FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Erpeng Chao,Jieying Li,Liuping Fan
This study provides valuable insights into the structural and functional characteristics of bigels containing hydrophilic (catechin, CAT) and lipophilic (curcumin, CUR) compounds, emphasizing the relationship between their rheological properties and digestive behavior. By adjusting the oleogel-to-hydrogel (OG-to-HG) ratios, bigels were tailored to exhibit distinct mechanical properties and digestion behaviors. The bicontinuous structure formed at a 5:5 OG-to-HG ratio (sample O5H5) exhibited delayed lipolysis and enhanced bioaccessibility of CUR (68.16% ± 1.78%) and CAT (56.16% ± 1.78%). This was supported by its high thixotropic recovery rate (76.43% ± 0.10%), longest delay time ( =12.33 ± 0.44 s), and optimal stress-stiffness ratio (S value = 0.81 ± 0.02), outperforming other structural configurations (OG-in-HG and HG-in-OG). This structure hinders the accessibility of digestive enzymes and bile salts, thereby slowing the breakdown of the lipid phase. Correlation analysis indicated strong positive relationships between the creep recovery rate and both the free fatty acid (FFA) release rate (r = 0.98, p < 0.001) and the bioaccessibility of CUR (r = 0.92, p < 0.01) and CAT (r = 0.93, p < 0.01). These findings suggest that enhanced resistance to deformation in the bigel matrix contributes to improved network integrity and increased bioaccessibility of co-encapsulated nutraceuticals. This study underscores the potential of bigel-based co-delivery systems in personalized nutrition.
研究领域:
食品科学
·
营养学
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产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2025
·
IF 6.5
Zi-Yun Wu,Kang-Yu Qiu,Yan-Jun Gai,Jia-Hui Wu,Bo-Xuan Zhou,Qing-Feng Shi
Breast cancer is one of the most common cancers among women worldwide, exhibiting notably high incidence and mortality rates. Despite its high fatality, a comprehensive study that mechanism and treatment of herbal medicines has not yet been conducted. Quercetin, a natural flavonoid, exhibits multi-targeted therapeutic potential against breast cancer. The aim of this study is to investigate and assess the mechanism and treatment of quercetin in breast cancer. We collected articles published within five years using PubMed, Google Scholar, and Web of Science with “breast cancer” and “quercetin” as
研究领域:
肿瘤学
·
药理学
·
天然产物
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Systems Microbiology and Biomanufacturing
·
2023
·
IF 0
Lin Rui,Chen Xingguang,Peng Zhengcong,Li Wenzhe,Chu Jiyang,Lu Jian,Xie Guangfa,Wu Dianhui
Herbs are rich in polyphenols compounds that are often added to beer to boost its antioxidant ability. To prove herbs can efficiently enhance the antioxidant ability of beer, the total polyphenols and flavonoids content, the distribution of phenolics profile, and antioxidant ability in commercial herbal beers were analyzed in this work. The results showed that most herbal beers had stronger antioxidant ability than conventional beers. The total polyphenols content in most herbal beers (250.8–1063.5 mg/L) was higher than that in conventional beers (179.2–308.4 mg/L), especially free phenolic acids (3.151–26.469 mg/L) such as gallic acid (0.248–2.853 mg/L), chlorogenic acid (0.422–6.420 mg/L), vanillic acid (0.567–10.256 mg/L), and caffeic acid (0.422–10.093 mg/L), which can explain the strong antioxidant ability of herbal beers to a certain extent. Among them, roselle beer (ROL) and jasmine beer (JAS) performed the strongest antioxidant ability. Furthermore, according to the distribution of phenolics profile, it was found that ROL and JAS had highest content of flavonoids including catechol, epicatechin, and quercetin compared with all beers. This was an important reason why ROL and JAS had the strongest antioxidant ability. In a word, the addition of herbs in beer brewing can effectively improve the content of polyphenols and antioxidant ability of beer, especially the herbs rich in flavonoids have the most significant contribution to the antioxidant ability of beer, which is helpful to improve beer quality.
