The wide application of antibiotics and nanoparticles has made their coexistence in soil a new environmental problem, and the coexistence of multiple pollutants in soil may impact their environmental behaviour. In this study, by dividing soil into coarse particle (CP) and fine particle (FP) phases via differential centrifugation, oxytetracycline (OTC) and TiO 2 nanoparticles (NPs) were selected as two typical pollutants to study their coadsorption behaviour on Lou soil. The coadsorption mechanism of OTC and TiO 2 NPs on Lou soil was discussed through their morphology and characteristics by using SEM, XRD, BET specific surface, XPS and FT-IR analyses. The adsorption capacity of OTC on the FP phase was much greater than that on the CP phase. Hydrogen bonding and charge attraction are the main adsorption mechanisms of OTC on both the CP and FP phases. π-π interactions are another main adsorption mechanism of OTC sorption on the FP phase. Hydrogen bonding and charge attraction are the main mechanisms of TiO 2 NPs sorption on soil. OTC and TiO 2 NPs compete on the surface of soil particles through charge attraction and hydrogen bonding, thus inhibiting their adsorption.
Purpose The objective of this study is to elucidate the sensitizing effect of mesoporous silica nanoparticles (MSNs) on shear wave elastography (SWE) and to investigate the potential application of MSNs as a sensitizer to enhance the sensitivity of SWE in the diagnosis of metabolic-associated steatohepatitis (MASH). Materials and methods The in vitro gelatin models with varying ratios were assessed using SWE to identify the gelatin ratio that most closely approximates with human liver stiffness. Following the characterization of the dispersion properties of MSNs, in vitro models incorporating MSNs of different particle sizes were developed. The variations in shear wave velocity (SWV) within these models were measured and subjected to statistical analysis using SWE. The biocompatibility of the MSNs was evaluated, and the MSN solution was subsequently administered into a MASH animal model. The sensitizing effect of SWE on rat liver was then analyzed statistically. Results The in vitro model demonstrated that MSNs with smaller particle sizes (100 nm and 200 nm) facilitated the propagation of SWV, thereby enhancing the sensitivity of SWE ( P < 0.05). Additionally, the cell viability and hemolysis ratio of 100 nm MSNs were superior to those of 200 nm MSNs (P < 0.05). In vivo animal model experiments indicated that 100 nm fluorescence-modified MSNs could penetrate the MASH liver and elevate the liver stiffness value as measured by SWE. Conclusion MSNs have the potential to enhance the sensitivity of SWE in the diagnosis of MASH. This approach offers novel insights for improving the efficacy of SWE in clinical diagnostic and therapeutic applications.
危险品化学品经营许可证（带存储）