Journal of Integrative Neuroscience
·
2024
·Vol. 23
·期 1
·6
·
IF 2.5
Dongxia Duan,Xiaojin Wu,Usman Ali,Di Wang,Xue Li,Ruimei Liu,Le Ma,Yemeng Mao,Yan Ma
Background: Metformin has been shown to have potent analgesic effects; however, the underlying mechanism of synaptic plasticity mediating analgesia remained ambiguous. Methods: In this study, animal behavioral tests, whole-cell patch‑clamp recording, immunofluorescence staining, and network pharmacology techniques were applied to elucidate the mechanisms and potential targets of metformin-induced analgesia. Results: Single or consecutive injections of metformin significantly inhibited spinal nerve ligation (SNL)-induced neuropathic pain, and formalin-induced acute inflammatory pain. Network pharmacology analysis of metformin action targets in pain database-related targets revealed 25 targets, including five hub targets (nitric oxide synthase 1 (NOS1), NOS2, NOS3, epidermal growth factor receptor (EGFR), and plasminogen (PLG)). Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis demonstrated that metformin-induced analgesia was markedly correlated with calcium signaling and synaptic transmission. Intrathecal injection of metformin significantly reversed nerve injury-induced c-Fos (neural activity biomarker) mRNA and protein expression in neuropathic rats by regulating NOS2 expression. In addition, whole-cell recordings of isolated spinal neurons demonstrated that metformin dose-dependently inhibited the enhanced frequency and amplitude of miniature excitatory synaptic currents (mEPSCs) but did not affect those of miniature inhibitory synaptic currents (mIPSCs) in neuropathic pain. Conclusions: This study further demonstrated that metformin might inhibit spinal glutamatergic transmission and abnormal nociceptive circuit transduction by monitoring synaptic transmission in pain. Results of this work provide an in-depth understanding of metformin analgesia via synaptic plasticity.
研究领域:
药理学
·
神经科学
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疼痛研究
·
突触生理学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2022
·Vol. 10
·期 14
·5534-5541
·
IF 8.067
Qian Yang,Jinsong Huang,Qizhen Chen,Cihai Chen,Huipeng Chen,Tailiang Guo
Artificial synaptic transistors have shown great potential in artificial intelligence due to their low energy consumption, high scalability, similarity to biological neurons and precise regulation of channel conductance. A key step to achieving multifunctional synaptic transistors is to regulate synaptic weight in a fixed synaptic device using the same materials. However, the intrinsic properties of the films used for this purpose are affected by some uncertain factors, such as complicated processing and poor accuracy. Herein, a multifunctional synaptic transistor based on a thermo-denatured polar polymer material poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PAMPSA) is reported. Typical synaptic characteristics such as excitatory post synaptic current (EPSC), paired pulse facilitation (PPF) and long term potentiation (LTP) were successfully simulated under different annealing temperatures. More importantly, we have demonstrated that the polarization degree of PAMPSA was directly influenced by the annealing temperatures, and that even small temperature changes (<20 °C) would allow a wide regulation range of synaptic weight, indicating that the synaptic weight can be modulated purposefully and precisely. Hence, this work provides a simple, convenient and accurate approach to regulate synaptic weight and the memory retention of an artificial synapse via modulation of the annealing temperature, which facilitates a wide simulation range of artificial synapses and the development of artificial neuromorphic devices.
研究领域:
神经形态计算
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材料科学
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生物医学工程
✓ 已验证
DOI
高影响因子
IEEE TRANSACTIONS ON ELECTRON DEVICES
·
2024
·Vol. 71
·期 10
·6430-6434
·
IF 2.9
Wenlan Xiao,Yao Dong,Ranran Ci,Guoxia Liu,Fukai Shan
As an alternative for the future computer, the brain-like neuromorphic computing systems have been widely concerned for the characteristics of power efficiency, self-learning, and parallel computing. Meanwhile, the simulation of the synaptic behavior based on electronic devices has attracted widespread attention in past decades. In this report, indium-aluminum–zinc-oxide (InAlZnO) nanofibers were prepared by electrospinning, and the synaptic transistors based on InAlZnO nanofibers were integrated and investigated. With the excitatory response modes, the basic biological functions, including excitatory postsynaptic current (EPSC), paired-pulse facilitation (PPF), high-pass filtering properties, short-term memory (STM), and long-term memory (LTM), were simulated by the synaptic transistor. It is found that low-power consumption (~75 fJ/spike) and nonvolatility of the channel conductance for the synaptic transistor based on the InAlZnO nanofibers have been achieved. The pattern recognition training based on the long-term potentiation (LTP)/depression characteristics was developed by CrossSim simulation platform, and a recognition accuracy of 95.6% was achieved by using the Modified National Institute of Standards and Technology database. This work demonstrates a new approach for the establishment of the large-scale, energy-efficient artificial synapses for neuromorphic computing.
