CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Kui Liu,Kuibao Zhang,Ting Deng,Jianjun Zeng,Baozhu Luo,Haibin Zhang
Gd 2 Zr 2 O 7 ceramic is considered as one of the most promising host minerals for the immobilization of high-level radioactive wastes . Here, the effects of grain size on the aqueous durability of Gd 2 Zr 2 O 7 ceramics were studied. Two kinds of leaching experiments were used to research Gd 2 Zr 2 O 7 ceramic powders and bulks with different grain sizes (5 nm, 78 nm, 1 μm and 18 μm). The results demonstrate that the normalized leaching rates decrease with the increase of grain size. Through characterization and analysis, it is concluded that the hydrolysis reactions of Gd 2 Zr 2 O 7 occur in the leaching experiment and the hydrolysates are Gd(OH) 3 and Zr(OH) 4 . Besides, all the samples after leaching exhibit slight lattice contraction, which decreases with the increase of crystal grain size. The influence of leaching on the elemental distribution is most significant for the sample with grain size of 5 nm. This study has theoretical guiding significance for the application of Gd 2 Zr 2 O 7 immobilization.
研究领域:
材料科学
·
核废料管理
·
环境化学
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
·
2018
·
IF 4.7
Qiming Wang,Shourui Li,Qiang He,Wenjun Zhu,Duanwei He,Fang Peng,Li Lei,Leilei Zhang,Qiang Zhang,Lijie Tan,Xin Li,Xiaodong Li
Zinc oxide, ZnO, an important technologically relevant binary compound, was investigated by reciprocating compress the sample in a diamond anvil cell using in situ high-pressure synchrotron X-ray diffraction at room temperature. The starting sample (∼200 nm) was compressed to 20 GPa and then decompressed to ambient condition. The quenched sample, with average grain size ∼10 nm, was recompressed to 20 GPa and then released to ambient condition. The structural stability and compressibility of the initial bulk ZnO and quenched nano ZnO were compared. Results reveal that the grain size and the fractional cell distortion have little effect on the structural stability of ZnO. The bulk modulus of the B4 (hexagonal wurtzites structure) and B1 (cubic rock salt structure) phases for bulk ZnO under hydrostatic compression were estimated as 164(3) and 201(2) GPa, respectively. Importantly, the effect of pressure in atomic positions, bond distances, and bond angles was obtained. On the basis of this information, the B4-to-B1 phase transformation was demonstrated to follow the hexagonal path rather than the tetragonal path. For the first time, the detail of the intermediate hexagonal ZnO, revealing the B4-to-B1 transition mechanism, was detected by experimental method. These findings enrich our knowledge on the diversity of the size influences on the high-pressure behaviors of materials and offer new insights into the mechanism of the B4-to-B1 phase transition that is commonly observed in many other wurzite semiconductor compounds.
研究领域:
材料科学
·
物理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DRUG DELIVERY
·
2018
·
IF 3.095
Bin Ma,Lizhen He,Yuanyuan You,Jianbin Mo,Tianfeng Chen
Nanomaterials-based drug delivery systems display potent applications in cancer therapy, owing to the enhanced permeability and retention effect and diversified chemical modification. In this study, we have tailored and synthesized different sized mesoporous silica nanoparticles (MSNs) through reactant control to investigate the relevancy of nanoparticle size toward anticancer efficacy and suppressing cancer multidrug resistance. The different sized MSNs loaded with anticancer ruthenium complex (RuPOP) and conjugated with folate acid (FA) to enhance the selectivity between cancer and normal cells. The nanosystem (Ru@MSNs) can specifically recognize HepG2 hepatocellular carcinoma cells, thus enhance accumulation and selective cellular uptake. The smaller sized (20 nm) Ru@MSNs exhibit higher anticancer activity against HepG2 cells, while the larger sized (80 nm) Ru@MSNs exhibit higher inhibitory effect against DOX-resistant hepatocellular carcinoma cells (R-HepG2). Moreover, Ru@MSNs induced ROS overproduction in cancer cells, leading to DNA damage and p53 phosphorylation, consequently promoting cancer cells apoptosis. Ru@MSNs (80 nm) also inhibited ABCB1 and ABCG2 expression in R-HepG2 cells to prevent drug efflux, thus overcome multidrug resistance. Ru@MSNs also inhibited tumor growth in vivo without obvious toxicity in major organs of tumor-bearing nude mice. Taken together, these results verify the size effects of MSNs nanosystem for precise cancer therapy.
