The production of amine intermediates from biomass is capturing increasing attention. Herein, an efficient conversion of furfural to furfural amine over RuCo/AC catalyst under hydrothermal conditions has been investigated. The effects of different carriers, bimetals, and reaction conditions were systematically investigated in green solvents (water). Fully conversion of furfural and high furfural amine yield (92.13%) at 80 ℃ for 1 h over 4Ru1Co/AC. The excellent catalytic performance of 4Ru1Co/AC was attributed to its high acidity and good hydrogenation ability, as well as the synergistic effect between Ru-Co alloy formations and the activated carbon. Importantly, the highly selective preparation of furfural to furfural amine is a promising way to high-value utilization of cellulosic biomass in green solvents.
The objective of this study was to develop an injectable hydrogel based on furfuryl amine-conjugated hyaluronic acid (FA- conj -HA) and evaluate the in vivo anti-4 T1 tumor activity of doxorubicin-loaded hydrogel (DOX@FA- conj -HA gel ). The cargo-free hydrogel (FA- conj -HA gel ) was fabricated through a Diels-Alder reaction at 37 °C with FA- conj -HA as a gel material and four armed poly(ethylene glycol)2000-maleimide (4-arm-PEG2000-Mal) as a cross-linker. The bio-safety of FA- conj -HA gel were assessed, and the in vivo antitumor activity of DOX@FA- conj -HA gel was also investigated. Many 3D network structures were observed from scanning electron microscope (SEM) photograph, confirming the successful preparation of FA- conj -HA gel . The absence of cytotoxicity from FA- conj -HA gel was proved by the high viability of 4 T1 cells. In vivo bio-safety studies suggested that the obtained FA- conj -HA gel did not induce acute toxicity or other lesions in treated mice, confirming its high bio-safety. The reduced tumor volumes, hematoxylin-eosin staining (H&E), and TdT-mediated dUTP-biotin nick end labeling (TUNEL) analysis indicated the potent in vivo anti-4 T1 tumor effects of DOX@FA- conj -HA gel . In conclusion, the favorable bio-safety and potent antitumor activity of DOX@FA- conj -HA gel highlighted its potential application in oncological therapy.
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