CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Huixin Wang,Wenshen Wang,Chengpan Li,Ao Xu,Bensheng Qiu,Fenfen Li,Weiping Ding
Microneedles (MNs) are an attractive strategy for the efficient, painless transdermal delivery of drugs with low systemic toxicity. In this work, a novel near-infrared (NIR) light-triggered separable microneedle system was fabricated to supply controlled chemo-thermal therapy to superficial tumors by co-loading a self-developed NIR-II fluorescence fluorophore Flav7 and the antitumor drug doxorubicin (DOX) in phase-change polycaprolactone (PCL) arrowheads on a soluble base. For the MNs we proposed, Flav7 offers MNs with NIR light-triggered heating generation and drug release properties as well as a NIR-II imaging ability for guiding combined chemo-thermal therapy, and the soluble supporting base ensures that the needle arrows are embedded in the skin after insertion and endows the MNs with a separation ability to reduce the contact time of the MNs with the skin. In vitro studies showed that Flav7 + DOX-loaded MNs exhibited adequate insertion abilities, stable thermal properties, and desirable light-activated melting effects and drug release capabilities. In vivo studies showed that the Flav7 + DOX-loaded MNs presented a remarkable NIR-II imaging ability, a good biosafety to the major organs, and a strong tumor-killing ability. It is worth noting that all of the treated breast cancer mice survived for 50 days without tumor recurrences or major organ damage. This study presented a promising MN system loaded with the multipurpose small molecule Flav7 that can be used for high-efficiency light-activated drug release for chemotherapy and high-performance light-controlled thermotherapy of tumors and also for remarkable NIR-II fluorescence imaging to guide chemo-thermal therapy.
研究领域:
生物医学工程
·
肿瘤学
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2025
·
IF 12.1
Xinran Wang,Heng Dai,Yichun Liu,Linglu Kuang,Hao Song,Zhaowei Teng,Dawei Wang,Ting Wang,Xuhui Xu
Near-infrared (NIR) luminescence has emerged as a powerful tool in biological imaging due to its nondestructive nature, high spatiotemporal resolution, and deep tissue penetration. However, traditional NIR imaging often fails to provide detailed information about hard tissues such as bones. In this study, an approach for simultaneous imaging of soft and hard tissues using Lu 1.5 Mg 1.5 Al 3.5 Si 1.5 O 12 : Yb 3+ as an NIR scintillator is presented. Under X-ray irradiation, Lu 1.5 Mg 1.5 Al 3.5 Si 1.5 O 12 : Yb 3+ scintillator emits NIR emission with a peak at 970 nm with thermal quenching resistance, which is strongly absorbed by soft tissues, enabling soft tissue imaging. Additionally, the scintillator provides a high signal-to-noise ratio for X-ray imaging, allowing for high-resolution imaging of hard tissues, unaffected by ambient light, with a spatial resolution of up to 203 µm. By leveraging X-ray as the sole excitation source, this method provides a comprehensive view of internal biological structures, including vascular and skeletal tissues, with high resolution and minimal interference. This innovation holds great promise for advancing medical imaging technologies and enhancing diagnostic capabilities.
研究领域:
医学影像学
·
生物物理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2019
·
IF 2.931
Chunqing Li,Qi Sun,Qiang Zhao,Xinjian Cheng
It’s of vital importance to detect heavy metals in environment and living cells. In this work, four near-infrared regions boron dipyrromethene (BODIPY) probes (QBPH, PBPH, QBP and PBP) are constructed based on two BODIPY precursors (QB, PB) for sensing of Fe 3+ . As expected, these four probes exhibit obvious colorimetric and ratiometric response to Fe 3+ . In addition, QBP and PBP display highly sensitive and selective performance for detection of Fe 3+ . More importantly, QBP and PBP are successfully applied to near infrared imaging and detection of Fe 3+ in living A549 cells; it indicates that these novel designed probes could be a useful tool for the studies of Fe 3+ in living cells.
研究领域:
生物化学
·
分析化学
·
细胞生物学
✓ 已验证
DOI
高影响因子
Progress in Natural Science-Materials International
·
2024
·
IF 4.8
Qinli Ye,Jinhui Lin,Guoxiang Wang,Shuwen Zeng,Tao Jiang,Xiang Gao,Muhammad Danang Birowosuto,Wei Xiong,Chenjie Gu
Infrared thermography technology is a noninvasiveness and real-time imaging method, it has attracted enormous attentions for blood flow imaging. However, the implementation of infrared thermography technology is still limited by the poor imaging quality caused by the low temperature discrimination between the target blood vessel and background. Herein, we reported a flexible and low-cost MXene based photothermal microheater for enhancing the infrared imaging of blood flow. In the experiment, MXene films with specific thickness was prepared by vacuum filtering different concentrations of MXene colloidal solutions. Thereafter, the microheaters were fabricated by assembling the MXene films on the PU tape/PDMS substrate, and then sealed with another layer of pure PDMS film on the top of MXene film. The photothermal performance of the microheaters were evaluated by using an 808-nm laser as the exciting source. Experimental results show that the optimal microheater (MXene content: 17.5 mg) can reach a safe temperature of 41.5 °C with 43.9 s under the light irradiation of 100 mW·cm −2 . Moreover, it can be stabilized at the equilibrium temperate for over 25 min. Finally, the above optimal microheater was used to accurately heat the simulated blood vessel. It shows that temperature difference of 3.3 °C can be induced between the heated blood vessel and environment. As a result, it significantly enhances the quality of the infrared imaging of the blood flow in the simulated vascular network.