研究领域:
食品科学
·
植物化学
·
营养学
·
酿造工艺
✓ 已验证
DOI
FOOD CHEMISTRY
·
2018
·
IF 4.946
Yike Yue,Sheng Geng,Yue Shi,Guizhao Liang,Jinshui Wang,Benguo Liu
Zein has the potential application of establishing the delivery systems for flavonoids . But there are few reports about the effect of the molecular structures of flavonoids on their interaction with zein . In this study, the binding behaviour of 21 flavonoids and zein was investigated by spectrofluorimetry. The corresponding 3D-QSAR model was also established by Topomer CoMFA method, whose steric and electrostatic field analysis could explain the binding performance of the tested flavonoids with zein. The fluorescence analysis suggested that the flavonoids could interact with zein by forming the complex at the molar ratio of 1. The flavonoids with glucosyl groups at ring A exhibited the outstanding binding capacity with zein, and their binding process with zein was driven by hydrophobic force. The synchronous and 3D fluorescence spectra showed that there was no apparent change in the microenvironment surrounding the tyrosine residues of zein during the interaction.
研究领域:
食品科学
·
生物化学
✓ 已验证
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Shen Zhang,Songnan Hu,Yan Zhou,Minting Xie,Yuhe Liao,Fengxia Yue
Lignin contains benzene rings, carbonyl groups, and phenolic groups that serve as natural macromolecular UV absorber. However, lignin provides insufficient protection in the UVA region because it lacks a long conjugated structure. In this study, we propose a flavonoids-in-lignin coextraction strategy to improve lignin’s UVA protection performance. Flavonoids-containing lignin was isolated from Musa basjoo (Musa basjoo Siebold) and Moso bamboo (Phyllostachys edulis) leaves using l-cysteine (l-cys)-assisted extraction, and the contents of flavonoids in lignin could be further enhanced by employing non-dewaxed sources. Lignin’s UV-protective performance and antioxidant activity were improved as more flavonoids were reserved. Particularly, lignin isolated from non-dewaxed bamboo leaves (NBL) exhibited the best UV protection performance, achieving a sun protection factor (SPF) value of 40.99 with the addition of 5 wt % lignin into SPF 15 commercial sunscreen, representing a 143% enhancement, and a UVA protection factor (PFA) value of 12.17, reflecting a 109% increment. The sunscreens prepared from flavonoid-rich lignin maintained SPF values exceeding 30 and PFA values exceeding 9 (PA+++) even after 8 h of UV irradiation, indicating their long-term UV-protective properties. Furthermore, flavonoids-in-lignin coextraction demonstrated superior UV-protective performance compared to alkali lignin with adscititious flavonoid extracts. This study leverages the inherent advantages of natural plant cell wall components through a straightforward coextraction strategy, further unlocking the potential of lignin for sunscreen applications.
研究领域:
植物学
·
材料科学
·
化妆品科学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Zhongyong Xu,Xiongfei Zhao,Mei Zhou,Zhijun Zhang,Tianyi Qin,Dong Wang,Lei Wang,Xiaojun Peng,Bin Liu
Increasing demand for detecting environmental and biological analytes in aqueous solutions based on fluorescent probes has raised the bar for the fluorophores used. Especially, the twisted intramolecular charge transfer (TICT) state of fluorophore can trigger the formation of a charge-separated non-emissive specie, leading to a low fluorescence brightness. In this work, we performed a simple donor engineering on the flavonoid-based fluorophores to regulate the TICT formation. A systematic study on relationship between donor structure and photophysical properties has been carried out. Among a series of flavonoids, the methylpiperazine-substituted one exhibited the strongest fluorescence brightness in water since the methylpiperazine could rigidify the rotation of donor moiety to suppress TICT state. Moreover, a novel fluorescent probe based on this flavonoid successfully realized the cysteine detection both in water and in living cells. This work confirmed the validity of design strategy by inhibiting TICT to enhance the fluorescence brightness, and also provided a practical flavonoid-based fluorophore for further bioimaging applications.