研究领域:
材料科学
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微电子学
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纳米科技
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神经形态工程
·
氧化物半导体
✓ 已验证
DOI
高影响因子
APPLIED PHYSICS LETTERS
·
2024
·Vol. 124
·期 16
·
IF 3.5
Li Xi'an,Feng Yanyan,Shi Lei,Zhou Jianlin,Ni Yao
The ability of artificial synapses to replicate multiplexed-transmission is a significant advancement in emulating complex brain activities. However, it generally required more stringent material requirements of intrinsic-ambipolarity and more complex structures of P/N dual-channel. Here, we proposed a far-gate synaptic transistor (FGST) just using a single-channel composed of a common unipolar semiconductor to emulate the cooperation and competition between two excitatory neurotransmitters. FGST exhibits a unique ion-charge dual-transfer mechanism, enabling distinct behavioral regulation modes with switchable synaptic plasticity: ion-dominant potentiation-depression with short-term plasticity and hole-dominant potentiation with enhanced memory. Moreover, FGST with dual-excitatory enhancement can be used for temporal contrast encoding, dividing currents into multiple memory states based on a fixed threshold; by comparing the variations in postsynaptic currents with different thresholds, it offers a method for further expanding the number of temporal states in the device. This work is a step toward constructing multifunctional artificial intelligent systems.
研究领域:
神经科学
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材料科学
·
人工智能
✓ 已验证
DOI
高影响因子
MATERIALS & DESIGN
·
2021
·
IF 7.991
Peng Shi,Dong Wang,Tongliang Yu,Ruofei Xing,Zhenfa Wu,Shishen Yan,Lin Wei,Yanxue Chen,Huixue Ren,Chunfeng Yu,Fangjun Li
In the past few years, synaptic device has become a hot topic in material science because of the urgent demand of neuromorphic computing. Ionic liquids gated three-terminal synaptic transistors have drawn extensive attention due to their outstanding energy efficiency, linearity, and symmetry. However, utilization of liquid electrolyte is not appropriate for the requirement of the practical application. Herein, a novel three-terminal synaptic transistor is designed and constructed using a solid-state electrolyte gate and a brownmillerite SrFeO 2.5 thin film channel. Topotactic phase transformation can be induced between insulative brownmillerite SrFeO 2.5 and conductive perovskite SrFeO 3−δ . Nonvolatile conductance switching of the SrFeO x film can be realized by inserting and extracting of oxygen ions with electrolyte gating. The essential synaptic learning functions including excitatory postsynaptic current, and short-term/long-term plasticity, are successfully mimicked in the three-terminal synaptic transistor. This synapse device achieves a large scale adjusted range and multistable plasticity, demonstrating a new way to achieve key component of upcoming neuromorphic circuitry.
研究领域:
材料科学
·
类脑计算
·
电子学
✓ 已验证
DOI
高影响因子
ENVIRONMENTAL RESEARCH
·
2025
·
IF 7.7
Xiang Zuo,Huijuan Bai,Jinyu Qiu,Ruimin Li,Xiaochen Kuang,Yudi Zhao,Jingyi Tuo,Qili Zhao,Xin Zhao,Xizeng Feng
Anxiety Disorder is a common neurological disorder for which ubiquitous environmental endocrine disruptors may be risk factors. 17β-trenbolone (17-TB) has been recognized as a potential environmental endocrine disruptor and its neurotoxic effects have attracted attention. Tachykinin receptor 3 (TACR3), a G protein-coupled receptor involved in pubertal anxiety, and its underlying neural mechanisms remain enigmatic. Therefore, this study investigated the possible relationship between 17-TB and TACR3, testosterone (T), and synaptic plasticity. Our results showed that adolescent male Balb/c mice developed significant anxiety-like behavior after four weeks of exposure to environmentally relevant concentrations of 17-TB (100 μg/kg/day). Transcriptomic RNA-Seq results showed that 17-TB affected abnormal synaptic transmission signals in the hippocampus. Electrophysiological results showed that 17-TB reduced the activity of hippocampal dentate gyrus (DG) neurons and led to the downregulation of hippocampal TACR3 and T levels. In addition, Western blot, immunohistochemistry, ELISA, and qRT-PCR showed that 17-TB exposure led to the downregulation of key hippocampal synaptic proteins PSD95, Gephyrin, and Syn, and induced a metabolic imbalance in glutamate (Glu)/GABA signaling, affecting dopamine signaling. Interestingly, testosterone supplementation (10 mg/kg/day) was effective in ameliorating the above phenomena and alleviating anxiety-like behaviors. These results suggest that 17-TB modulates anxiety-related synaptic plasticity by regulating hippocampal TACR3 and T interactions in vivo. In conclusion, our study contributes to understanding the neurobehavioral and potential mechanistic effects of environmental 17-TB exposure in mammals. It alerts the public to the health risks of chemicals to mammals and suggests new research directions and potential therapeutic targets.
