FEBS LETTERS
·
2018
·Vol. 592
·期 20
·3438-3445
·
IF 2.999
Dongxin Zhao,Kui Lu,Guangbin Liu,Li Ma,Hanjing Zhu,Juan He
Mutations in breast cancer susceptibility gene 2 ( BRCA2 ) can lead to chromosomal instability and result in breast cancer, which is strongly associated with p53 mutations. Here, based on the crystal structure of BRC4 and p53, the spatial structure of BRC2 and p53 (171–192) was simulated, providing structural basis for the site-specific mutation of BRC2. The BRC analogous peptides and p53 (171–192) were synthesized, and the interaction between the mutant peptide and p53 (171–192) was studied using circular diachronic spectroscopy and fluorescence spectroscopy. The results show that the mutations of amino acid residues constituting the BRC2 α-helix significantly affect the structure and interaction of BRC analogs and p53 (171–192), which provides support for understanding the structure of the BRC repeat motifs and its interaction pattern with p53.
研究领域:
分子生物学
·
癌症研究
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF FOOD PROCESSING AND PRESERVATION
·
2020
·Vol. 44
·期 5
·e14433
·
IF 1.405
Mai-Rui Gao,Qian-Da Xu,Wei-Cai Zeng
The effect and action mechanism of tea polyphenols (TP) on the tenderness of yak meat were investigated. With the treatment of TP at the low concentrations, the myofibril fragmentation index (MFI) value of yak meat was increased and its microstructure was obviously changed. By using fluorescence spectroscopy and the determination of surface hydrophobicity, the tertiary structure of myofibrillar protein (MP) showed the obvious changes with the treatment of epigallocatechin gallate (EGCG). In addition, the secondary structure of MP was also obviously changed according to the measurement of circular dichroism (CD) spectrum, while the α-helix structure of MP decreased and the β-sheet increased. Furthermore, according to the analysis of molecular docking, EGCG could interact tightly with myofibril protein by hydrogen bonds, and changed its spatial configuration and molecular force. All results suggested that TPs showed the potentially value to improve the tenderness of yak meat in food industry. Practical applications Yak meat is more and more popular by its high nutrition value. But due to its special myofibril protein, the tenderness of yak meat is unfavorably and affects its sensory properties, which may limit its processing and consumption in food industry. In present study, TPs was used to improve the tenderness of yak meat by changing the spatial configuration and molecular force of myofibril protein, which suggested that TPs showed the potential value to enhance the quality of yak meat during its processing in food industry.
研究领域:
食品科学
·
生物化学
✓ 已验证
DOI
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2020
·
IF 6.513
Haisong Wang,Jinran Chen,Pengfei Ren,Yiwen Zhang,Stanley Omondi Onyango
In this study, the impact of ultrasound irradiation on the structural characteristics and antioxidant properties of yellow tea polysaccharides with different molecular weights (Mw) were investigated. Native yellow tea polysaccharide containing YTPS-3N, YTPS-5N and YTPS-7N were prepared through precipitation with ethanol at various concentrations of 30%, 50%, and 70%, respectively, and irradiated with high intensity ultrasound (20 kHz) for 55 min to yield yellow tea polysaccharide including YTPS-3U, YTPS-5U and YTPS-7U. The molecular weight (Mw) of YTPS-3N (from 37.7 to 15.1 kDa) and YTPS-5N (from 14.6 to 5.2 kDa) sharply decreased upon ultrasound irradiation, coincidentally particle size (Zavg) was also significantly reduced for YTPS-3N (40%), YTPS-5N (48%) and YTPS-7N (54%). The high-performance liquid chromatography and Fourier transform-infrared spectroscopy analysis revealed a partial degradation of native yellow tea polysaccharide treated with ultrasound, though the monosaccharide composition was not altered. Furthermore, changes in morphology and the breakdown of native yellow tea polysaccharide upon irradiation was confirmed with the circular dichroism spectrum, atomic force and scanning electron microscopy. As a consequence, irradiation of yellow tea polysaccharide increased free radical scavenging activity with YTPS-7U exhibiting the highest levels of 2, 2-diphenyl-1-picrylhydrazyl free radical, superoxide and hydroxyl radicals scavenging activity. These results suggest that the alteration of the spatial structure of yellow tea polysaccharide can enhance its antioxidant activity which is an important property for functional foods or medicines.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Rui Wang,Pei-Feng Guo,Jin-Peng Yang,Yan-Yan Huang,Lang-Hong Wang,Jian Li,Song-Yi Lin,Qing-Lin Sheng,Xin-An Zeng,Yong-Xin Teng