研究领域:
化学
·
生物化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Food Bioscience
·
2023
·
IF 5.2
Xuewen Dong,Jie Tang,Xiaoting Qin,Shenglan Tian,Huasi Lin,Qiang Yu,Xiaobo Hu,Mingyong Xie
The research was conducted to investigate the quality changes of basic physicochemical indicators, functional components and appearance, such as, pH, total color difference, Browning Index, polyphenols, flavonoids , anthocyanins , VC, and 5-hydroxymethylfurfural content and so on of Dendrobium officinale flower juice (DOFJ) under the dark storage conditions of 4, 25 and 37 °C and the natural light irradiation storage conditions of 25 °C for 8 weeks. Correlation and path analyses were used to analyze the causes of color degradation of DOFJ. Although measures had been taken during the preparation process to inhibit enzymatic browning by deactivating the activity of polyphenol oxidase (PPO), DOFJ was still unstable under four storage conditions, especially for color degradation. With the increase of temperature and time, the basic physicochemical indexes did not change significantly, but the content of functional components gradually decreased, and the appearance gradually deteriorated. The path analysis indicated that anthocyanins degradation was the key factor of color degradation of DOFJ, and low temperature and light protection could delay the degradation of anthocyanins. The main cause of color degradation of DOFJ during storage was identified, which provided a basis for further inhibiting color degradation of flower juice.
研究领域:
食品科学
·
植物化学
✓ 已验证
产品关联
DOI
高影响因子
ENZYME AND MICROBIAL TECHNOLOGY
·
2025
·
IF 3.7
Chen-Xin Guo,Jiyan Li,Yu Wang,Tang Li,Heng Yin
Stevia rebaudiana , a perennial herb, is recognized not only for its sweet steviol glycosides but also for its rich flavonoid content, which confer pharmacological properties including anti-inflammatory, antimicrobial, and anticancer activities. However, the enzymatic basis underlying flavonoid modification in S. rebaudiana remains poorly understood. In this study, we identified, cloned, and heterologously expressed a novel flavonoid glycosyltransferase gene, SrUGT72B1 in E. coli . The recombinant SrUGT72B1 catalyzed the glycosylation of multiple flavonoids using UDP-glucose as the primary sugar donor, and exhibited broad substrate promiscuity toward apigenin, luteolin, phloretin and kaempferol. In addition to UDP-glucose, SrUGT72B1 also accepted UDP-xylose and UDP-rhamnose, with UDP-glucose exhibiting the highest catalytic efficiency. Biochemical characterization revealed that the enzyme functions optimally at pH 9.0 and 50 °C. Notably, SrUGT72B1 demonstrates regioselective 5-O-glycosylation toward apigenin, a rare activity among plant glycosyltransferases. Molecular docking and molecular dynamics simulations provided structural insights into this unique regioselectivity and substrate recognition. Together, these findings establish SrUGT72B1 as a previously uncharacterized flavonoid 5-O-glycosyltransferase, expanding the functional landscape of plant UGTs and offering potential applications in the biosynthesis of value-added flavonoid glycosides.
研究领域:
植物学
·
生物化学
·
分子生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Xianwen Song,Zequn Zhang,Zhaolong Shen,Jun Zheng,Xi Liu,Yaqiong Ni,Jun Quan,Xiaorong Li,Gui Hu,Yi Zhang
Hydrogels have attracted widespread attention for breaking the bottlenecks faced during facile drug delivery. To date, the preparation of jelly carriers for hydrophobic drugs remains challenging. In this study, by evaporating ethanol to drive the formation of hydrogen bonds, hydrophilic poly(vinyl alcohol) (PVA) and certain hydrophobic compounds [luteolin (LUT), quercetin (QUE), and myricetin (MYR)] were rapidly prepared into supramolecular hydrogel within 10 min. The gelation performance of these three hydrogels changed regularly with the changing sequence of LUT, QUE, and MYR. An investigation of the gelation pathway of these hybrid gels reveals that the formation of this type of gel follows a simple supramolecular self-assembly process, called “hydrophobe–hydrophile crosslinked gelation”. Because the hydrogen bond between PVA and the drug is noncovalent and reversible, the hydrogel has good plasticity and self-healing properties, while the drugs can be controllably released by tuning the output stimuli. Using a rat sidewall-cecum abrasion adhesion model, the as-prepared hydrogel was highly efficient and safe in preventing postsurgical adhesion. This work provides a useful archetypical template for researchers interested in the efficient delivery and controllable release of hydrophobic drugs.
