Food & Function
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2025
·
IF 5.4
Kuang Yao,Feng Yao,Xue Songwen,Yun Huang,Qiong Shao,Lichun Chen
Sugar alcohols are a class of low digestible carbohydrates that are commonly used as sweeteners and humectants in foods. Sugar alcohols of different chain lengths may have different effects on the structure and function of cell membranes, but their specific mechanisms of action and their relationship with osmosis have not been systematically studied. In this study, the effects of three sugar alcohols with different chain lengths, erythritol (Ery), xylitol (Xyl) and sorbitol (Sor), on the permeability of cell membranes were investigated using living cell membranes and artificial multilamellar vesicles (MLVs) models. The results of fluorescence microscopy showed that Ery had the greatest effect on the structure of MLVs, resulting in significant deformation of MLVs. This was closely followed by Xyl and Sor, which had relatively little effect on vesicle structure. In addition, cellular experiments showed that Ery failed to significantly increase intracellular reactive oxygen species (ROS) levels as well as maintain the membrane potential cell membrane potential at the same concentration compared to Xyl and Sor, which enhanced membrane adsorption and slowed down the decrease of membrane potential. These results suggest that sugar alcohols with different chain lengths have different permeation effects on biological membranes and provide a theoretical basis for understanding their functions in physiological environments.
研究领域:
食品科学
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生物物理学
·
膜生物学
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碳水化合物化学
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细胞生理学
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产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2024
·
IF 3.7
Yugang Shu,Jiaguang Zheng,Chengguo Yan,Ao Xia,Meiling Lv,Zhenxuan Ma,Zhendong Yao
NaBH 4 was widely regarded as a low-cost hydrogen storage material due to its high-mass hydrogen capacity of approximately 10.8% (mass) and high volumetric hydrogen capacity of around 115 g·L –1 . However, it exhibits strong stability and requires temperatures above 500 °C for hydrogen release in practical applications. In this study, two polyhydric alcohols, xylitol and erythritol (XE), were prepared as a binary eutectic sugar alcohol through a grinding-melting method. This binary eutectic sugar alcohol was used as a proton-hydrogen carrier to destabilize NaBH 4 . The 19NaBH 4 -16XE composite material prepared by ball milling could start releasing hydrogen at 57.5 °C, and the total hydrogen release can reach over 88.8% (4.45% (mass)) of the theoretical capacity. When the 19NaBH 4 -16XE composite was pressed into solid blocks, the volumetric hydrogen capacity of the block-shaped composite could reach 67.2 g·L –1 . By controlling the temperature, the hydrogen desorption capacity of the NaBH 4 -XE composite material was controllable, which has great potential for achieving solid-state hydrogen production from NaBH 4 .
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
Analytical Methods
·
2025
·
IF 2.6
Mo Chen,lidi Gao,Huiying Liu,Jiawen Yu,Fuquan Zhao,Ming Li Bai,Hongtao Chu,Ming Zhao,Shili Qin
A separation and determination method of dithiothreitol (DTT), as an important small molecule reducing agent, and dithioerythritol (DTE), as a C3-epimer of DTT, was developed by capillary electrochromatography. A functional MOF (His-ZIF-93) was first prepared by using ZIF-93 (synthesized via coordination between 4-methylimidazole-5-carbaldehyde and Zn2+) as the framework and D-histidine (D-His) as a modifier, and then was bonded to the inner wall of the capillary column to obtain His-ZIF-93 column by Schiff base reaction. The results showed that the baseline separation of DTT and DTE was easily obtained under a very wide experimental conditions with a extremely short analysis time with less than 3 min. Separation mechanism was proved by the binding constant experiments. There was a good linearity between concentration (0.10-5.0 mg/mL) and peak area of DTT and DTE (R2 ≥ 0.996), and the relative standard deviations for the peak area and the retention time were less than 0.93%. The average impurity content of DTE in a 5.0 mg/mL DTT were 0.79%. Thus, the method was able to realize for the simple and fast separation and precise quantification of DTT and DTE.