As an emerging protein modification technology, pulsed electric field (PEF) technology in modifying soybean protein isolates (SPI) suffers from unclear mechanism and controversial changes in aggregation structure. To address these issues, the effects of PEF treatment with different electric field intensities (5–30 kV/cm) on the aggregation behavior and spatial structure of SPI were investigated. The results showed that the SPI aggregates exhibited a trend of depolymerization followed by reaggregation with the increase of PEF intensity. At 10 and 15 kV/cm, the polarization effect of PEF induced the unfolding of the tertiary structure of SPI, leading to the enhancement of the electronegativity of the side chains, and the electrostatic repulsive force between the molecules promoted the depolymerization of SPI aggregates. However, with the withdrawal of PEF, the structure of the SPI was partially reversible, resulting in a limited depolymerization effect. When the PEF intensity reached 20 kV/cm and above, SPI underwentstructure unfolding, subunit dissociation, continuous exposure of hydrophobic groups and sulfhydryl groups, and ultimately reaggregation mediated by hydrophobic interactions and disulfide bonding, resulting in the formation of high molecular weight soluble and insoluble protein aggregates. In addition, the formation of free radicals under strong electric fields (≥20 kV/cm) accelerated the oxidation of SPI and promoted the rapid formation of disulfide bonds. This study provides a theoretical basis for the targeted regulation of SPI aggregation structure by PEF.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
PLASMA SCIENCE & TECHNOLOGY
·
2019
·Vol. 21
·期 5
·054006
·
IF 1.193
Yan HUI,Na LU,Pengzhen LUO,Kefeng SHANG,Nan JIANG,Jie LI,Yan WU
The classification of spatial characteristics and discharge modes of dielectric barrier discharge (DBD) are gaining increasing attention in industrial applications, especially in the field of surface treatment of materials. In this work, gray level histogram (GLH) and Fourier energy spectrum based on the digital image processing technology are applied to investigate the spatial structure and discharge mode of mesh-plate DBD. The coefficient of variation (CV) is calculated to describe the uniformity of the discharge. The results show that the discharge mode of mesh-plate DBD changes from periodic discharge to filamentary discharge when the applied voltage increases from 11–15 kV. Moreover, a more regular spatial structure is obtained under lower applied voltages during the discharge process. It is also found that the apertures of mesh electrodes which are below 1 mm have smaller values of CV compared to plate electrodes, indicating more uniform discharge. Finally, polypropylene is treated by mesh-plate DBD for surface modification. The hydrophilicity is significantly improved as the water contact angle decreased by 64°, and the dyeing depth is also enhanced.
研究领域:
材料科学
·
等离子体技术
·
表面处理
✓ 已验证
DOI
高影响因子
Arabian Journal of Chemistry
·
2023
·
IF 6
Jia-Hao Gao,Pei-Pei Huang,Jie Liu,Nan Zheng,Dong Wang,Si-Yu Yue,Er-Nu Liu,Quan Liu,Bo Liu,Jiu-Fu Lu
Three new metal coordination polymers with different spatial structure, namely {[Co 2 (H 2 O) 6 (4-PDCA) 2 ] 2 ·3H 2 O} n ( SNUT-12 ), {[Cd(H 2 O) 2 (4-PDCA)]·2H 2 O} n ( SNUT-13 ) and [Zn 2 (4-PDCA) 2 ] n ( SNUT-14 ), where H 2 (4-PDCA) = 1-(4-carboxyphenyl)-5-methyl-4-oxo-1,4-dihydropyridazine-3-carboxylic acid, were synthesized by changing the central ion with the same ligand under solvothermal and hydrothermal conditions, which were further characterized by single crystal X-ray diffraction, powder XRD, FT-IR and TGA . Single crystal X-ray analysis revealed that SNUT-12 exhibits a 1D infinite zigzag chains which were constructed by Cobalt(II) ion and 4-PDCA 2− ligand, SNUT-13 features a 2D ladder-like structure. Meanwhile, SNUT-14 displays 2-fold 3D → 3D parallel interpenetrating frameworks. In addition, SNUT-12 exhibited high electrocatalytic oxygen evolution reaction, and SNUT-13, SNUT-14 showed strong fluorescence at room temperature .
