toxicity of AVM@HMONs@PDA for Panonychus citri (McGregor) was enhanced 4.0-fold compared with the commercial emulsifiable concentrate. In the field trial, at day 28 after spraying, AVM@HMONs@PDA was significantly more control effective than AVM-EC in controlling the P. citri (McGregor), even at a 50% reduced dosage. Moreover, HMONs@PDA was safe for crops. This research presents a novel preparation approach for HMONs, and it also offers a promising nanoplatform for the precise release of pesticides.
研究领域:
纳米技术
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农业科学
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材料科学
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害虫管理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Nano
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2020
·
IF 14.588
Ke Li,Chuanchuan Lin,Ye He,Lu Lu,Kun Xu,Bailong Tao,Zengzilu Xia,Rui Zeng,Yulan Mao,Zhong Luo,Kaiyong Cai
As an increased product of high-rate aerobic glycolysis in tumors, lactate could regulate the immunosuppressive tumor microenvironment (TME). A PEG-CDM surface modified, GSH-dependent responsive hollow mesoporous organosilica nanoplatform loaded with hydroxycamptothecin (HCPT) and siMCT-4 was administrated for synergistic tumor chemo-immunotherapy. The nanoplatform cascaded responded to the weak acid TME and the high level of GSH in tumor cells. HCPT and siMCT-4 were continuously released from the nanoplatform for chemotherapy and inhibiting intracellular lactate efflux. The increased intracellular lactate and HCPT effectively induced tumor cell apoptosis. Moreover, the decreased extracellular lactate polarized tumor-associated macrophages (TAMs) phenotype from M2 type to M1 type and restored CD8+ T cell activity in vivo. The results demonstrated that the nanoplatform effectively removed the immunosuppressive TME, inhibited tumor growth, and suppressed lung metastasis of B16F10 cells and 4T1 cells via the combination of inhibiting lactate efflux and chemotherapy. Accordingly, it suggested a strategy to transform immunosuppressive tumors into “hot” tumors and inhibit the tumor growth with high efficiency in vivo.
研究领域:
纳米技术
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肿瘤学
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药学
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免疫治疗
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）