研究领域:
生物医学工程
·
材料科学
·
医学影像学
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Ge Mu,Xiaolong Zheng,Yimei Tan,Yanfei Liu,Qun Hao,Kangkang Weng,Xin Tang
Room-temperature operation or high-operation temperature (HOT) is essential for mid-wave infrared (MWIR) optoelectronics devices providing low-cost and compact systems for numerous applications. Colloidal quantum dots (CQDs) have emerged as a rising candidate to enable photodetectors to operate at HOT or room temperature and develop the next-generation infrared focal plane array (FPA) imagers. Here, band-engineered heterojunctions are demonstrated to suppress dark current with well-passivated mercury telluride (HgTe) CQDs enabling room-temperature MWIR imaging by single-pixel scanning and 640 × 512 FPA sensitive thermal imaging above 250 K. As a result, the room-temperature detectivity reaches as high as 1.26 × 10 10 Jones, and the noise equivalent temperature difference ( NETD ) is as good as 25 mK up to 200 K.
研究领域:
材料科学
·
光学工程
·
电子工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYST
·
2020
·Vol. 146
·期 3
·1032-1039
·
IF 3.978
Jianlin Pu,Chang Liu,Bin Wang,Pei Liu,Yanzi Jin,Jiucun Chen
Carbon dots (CDs) have demonstrated considerable potential for use in sensing and bioimaging applications based on their unique intrinsic properties. However, CDs have typically been used as fluorescence sensors, as opposed to indicators, based on their ultraviolet absorption and discoloration performance. In this study, orange red-emitting CDs with a high quantum yield (QY) of 53% were constructed from 2,3-diaminopyridine via solvothermal synthesis. Different from the fluorescence quenching behavior reported previously, the constructed CDs demonstrated a unique character in their ultraviolet absorption and fluorescence emission in the presence of Fe3+. The color of the CD solution varied from mauve to orange following the addition of Fe3+ at concentrations exceeding 1 μM, which enabled these CDs to be used in the determination of the presence of Fe3+ in lake water. In addition, due to their negligible cytotoxicity, good solubility, and adequate dispersity, an outstanding cellular probe with near-infrared fluorescence was established. Overall, this study presents a unique CD-based sensor, details its fluorescence mechanism, visual colorimetry, and ultraviolet absorption variations, and confirms its applicability in near-infrared cellular imaging and environmental analyses.
研究领域:
分析化学
·
生物医学工程
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
BIOMATERIALS
·
2014
·
IF 8.312
Yang Wang,Tao Liu,Erlong Zhang,Shenglin Luo,Xu Tan,Chunmeng Shi
Personalized oncology significantly relies on the development of theranostic agents to integrate cancer therapeutics and diagnostics. Current strategy for development of such multifunctional agents requires multistep chemical conjugation with cancer specific ligands, contrast agents and therapeutic drugs. In this study, we reported a near infrared (NIR) heptamethine indocyanine dye, IR-780, which selectively accumulated in the mitochondria of drug-resistant human lung cancer cells (A549/DR) and significantly inhibited cell growth, self-renewal and migration without the need of any chemical conjugation. IR-780 was also able to induce A549/DR cell apoptosis by disrupting the mitochondrial function. Furthermore, IR-780 dye exhibited remarkable tumoricidal activity and inhibited tumor recurrence in mouse syngeneic Lewis lung carcinoma xenograft model. With the unique properties of targeting, near infrared imaging and inhibitive effect to the drug-resistant cancer cells both in vitro and in vivo, IR-780 may represent a potential theranostic agent for tumor recurrence.