研究领域:
化学
·
材料科学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry A
·
2020
·Vol. 8
·期 15
·7395-7404
·
IF 11.301
Qiuyan Duan,Chenghua Zhang,Song Sun,Yang Pan,Xiong Zhou,Yang Liu,Kun Chen,Cunshuo Li,Xianzhou Wang,Wenzhi Li
Lean methane combustion through efficient catalysis is an intensely important way to reduce environmental pollution. Notably, palladium-based catalysts are promising catalytic materials. The small size of palladium particles is a crucial factor to improve the catalytic activity. In this study, we proposed a new pathway to minimize the size of palladium particles for palladium-based catalysts from the perspective of material preparation. We first built double spatial barriers on the interface between the support and the active species to prepare atomically dispersed palladium species catalysts. To be specific, organo-silane was employed as a surfactant to modify the zirconia support and palladium acetate was selected as the palladium precursor, taking advantage of the spatial structure of alkane chains combined with silicon atoms and palladium acetate in toluene. Under a lean methane reaction environment, 0.23 wt% atomically dispersed palladium species deposited on decorated zirconia (donated as 0.23 wt% Pd/SiO2–ZrO2) displayed high catalytic activity with 100% conversion at a temperature of around 400 °C with gas hourly space velocity (GHSV) of 30 000 ml g−1 h−1, higher than that of pristine zirconia loaded with 0.23 wt% palladium nanoparticles (donated as 0.23 wt% Pd/ZrO2), which removed all lean methane at around 600 °C under the same conditions. As the palladium loading increased on the modified support, the 1.38 wt% Pd/SiO2–ZrO2 catalyst had a comparable catalytic activity and fully converted lean methane at around 330 °C. The lean methane combustion reaction pathway for the 0.23 wt% Pd/SiO2–ZrO2 catalyst was investigated by in situ NAP-XPS and in situ DRIFTS. Hydroxyl groups formed during the reaction were transferred to the silica, which could reduce the formation of the inactive Pd(OH)x species and expose more active sites to improve the catalytic activity. It is hoped that this study will provide a novel method to improve the utilization of palladium species in practical applications.
研究领域:
催化化学
·
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2021
·Vol. 223
·期 2
·2100341
·
IF 2.527
Yuhang Zhang,Rui Li,Lijing Chang,Yang Ma,Yanjun Hou,Haijun Niu
The development prospect of conductive electrochromic (EC) polymers requires the design of polymers with high performance and good stability. Here, a new scheme is designed to enhance EC properties by adjusting the monomer molecular structure. Four monomers with different structures based on thiophene and 3,4-ethylenedioxythiophene (EDOT) are designed and synthesized. The corresponding polymer films (P1, P2, P3, and P4) are prepared by electrochemical polymerization at low applied potential. The spatial structure–performance relationship of precursors with different structures and polymers is systematically discussed. In the electropolymerization experiments, it is noted that P3 has no EC property. This may be connected to the spatial structure of P3 polymerization which is not suitable for charge transporting. By contrast, the other three polymers exhibit excellent electrochemical properties. The diffusion rate higher of P1 has also been corroborated by using electrochemical impedance spectroscopy (EIS) spectrum. The P1 film has the best stability and fastest colorized time among the samples; such superior electrochemical property may be associated with the closely stacked formed by the unique sheet-like spatial structure. The design of the space structure has a significant impact on the optical and electrical properties of the polymer film.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Wei Ji,Guofeng Liu,Zijian Li,Chuanliang Feng
For CH···O hydrogen bonds in assembled structures and the applications, one of the critical issues is how molecular spatial structures affect their interaction modes as well as how to translate the different modes into the macroscopic properties of materials. Herein, coumarin-derived isomeric hydrogelators with different spatial structures are synthesized, where only nitrogen atoms locate at the ortho, meso, or para position in the pyridine ring. The gelators can self-assemble into single crystals and nanofibrous networks through CH···O interactions, which are greatly influenced by nitrogen spatial positions in the pyridine ring, leading to the different self-assembly mechanisms, packing modes, and properties of the nanofibrous networks. Typically, different cell proliferation rates are obtained on the different CH···O bonds driving nanofibrous structures, implying that tiny variation of the stereo-position of nitrogen atoms can be sensitively detected by cells. The study paves a novel way to investigate the influence of isomeric molecular assembly on macroscopic properties and functions of materials.