研究领域:
分析化学
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生物化学
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Ala’a Mhmoued Abdllh Alboull,Hao Jiang,Tasneem Omda Edrees Isaa,Zhiyong Dong,Tadele Eticha,Guobao Xu
Sugar alcohols are low-calorie sugar substitutes commonly used in sugar-free products. In this study, we report for the first time Ru(bpy)32+ electrochemiluminescence (ECL) of sugar alcohols. Ru(bpy)32+ ECL of sugar alcohols, including sorbitol, mannitol, isbitol (also called isomalt, isomaltitol, and palatinitol), maltitol, lactitol, xylitol, and erythritol, was investigated. The applicability of the Ru(bpy)32+ ECL system for sugar alcohol detection was demonstrated by using sorbitol as a representative analyte. The optimized system exhibited excellent analytical performance, with a wide linear detection range from 0.5 μM to 5 mM and a low detection limit of 0.026 μM (S/N = 3). In practical applications, the system demonstrated outstanding accuracy in detecting sorbitol in pharmaceutical samples, with recovery rates ranging from 97.75 to 104.00%. These findings establish the Ru(bpy)32+ ECL as an effective and sensitive method for the detection of sugar alcohols.
研究领域:
分析化学
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电化学
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食品科学
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药物分析
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产品关联
DOI
PubMed
高影响因子
SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2023
·
IF 6.9
Xuefeng Shao,Yeke Chenxu,Binrui Wang,Nan Zhang,Yanping Yuan
Towards latent heat storage for days, or even extending to months in the context of solar energy utilization, the exploration of phase change materials (PCMs) with stable supercooling and the following crystallization triggering are carried out. The present work confirmed the persistent supercooling property of the xylitol/erythritol eutectic mixture. The coupled technique combining mechanical agitation with seeding was proposed to trigger crystallization, so as to facilitate the heat retrieval whenever heat is in demand. The xylitol/erythritol eutectic keeps supercooling state without crystallization at ambient temperature for at least 10 days, thus it can serve as applicable PCM for controllable heat retrieval. Such severe supercooling is mainly attributed to the particular molecular structure of polyalcohols and dramatic increase of dynamic viscosity . In particular, on the basis of secondary nucleation principle, the coupled technique combining mechanical agitation and seeding can be a preferable technique to efficiently trigger crystallization of the present eutectic PCM , so as to realize controllable heat retrieval. Such combined technique has main advantages of high efficiency and reproducible crystallization process . The agitation duration is shortened to 1.8 min with seeding, in comparison to a longer value of 43.3 min without seeding. Although the single technique of mechanical agitation can also trigger the crystallization, the agitation is found to be time-consuming and the triggered crystallization process is in poor consistency among parallel specimens. Furthermore, the crystallization initiating is greatly advanced with high agitation rate (300 r/min), and the agitation duration to sufficiently activate crystallization can be significantly shortened. The results suggest that appropriately high agitation rate favors the efficient heat retrieval. The obtained results are helpful to gain a better understanding on the supercooled PCMs based controllable heat retrieval.