研究领域:
肿瘤学
·
纳米医学
·
药物递送
·
分子生物学
·
转化医学
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Luomeng Chao,Changwei Sun,Jiaxin Li,Miao Sun,Jia Liu,Yonghong Ma
Although the optical properties of nanocrystalline cesium tungsten bronze have been widely studied, there is a lack of research on the effect of particle size on its optical properties. In order to further investigate size and shape effect on the NIR shielding performance, cesium tungsten bronze nanoparticles with different sizes and morphologies were prepared by two methods. The size of irregular shaped samples prepared by solvothermal method is tens of nanometers, while the size of hexagonal prism shaped samples prepared by solid state reaction method is hundreds of nanometers. The element spectrums shows that there are more oxygen vacancies in large particles than in small particles. The NIR shielding performance of large particles far lower than that of small particles, indicating that the influence of shape and size on optical properties is more obvious than that of oxygen vacancy. Theoretical calculation on hexagonal prism shaped particles exhibits that the NIR extinction of large aspect ratio is better at longer wavelength and small aspect ratio is better at shorter wavelength.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2017
·
IF 2.536
Jian Zhu,Zhu-Jun Zhao,Jian-Jun Li,Jun-Wu Zhao
Mercury ions-induced fluorescence quenching properties of CdTe quantum dots (QDs) have been studied using the fluorescence spectroscopic techniques. By using the hydrothermal method , the CdTe QDs with different particles sizes from 1.98 to 3.68 nm have been prepared, and the corresponding fluorescence emission wavelength is changed from 518 to 620 nm. The fluorescence of QDs is enhanced after linking Bovine serum albumin (BSA) onto the surface of the QDs. Experimental results show that the fluorescence intensity of BSA-coated CdTe QDs could be effectively quenched when Hg 2 + react with BSA-coated CdTe QDs. Interestingly, both the sensing sensitivity and selectivity of this fluorescence probe could be improved when the particle size of the QDs decreases. Thus the BSA-coated CdTe QDs with green fluorescence emission have better advantages than the BSA-coated CdTe QDs with red fluorescence for Hg 2 + detection. Interference experiment results indicate that the influence from other metal ions could be neglected in the detection, and the Hg 2 + could be specifically detected. By using this BSA-coated CdTe QDs-based fluorescence probe, the Hg 2 + could be detected with an ultra-low detection limit of nanomole level, and the linear range spans a scope from 0.001 to 1 μmol/L.
研究领域:
分析化学
·
环境科学
·
生物医学
✓ 已验证
DOI
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2020
·
IF 3.408
Xiangying Ma,Yanqiu Zhu,Liuyu Lu,Cuiyi Liang,Qifeng Chen,Yanjuan Liao
Spherical cadmium sulfide (CdS), with five kinds of particle size ranging from 31 nm to 117 nm were synthesized by microemulsion method. The phase composition and morphology of CdS were characterized by field emission scanning electron microscopy (FE-SEM) and X-ray diffraction (XRD), respectively. Based on solution thermodynamic theory, combined with thermochemical cycle theory and thermodynamic theory, the theoretical models and the relationships between molar surface thermodynamic functions and partial mole surface thermodynamic functions of spherical nanomaterials with different particle sizes were deduced and established. The law and reason of particle size and temperature effects on surface thermodynamic function for cadmium sulfide nanospheres , as well as particle size effects on the prescribed thermodynamic function, were discussed. Results show that the ratio of partial molar surface thermodynamic functions to molar surface thermodynamic functions of CdS nanospheres ( G N P s : G m s , H N P s : H m s , S N P s : S m s )have the value of 2:3. The reciprocal of particle size is linearly proportional to the molar surface thermodynamic functions, which agreed well with the theoretical thermodynamic models of spherical nanoparticles . With the same particle size, G m s , S m s and H m s all increase as temperature increases. At 298.15 K, the absolute value of Δ f G m b , θ and Δ f H m n , θ both increase while S m n , θ decreases with the particle size of CdS nanospheres increase.
