SENSORS AND ACTUATORS B-CHEMICAL
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2024
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IF 8
Yan-nan Wang,Liyun Qin,Zhenyu Yuan,Jin Li,Fanli Meng
This study presents a humidity sensor based on a large-core-offset hollow core optical fiber (LD-HCF) combined with polyvinyl alcohol carbon quantum dots (PVA-CQDs) nanocomposite microfiber for monitoring human respiratory. PVA-CQDs was introduced into the hollow core structure of LD-HCF to develope the respiratory sensor. The sensor has been integrated into a respiratory monitoring mask, exposed to ultraviolet (UV) light and demonstrated with a humidity sensitivity of 0.1721 nm/%RH as well as response and recovery times of 0.232 s and 0.252 s, respectively. The mask provides the real-time monitoring of human respiratory rates during various activities, including walking, standing, coughing, running, apnea 1 time and apnea 3 times. The typical respiratory patterns have been classified with a remarkable accuracy of 97.62 % using a WOA-1D CNN-LSTM neural network. The respiratory monitoring device is proposed by optical fiber, offering a promising potential in the real-time monitoring for healthcare process.
研究领域:
生物医学工程
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光学传感
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人工智能应用
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产品关联
DOI
高影响因子
SENSORS
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2023
·Vol. 24
·期 1
·160
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IF 3.9
Yangyang Xu,Xian Zhang,Xiao-Song Zhu,Yi-Wei Shi
In this paper, the silver-coated large-core suspended-core fiber (LSCF) probe was fabricated by the dynamic chemical liquid phase deposition method for surface-enhanced Raman scattering (SERS) sensing. The 4-mercaptophenylboronic acid (4-MPBA) monolayer was assembled in the LSCF as the recognition monolayer. Taking advantage of the appropriate core size of the LSCF, a custom-made Y-type optical fiber patch cable was utilized to connect the semiconductor laser, Raman spectrometer, and the proposed fiber SERS probe. The SERS signal is propagated in the silver-coated air channels, which can effectively reduce the Raman and fluorescence background of the silica core. Experiments were performed to measure the Raman scattering spectra of the 4-MPBA in the silver-coated LSCF in a non-enhanced and enhanced case.The experiment results showed that the Raman signal strength was enhanced more than 6 times by the surface plasmon resonance compared with the non-enhanced case. The proposed LSCF for SERS sensing technology provides huge research value for the fiber SERS probes in biomedicine and environmental science. The combination of SERS and microstructured optical fibers offers a potential approach for SERS detection
研究领域:
生物医学
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环境科学
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光学工程
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DOI
PubMed
高影响因子
TALANTA
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2022
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IF 6.556
Like Li,Ya-nan Zhang,Wanlu Zheng,Xuegang Li,Yong Zhao
An optical fiber SPR biosensor based on multimode fiber (MMF)- hollow core fiber (HCF)-MMF is proposed and experimentally confirmed for in situ DNA hybridization analysis. In order to improve the sensitivity of DNA hybridization detection, a sandwich model based on gold nanoparticles (AuNPs) amplification is proposed. In this model, the probe DNA (pDNA) is first modified on the optical fiber sensing area by covalent bonding, and then the biotinylated target DNA (tDNA) is modified on the AuNPs by the high affinity between biotin and streptavidin. Finally, the tDNA on the surface of the AuNPs specifically hybridizes with the pDNA on the optical fiber to form a sandwich model. The near field coupling enhancement between AuNPs and gold film and the high mass ratio of AuNPs give high sensitivity to DNA hybridization detection. Experimental results show that the sandwich-type fiber SPR sensor has a log-linear response in the DNA concentration range of 1 pM–10 nM, and the sensitivity and detection limit are 4.04 nm/log(μM) and 1pM, respectively. This is 1.44 times more sensitive than that without sandwich assay. In addition, the DNA sensor has good specificity and stability, which foreshadows its great application potential in the fields of disease diagnosis, microbial detection and environmental science.
研究领域:
生物传感
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纳米技术
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光纤技术
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生物医学工程
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分析化学
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产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
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2024
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IF 10.7
Ben Li,Qi Wang
In this article, a novel U-tapered hollow-core fiber (HCF) surface plasmon resonance (SPR) biosensor coated with PtS 2 for early-stage gastric carcinoma (GC) diagnosis was demonstrated. The article proposed the first investigation to detect Interleukin-10 (IL10) and Interleukin-1β (IL1β) which were associated with the risk of developing gastric carcinoma, using optical fiber SPR technology. Herein, the sensitivity of sensor was effectively improved through a combination of tapered and U-shaped structures. Additionally, to further enhance the detection capability, two-dimensional material PtS 2 was utilized to increase the surface electric field intensity of the sensor. Simultaneously, optimization of structural parameters such as taper ratio, bending diameters, and Au film thickness was conducted. Ultimately, the designed sensor achieved a remarkable sensitivity of 13210 nm/RIU within the refractive index (RI) range of 1.33–1.37. The sensor demonstrated exceptional performance, achieving sensitivities of 3.64 nm/(ng/ml) and 7.46 nm/(ng/ml) for the detection of IL10 and IL1β biomarkers, respectively, along with limit of detection (LOD) of 2.74 pg/ml and 1.33 pg/ml, and successfully detecting the presence of these biomarkers in the serum of gastric cancer patients. Overall, the proposed sensor exhibits significant potential in early gastric cancer detection and advances the application of optical fiber SPR sensors in trace biodetection.
研究领域:
光纤技术
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生物传感
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癌症诊断
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纳米材料
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产品关联
DOI
PubMed
高影响因子
OPTICAL FIBER TECHNOLOGY
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2024
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IF 2.6
Yuhao Chen,Xiaozhan Yang
A Michelson interference dimethyl methyl phosphate (DMMP) fiber sensor with a single-mode (SMF)-dislocated single-mode (DSMF)-hollow-core fiber (HCF) structure is proposed. To fabricate the Michelson interference structure of SMF-DSMF-HCF, one end of the DSMF was misaligned and fused to the SMF, the other end was fused to the HCF to generate a reflective surface. The structure, elemental composition, and surface morphology of ZIF-8@Ag were analyzed using X-ray diffraction, X-ray photoelectron spectroscopy, and scanning electron microscopy after the ZIF-8@Ag/PDDA composite was coated on the surface of DSMF. The result shows that the sensitivity and the detection limit of the sensor are 45.71 dB/ppm and 0.1431 ppb, respectively, and the response/recovery time is around 14/12 s. The sensor also has excellent selectivity and stability.
研究领域:
光学工程
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传感器技术
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材料科学
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化学传感
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产品关联
DOI
高影响因子
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