研究领域:
材料科学
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热能存储
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物理化学
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能源材料
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传热学
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DOI
高影响因子
POLYMER
·
2024
·
IF 4.1
Rui Hong,Ri-Tong Lan,Yue Ren,Lu Xu,Yun-Xiang Xu,Nouman Ali Shah,Rizwan M. Gul,Shishu Huang,Lingli Li,Jia-Zhuang Xu,Zhong-Ming Li,Ka Li
Oxidation resistance is strongly necessary for the use of crosslinked ultrahigh molecular weight polyethylene (UHMWPE) in artificial joints. The hybrid antioxidant strategy emerged as a promising alternative to the single rival that relies on vitamin E (VE). The goal of this study was to investigate the universality of the antioxidant synergy between VE and sugar alcohol (SA). Three types of SA, including D-sorbitol, maltitol and erythritol, were employed to cooperate with VE. Compared to the use of VE alone, these hybrid antioxidants generally enabled the corresponding UHMWPE composites with prolonged oxidation induction time (OIT) and increased crosslink density. The correlation between OIT and crosslink density of VE/SA-stabilized UHMWPE composites showed low attenuation. The applicability of the hybrid antioxidants to protect UHMWPE against oxidation was further demonstrated using the in vitro clinically relevant accelerated aging. Among the used SA, D-sorbitol exhibited the strongest ability to enhance the synergetic efficiency. The possible mechanism was revealed from the following aspects: the number of secondary hydroxyls per molecular mass and the molecular polarity determined via polarity parameter calculation. These findings provide significant insights for fabricating UHMWPE bearing materials with superior comprehensive performance and extended service longevity.
研究领域:
材料科学
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生物医学工程
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高分子化学
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产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2016
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IF 1.835
Chunying Zhu,Xiaofen Ren,Youguang Ma
Densities (ρ) and viscosities (η) of aqueous xylitol solutions with glycine, l-alanine, l-valine, l-threonine, or l-arginine were measured at T = (293.15 to 323.15) K under atmospheric pressure. The density values were utilized to further calculate the apparent molar volume (Vφ), the limiting partial molar volumes of amino acids (Vφ0), the limiting partial molar volumes of transfer (ΔtrVφ0) and the interaction coefficients Vab, Vabb, Vabbb. The viscosity data were used to obtain viscosity B-coefficient, the free energies of activation per mole of solvent (Δμ10≠) and solute (Δμ20≠). The limiting partial molar volumes of transfer and the free energies of activation per mole of both solvent (Δμ10≠) and solute (Δμ20≠) were analyzed based on the cosphere overlap model and transition state theory, respectively. The hydration number of amino acid was determined using the obtained limiting partial molar volume and viscosity B-coefficient.
研究领域:
生物化学
·
物理化学
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产品关联
DOI
高影响因子
FUEL PROCESSING TECHNOLOGY
·
2014
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IF 3.019
Dong-Can Lv,Yun-Quan Liu,Shui-Rong Li,Yue-Yuan Ye,Duo Wang
In this work, direct production of heavier hydrocarbons from biomass-derived xylitol by reduction with hydroiodic acid (HI) in the presence of phosphorous acid (H 3 PO 3 ) was studied. The effects of the feed ratio of raw materials, mixing intensity, and reaction time on catalytic performance were investigated by experiments. It was found that the molar ratio of xylitol/HI and H 2 O/HI had significant effects on the conversion of xylitol and yield of hydrocarbons. A maximum yield of 80.3% for hydrocarbons was achieved at a xylitol/HI/H 3 PO 3 /H 2 O molar ratio of 0.4:1:2:12, a mixing intensity of 800 rpm, and a reaction time of 12 h. High performance liquid chromatography (HPLC) and gas chromatograph/mass spectrometer (GC/MS) were used to determine the amount of xylitol and to analyze the composition of hydrocarbon products, respectively. The hydrocarbons obtained are mainly C 10 and C 15 hydrocarbons with aromatic rings , which have a high heating value of 43 kJ/g, making them suitable for diesel or/and jet fuel substitutes.
研究领域:
生物化学
·
可再生能源
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DOI
高影响因子
npj Science of Food
·
2025
·Vol. 9
·期 1
·1-10
·
IF 7.8
Chen Lichun,Yao Feng,Xue Songwen,Yao Kuang,Huang Yun,Zhao Huimin,Shao Qiong
Sugar alcohols are natural sweeteners with various physiological functions, commonly used in low-calorie foods and pharmaceuticals. Current research primarily focuses on their sweetening properties and metabolic effects, often overlooking their interactions with cell membranes. This study built a giant phospholipid vesicle model to examine vesicle deformation in erythritol (Ery) and xylitol (Xyl) environments. The permeation of these sugar alcohols through real cell membranes was also investigated. Fluorescence microscopy and zeta potential measurements showed that osmotic stress from concentration gradients disrupted vesicle membrane structure. Ery and Xyl reduced ROS levels in HEK-293 cells and influenced membrane permeability. Notably, Xyl increased vesicle adsorption on the cell membrane at the same concentration. The findings indicate that sugar alcohols interact with membrane lipids through hydrogen bonds or other non-covalent interactions, modifying cell membrane structure and properties, thus providing a theoretical foundation for understanding their role in physiological environments.