研究领域:
生物材料学
·
药剂学
·
医学
✓ 已验证
DOI
PubMed
高影响因子
TALANTA
·
2019
·
IF 4.916
Mohammad Chand Ali,Jia Chen,Haijuan Zhang,Zhan Li,Liang Zhao,Hongdeng Qiu
The efficient extraction of natural products from biomass is deemed an essential area of interest using green technology in the pharmaceutical and biochemical industries. In recent years, deep eutectic solvents (DESs) have been paying broad interest as compatible, safe, and inexpensive solvents. In this study, we addressed, for the first time, to give a fruitful illustration to extract bioactive compounds from favourite Lycium barbarum L. fruits using DESs as green designer solvents, and displaying the tuneability of DESs to extract bioactive compounds from biomass efficiently. Among the studied DESs, the 1 : 2 M mixture of choline chloride and p -toluene sulfonic acid (DESs-6) with an ultra-sound assisted extraction (UAE) method was more efficient to get high extraction yields of flavonoids including myricetin (57.2 mg/g), morin (12.7 mg/g), and rutin (9.1 mg/g) in net DESs. The resulting extraction method in which 50 mg of sample powder was extracted by UAE for 1.5 h using DESs-6 was found to be a more efficient process than conventional extraction methods such as heating plus stirring. Operational conditions including the extractant to sample solid ratio, the effect of water content, the effect of temperature, recycling of DESs, and the effect of ultra-sound irradiation time were investigated. The proposed DESs based extraction procedure attained recovery for flavonoids were in the range 75.6%–96.9%. Therefore, p -toluenesulfonic acid-based DESs may have strong potential as promising materials for the green and efficient extraction of pharmaceutical compounds from other plants or fruits.
研究领域:
植物化学
·
天然产物研究
·
药学
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2014
·Vol. 6
·期 9
·2894-2899
·
IF 1.938
Bowen Xiao,Huijuan Wang,Xijuan Zhao,Yuanfang Li
Selective recognition of ortho-dihydroxy-substituted flavonoids has been developed based on their specific interaction with the fluorescent complex, 4-(methylphenyl)-2,2′:6′,2′′-terpyridine–Zn(II) (mptpy–Zn(II)). Six related flavonoids, including quercetin, naringenin, genistein, luteolin, daidzein, and morin, which have hydroxyl substituents in different positions, have been investigated. It has been observed that the ortho-3′,4′-dihydroxy substituents in luteolin and quercetin play an important role in the fluorescence quenching of mptpy–Zn(II) as ternary complexes are formed between luteolin/quercetin and mptpy–Zn(II). The quenching constants and fluorescence lifetime measurements indicated that the quenching was static. As the easy oxidation of 3-hydroxy and 4′-hydroxy in quercetin reduced the number of ortho-dihydroxy groups, luteolin had a greater quenching efficiency than quercetin under the same conditions. Furthermore, this fluorimetric method was successfully applied in the determination of the luteolin content in Lamiophlomis capsules from two factories, with satisfactory results compared with an HPLC method.
研究领域:
分析化学
·
药理学
·
植物化学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2019
·
IF 5.399
Nan Yang,Ruixia Qiu,Shuo Yang,Kangning Zhou,Chengtao Wang,Shiyi Ou,Jie Zheng
Bakery products with fruit fillings are growing fast. Blueberry-filled pastries are widely consumed in China. This study aimed to investigate the effects of two thermal processing procedures (stir-frying and baking) on flavonoid profile, antioxidant property, and hydroxymethylfurfural (HMF) formation during preparation of blueberry-filled pastries. Stir-frying contributed the most to the variations in these values in blueberry filling. Anthocyanins (48%–53% reduction in total) were more susceptible to thermal processing than flavonols (11%–16%). Among anthocyanins, delphinidin glycosides (61%–67% reduction) were the most unstable, followed by malvidin (52%–58%), petunidin (40%–45%), and cyanidin (38%–41%). A high level of HMF (300 mg/kg) was formed during stir-frying. Except for anthocyanins, baking did not significantly influence HMF formation, flavonol degradation, and antioxidant property in the fillings. Stir-frying processing conditions rather than baking must be further investigated for nutrient retention and HMF inhibition.
研究领域:
食品科学
·
营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）