研究领域:
材料科学
·
热力学
✓ 已验证
DOI
高影响因子
Nano Research
·
2018
·Vol. 11
·期 6
·3396-3410
·
IF 7.994
Wu Dongyan,Wang Huaisong,Hou Xiaoshuang,Chen Huan,Ma Yu,Hou Yanglong,Hong Jin,Ding Ya
Studies on the influence of one critical parameter (e.g., size), targeting a specific disease, while keeping other factors unchanged, are important for improving understanding and application of the molecular design of biomedical nanomaterials. In this study, we used doxorubicin (Dox)-conjugated gold nanoparticles (GNPs) to investigate the effects of the size of the gold core (10, 20, or 60 nm) on the performance of their conjugates. We found that all three conjugates differed slightly in their physicochemical properties, facilitating a direct and accurate assessment of the size effects of GNP-Dox conjugates on their in vitro and in vivo performance. The cytological properties (the cell penetration rate and efficiency, as well as the cytotoxicity) and antitumor performance (the intratumoral penetration, treatment efficacy, and biodistribution) were highly correlated to the size of the inorganic core. Among all test groups, although the conjugate with a 60-nm gold core had the highest drug loading and release efficiency, the conjugate with a 10-nm gold core displayed the best antitumor efficacy toward the liver cancer models. This was because it showed the deepest tumor permeability and the highest tumor cell-killing ability of Dox transported by the relatively small GNPs. This study provides important evidence for better understanding the effect of size on in vitro and in vivo properties of potential therapeutic nanosystems and their structure design.
研究领域:
纳米医学
·
肿瘤学
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale Advances
·
2022
·Vol. 4
·期 5
·1414-1421
·
IF 5.598
Hui Zhang,Jianping Zhang,Yi Chen,Tianze Wu,Mingzhu Lu,Zhenxia Chen,Yu Jia,Yongtai Yang,Yun Ling,Yaming Zhou
The size modulation of hollow carbon nanospheres (HCSs) has attracted great interest in the contexts of cellular uptake, drug delivery and bioimaging. In this study, a facile fabrication method was specifically used to minimize all influencing factors except for the particle size. A series of nanoparticles of hollow carbon nanospheres embedded with magnetic resonance imaging (MRI) nanoagent γ-Fe2O3 and GdPO4 nanoparticles (Fe–Gd/HCS), were successfully prepared and applied to in vitro/vivo evaluation with well-defined sizes of ∼100 nm (Fe–Gd/HCS-S), ∼200 nm (Fe–Gd/HCS-M), and ∼300 nm (Fe–Gd/HCS-L), respectively. Then the in vitro size effect of Fe–Gd/HCS was systematically investigated by bio-TEM, CLSM, CCK-8 assay, and flow cytometry revealing that Fe–Gd/HCS could be internalized and the cellular uptake amounts increase with the decrease of size. Furthermore, the in vivo size-effect behavior of Fe–Gd/HCS (∼100 nm, ∼200 nm, ∼300 nm) was tracked by MRI technique, demonstrating that all Fe–Gd/HCS can distinguish the liver, in which Fe–Gd/HCS with the smallest particle size exhibited the best performance among these nanoparticles. By leveraging on these features, Fe–Gd/HCS-S (∼100 nm) was further chosen as a theranostic agent, preliminarily presenting its capability for multi-modal imaging and therapy.
研究领域:
纳米医学
·
生物材料
·
医学影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Mingshuai Sun,Fumin Wang,Guojun Lv,Xubin Zhang
S-containing silane coupling agents (SCA) with various structures were chosen as regulators to synthesize PdC nanoparticles in different sizes for semi-hydrogenation of acetylene. Characterization and catalytic performance demonstrate that the catalytic property of PdC is deeply influenced by particle size. PdC particles prepared by employing SCA containing sulfhydryl has a smaller size and narrow diameter distribution. They exhibited better inhibition on ethane formation than those by containing thioether bond. Catalysts with larger PdC particles have lower selectivity to C4 and green oil. Reaction paths on typical (1 1 1) surface of PdC nanoparticles with different dimensions were investigated by DFT calculations. It reveals that within a certain particle size range (∼2.6 nm), surfaces of smaller PdC particles have weaker adsorption strength of ethylene. As particle size exceeds 2.6 nm, the adsorption strength no longer increases. C4 and green oil are more likely to be generated when PdC particles are around 2 nm, and the size smaller or larger than 2 nm will weaken the tendency of C4 and green oil formation.