研究领域:
材料科学
·
生物学
·
医学
✓ 已验证
DOI
PubMed
高影响因子
COMPOSITES SCIENCE AND TECHNOLOGY
·
2025
·
IF 9.8
Qixiong Zhang,Zhibiao Zhu,Jiujun Zhu,Hai Jiang,Yafei Hou,Jing Cuan,Weiping Li
The growing demand for renewable energy storage has highlighted the demand of dielectric capacitors with high performances. While multilayer composites show promise by combining insulation layers and polarization layers, their performance optimization remains challenging due to complex layers number and insulation/polarization volume content dependent behaviors. This work presents an optimized multilayer composite via spatial structure design that strategically combines the Ni(OH) 2 @PDI/P(VDF-HFP) (NPP) insulation layers and Ni(OH) 2 /P(VDF-HFP) (NP) polarization layers. Through precise regulation of layers number and NPP volume content within the multilayer composite, the optimized interlayer interfacial effects, the coupling effects of insulation and polarization layers, as well as the related intralayer contributions result in a significantly discharged enhanced energy storage density of 32.1 J/cm 3 and a high charge-discharge efficiency of 80.7 % at 705.7 MV/m for the 4 layers 62.5 vol% NPP/NP composite. Our findings provide both fundamental insights into multilayer dielectric design and a practical strategy for developing high-capacity energy storage dielectrics for renewable energy storage applications .
研究领域:
材料科学
·
介电物理
·
能源存储
·
高分子复合材料
·
纳米功能材料
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2024
·
IF 8.1
Xi Bin Yue,Ying Jie Liu,Li Wei Lai,Xi Hao Wang,Hui Peng,Qiu Gen Zhang,Ai Mei Zhu,Qing Lin Liu
Improving the microphase separation structure of membranes is considered an effective strategy to solve the trade-off problem, which can increase the conductivity and reduce the swelling. This article designs poly(aryl alkylene) AEMs with different aryl backbone chains (biphenyl, p-terphenyl and m-terphenyl), with the goal of examining the effect of spatial structure main chains on the membrane performance. It is found that the membrane (m-QTPNP) has a better microphase separation structure and a conductivity of 143.5 mS cm −1 (80 °C) via SAXS, TEM and AFM. Due to the lower IEC (2.23 meq g −1 ), m-QTPNP has a good anti-swelling performance. During tensile testing, the elongation at break of m-QTPNP can reach 105.5% (wet state). Moreover, due to the obvious microphase separation, the attack of OH − on the quaternized groups is reduced, and m-QTPNP has a conductivity retention rate of 95.5% (80 °C, 2 M NaOH, 1560 h). In addition, the peak power density (PPD) of the H 2 /O 2 single cell equipped with m-QTPNP can reach 749 mW cm −2 (80 °C). After 90 h of durability testing, the voltage decayed to 92.2%, with a decay rate of 0.54 mV h −1 .
研究领域:
材料科学
·
能源化学
·
高分子化学
✓ 已验证
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2020
·
IF 16.683
Dewang Zeng,Yu Qiu,Min Li,Li Ma,Dongxu Cui,Shuai Zhang,Rui Xiao
Chemical looping redox cycle of oxygen storage materials offers a versatile platform to convert methane to value-added products in a clean and efficient manner. However, the highly dynamic nature of the oxygen diffusion process restrains the selective formation of the target products over a long reaction period. In this work, we show the oxygen storage materials-comprising of iron oxides and zirconium oxide support, with the nickel catalyst controllably deposited—that significantly enhanced the syngas selectivity. Mechanistic study indicated the oxygen releasing rate can be well controlled within a long reaction period by the specific spatial structure, demonstrating a new strategy to tune the oxygen diffusion in chemical looping process. Through the observed spatial effects, this work can be also extended to develop more oxygen storage materials for the other chemical looping applications, e.g. methane reforming, methane oxidative coupling, ethane oxidative dehydrogenation, etc .
研究领域:
催化化学
·
能源化学
·
材料化学
·
化学工程
·
多相催化
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）