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SPECTROSCOPY LETTERS · 2020 · IF 0.88

Molecular spectroscopic behaviors of beta-arbutin in anti-skin cancer

Yanbin Su,Xuwei Sun,Ruixue Wu,Xing Zhang,Yunzhou Tu

The purpose of this study was to explore the molecular spectroscopic behaviors of the beta-arbutin on the toxic aldehyde of trans-crotonaldehyde in anti-skin cancer. Results revealed that both hydroxymethyl and phenolic hydroxyl of beta-arbutin led to the shift of the maximum ultraviolet peak of trans-crotonaldehyde from a very significant absorption peak at 300 nm to a very weak absorption peak at 310 nm and the significant shift of the aldehyde Raman band at 1689/cm of the toxic trans-crotonaldehyde in mitochondria and aldehyde dehydrogenase, respectively. The beta-arbutin acting on the toxic trans-crotonaldehyde highlighted the potential of anti-skin cancer and provided a valuable clue for the new application of the beta-arbutin.

CAS / MDL: 76-03-9

研究领域: 药学化学 · 光谱学 · 癌症研究

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INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE · 2018 ·Vol. 41 ·期 6 ·3195-3202 · IF 2.784

Effect of lithocholic acid on biologically active α,β-unsaturated aldehydes induced by H2O2 in glioma mitochondria for use in glioma treatment

Dan Wang,Li Bie,Yanbin Su,Haoran Xu,Fengrong Zhang,Yanwen Su,Bo Zhang

Lithocholic acid (LCA) is known to kill glioma cells while sparing normal neuronal cells. However, the anti-glioma mechanism of LCA is unclear at present. Although malondialdehyde (MDA) is not specific to detect tumors, biologically active α,β-unsaturated aldehydes can be used to detect the outcome of gliomas, especially the mitochondria, as a research tool. The purpose of this research was to determine the optimum conditions for a lipid peroxidation model, according to changes in the aldehydes formed from the reaction between 2-thiobarbituric acid and biologically active α,β-unsaturated aldehydes. Experimental methods and procedures were successfully established for a model of lipid peroxidation induced by H2O2 in glioma mitochondria for glioma treatment and optimum conditions for LCA treatment were determined. The optimal conditions for the model were a glioma mitochondrial concentration of 1.5 mg/ml, H2O2 concentration of 0.3 mg/ml, duration of action of 30 min, and addition of 4.0 ml of 46 mM thiobarbituric acid. The effect of LCA, as determined by changes in the UV peaks at 450, 495, and 532 nm, was optimal at a concentration of 100 µM, a duration of action of 15 min, and in an acidic microenvironment. The study concluded that a suitable concentration of LCA has anti-glioma effects as determined by the effect on changes in the UV peaks at 450, 495 and 532 nm and the mitochondrial model developed should be conducive to further in-depth research.

CAS / MDL: 7722-84-1 434-13-9

研究领域: 癌症研究 · 神经科学 · 药理学 · 细胞生物学

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Molecular spectroscopic behaviors of beta-arbutin in anti-skin cancer

Effect of lithocholic acid on biologically active α,β-unsaturated aldehydes induced by H2O2 in glioma mitochondria for use in glioma treatment