研究领域:
神经科学
·
毒理学
·
内分泌学
✓ 已验证
DOI
PubMed
高影响因子
Life Sciences in Space Research
·
2022
·
IF 2.73
Fang Chen,Ning Jiang,Yi Wen Zhang,Meng Zhou Xie,Xin Min Liu
During the long-term orbital flight, exposure to microgravity negatively affects the astronauts' development of cognition, characterized by learning and memory decline. Gastrodia elata Blume (GEB) has a significant protective effect on cognitive impairment and has been used in Asia for centuries as a functional product. A previous study demonstrated that GEB could improve memory loss in mice caused by circadian rhythm disorders. However, the effects of GEB on cognitive dysfunction caused by weightless environments have not been investigated. In this study, mice received daily treatment with GEB (0.5, 1 g·kg −1 d −1 , i.g) and Huperzine A(Hup, 0.1 mg·kg −1 d −1 , i.g) orally until the end of the behavioral test (New object recognition test (NORT). Malondialdehyde (MDA) and nitric oxide (NO) levels were detected by kits, and expression of brain-derived neurotrophic factor (BDNF), protein kinase B (AKT), phosphorylated Akt (P-AKT), synaptophysin (SYN) and postsynaptic density 95(PSD95) in hippocampus were detected by western blotting . The results show that administration of GEB (0.5, 1 g·kg −1 d −1 , i.g) and Hup (0.1 mg·kg −1 d −1 , i.g) remarkably reverse HLS-induced learning and behavioral memory disorders, which were associated with significant changes in MDA and NO levels. Additionally, the protein expressions of BDNF, P-AKT/AKT, SYN, and PSD95 were significantly increased in the hippocampus. In summary, our findings will improve the reference for developing GEB as a functional product that improves memory decline.
研究领域:
神经科学
·
药理学
·
航天医学
✓ 已验证
DOI
PubMed
高影响因子
Applied Materials Today
·
2025
·
IF 6.9
Lingling Zhang,Zhenyu Li,Juan Luo,Jinli Fu,Chunli Jiang,Chunhua Luo,Chang Yang,Xiaodong Tang,Hechun Lin,Yan Cheng,Hui Peng
Lead-free halide perovskite materials have attracted increasing attention for neuromorphic applications owing to their non-toxicity, photoresponsivity, and transport properties. Herein, a two-terminal optoelectronic synaptic device based on CsCu 2 I 3 thin films was fabricated via a single-source thermal evaporation method. The ITO/CsCu 2 I 3 /Au device exhibited the versatile synaptic behaviours under both electrical and optical stimulation, benefiting from the excellent optoelectronic properties of CsCu 2 I 3 . Under electrical stimulation, the device achieved reliable resistive switching, low energy consumption (10.8 nJ), and a digit recognition accuracy of 97.17 %. Under optical stimulation, the device demonstrated reversible learning-forgetting-relearning behaviour, and frequency-dependent responses that enable high-pass filter for image sharpening. Notably, a classical Pavlovian conditioning process was successfully mimicked owing to its multi-wavelength photoresponsivity. This work provides a scalable and eco-friendly platform for multifunctional neuromorphic computing, in-sensor processing, and artificial perception systems.
✓ 已验证
产品关联
DOI
高影响因子
Advanced Science
·
2025
·
IF 14.1
Feng Gao,Zhongkun Zhang,Minzi Ju,Liang Bian,Huijuan Wang,Sibo Zhao,Ningbo Cai,Yu Wang,Yanpeng Jia,Ling Shen,Yuan Zhang,Honghong Yao
RNA therapeutics have recently shown significant promise in treating a variety of diseases, including cancers, infectious diseases, and genetic disorders. However, their potential in addressing neuropsychiatric disorders has been limited by the lack of an efficient delivery system to the central nervous system (CNS). Here, a novel nanoemulsion platform, perillyl alcohol nanoemulsions (PANEs) is introduced, designed for the therapeutic delivery of circDYM to brain and alleviated depressive-like behaviors. PANEs successfully encapsulated circDYM using cationic lipid compositions, enhancing its delivery efficiency to the mouse brain via its perillyl alcohol phase. The optimized formulation, PANE2-4, significantly improved the brain delivery efficiency of circDYM compared to both free circDYM and standard lipid nanoparticle formulations. Intranasal administration of PANE2-4-circDYM effectively alleviated depressive-like behaviors in the LPS-induced mouse model of depression. This effect is achieved by reducing the CD11b + CD45 dim microglia population and iNOS expression, restoring the expression of protein-95 (PSD-95) and synaptophysin. These findings indicated that PANE represents an efficient platform for delivering circRNAs to the brain, and intranasal administration of PANE2-4-circDYM is a promising strategy for ameliorating LPS-induced depressive-like behaviors.