研究领域:
催化化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Micro & Nano Letters
·
2019
·Vol. 14
·期 13
·1340-1343
·
IF 0.975
Zijun He,Huanfeng Tang,Zaiyin Huang
Four different sizes of cuprous oxides (Cu 2 O) nanocubes in the range of 40–120 nm were synthesised by liquid phase reduction method. The morphology, size, and structure of synthesised Cu 2 O nanocubes were characterised by scanning electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. In-situ microcalorimetry was used to calculate the conventional and surface thermodynamic functions of Cu 2 O nanocubes by combining thermodynamic principles and transition state theory. The effect of particle size on conventional thermodynamic functions and surface thermodynamic functions were investigated and analysed, whose results were supported by the established thermodynamic models. Results showed that both the standard molar enthalpy of formation and the standard molar entropy of formation were increased with decreasing particle size, while the standard molar Gibbs energy of formation decreased. Also, the molar surface Gibbs energy, molar surface enthalpy, and molar surface entropy grew with the reduction of particle size, which correlated well with the models. Such a property is of scientific significance for enriching and developing disciplines such as surface physics and surface thermodynamics.
研究领域:
材料科学
·
表面物理
·
热力学
✓ 已验证
产品关联
DOI
高影响因子
Discover Applied Sciences
·
2025
·Vol. 7
·期 7
·728
·
IF 0
Lan Tian,Ding Xiaofan,Xiao Songtao,Yuan Zhongwei,Yan Taihong,Chen Qi,Li Tianchi,Zheng Weifang
Developing effective iodine capture technologies is critical for both nuclear safety and environmental protection. This study investigates the iodine adsorption properties of ZIF-8, a metal–organic framework (MOF). ZIF-8 samples with varying particle sizes (∼50 nm, 90 nm, 150 nm, and 8 μm) were synthesized and tested for iodine vapor adsorption at 80 °C. Iodine uptake continuously increased with time, reaching ~ 3500 mg/g after 24 h without reaching equilibrium, with no significant dependence on particle size. Structural changes in ZIF-8 were observed, as iodine accumulation led to the breakdown of the framework into an amorphous gel-like substance, representing a previously unreported phase transformation. SEM and XRD characterization confirmed the collapse of the crystalline structure after iodine loading. These results indicate that iodine adsorption in ZIF-8 involves strong chemisorption in addition to physical uptake, causing irreversible framework transformations. This work highlights the influence of particle size and provides important insights for using ZIF-8 in effective radioactive iodine capture.
研究领域:
材料科学
·
环境化学
·
核安全
·
吸附科学
·
金属有机框架化学
✓ 已验证
产品关联
DOI
RSC Advances
·
2016
·Vol. 6
·期 17
·13698-13709
·
IF 3.289
Ying Hao,YiXing Huang,YunQi He,JinRong Peng,LiJuan Chen,Xun Hu,ZhiYong Qian
In this study, we successfully prepared MPEG–PDLLA polymer micelles with two different particle sizes, A and B. DLS and TEM assays demonstrated that the particle sizes of the polymer micelles A and polymer micelles B were about 25 nm and 150 nm respectively. The stability of the MPEG–PDLLA polymer micelles in vitro revealed that the free Cy5.5 dye had been successfully loaded into the polymer micelles as a fluorescence marker and the fluorescence wasn’t quenched until 72 h. The cellular uptake of the polymer micelles was time-dependent and micelles A (particle size 25 nm) showed a higher efficiency to be internalized into the cytoplasm of MCF-7 cells than micelles B (particle size 150 nm). Furthermore, in vivo and in vitro biodistribution and tumor-targeting of polymer micelles MPEG–PDLLA were investigated in female MCF-7 tumor-bearing balb/cA-nu mice with an IVIS imaging system. The results showed that polymer micelles A (particle size 25 nm) had a time dependent biodistribution and tumor site accumulation in mice bearing MCF-7 tumors. Meanwhile, the NIR fluorescence intensity of polymer micelles B (particle size 150 nm) in tumor sites showed a pattern of a rise, a peak and then a decline. What’s more, the distribution of the polymer micelles in the tissue slices demonstrated the same results. Consequently, the results indicated that the micelles with a smaller particle size (25 nm) could be more efficiently internalized into cells and increase the enhanced permeation and retention (EPR) effect in tumor tissue. Therefore, a reasonable small size of micelles may be a key factor for a high-performance anti-cancer drug delivery system.
研究领域:
药剂学
·
肿瘤学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）