Schisandrin B (Sch B), a natural lignan extracted from schisandra chinesis, has exhibited various pharmacological activities including anticancer effects. However, studies on the preclinical toxicokinetic profile of Sch B have not been publicly reported. This study aimed to investigate the preclinical concomitant toxicokinetics of multiple administration of Sch B. Sch B was administered orally to rats and dogs at 150, 300, and 600 mg/kg/day and 50, 100, and 200 mg/kg/day, respectively, for 26 weeks. Plasma concentrations of Sch B were determined by a validated HPLC–MS/MS method. According to the toxicokinetic results, significant gender differences were observed in the rats, and females had higher exposures than males for each dosing group. Toxicokinetic analysis demonstrated a notable accumulation in the plasma of dogs during the repeated administration of Sch B, and the degree of accumulation increased with the increase of the dose. The findings of this study indicated that there were differences in the concomitant toxicokinetics of Sch B between rats and dogs. These results can inform clinical studies and provide valuable insights for future human Sch B risk assessments.
Haoxia Ma,Hongfa Yu,Jinliang Tian,Yongshan Tan,Bo Da
Icing pressure testing was conducted to investigate the icing pressure ( I p ) of chloride-based deicers and discuss the relation between I p and the freeze-thaw deterioration of concrete induced by chloride deicers. During the icing pressure test, when the solution transformed from the liquid to the solid phase, undercooling occurred, and the heat of the liquid-solid phase transformation was released. The I p of chloride deicers and water reached a plateau near −30 °C. The stable I p value of water was the highest of that of the chloride solutions followed by that of 3.5% NaCl; the I p of 3.5% CaCl 2 was slightly higher than that of 3.5% MgCl 2 . The concept of the I p cumulative effect with time ( S ) was first proposed to determine the freeze-thaw destruction induced by chloride-based deicers. The durable life of the concrete exposed to chloride-based deicers decreased with the S of the deicers, and the mass loss of the concrete increased with the S of the deicers.
危险品化学品经营许可证（带存储）