研究领域:
神经科学
·
药剂学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Jiuzhou Ren,Hui Liang,Jiacheng Li,Ying Chen Li,Wei Mi,Liwei Zhou,Zhe Sun,Song Xue,Gangri Cai,Jin Shi Zhao
Memristors will be critical components in the next generation of digital technology and artificial synapses. Researchers are investigating innovative mechanistic understanding of the memristor devices based on low-cost, solution-processable, and organic materials as promising candidates. Here, we demonstrate a novel polyelectrolyte-based memristor device, which is simply prepared by spin-coating poly(acrylic acid) (PAA) and polyethylenimine (PEI) on an indium tin oxide (ITO) substrate followed by a magnetron sputtering of the ITO as the top electrode. The device has a potential to achieve excellent resistive switching (RS) performance and synapse functionality as well as greater flexibility and transmittance when compared to the oxide-based memories. An on/off resistance ratio of 50 can be maintained without degradation for up to 20 000 cycles (flat state) and over 4000 cycles (bending to a 2 mm radius 10 000 times) in the DC sweep mode. Moreover, the device performs various synaptic functions, including spike-timing-dependent plasticity, pulse pair plasticity, and short-term and long-term plasticity in the potentiation and depression processes. The counterions and two oppositely charged polyelectrolyte chains can move in and out of each other depending on the applied electrical potential (pulse), resulting in a change in the potential drop at the interface of the polyelectrolyte bilayer and its electrodes, which can be attributed to the RS mechanism and various synaptic functions. This insight may accelerate the technological deployment of the organic resistive memories.
研究领域:
材料科学
·
神经形态计算
·
电子工程
✓ 已验证
DOI
PubMed
高影响因子
Advanced Electronic Materials
·
2021
·Vol. 7
·期 8
·2100291
·
IF 7.295
Jie Lao,Wen Xu,Chunli Jiang,Ni Zhong,Bobo Tian,Hechun Lin,Chunhua Luo,Jadranka Travas-Sejdic,Hui Peng,Chun-Gang Duan
Artificial synapse of neuromorphic computing has been attracting significant attention as an alternative concept for next-generation computing. Here, a two-terminal synaptic device based on potassium iodide (KI) and CH 3 NH 3 PbI 3 (MAPbI 3 ) hybrid film (KI–MAPbI 3 ) is reported. The use of KI as an additive in the film preparation process greatly reduces grain boundaries, facilitating the improvement of device performance. The prepared synaptic device exhibits dual response to electric and light stimuli due to the unique properties of MAPbI 3 . Besides the successful simulation of biological synaptic functionalities such as paired-pulse facilitation (PPF), plasticity in long-term potentiation (LTP), and long-term depression (LTD), the learning behavior of human under different moods and Pavlov's dog experiment are also simulated by combining electric and light stimuli. For image recognition, the simulation result shows that the device achieves an accuracy of 84.2% under light illumination after only 1500 learning phases.
研究领域:
神经形态计算
·
材料科学
·
仿生学
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Xianjun Qi,Junying Zhang,Jianing Cai,Xuming Chu,Xiaohong Shao,Zhi-Ling Hou
Neuromorphic devices have gained considerable attention in mimicking the perception and memory of brains. As a type of neuromorphic device, broadband responsive optical synapses are urgently needed. In this work, an artificial optical synapse based on topological insulator Bi 2 Te 3 nanosheets is constructed by a simple solvothermal method, which can be sensitively modulated by wide spectral light from visible to near-infrared. The Bi 2 Te 3 nanosheets were fabricated as a photodetector through a spin-coating route, which exhibits a remarkable photoresponse with a maximum responsivity of 27.4 mA W −1 and a maximum detectivity of 4.21×10 10 Jones. The Bi 2 Te 3 photodetector showed a unique memory effect for light sources with different wavelengths, confirming its potential as an artificial optical synapse. Its photoresponse to infrared light showed no significant difference compared to visible light with higher energy, which lights up the future of developing broadband-responsive optical synaptic devices.
研究领域:
材料科学
·
纳米技术
·
类脑工程
·
光电技术
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）