研究领域:
生物物理学
·
细胞生物学
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产品关联
DOI
PubMed
高影响因子
Frontiers in Chemistry
·
2020
·
IF 3.693
Yang Juncheng,Jia Yihong,Fan Chao,Cheng Yu,Pan Cheng,Huang Benhua,Meng Xu,Zhang Junjie,Zheng Aqun,Ma Xiaomo,Li Xiaoyong,Luque Rafael,Sun Yang
The aqueous room temperature mono-dehydration of sugar alcohols (D-sorbitol and D-mannitol) was conducted using functionalized yttrium oxide nanocatalysts prepared via sol-gel methods. Materials exhibited high selectivity to mono-dehydration products. Solvent and catalyst effects were also investigated and discussed. The introduction of titanium into the yttrium oxide framework would decrease both substrate conversion and mono-dehydration efficiency. In addition, studies of the catalytic mechanism indicate high mono-dehydration efficiency may come from the stability of the formed intermediate during catalysis. This work provides a highly efficient and benign system for catalytic mono-dehydration of sugar alcohols.
研究领域:
化学工程
·
催化科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Meng-Jie Tang,Yu-Tong Ye,Zhen-Zhen Li,Mi-Zhuan Li,Pan-Pan Chen,Qi-Le Zuo,Mian Li,Zhong-Xiu Chen
The effects of metformin on invertase activity and its inhibition on sucrose digestion were studied. The rapid unfolding kinetics of invertases, followed a two-state model with an inactive intermediate formation. The dynamic interaction between metformin and invertase caused the secondary structure of the enzyme to become less β-sheet, more α-helix, and random coiling oriented, which weakened the binding force between enzyme and its substrate. Metformin acted as a chaotrope and disrupted the hydrogen bonds of water, which facilitated the unfolding of invertase. However, some sugar alcohols, which promoted the H-bond formation of water, could repair the secondary structure of metformin-denatured invertase and therefore regulate the enzyme activity. This research enriches our understanding of the mechanism of enzyme unfolding induced by guanidine compounds. Moreover, because metformin and sugar substitutes are of concern to diabetes, this research also provides useful information for understanding the activity of the digestive enzyme that coexists with metformin and sugar alcohols.
研究领域:
生物化学
·
药理学
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产品关联
DOI
PubMed
高影响因子
FLUID PHASE EQUILIBRIA
·
2013
·
IF 2.379
Xiang Liu,Yonghong Hu,Wenge Yang,Yan Liu,Mengmeng Liang
Data on corresponding solid–liquid equilibrium of erythritol in methanol, ethanol and methanol + ethanol was measured with temperature range from 283.15 K to 333.15 K under atmospheric pressure by employing the gravimetric method. The experimental results indicated that the solubility of erythritol in the solvents increases with increasing both temperature and mass fraction of organic solvents. The experimental data were well-correlated with the modified Apelblat equation, the λh equation and the van’t Hoff equation. In addition, the calculated solubilities showed good agreement with the experimental results. It was found that the modified Apelblat equation could obtain the better correlation results than the other two models. The standard enthalpy, standard entropy, and Gibbs free energy change of solution of erythritol were calculated from the solubility data by using the modified Apelblat model and the van’t Hoff equation. What's more, the experimental data and model parameters would be useful for optimizing the process of purification of erythritol in industry.
研究领域:
食品科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）