研究领域:
肿瘤学
·
药理学
·
细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
Biomaterials Science
·
2016
·Vol. 4
·期 11
·1638-1645
·
IF 3.614
Le Liu,Zheng Ruan,Tuanwei Li,Pan Yuan,Lifeng Yan
Near infrared (NIR) imaging-guided photodynamic therapy (PDT) is attractive, especially the utilization of one dye as both a photosensitizer and fluorescent probe, and the as-synthesized BODIPY-Br2 molecule is a candidate. Here, a galactose targeted amphiphilic copolymer of a polypeptide was synthesized and its micelles work as nanocarriers for BODIPY for targeting the NIR imaging-guided PDT of hepatoma cancer cells. At the same time, BODIPY could light up the cytoplasm for real-time imaging and kill cancer cells when the light was switched on. In vitro tests performed on both HepG2 and HeLa cells confirmed that the as-prepared PMAGP-POEGMA-PLys-B micelles showed efficient cell suppression of the cells with galactose receptors in the presence of light under an extremely low energy density (6.5 J cm−2). This protocol highlights the potential of polypeptides as biodegradable carriers for NIR image-guided and confined targeting photodynamic therapy.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Device
·
2025
·
IF 8
Hao Wang,Wenjia Zhou,Yunlong Liu,Haobo Wu,Si Peng,Wei Xuan Liu,Ruiqi Xu,Wei Zhou,Mingyu Ma,Gaoqi Liu,Juan Du,Yuxin Leng,Zhiqun Lin,Wei Lu,Zhijun Ning
An upconversion device uses a methodology for direct infrared imaging, but the performance is limited by the inefficient carrier transmission between infrared detecting and emitting layers. Herein, we developed an upconversion infrared imaging device by integrating infrared quantum dots and a perovskite quantum well emitter. The energy level of the perovskite quantum well aligns well with the infrared quantum dot, leading to an effective carrier transition between them, generating a photon conversion efficiency of over 10% and a high on-off ratio of 45.5. The device shows a resolution of 11 μm, 3-fold higher than the best value achieved for solution-processed infrared upconversion devices. Furthermore, based on solution-phase ligand exchange, a large-area homogeneous 3 × 3 cm upconversion device is fabricated. The large-area device shows an estimated pixel scale of over 7 million pixels, enabling it to be used for direct infrared visualization.
研究领域:
光学工程
·
材料科学
·
电子工程
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2018
·
IF 3.997
Xijian Liu,Yeying Wang,Qiyang Yu,Guoying Deng,Qian Wang,Xinhui Ma,Qiugen Wang,Jie Lu
A multifunctional selenium nanocomposite (selenium@silica core-shell nanoshperes for loading indocyanine green(ICG)/Doxorubicin(DOX)) was fabricated to reach visible and efficient cancer treatment. The Se@SiO 2 -ICG nanocomposites could be used not only as excellent photothermal agents but also as carriers for DOX delivery. In addition, the Se@SiO 2 -ICG/DOX nanocomposites exhibited excellent fluorescence imaging and infrared imaging performance. Tumor could be effectively inhibited by Se@SiO 2 -ICG/DOX due to the triple treatment of photothermal effect and chemotherapy of selenium and DOX. Thus, the Se@SiO 2 -ICG/DOX nanocomposites have a great potential in imaging guiding synergistic treatment of cancer.
研究领域:
肿瘤学
·
纳米医学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DYES AND PIGMENTS
·
2017
·
IF 3.473
Yang Liu,Zhensheng Li,Li Chen,Zhigang Xie
Near-infrared (NIR) multifunctional BODIPY-Platinum (BODIPY-Pt) conjugates were synthesized, which compose of fluorescent borondipyrromethene (BODIPY) dyes and therapeutic agents of cisplatin. BODIPY-Pt conjugates combined the NIR imaging, photodynamic therapy (PDT) and chemotherapy in one. BODIPY-Pt possesses the excellent phototoxicity at low concentration upon radiation and comparable chemotherapeutic toxicity with cisplatin. The cellular uptake and distribution were validated by confocal laser scanning microscopy . In addition, the in vivo studies on bearing U14 tumor-bearing mice demonstrated that the BODIPY-Pt conjugates simultaneously keep the fluorescent imaging and antitumor effect.
研究领域:
药理学
·
生物医学工程
·
肿瘤学
✓ 已验证
DOI
高影响因子
DYES AND PIGMENTS
·
2021
·
IF 4.889
Youliang Tian,Quan Cheng,Huiping Dang,Hongyun Qian,Changchang Teng,Kai Xie,Lifeng Yan
In PDT, high doses of photosensitizers can lead to prolonged patient photosensitivity and undesired side effects. As a classic fluorescent dye, BODIPY has attracted much attention in optical diagnosis and therapy due to its excellent stability, effective singlet oxygen production, and flexible modification. Herein, we synthesized successfully two organic near-infrared BODIPY derivatives with active groups. NO 2 -BDPI could be transformed into NH 2 -BDPI after responding to hydrogen sulfide in solution and brought an apparent color change. And both dyes possessed excellent single oxygen production capacity ( Φ Δ = 0.629 for NO 2 -BDPI and Φ Δ = 0.688 for NH 2 -BDPI). After being encapsulated with an amphiphilic polypeptide , NH 2 -BDPI could be assembled into nano–NH 2 –BDPI particles that own good water solubility and passively tumor-targeting via the enhanced permeability and retention (EPR) effect. Benefiting from the admirable cellular uptake and excellent intracellular ROS generation in vitro , the nano–NH 2 –BDPI shows splendid PDT effect towards 4T1 and HeLa cells under very low doses (0.24 μM) and NIR power density (660 nm 10 mW/cm 2 ). In vivo experiment, the nano-photosensitizer exhibited highly effective tumor suppression and ablation under a 40 mW/cm 2 NIR irradiation. The exploration demonstrated the commendable PDT effect of NH 2 -BDPI and made it be a potential candidate for further NIR imaging-guided PDT research in clinical application.
研究领域:
医学
·
药学
·
生物材料
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）